PE20121643A1 - Polipeptidos del factor ix modificados y usos de los mismos - Google Patents
Polipeptidos del factor ix modificados y usos de los mismosInfo
- Publication number
- PE20121643A1 PE20121643A1 PE2012000114A PE2012000114A PE20121643A1 PE 20121643 A1 PE20121643 A1 PE 20121643A1 PE 2012000114 A PE2012000114 A PE 2012000114A PE 2012000114 A PE2012000114 A PE 2012000114A PE 20121643 A1 PE20121643 A1 PE 20121643A1
- Authority
- PE
- Peru
- Prior art keywords
- polypeptide
- remains
- factor
- polypeptides
- conjugate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
SE REFIERE A UN POLIPEPTIDO DEL FACTOR IX QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS DE SEC ID Nº 2 QUE SE HA MODIFICADO INTRODUCIENDO UNA O MAS SUSTITUCIONES DE AMINOACIDOS EN LOS RESTOS DE AMINOACIDOS 85, 86, 87, 338 Y 410, Y QUE COMPRENDE ADICIONALMENTE UNO O MAS SITIOS DE GLUCOSILACION. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN CONJUGADO QUE COMPRENDE i) EL POLIPEPTIDO DEL FACTOR IX, ii) UNO O MAS RESTOS DE AZUCARES UNIDOS A DICHOS SITIOS DE GLUCOSILACION, Y iii) UNO O MAS RESTOS POLIMERICOS UNIDOS COVALENTEMENTE A UNO O MAS RESTOS DE AZUCAR TAL COMO POLIETILENGLICOL. DICHO POLIPEPTIDO O CONJUGADO SON UTILES EN EL TRATAMIENTO DE LA HEMOFILIA B
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23055109P | 2009-07-31 | 2009-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121643A1 true PE20121643A1 (es) | 2012-11-25 |
Family
ID=43529743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000114A PE20121643A1 (es) | 2009-07-31 | 2010-08-02 | Polipeptidos del factor ix modificados y usos de los mismos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20120164130A1 (es) |
| EP (1) | EP2461821A4 (es) |
| JP (1) | JP2013500726A (es) |
| KR (1) | KR20120060209A (es) |
| CN (1) | CN102573890A (es) |
| AU (1) | AU2010278721A1 (es) |
| BR (1) | BR112012002072A2 (es) |
| CA (1) | CA2769258A1 (es) |
| CL (1) | CL2012000238A1 (es) |
| CR (1) | CR20120052A (es) |
| CU (3) | CU20120018A7 (es) |
| DO (1) | DOP2012000030A (es) |
| EA (1) | EA201290069A1 (es) |
| EC (1) | ECSP12011637A (es) |
| GT (1) | GT201200023A (es) |
| IN (1) | IN2012DN00908A (es) |
| MX (1) | MX2012001346A (es) |
| PE (1) | PE20121643A1 (es) |
| SG (1) | SG178119A1 (es) |
| WO (1) | WO2011014890A1 (es) |
| ZA (1) | ZA201200716B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2101821B1 (en) | 2006-12-15 | 2014-08-13 | Baxter International Inc. | Factor viia- (poly) sialic acid conjugate having prolonged in vivo half-life |
| ES2940323T3 (es) | 2008-09-15 | 2023-05-05 | Uniqure Biopharma B V | Mutante de polipéptido factor IX, sus usos y un método para su producción |
| ES2856055T3 (es) | 2009-07-27 | 2021-09-27 | Baxalta GmbH | Glicopolisialilación de proteínas diferentes de las proteínas de coagulación de la sangre |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| SG178051A1 (en) | 2009-07-27 | 2012-03-29 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
| MX2012001207A (es) | 2009-07-27 | 2012-05-08 | Baxter Int | Conjugados proteicos de coagulacion sanguínea. |
| SG187171A1 (en) * | 2010-07-30 | 2013-02-28 | Baxter Int | Nucleophilic catalysts for oxime linkage |
| NZ612320A (en) | 2010-12-22 | 2015-06-26 | Baxter Healthcare Sa | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
| HUE036523T2 (hu) * | 2011-12-19 | 2018-07-30 | Dilafor Ab | Nem anti-koagulatív glikózaminoglikánok ismétlõdõ diszacharid egységgel és ezek gyógyászati alkalmazása |
| ES2744903T3 (es) * | 2012-11-20 | 2020-02-26 | Univ North Carolina Chapel Hill | Métodos y composiciones para proteínas del factor IX modificadas |
| MX2015012631A (es) * | 2013-03-13 | 2016-06-21 | Lilly Co Eli | Polipeptidos de leptina de canino modificados. |
| TW201519900A (zh) * | 2013-04-28 | 2015-06-01 | Bayer Healthcare Llc | 用於誘導對凝血因子蛋白之免疫耐受性的組成物及方法 |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| EA201890423A1 (ru) | 2015-08-03 | 2018-07-31 | Биовератив Терапьютикс Инк. | Слитые белки фактора ix, способы их получения и применения |
| US11708570B2 (en) | 2016-07-27 | 2023-07-25 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating Factor IX function |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520259A (zh) * | 2001-04-25 | 2004-08-11 | ���ݴ�ѧУ��ίԱ�� | 利用球状载体将第八因子/第九因子进行肝脏基因转移治疗血友病的方法 |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| JP4738346B2 (ja) * | 2003-12-03 | 2011-08-03 | ノヴォ ノルディスク アー／エス | ＧｌｙｃｏＰＥＧ化された第ＩＸ因子 |
| EP2423306A1 (en) * | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| US7700734B2 (en) * | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
-
2010
- 2010-08-02 EA EA201290069A patent/EA201290069A1/ru unknown
- 2010-08-02 US US13/388,288 patent/US20120164130A1/en not_active Abandoned
- 2010-08-02 AU AU2010278721A patent/AU2010278721A1/en not_active Abandoned
- 2010-08-02 MX MX2012001346A patent/MX2012001346A/es not_active Application Discontinuation
- 2010-08-02 KR KR1020127005191A patent/KR20120060209A/ko not_active Application Discontinuation
- 2010-08-02 WO PCT/US2010/044177 patent/WO2011014890A1/en active Application Filing
- 2010-08-02 IN IN908DEN2012 patent/IN2012DN00908A/en unknown
- 2010-08-02 CA CA2769258A patent/CA2769258A1/en not_active Abandoned
- 2010-08-02 CN CN2010800431356A patent/CN102573890A/zh active Pending
- 2010-08-02 BR BR112012002072A patent/BR112012002072A2/pt not_active IP Right Cessation
- 2010-08-02 JP JP2012523129A patent/JP2013500726A/ja active Pending
- 2010-08-02 PE PE2012000114A patent/PE20121643A1/es not_active Application Discontinuation
- 2010-08-02 EP EP10805185.5A patent/EP2461821A4/en not_active Withdrawn
- 2010-08-02 SG SG2012005757A patent/SG178119A1/en unknown
-
2012
- 2012-01-27 DO DO2012000030A patent/DOP2012000030A/es unknown
- 2012-01-30 CU CU20120018A patent/CU20120018A7/es unknown
- 2012-01-30 CL CL2012000238A patent/CL2012000238A1/es unknown
- 2012-01-30 CR CR20120052A patent/CR20120052A/es unknown
- 2012-01-30 GT GT201200023A patent/GT201200023A/es unknown
- 2012-01-30 EC EC2012011637A patent/ECSP12011637A/es unknown
- 2012-01-30 ZA ZA2012/00716A patent/ZA201200716B/en unknown
-
2013
- 2013-04-19 CU CU2013000057A patent/CU20130057A7/es unknown
- 2013-04-19 CU CU2013000058A patent/CU20130058A7/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201200716B (en) | 2013-07-31 |
| JP2013500726A (ja) | 2013-01-10 |
| DOP2012000030A (es) | 2012-02-29 |
| SG178119A1 (en) | 2012-03-29 |
| EA201290069A1 (ru) | 2012-07-30 |
| CR20120052A (es) | 2012-06-04 |
| KR20120060209A (ko) | 2012-06-11 |
| CN102573890A (zh) | 2012-07-11 |
| IN2012DN00908A (es) | 2015-04-03 |
| ECSP12011637A (es) | 2012-02-29 |
| CU20120018A7 (es) | 2012-06-21 |
| MX2012001346A (es) | 2012-02-17 |
| CU20130058A7 (es) | 2013-06-28 |
| CA2769258A1 (en) | 2011-02-03 |
| WO2011014890A1 (en) | 2011-02-03 |
| CL2012000238A1 (es) | 2012-10-05 |
| BR112012002072A2 (pt) | 2016-11-08 |
| AU2010278721A1 (en) | 2012-02-16 |
| US20120164130A1 (en) | 2012-06-28 |
| GT201200023A (es) | 2014-01-27 |
| CU20130057A7 (es) | 2013-06-28 |
| EP2461821A1 (en) | 2012-06-13 |
| EP2461821A4 (en) | 2013-07-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |