DK1036179T4 - Fremgangsmåde til fremstilling af polypeptider med egnet glycosilering - Google Patents
Fremgangsmåde til fremstilling af polypeptider med egnet glycosileringInfo
- Publication number
- DK1036179T4 DK1036179T4 DK98965223.5T DK98965223T DK1036179T4 DK 1036179 T4 DK1036179 T4 DK 1036179T4 DK 98965223 T DK98965223 T DK 98965223T DK 1036179 T4 DK1036179 T4 DK 1036179T4
- Authority
- DK
- Denmark
- Prior art keywords
- polypeptides
- preparation
- suitable glycosylation
- glycosylation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1997153681 DE19753681A1 (de) | 1997-12-03 | 1997-12-03 | Erythropoietin mit hoher spezifischer Aktivität |
EP98113409 | 1998-07-17 | ||
PCT/EP1998/007819 WO1999028455A1 (de) | 1997-12-03 | 1998-12-02 | Verfahren zur herstellung von polypeptiden mit geeigneter glykosilierung |
Publications (2)
Publication Number | Publication Date |
---|---|
DK1036179T3 DK1036179T3 (da) | 2006-03-06 |
DK1036179T4 true DK1036179T4 (da) | 2014-03-31 |
Family
ID=26042141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98965223.5T DK1036179T4 (da) | 1997-12-03 | 1998-12-02 | Fremgangsmåde til fremstilling af polypeptider med egnet glycosilering |
Country Status (10)
Country | Link |
---|---|
US (1) | US6673575B1 (da) |
EP (1) | EP1036179B2 (da) |
JP (2) | JP3394240B2 (da) |
AR (2) | AR018023A1 (da) |
AT (1) | ATE309350T1 (da) |
AU (1) | AU2051899A (da) |
DE (1) | DE59813187D1 (da) |
DK (1) | DK1036179T4 (da) |
ES (1) | ES2252876T5 (da) |
WO (1) | WO1999028455A1 (da) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7345019B1 (en) * | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
WO2002002793A1 (fr) * | 2000-07-05 | 2002-01-10 | Japan As Represented By Secretary Of Osaka University | Processus de production de glycoproteine |
US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
EP1373547A4 (en) * | 2001-03-27 | 2006-01-18 | Smithkline Beecham Corp | CONTROL OF GLYCOFORMS IN IGG |
PT1543106E (pt) * | 2002-07-15 | 2007-05-31 | Immunex Corp | Métodos e meios para controlar a sialilação de proteínas produzidas por células de mamíferos |
BR0316882A (pt) † | 2002-12-23 | 2005-10-25 | Bristol Myers Squibb Co | Melhora na qualidade de produtos em processos de cultura de células de mamìferos para a produção de proteìnas |
DE102004007658B4 (de) * | 2004-02-17 | 2008-12-18 | Bioceuticals Arzneimittel Ag | Verfahren zur Herstellung von rekombinanten Proteinen in eukaryontischen Wirtszellen |
EP1605057A3 (de) * | 2004-06-09 | 2006-11-02 | Klaus Heyne | Verfahren zur Herstellung hyperglykosylierter Proteine |
AR053416A1 (es) | 2005-11-10 | 2007-05-09 | Protech Pharma S A | Combinacion de glicoisoformas para el tratamiento o prevencion de la septicemia, linea celular transgenica productora de glicoformas de eritropoyetina, composicion farmaceutica que comprende a dicha combinacion, procedimientos para obtener la linea celular, procedimiento para producir dicha combinac |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
PL1969007T4 (pl) | 2005-12-20 | 2014-04-30 | Bristol Myers Squibb Co | Kompozycje i sposoby wytwarzania kompozycji |
CN105838699A (zh) | 2006-12-15 | 2016-08-10 | 巴克斯艾尔塔公司 | 具有延长的体内半衰期的因子VIIa-聚唾液酸结合物 |
DE102008002210A1 (de) * | 2008-06-04 | 2009-12-10 | Evonik Degussa Gmbh | Verfahren zur fermentativen Herstellung von Erythropoietin |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
CA2769244A1 (en) | 2009-07-27 | 2011-02-03 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
JP5908401B2 (ja) | 2009-07-27 | 2016-04-26 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 血液凝固タンパク質複合体 |
CN104530182A (zh) | 2009-07-27 | 2015-04-22 | 利普森技术有限公司 | 非凝血蛋白的糖基多唾液酸化 |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
WO2012050175A1 (ja) | 2010-10-15 | 2012-04-19 | 日本ケミカルリサーチ株式会社 | 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法 |
SG191298A1 (en) | 2010-12-22 | 2013-07-31 | Baxter Int | Materials and methods for conjugating a water soluble fatty acid derivative to a protein |
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
AU2013381687A1 (en) | 2013-03-12 | 2015-09-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9677105B2 (en) | 2013-03-14 | 2017-06-13 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
US9217168B2 (en) * | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US8956830B2 (en) | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
TWI771890B (zh) * | 2013-03-14 | 2022-07-21 | 美商安美基公司 | 用於增加重組蛋白質之甘露糖含量之方法 |
US9499614B2 (en) * | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9481901B2 (en) | 2013-05-30 | 2016-11-01 | Amgen Inc. | Methods for increasing mannose content of recombinant proteins |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
JP6652334B2 (ja) | 2014-05-31 | 2020-02-19 | Jcrファーマ株式会社 | ウリジンとn−アセチル−d−マンノサミンとを含有する培地 |
MA40021A (fr) * | 2014-06-03 | 2015-12-10 | Lupin Ltd | Processus de culture cellulaire destiné à produire une protéine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4935350A (en) | 1985-11-18 | 1990-06-19 | Amgen | Materials and methods for controlling plasmid copy number and stability |
US5856298A (en) * | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
JP3375140B2 (ja) | 1991-03-08 | 2003-02-10 | 森永製菓株式会社 | モノクローナル抗体生産用培地の作製法及びそのキット |
ES2164050T3 (es) | 1991-04-18 | 2002-02-16 | Toray Industries | Preparacion de compuestos de interleuquina-6. |
JPH06292592A (ja) | 1993-02-09 | 1994-10-21 | Snow Brand Milk Prod Co Ltd | 糖蛋白質の生産方法 |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
-
1998
- 1998-12-02 US US09/555,533 patent/US6673575B1/en not_active Expired - Lifetime
- 1998-12-02 EP EP98965223.5A patent/EP1036179B2/de not_active Expired - Lifetime
- 1998-12-02 DE DE59813187T patent/DE59813187D1/de not_active Expired - Lifetime
- 1998-12-02 DK DK98965223.5T patent/DK1036179T4/da active
- 1998-12-02 AT AT98965223T patent/ATE309350T1/de active
- 1998-12-02 JP JP2000523332A patent/JP3394240B2/ja not_active Expired - Lifetime
- 1998-12-02 WO PCT/EP1998/007819 patent/WO1999028455A1/de active IP Right Grant
- 1998-12-02 ES ES98965223.5T patent/ES2252876T5/es not_active Expired - Lifetime
- 1998-12-02 AU AU20518/99A patent/AU2051899A/en not_active Abandoned
- 1998-12-03 AR ARP980106124A patent/AR018023A1/es active IP Right Grant
-
1999
- 1999-10-07 AR ARP990105069A patent/AR020735A1/es unknown
-
2002
- 2002-11-05 JP JP2002321415A patent/JP4384400B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2003180392A (ja) | 2003-07-02 |
ATE309350T1 (de) | 2005-11-15 |
US6673575B1 (en) | 2004-01-06 |
ES2252876T5 (es) | 2014-04-03 |
WO1999028455A1 (de) | 1999-06-10 |
JP4384400B2 (ja) | 2009-12-16 |
AR020735A1 (es) | 2002-05-29 |
JP3394240B2 (ja) | 2003-04-07 |
DE59813187D1 (de) | 2005-12-15 |
AU2051899A (en) | 1999-06-16 |
EP1036179B1 (de) | 2005-11-09 |
ES2252876T3 (es) | 2006-05-16 |
AR018023A1 (es) | 2001-10-31 |
JP2001525342A (ja) | 2001-12-11 |
DK1036179T3 (da) | 2006-03-06 |
EP1036179B2 (de) | 2014-01-01 |
EP1036179A1 (de) | 2000-09-20 |
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