AR082941A1 - Metodo para conjugar un polimero hidrosoluble a una porcion de carbohidrato oxidado de una proteina terapeutica - Google Patents
Metodo para conjugar un polimero hidrosoluble a una porcion de carbohidrato oxidado de una proteina terapeuticaInfo
- Publication number
- AR082941A1 AR082941A1 ARP110102758A ARP110102758A AR082941A1 AR 082941 A1 AR082941 A1 AR 082941A1 AR P110102758 A ARP110102758 A AR P110102758A AR P110102758 A ARP110102758 A AR P110102758A AR 082941 A1 AR082941 A1 AR 082941A1
- Authority
- AR
- Argentina
- Prior art keywords
- soluble polymer
- water
- therapeutic protein
- oxidized carbohydrate
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Materiales y métodos para conjugar un polímero hidrosoluble a una porción de carbohidrato oxidado de una proteína terapéutica que comprende poner en contacto la porción de carbohidrato oxidado con un polímero hidrosoluble activado en condiciones que permiten la conjugación. Más específicamente, materiales y métodos antes mencionados, en donde el polímero hidrosoluble contiene un grupo aminooxi activo y en donde se forma un enlace de oxima o hidrazona entre la porción de carbohidrato oxidado y el grupo aminooxi en el polímero hidrosoluble, y en donde la conjugación se realiza en presencia de un catalizador nucleofílico.Reivindicación 1: Un método para conjugar un polímero hidrosoluble a una porción de carbohidrato oxidado de una proteína terapéutica, caracterizado porque comprende poner en contacto la porción de carbohidrato oxidado con un polímero hidrosoluble activado en condiciones que permiten la conjugación; dicho polímero hidrosoluble contiene un grupo aminooxi activo y se selecciona del grupo que consiste en polietilenglicol (PEG), PEG ramificado, PolyPEG® (Warwick Effect Polymers; Coventry, Reino Unido), ácido polisiálico (PSA), almidón, almidón de hidroxialquilo (HAS), almidón de hidroxietilo (HES), carbohidrato, polisacáridos, pululano, quitosano, ácido hialurónico, sulfato de condroitina, sulfato de dermatán, almidón, dextrano, carboximetil-dextrano, óxido de poliaquileno (PAO), polialquilenglicol (PAG), polipropilenglicol (PPG), polioxazolina, poliacriloilmorfolina, alcohol de polivinilo (PVA), policarboxilato, polivinilpirrolidona, polifosfaceno, polioxazolina, polietilen-co-anhídrido de ácido maleico, poliestireno-co-anhídrido de ácido de maleico, poli(1-hidroximetiletilen hidroximetilformal) (PHF), 2-metacriloiloxi-2’-etiltrimetilamoniofosfato (MPC); y dicha porción de carbohidrato oxidado por incubación con un amortiguador que comprende un agente de oxidación seleccionado del grupo que consiste en periodato de sodio (NalO4), tetraacetato de plomo (Pb(OAc)4) y perrutenato de potasio (KRuO4) en donde se forma un enlace de oxima entre la porción de carbohidrato oxidado y el grupo aminooxi activo en el polímero hidrosoluble; y en donde la formación del enlace de oxima se cataliza por medio de un catalizador nucleofílico seleccionado del grupo que consiste en ácido o-aminobenzoico, ácido m-aminobenzoico, ácido p-aminobenzoico, ácido sulfanílico, o-aminobenzamida, o-toluidina, m-toluidina, p-toluidina, o-anisidina, m-anisidina y p-anisidina. Reivindicación 23: El método de acuerdo con cualquiera de las reivindicaciones 2 - 22, caracterizado porque la proteína terapéutica es FIX. Reivindicación 24: El método de acuerdo con cualquiera de las reivindicaciones 2 - 22, caracterizado porque la proteína terapéutica es FVlIa. Reivindicación 25: El método de acuerdo con cualquiera de las reivindicaciones 2 - 22, caracterizado porque la proteína terapéutica es FVII. Reivindicación 53: Una proteína terapéutica modificada, caracterizada porque ha sido producida mediante el método de acuerdo con cualquiera de las reivindicaciones 1 - 52.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36918610P | 2010-07-30 | 2010-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082941A1 true AR082941A1 (es) | 2013-01-23 |
Family
ID=44629987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102758A AR082941A1 (es) | 2010-07-30 | 2011-07-29 | Metodo para conjugar un polimero hidrosoluble a una porcion de carbohidrato oxidado de una proteina terapeutica |
Country Status (25)
| Country | Link |
|---|---|
| EP (3) | EP4023247A1 (es) |
| JP (7) | JP6325818B2 (es) |
| KR (6) | KR102325780B1 (es) |
| CN (3) | CN103370082A (es) |
| AR (1) | AR082941A1 (es) |
| AU (1) | AU2011282571C1 (es) |
| BR (1) | BR112013001611B1 (es) |
| CA (1) | CA2806684C (es) |
| CY (1) | CY1121943T1 (es) |
| DK (1) | DK2598172T3 (es) |
| EA (2) | EA025738B9 (es) |
| ES (1) | ES2731626T3 (es) |
| HR (1) | HRP20190990T1 (es) |
| HU (1) | HUE043790T2 (es) |
| LT (1) | LT2598172T (es) |
| MX (1) | MX346271B (es) |
| NZ (1) | NZ605972A (es) |
| PL (1) | PL2598172T3 (es) |
| PT (1) | PT2598172T (es) |
| RS (1) | RS58900B1 (es) |
| SG (2) | SG187171A1 (es) |
| SI (1) | SI2598172T1 (es) |
| TR (1) | TR201908836T4 (es) |
| TW (1) | TWI534152B (es) |
| WO (1) | WO2012016131A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| CN103370082A (zh) * | 2010-07-30 | 2013-10-23 | 巴克斯特国际公司 | 用于肟键联的亲核性催化剂 |
| EA032056B1 (ru) | 2010-12-22 | 2019-04-30 | Баксалта Инкорпорейтид | Конъюгат терапевтического белка и производного жирной кислоты, способы получения конъюгата терапевтического белка и производного жирной кислоты (варианты) |
| IL235129B (en) * | 2012-04-16 | 2022-06-01 | Cantab Biopharmaceuticals Patents Ltd | Therapeutic compounds for subcutaneous administration |
| AU2013204754C1 (en) * | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
| MA39711A (fr) * | 2014-04-03 | 2015-10-08 | Nektar Therapeutics | Conjugués d'une fraction d'il-15 et d'un polymère |
| CN108884146A (zh) * | 2015-12-03 | 2018-11-23 | 百深公司 | 具有延长的半衰期及降低的配体结合性质的因子viii |
| WO2018017923A1 (en) * | 2016-07-22 | 2018-01-25 | Nektar Therapeutics | Conjugates of a factor viii moiety having an oxime-containing linkage |
| CN111093688A (zh) | 2017-05-15 | 2020-05-01 | 尼克塔治疗公司 | 长效白细胞介素-15受体激动剂以及相关免疫治疗组合物和方法 |
| US11845989B2 (en) | 2019-01-23 | 2023-12-19 | Regeneron Pharmaceuticals, Inc. | Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors |
| SG11202107497XA (en) | 2019-01-23 | 2021-08-30 | Regeneron Pharma | Treatment of ophthalmic conditions with angiopoietin-like 7 (angptl7) inhibitors |
| CA3210480A1 (en) | 2021-02-26 | 2022-09-01 | Regeneron Pharmaceuticals, Inc. | Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54113492A (en) | 1978-02-24 | 1979-09-05 | Sanyo Chem Ind Ltd | Preparation of glucoprotein derivative |
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US5198349A (en) | 1986-01-03 | 1993-03-30 | Genetics Institute, Inc. | Method for producing factor VIII:C and analogs |
| US5250421A (en) | 1986-01-03 | 1993-10-05 | Genetics Institute, Inc. | Method for producing factor VIII:C-type proteins |
| JPH0387173A (ja) | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体 |
| US5846951A (en) | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
| WO1994007510A1 (en) | 1992-10-02 | 1994-04-14 | Kabi Pharmacia Ab | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
| WO1994028024A1 (en) * | 1993-06-01 | 1994-12-08 | Enzon, Inc. | Carbohydrate-modified polymer conjugates with erythropoietic activity |
| US5621039A (en) | 1993-06-08 | 1997-04-15 | Hallahan; Terrence W. | Factor IX- polymeric conjugates |
| US5574187A (en) * | 1994-10-06 | 1996-11-12 | Uniroyal Chemical Company, Inc. | Process of preparing para substituted phenylamines |
| WO1996040662A2 (en) | 1995-06-07 | 1996-12-19 | Cellpro, Incorporated | Aminooxy-containing linker compounds and their application in conjugates |
| US6531298B2 (en) | 1997-07-21 | 2003-03-11 | The University Of North Carolina At Chapel Hill | Factor IX antihemophilic factor with increased clotting activity |
| US7074878B1 (en) | 1999-12-10 | 2006-07-11 | Harris J Milton | Hydrolytically degradable polymers and hydrogels made therefrom |
| US6413507B1 (en) | 1999-12-23 | 2002-07-02 | Shearwater Corporation | Hydrolytically degradable carbamate derivatives of poly (ethylene glycol) |
| EP1335931B1 (en) | 2000-05-16 | 2005-12-21 | Lipoxen Technologies Limited | Derivatisation of proteins in aqueous solution |
| AU2004236174B2 (en) | 2001-10-10 | 2011-06-02 | Novo Nordisk A/S | Glycopegylation methods and proteins/peptides produced by the methods |
| US7265084B2 (en) | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| MXPA04004336A (es) | 2001-11-07 | 2005-05-16 | Nektar Therapeutics Al Corp | Polimeros ramificados y sus conjugados. |
| EP1681303B1 (en) | 2002-09-11 | 2013-09-04 | Fresenius Kabi Deutschland GmbH | HASylated polypeptides, especially HASylated erythropoietin |
| BR0314107A (pt) | 2002-09-11 | 2005-07-19 | Fresenius Kabi De Gmbh | Método de produção de derivados de hidroxialquil amido |
| CA2521784C (en) | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| CN1832762B (zh) * | 2003-08-08 | 2012-09-05 | 弗雷泽纽斯卡比德国有限公司 | 羟烷基淀粉与g-csf的偶联物 |
| BRPI0412671A (pt) | 2003-08-08 | 2006-10-03 | Fresenius Kabi De Gmbh | conjugados de um polìmero e uma proteìna ligados por um grupo de ligação de oxima |
| WO2005014655A2 (en) * | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| RU2333223C2 (ru) | 2003-08-12 | 2008-09-10 | Лайпоксен Текнолоджиз Лимитед | Альдегидные производные сиаловой кислоты, способы их получения, конъюгаты альдегидных производных сиаловой кислоты и фармацевтическая композиция на их основе |
| US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
| US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| KR101237884B1 (ko) | 2003-12-03 | 2013-02-27 | 바이오제너릭스 에이지 | 글리코 peg화 과립구 콜로니 자극인자 |
| ES2593318T3 (es) | 2004-08-12 | 2016-12-07 | Lipoxen Technologies Limited | Derivados de ácido siálico |
| EP1799249A2 (en) | 2004-09-10 | 2007-06-27 | Neose Technologies, Inc. | Glycopegylated interferon alpha |
| US7884075B2 (en) | 2004-12-27 | 2011-02-08 | Baxter International Inc. | Polymer-factor VIII-von Willebrand factor-conjugates |
| AU2006259225B2 (en) | 2005-06-16 | 2012-05-31 | Nektar Therapeutics | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| CN101535339B (zh) * | 2006-09-01 | 2014-11-12 | 诺沃-诺迪斯克保健股份有限公司 | 改性糖蛋白 |
| EP2059527B1 (en) * | 2006-09-01 | 2014-12-03 | Novo Nordisk Health Care AG | Modified glycoproteins |
| ES2521490T3 (es) | 2006-12-15 | 2014-11-12 | Baxter International Inc. | Conjugado de factor VIIa - ácido (poli)siálico con una vida media in vivo prolongada. |
| EP2201953A4 (en) * | 2007-08-27 | 2011-08-03 | Univ Nagoya Nat Univ Corp | USE OF RIBAVIRIN IN BLOOD COAGULATION DISORDER |
| GB0908393D0 (en) * | 2009-05-15 | 2009-06-24 | Almac Sciences Scotland Ltd | Labelling method |
| ES2590679T3 (es) * | 2009-07-27 | 2016-11-23 | Lipoxen Technologies Limited | Glicopolisialilación de proteínas diferentes a proteínas de coagulación de la sangre |
| KR101832937B1 (ko) * | 2009-07-27 | 2018-02-28 | 박스알타 인코퍼레이티드 | 혈액 응고 단백질 복합체 |
| PE20121643A1 (es) * | 2009-07-31 | 2012-11-25 | Bayer Healthcare Llc | Polipeptidos del factor ix modificados y usos de los mismos |
| CN103370082A (zh) * | 2010-07-30 | 2013-10-23 | 巴克斯特国际公司 | 用于肟键联的亲核性催化剂 |
-
2011
- 2011-07-29 CN CN2011800476351A patent/CN103370082A/zh active Pending
- 2011-07-29 KR KR1020217018874A patent/KR102325780B1/ko active IP Right Grant
- 2011-07-29 SG SG2013005160A patent/SG187171A1/en unknown
- 2011-07-29 KR KR1020217007514A patent/KR102269494B1/ko active IP Right Grant
- 2011-07-29 RS RS20190779A patent/RS58900B1/sr unknown
- 2011-07-29 KR KR1020207006813A patent/KR102172133B1/ko active IP Right Grant
- 2011-07-29 PT PT11741727T patent/PT2598172T/pt unknown
- 2011-07-29 CN CN201810090885.7A patent/CN108079312A/zh active Pending
- 2011-07-29 LT LTEP11741727.9T patent/LT2598172T/lt unknown
- 2011-07-29 CN CN201810089901.0A patent/CN108079311A/zh active Pending
- 2011-07-29 WO PCT/US2011/045873 patent/WO2012016131A1/en active Application Filing
- 2011-07-29 CA CA2806684A patent/CA2806684C/en active Active
- 2011-07-29 SI SI201131742T patent/SI2598172T1/sl unknown
- 2011-07-29 MX MX2013001261A patent/MX346271B/es active IP Right Grant
- 2011-07-29 JP JP2013521998A patent/JP6325818B2/ja active Active
- 2011-07-29 EP EP21207146.8A patent/EP4023247A1/en active Pending
- 2011-07-29 KR KR1020207030594A patent/KR102229967B1/ko active IP Right Grant
- 2011-07-29 HU HUE11741727A patent/HUE043790T2/hu unknown
- 2011-07-29 DK DK11741727.9T patent/DK2598172T3/da active
- 2011-07-29 EP EP11741727.9A patent/EP2598172B1/en active Active
- 2011-07-29 TW TW100126974A patent/TWI534152B/zh active
- 2011-07-29 BR BR112013001611-6A patent/BR112013001611B1/pt active IP Right Grant
- 2011-07-29 NZ NZ60597211A patent/NZ605972A/en unknown
- 2011-07-29 KR KR1020137004971A patent/KR101969601B1/ko active IP Right Grant
- 2011-07-29 EA EA201300190A patent/EA025738B9/ru not_active IP Right Cessation
- 2011-07-29 KR KR1020197010071A patent/KR102088852B1/ko active IP Right Grant
- 2011-07-29 EP EP18208032.5A patent/EP3505186B1/en active Active
- 2011-07-29 AR ARP110102758A patent/AR082941A1/es active IP Right Grant
- 2011-07-29 PL PL11741727T patent/PL2598172T3/pl unknown
- 2011-07-29 ES ES11741727T patent/ES2731626T3/es active Active
- 2011-07-29 TR TR2019/08836T patent/TR201908836T4/tr unknown
- 2011-07-29 EA EA201691292A patent/EA201691292A1/ru unknown
- 2011-07-29 SG SG10201913078SA patent/SG10201913078SA/en unknown
- 2011-07-29 AU AU2011282571A patent/AU2011282571C1/en active Active
-
2015
- 2015-06-11 JP JP2015118007A patent/JP2015164958A/ja not_active Withdrawn
-
2017
- 2017-05-19 JP JP2017099807A patent/JP2017137358A/ja not_active Withdrawn
-
2019
- 2019-03-28 JP JP2019064337A patent/JP6757823B2/ja active Active
- 2019-03-28 JP JP2019064338A patent/JP2019116501A/ja not_active Withdrawn
- 2019-05-31 HR HRP20190990TT patent/HRP20190990T1/hr unknown
- 2019-06-19 CY CY20191100632T patent/CY1121943T1/el unknown
-
2020
- 2020-11-26 JP JP2020196260A patent/JP7054407B2/ja active Active
-
2021
- 2021-12-27 JP JP2021212106A patent/JP7258999B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR082941A1 (es) | Metodo para conjugar un polimero hidrosoluble a una porcion de carbohidrato oxidado de una proteina terapeutica | |
| AR084576A1 (es) | Materiales y metodos para conjugar un derivado de acido graso hidrosoluble a una proteina | |
| EP2641590B1 (en) | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration | |
| Manna et al. | Chitosan derivatives as carriers for drug delivery and biomedical applications | |
| JP2013500343A5 (es) | ||
| AR077600A1 (es) | Conjugados de proteinas de coagulacion sanguinea | |
| AR071420A1 (es) | Composicion de pastilla para chupar oral que comprende un principio activo de nicotina y procedimiento para fabricarla | |
| MXPA05007163A (es) | Derivados polimericos de acido maleamico y sus bioconjugados. | |
| BRPI0711380A2 (pt) | hidrogéis de misturas de polissacarídeos para engenharia de tecido e como veículos de compostos ativos | |
| RU2007128946A (ru) | Способные к биодеградации суперабсорбирующие полимерные гидрогели и способ их получения | |
| RU2010117016A (ru) | Хитозановая композиция | |
| NO20084292L (no) | Formulering for legemiddellevering til kolon | |
| Tokatlian et al. | Protease degradable tethers for controlled and cell-mediated release of nanoparticles in 2-and 3-dimensions | |
| US10799600B1 (en) | Targeted nanoparticles | |
| AR080572A1 (es) | Suspensiones de nanoparticulas que contienen polimero de carboxivinilo | |
| RU2016121611A (ru) | Конъюгаты белков свертывания крови | |
| Bera et al. | Erlotinib-loaded carboxymethyl temarind gum semi-interpenetrating nanocomposites | |
| RU2751231C2 (ru) | Способ получения хитозана с низким содержанием эндотоксина | |
| Yang et al. | Preparation and application of cyclodextrin immobilized polysaccharides | |
| Song et al. | Effect of net surface charge on physical properties of the cellulose nanoparticles and their efficacy for oral protein delivery | |
| RU2008103037A (ru) | Способ получения глюкозочувствительных полимерных гидрогелей | |
| AR052033A1 (es) | Composicion farmaceutica que comprende inhibidor de topoisomerasa i | |
| EA028186B9 (ru) | Способ конъюгации водорастворимого полимера с терапевтическим белком (варианты) и полученный модифицированный белок | |
| FR2887892B1 (fr) | Polymeres fluorescents en solution aqueuse et procede de preparation de polymeres fluorescents solubles en solution aqueuse | |
| Wang et al. | A tumour microenvironment-responsive polymeric complex for targeted depletion of tumour-associated macrophages (TAMs) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |