HUE036523T2 - Nem anti-koagulatív glikózaminoglikánok ismétlõdõ diszacharid egységgel és ezek gyógyászati alkalmazása - Google Patents

Nem anti-koagulatív glikózaminoglikánok ismétlõdõ diszacharid egységgel és ezek gyógyászati alkalmazása

Info

Publication number
HUE036523T2
HUE036523T2 HUE12858809A HUE12858809A HUE036523T2 HU E036523 T2 HUE036523 T2 HU E036523T2 HU E12858809 A HUE12858809 A HU E12858809A HU E12858809 A HUE12858809 A HU E12858809A HU E036523 T2 HUE036523 T2 HU E036523T2
Authority
HU
Hungary
Prior art keywords
coagulative
glycosaminoglycans
medical use
disaccharide unit
repeating disaccharide
Prior art date
Application number
HUE12858809A
Other languages
English (en)
Inventor
Hans-Peter Ekre
Per-Olov Eriksson
Ulf Lindahl
Erik Holmer
Original Assignee
Dilafor Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48668970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE036523(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dilafor Ab filed Critical Dilafor Ab
Publication of HUE036523T2 publication Critical patent/HUE036523T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
HUE12858809A 2011-12-19 2012-12-19 Nem anti-koagulatív glikózaminoglikánok ismétlõdõ diszacharid egységgel és ezek gyógyászati alkalmazása HUE036523T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161577223P 2011-12-19 2011-12-19

Publications (1)

Publication Number Publication Date
HUE036523T2 true HUE036523T2 (hu) 2018-07-30

Family

ID=48668970

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12858809A HUE036523T2 (hu) 2011-12-19 2012-12-19 Nem anti-koagulatív glikózaminoglikánok ismétlõdõ diszacharid egységgel és ezek gyógyászati alkalmazása

Country Status (28)

Country Link
US (1) US9475888B2 (hu)
EP (1) EP2794665B1 (hu)
JP (2) JP6543467B2 (hu)
KR (1) KR102135485B1 (hu)
CN (1) CN104144950B (hu)
AU (1) AU2012354229B2 (hu)
BR (1) BR112014014454B1 (hu)
CA (1) CA2856492C (hu)
CL (1) CL2014001651A1 (hu)
CO (1) CO7061069A2 (hu)
CY (1) CY1119899T1 (hu)
DK (1) DK2794665T3 (hu)
ES (1) ES2656613T3 (hu)
HK (1) HK1202883A1 (hu)
HR (1) HRP20180124T1 (hu)
HU (1) HUE036523T2 (hu)
IL (1) IL232905A (hu)
LT (1) LT2794665T (hu)
ME (1) ME02994B (hu)
MX (1) MX351104B (hu)
NO (1) NO2904345T3 (hu)
PL (1) PL2794665T3 (hu)
PT (1) PT2794665T (hu)
RS (1) RS56874B1 (hu)
RU (1) RU2617764C2 (hu)
SI (1) SI2794665T1 (hu)
WO (1) WO2013095279A1 (hu)
ZA (1) ZA201403640B (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
CA2868479A1 (en) * 2012-03-26 2013-10-03 Dilafor Ab Method for treatment of labor arrest
MX2014011505A (es) * 2012-03-26 2014-12-05 Dilafor Ab Terapias para inducir el parto.
AU2013260209A1 (en) * 2012-05-08 2014-11-20 Dilafor Ab Treatment of postpartum haemorrhage with chemically modified heparin or heparan sulphate and a uterotonic agent
GB2515315A (en) 2013-06-19 2014-12-24 Dilafor Ab New Processes
CN103788222B (zh) * 2014-01-08 2016-08-31 中国科学院昆明植物研究所 Fuc3S4S取代的低聚糖胺聚糖及其制备方法
SG11201609026UA (en) * 2014-04-30 2016-11-29 Agency Science Tech & Res Heparan sulphates
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
KR20220142508A (ko) 2020-02-17 2022-10-21 딜라포 아베 자간전증 치료용 타폭시파린
WO2023213788A1 (en) 2022-05-03 2023-11-09 Dilafor Ab New medical use of tafoxiparin
EP4272749A1 (en) 2022-05-03 2023-11-08 Dilafor AB New medical use of tafoxiparin

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1136620A (en) * 1979-01-08 1982-11-30 Ulf P.F. Lindahl Heparin fragments having selective anticoagulation activity
JPS63246396A (ja) * 1987-03-31 1988-10-13 Shiseido Co Ltd モノクロ−ナル抗体
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
SE9002550D0 (sv) * 1990-08-01 1990-08-01 Kabivitrum Ab Heparinfragment
SE9003181D0 (sv) 1990-10-04 1990-10-04 Kabivitrum Ab Use of heparin fraction
US5280016A (en) 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
US5250519A (en) 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
JPH0532703A (ja) * 1991-07-26 1993-02-09 Terumo Corp 低分子量ヘパリン誘導体の製造法
WO1994008595A1 (en) * 1992-10-13 1994-04-28 Virginia Commonwealth University Use of non-anticoagulant heparin for treating ischemia/reperfusion injury
US5527785A (en) 1993-05-14 1996-06-18 The Regents Of The University Of California Selectin receptor modulating compositions
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
DE69623840D1 (de) * 1995-03-31 2002-10-31 Hamilton Civic Hospitals Res Zusammensetzung zur Hemmung der Thromboseentstehung
US5993810A (en) 1996-03-15 1999-11-30 Lebovitz; Shamir Israel Method of softening or ripening the cervix of a female mammal using collagenase
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
JP4203611B2 (ja) 1996-10-15 2009-01-07 生化学工業株式会社 子宮頸管熟化剤
GB9711443D0 (en) * 1997-06-03 1997-07-30 Leo Pharm Prod Ltd Chemical suppositions
AU1173599A (en) * 1997-11-20 1999-06-15 Ikuo Yamashina Low-molecular heparin modification and remedy for skin ulcer
US6596705B1 (en) 1998-02-09 2003-07-22 The Regents Of The University Of California Inhibition of L-selectin and P-selection mediated binding using heparin
EP1059304B1 (en) 1998-02-26 2006-04-26 Seikagaku Corporation Novel polysaccharide derivatives, process for the production thereof and medicinal compositions containing the same as the active ingredient
US6028061A (en) 1998-06-18 2000-02-22 Children's Medical Center Corp Angiogenesis inhibitors and use thereof
DE69918523T2 (de) * 1998-07-31 2005-07-28 Seikagaku Corp. Neues glycosaminoglycan und dieses enthaltendes arzneimittel
WO2000013019A1 (en) * 1998-08-26 2000-03-09 The Collaborative Group, Ltd. Receptor for underivatized, aqueous soluble beta-(1,3)-glucan
CA2377734A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
PT1319183E (pt) * 2000-09-12 2009-06-29 Massachusetts Inst Technology Métodos e produtos relacionados a heparina de baixo peso molecular
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
US20040072796A1 (en) 2002-04-18 2004-04-15 Embury Stephen H. Method and composition for preventing pain in sickle cell patients
US8071569B2 (en) 2002-09-20 2011-12-06 Mousa Shaker A Oxidized heparin fractions and their use in inhibiting angiogenesis
JP2005106694A (ja) * 2003-09-30 2005-04-21 Mochida Pharmaceut Co Ltd 敗血症早期検出及び重篤度評価
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
US20060040896A1 (en) * 2004-08-18 2006-02-23 Paringenix, Inc. Method and medicament for anticoagulation using a sulfated polysaccharide with enhanced anti-inflammatory activity
US7741311B2 (en) 2005-01-03 2010-06-22 Shaker Mousa Composition and method for treating occlusive vascular diseases, nerve regeneration, and wound healing
BRPI0613677A2 (pt) 2005-07-22 2011-01-25 Trf Pharma Inc método para tratar doença de célula falsiforme e sequelas da doença de célula falsiforme
AU2006272780A1 (en) * 2005-07-22 2007-02-01 The Regents Of The University Of California Heparin compostions and selectin inhibition
EP2016394A4 (en) * 2006-04-04 2013-04-24 Singulex Inc METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES
CA2652205A1 (en) * 2006-05-25 2007-12-06 Mallik Sundaram Low molecular weight heparin composition and uses thereof
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
US9351992B2 (en) 2007-11-02 2016-05-31 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
CN101842392B (zh) * 2007-11-02 2014-08-27 动量制药公司 非抗凝血剂的多糖组合物
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
WO2009073184A1 (en) 2007-12-03 2009-06-11 Florida State University Research Foundation, Inc. Compositions for inducing labor and associated methods
AU2009231634B2 (en) 2008-04-04 2014-05-15 University Of Utah Research Foundation Alkylated semi-synthetic glycosaminoglycosan ethers, and methods for making and using thereof
CN102361911A (zh) * 2009-03-27 2012-02-22 阿克塔马克斯手术器材有限责任公司 聚甘油醛
DK2419736T3 (da) 2009-04-16 2014-04-22 Momenta Pharmaceuticals Inc Fremgangsmåder til vurdering af aktivitet af en polysaccharidsammensætning
WO2011000032A1 (en) 2009-06-30 2011-01-06 Walter And Eliza Hall Institute Of Medical Research Sulfated polysaccharides having antiplasmodial activity and methods and products for identifying antiplasmodial activity
EP2461821A4 (en) * 2009-07-31 2013-07-03 Bayer Healthcare Llc MODIFIED POLYPEPTIDES OF FACTOR IX AND USES THEREOF
US9066991B2 (en) * 2009-12-22 2015-06-30 Lifebond Ltd. Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
CA2868479A1 (en) 2012-03-26 2013-10-03 Dilafor Ab Method for treatment of labor arrest
MX2014011505A (es) 2012-03-26 2014-12-05 Dilafor Ab Terapias para inducir el parto.

Also Published As

Publication number Publication date
JP2015500388A (ja) 2015-01-05
CA2856492A1 (en) 2013-06-27
CL2014001651A1 (es) 2014-10-10
CN104144950B (zh) 2017-09-05
KR102135485B1 (ko) 2020-07-17
KR20140113652A (ko) 2014-09-24
DK2794665T3 (da) 2018-01-29
LT2794665T (lt) 2017-12-27
NO2904345T3 (hu) 2018-07-21
MX2014007122A (es) 2015-03-05
HRP20180124T1 (hr) 2018-02-23
CN104144950A (zh) 2014-11-12
PL2794665T3 (pl) 2018-04-30
IL232905A (en) 2017-02-28
WO2013095279A1 (en) 2013-06-27
EP2794665A1 (en) 2014-10-29
JP2018111825A (ja) 2018-07-19
ES2656613T3 (es) 2018-02-27
CO7061069A2 (es) 2014-09-19
ME02994B (me) 2018-10-20
CY1119899T1 (el) 2018-06-27
RU2014129816A (ru) 2016-02-20
PT2794665T (pt) 2018-01-24
AU2012354229A1 (en) 2014-06-05
CA2856492C (en) 2017-01-10
SI2794665T1 (en) 2018-03-30
BR112014014454B1 (pt) 2021-03-09
ZA201403640B (en) 2017-06-28
HK1202883A1 (en) 2015-10-09
RS56874B1 (sr) 2018-04-30
JP6543467B2 (ja) 2019-07-10
AU2012354229B2 (en) 2016-12-01
MX351104B (es) 2017-10-02
US20150011505A1 (en) 2015-01-08
EP2794665A4 (en) 2015-08-26
US9475888B2 (en) 2016-10-25
RU2617764C2 (ru) 2017-04-26
EP2794665B1 (en) 2017-11-22
IL232905A0 (en) 2014-07-31
BR112014014454A2 (pt) 2017-06-13

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