ATE210150T1 - Verfahren zur herstellung von interleukin-6 zusammensetzungen - Google Patents

Verfahren zur herstellung von interleukin-6 zusammensetzungen

Info

Publication number
ATE210150T1
ATE210150T1 AT92908258T AT92908258T ATE210150T1 AT E210150 T1 ATE210150 T1 AT E210150T1 AT 92908258 T AT92908258 T AT 92908258T AT 92908258 T AT92908258 T AT 92908258T AT E210150 T1 ATE210150 T1 AT E210150T1
Authority
AT
Austria
Prior art keywords
human interleukin
compositions
composition containing
saccharide chain
producing interleukin
Prior art date
Application number
AT92908258T
Other languages
English (en)
Inventor
Shingou Sakurai
Masanobu Naruto
Makoto Kihara
Keizo Hanada
Emiko Sano
Shigeru Ichikura
Jun Utsumi
Kazuo Hosoi
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries filed Critical Toray Industries
Application granted granted Critical
Publication of ATE210150T1 publication Critical patent/ATE210150T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
AT92908258T 1991-04-18 1992-04-17 Verfahren zur herstellung von interleukin-6 zusammensetzungen ATE210150T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8660291 1991-04-18
JP8828491 1991-04-19
PCT/JP1992/000487 WO1992018537A1 (fr) 1991-04-18 1992-04-17 Composition a base d'interleukine 6 et procede de production

Publications (1)

Publication Number Publication Date
ATE210150T1 true ATE210150T1 (de) 2001-12-15

Family

ID=26427716

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92908258T ATE210150T1 (de) 1991-04-18 1992-04-17 Verfahren zur herstellung von interleukin-6 zusammensetzungen

Country Status (10)

Country Link
EP (1) EP0550756B1 (de)
KR (1) KR930700550A (de)
AT (1) ATE210150T1 (de)
AU (1) AU1554592A (de)
CA (1) CA2085744A1 (de)
DE (1) DE69232259T2 (de)
ES (1) ES2164050T3 (de)
FI (1) FI925745A (de)
TW (1) TW221379B (de)
WO (1) WO1992018537A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
US6673575B1 (en) 1997-12-03 2004-01-06 Roche Diagnostics Gmbh Method for preparing polypeptides with appropriate glycosilation
NZ512185A (en) 1998-12-09 2004-02-27 Dow Chemical Co A method for manufacturing glycoproteins having human- type glycosylation in plant cells
BRPI0015031B1 (pt) 1999-10-26 2017-05-30 Plant Res Int B V método para prover uma planta transgênica capaz de expressar um anticorpo com galactosilação terminal e método para obtenção de uma glicoproteína desejada ou fragmento funcional da mesma
IL156879A0 (en) 2001-01-19 2004-02-08 Dow Chemical Co Method for secretory production of glycoprotein having human-type sugar chain using plant cell
EP1485492B1 (de) 2002-03-19 2011-12-21 Stichting Dienst Landbouwkundig Onderzoek Gntiii (udp-n-acetylglucosamin:beta-d-mannosid-beta(1,4)-n-acetylglucosaminyltransferase iii) expression in pflanzen
EP2339004B1 (de) 2002-03-19 2015-02-25 Stichting Dienst Landbouwkundig Onderzoek Optimierung von Glycanprozessierung in Pflanzen
CL2003002461A1 (es) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
CA2684370C (en) 2007-04-17 2017-10-17 Plant Research International B.V. Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6062997A (ja) * 1983-09-17 1985-04-11 Mochida Pharmaceut Co Ltd インタ−フエロンの生産方法
DE3519011A1 (de) * 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
JPS62153755A (ja) * 1985-12-27 1987-07-08 Showa Denko Kk クロマトグラフイ−用吸着担体
JP2648860B2 (ja) * 1986-05-08 1997-09-03 イエダ リサーチ アンド デベロップメント コンパニー リミテッド ヒトインターフエロン−β２Ａ及びヒトインターフエロン−β２Ｂ、該インターフエロンをコードする遺伝子を含むベクター、該インターフエロンを産生するセルライン及び該インターフエロンの医薬品としての用途
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
JP2676336B2 (ja) * 1986-08-06 1997-11-12 忠三 岸本 ヒトｂ細胞分化因子の遺伝子
JPS63150297A (ja) * 1986-12-12 1988-06-22 Ajinomoto Co Inc 新規ｂ細胞分化因子蛋白標品
DE3851685D1 (de) * 1987-10-13 1994-11-03 Thomae Gmbh Dr K Verfahren zur Herstellung von Proteinen.
JPH03133935A (ja) * 1989-10-19 1991-06-07 Toray Ind Inc ヒト天然型インターロイキン６組成物

Also Published As

Publication number Publication date
WO1992018537A1 (fr) 1992-10-29
ES2164050T3 (es) 2002-02-16
DE69232259T2 (de) 2002-06-13
EP0550756A4 (de) 1994-04-27
TW221379B (de) 1994-03-01
CA2085744A1 (en) 1992-10-19
FI925745A0 (fi) 1992-12-17
EP0550756B1 (de) 2001-12-05
FI925745A (fi) 1992-12-17
AU1554592A (en) 1992-11-17
KR930700550A (ko) 1993-03-15
EP0550756A1 (de) 1993-07-14
DE69232259D1 (de) 2002-01-17

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