ES2164050T3 - Preparacion de compuestos de interleuquina-6. - Google Patents

Preparacion de compuestos de interleuquina-6.

Info

Publication number
ES2164050T3
ES2164050T3 ES92908258T ES92908258T ES2164050T3 ES 2164050 T3 ES2164050 T3 ES 2164050T3 ES 92908258 T ES92908258 T ES 92908258T ES 92908258 T ES92908258 T ES 92908258T ES 2164050 T3 ES2164050 T3 ES 2164050T3
Authority
ES
Spain
Prior art keywords
human interleukin
interleuquine
compounds
preparation
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92908258T
Other languages
English (en)
Inventor
Shingou Sakurai
Masanobu Naruto
Makoto Kihara
Keizo Hanada
Emiko Sano
Shigeru Ichikura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of ES2164050T3 publication Critical patent/ES2164050T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts

Abstract

SE PRESENTA UNA COMPOSICION QUE CONTIENE INTERLEUQUINA 6 HUMANA QUE TIENE UNA CADENA DE SACARIDO, ASI COMO UN PROCESO PARA PRODUCIR LA INTERLEUQUINA 6 HUMANA CULTIVANDO CELULAS EN UN MEDIO QUE CONTENGA ACIDO ASCORBICO O UNO DE SUS DERIVADOS, Y UN PROCESO PARA PURIFICAR LA SOLUCION DE INTERLEUQUINA 6 HUMANA CRUDA MEDIANTE CROMATOGRAFIA USANDO UN PORTADOR DE HEPARINA. LA INVENCION HACE POSIBLE PRODUCIR UNA COMPOSICION DE ALTA CALIDAD QUE CONTIENE INTERLEUQUINA 6 HUMANA QUE TIENE UNA CADENA DE SACARIDO PARA DE ESTA FORMA APLICAR LA MISMA EN USOS MEDICOS Y ESTABLECER UN PROCESO PARA LA PRODUCCION EN MASA DE LA INTERLEUQUINA 6 HUMANA.
ES92908258T 1991-04-18 1992-04-17 Preparacion de compuestos de interleuquina-6. Expired - Lifetime ES2164050T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8660291 1991-04-18
JP8828491 1991-04-19

Publications (1)

Publication Number Publication Date
ES2164050T3 true ES2164050T3 (es) 2002-02-16

Family

ID=26427716

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92908258T Expired - Lifetime ES2164050T3 (es) 1991-04-18 1992-04-17 Preparacion de compuestos de interleuquina-6.

Country Status (10)

Country Link
EP (1) EP0550756B1 (es)
KR (1) KR930700550A (es)
AT (1) ATE210150T1 (es)
AU (1) AU1554592A (es)
CA (1) CA2085744A1 (es)
DE (1) DE69232259T2 (es)
ES (1) ES2164050T3 (es)
FI (1) FI925745A (es)
TW (1) TW221379B (es)
WO (1) WO1992018537A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
ES2252876T5 (es) 1997-12-03 2014-04-03 Roche Diagnostics Gmbh Proceso para preparar polipéptidos con glicolización adecuada
PT1137789E (pt) 1998-12-09 2010-10-21 Phyton Holdings Llc Um método para produzir glicoproteínas possuindo glicosilação de tipo humano
BRPI0015031B1 (pt) 1999-10-26 2017-05-30 Plant Res Int B V método para prover uma planta transgênica capaz de expressar um anticorpo com galactosilação terminal e método para obtenção de uma glicoproteína desejada ou fragmento funcional da mesma
US20040214273A1 (en) 2001-01-19 2004-10-28 Kazuhito Fujiyama Method for secretory production of glycoprotein having human-type sugar chain using plant cell
KR101070518B1 (ko) 2002-03-19 2011-10-05 스티칭 디엔스트 랜드보위쿤디그 온데조에크 식물에서의 ｇｎｔⅲ 발현
EP2339004B1 (en) 2002-03-19 2015-02-25 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
CL2003002461A1 (es) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
MX2009011109A (es) 2007-04-17 2009-12-01 Plant Res Int Bv Glicosilación tipo mamífera en plantas para la expresión de glicosil-transferasas no mamíferas.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6062997A (ja) * 1983-09-17 1985-04-11 Mochida Pharmaceut Co Ltd インタ−フエロンの生産方法
DE3519011A1 (de) * 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
JPS62153755A (ja) * 1985-12-27 1987-07-08 Showa Denko Kk クロマトグラフイ−用吸着担体
JP2648860B2 (ja) * 1986-05-08 1997-09-03 イエダ リサーチ アンド デベロップメント コンパニー リミテッド ヒトインターフエロン−β２Ａ及びヒトインターフエロン−β２Ｂ、該インターフエロンをコードする遺伝子を含むベクター、該インターフエロンを産生するセルライン及び該インターフエロンの医薬品としての用途
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
JP2676336B2 (ja) * 1986-08-06 1997-11-12 忠三 岸本 ヒトｂ細胞分化因子の遺伝子
JPS63150297A (ja) * 1986-12-12 1988-06-22 Ajinomoto Co Inc 新規ｂ細胞分化因子蛋白標品
DE3851685D1 (de) * 1987-10-13 1994-11-03 Thomae Gmbh Dr K Verfahren zur Herstellung von Proteinen.
JPH03133935A (ja) * 1989-10-19 1991-06-07 Toray Ind Inc ヒト天然型インターロイキン６組成物

Also Published As

Publication number Publication date
ATE210150T1 (de) 2001-12-15
TW221379B (es) 1994-03-01
FI925745A0 (fi) 1992-12-17
AU1554592A (en) 1992-11-17
WO1992018537A1 (fr) 1992-10-29
DE69232259T2 (de) 2002-06-13
KR930700550A (ko) 1993-03-15
EP0550756B1 (en) 2001-12-05
DE69232259D1 (de) 2002-01-17
EP0550756A4 (es) 1994-04-27
FI925745A (fi) 1992-12-17
EP0550756A1 (en) 1993-07-14
CA2085744A1 (en) 1992-10-19

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