ATE178616T1 - Verfahren zur herstellung von biologisch aktivem protein (z.b. tgf) - Google Patents
Verfahren zur herstellung von biologisch aktivem protein (z.b. tgf)Info
- Publication number
- ATE178616T1 ATE178616T1 AT90810922T AT90810922T ATE178616T1 AT E178616 T1 ATE178616 T1 AT E178616T1 AT 90810922 T AT90810922 T AT 90810922T AT 90810922 T AT90810922 T AT 90810922T AT E178616 T1 ATE178616 T1 AT E178616T1
- Authority
- AT
- Austria
- Prior art keywords
- tgf
- biologically active
- active protein
- producing biologically
- beta
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898927546A GB8927546D0 (en) | 1989-12-06 | 1989-12-06 | Process for the production of biologically active tgf-beta |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE178616T1 true ATE178616T1 (de) | 1999-04-15 |
Family
ID=10667491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90810922T ATE178616T1 (de) | 1989-12-06 | 1990-11-27 | Verfahren zur herstellung von biologisch aktivem protein (z.b. tgf) |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5650494A (de) |
| EP (2) | EP0891985A1 (de) |
| JP (1) | JP3048061B2 (de) |
| KR (1) | KR100203230B1 (de) |
| AT (1) | ATE178616T1 (de) |
| AU (1) | AU638075B2 (de) |
| CA (1) | CA2031430C (de) |
| DE (1) | DE69033040T2 (de) |
| DK (1) | DK0433225T3 (de) |
| ES (1) | ES2132066T3 (de) |
| FI (1) | FI103278B (de) |
| GB (1) | GB8927546D0 (de) |
| GR (1) | GR3030703T3 (de) |
| HU (1) | HU218144B (de) |
| IE (2) | IE990992A1 (de) |
| IL (1) | IL96549A (de) |
| MX (1) | MX172600B (de) |
| NO (1) | NO301768B1 (de) |
| NZ (1) | NZ236333A (de) |
| PH (1) | PH31649A (de) |
| PT (1) | PT96068B (de) |
| SG (1) | SG52690A1 (de) |
| ZA (1) | ZA909762B (de) |
Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| GB8927546D0 (en) * | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| DK0547102T3 (da) * | 1990-09-05 | 1999-04-19 | Natinco Nv | Opløseliggørelse af proteiner på aktiv form |
| GB9106678D0 (en) * | 1991-03-28 | 1991-05-15 | Ferguson Mark W J | Wound healing |
| DE69233022T2 (de) * | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| AU2738392A (en) * | 1991-11-11 | 1993-05-13 | Ciba-Geigy Ag | Novel hybrid transforming growth factors |
| US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
| CZ287715B6 (en) * | 1992-02-12 | 2001-01-17 | Bioph Biotech Entw Pharm Gmbh | DNA sequence, recombinant DNA molecule containing thereof, process for preparing protein from the group of TGF-beta substances, pharmaceutical preparation containing such protein, antibody or fragment thereof and its use |
| GB9206861D0 (en) * | 1992-03-28 | 1992-05-13 | Univ Manchester | Wound healing and treatment of fibrotic disorders |
| US6884787B2 (en) * | 2001-07-14 | 2005-04-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of transforming growth factor-beta 3 expression |
| DE4243729A1 (de) * | 1992-12-23 | 1994-06-30 | Behringwerke Ag | Verfahren zur Reaktivierung von gereinigten Membranproteinen |
| AU5955294A (en) * | 1993-01-08 | 1994-08-15 | Upjohn Company, The | Process for the purification and refolding of human respiratory syncytial virus fg glycoprotein |
| ATE211762T1 (de) | 1993-04-30 | 2002-01-15 | Biognostik Ges | Antisense-oligonukleotide zur behandlung des immunsuppressiven effektes des transformierenden wachstumsfaktor-beta1(tgf-beta1) |
| US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| US5411940A (en) * | 1993-09-29 | 1995-05-02 | Alcon Laboratories, Inc. | Use of TGF-β3 to reduce the formation of scar tissue in response to corneal trauma |
| JPH08503969A (ja) * | 1993-09-29 | 1996-04-30 | アルコン ラボラトリーズ，インコーポレイテッド | 増殖因子と組織形成抑制剤を含有する組成物 |
| US6027919A (en) | 1993-12-07 | 2000-02-22 | Genetics Institute, Inc. | BMP-12 and BMP-13 proteins and DNA encoding them |
| US5399677A (en) * | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
| AU689184B2 (en) | 1993-12-07 | 1998-03-26 | Genetics Institute, Llc | BMP-12, BMP-13 and tendon-inducing compositions thereof |
| TW440566B (en) * | 1994-07-25 | 2001-06-16 | Novartis Ag | Novel process for the production of biologically active dimeric protein |
| TW517059B (en) * | 1994-07-25 | 2003-01-11 | Ciba Geigy Ag | New process for the production of biologically active protein |
| JPH11505507A (ja) * | 1994-07-25 | 1999-05-21 | ノバルティス アクチェンゲゼルシャフト | 組換えヒルジンまたは表皮増殖因子のようなタンパク質の折りたたみ方法 |
| PT955313E (pt) * | 1995-04-19 | 2006-07-31 | Bioph Biotech Entw Pharm Gmbh | Nova proteina e processo para a sua producao |
| US5714371A (en) * | 1995-05-12 | 1998-02-03 | Schering Corporation | Method for refolding insoluble aggregates of hepatitis C virus protease |
| US5800811A (en) * | 1995-06-06 | 1998-09-01 | Hall; Frederick L. | Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site |
| US6352972B1 (en) * | 1995-06-06 | 2002-03-05 | Marcel E. Nimni | Bone morphogenetic proteins and their use in bone growth |
| US6040431A (en) | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
| WO1997016556A1 (en) | 1995-10-30 | 1997-05-09 | Massachusetts Institute Of Technology | Rationally designed polysaccharide lyases derived from heparinase i |
| EP0943690B1 (de) * | 1995-12-21 | 2006-11-29 | Ajinomoto Co., Inc. | Verfahren zur rückfaltung von menschlichem activin a |
| US20030185792A1 (en) * | 1996-01-22 | 2003-10-02 | Curis, Inc. | Morphogen analogs of bone morphogenic proteins |
| ATE364629T1 (de) * | 1996-01-22 | 2007-07-15 | Curis Inc | Methoden zur herstellung von op-1 morphogen analoge |
| US6664227B1 (en) | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
| US7811793B2 (en) | 1996-12-25 | 2010-10-12 | Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Process for preparing purified active monomer of bone-derived factor |
| US7723473B2 (en) | 1997-06-19 | 2010-05-25 | St. Louis University | Peptide antagonists of TGF-beta family members and therapeutic uses thereof |
| US6500920B1 (en) * | 1997-06-19 | 2002-12-31 | St. Louis University | Inhibitor of transforming growth factor β and A method of inhibiting the biological effects of transforming growth factor |
| ATE220564T1 (de) | 1997-08-14 | 2002-08-15 | Sulzer Innotec Ag | Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren |
| US20020052026A1 (en) | 1997-10-08 | 2002-05-02 | Steven M. Vicik | Methods of refolding proteins |
| DE19749259A1 (de) * | 1997-11-07 | 1999-05-12 | Dade Behring Marburg Gmbh | Verfahren zur Herstellung von funktionalem rekombinantem Gewebsfaktor |
| TR200002284T2 (tr) * | 1998-02-05 | 2000-11-21 | Smithkline Beecham Biologicals S.A. | Mage ailesinden tümör ile ilgili tümör türevleri |
| US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
| FR2776521B1 (fr) * | 1998-03-27 | 2000-12-15 | Pf Medicament | Utilisation de conjugues p40 actifs par voie nasale |
| US7056504B1 (en) | 1998-08-27 | 2006-06-06 | Massachusetts Institute Of Technology | Rationally designed heparinases derived from heparinase I and II |
| EP1109919A2 (de) | 1998-08-27 | 2001-06-27 | Massachusetts Institute Of Technology | Von heparinase i und ii abgeleitete heparinasen |
| US6933272B1 (en) | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| EP1117805A2 (de) * | 1998-10-07 | 2001-07-25 | STRYKER CORPORATION (a Michigan corporation) | Modifizierte proteine der tgf-beta superfamilie |
| US6846906B1 (en) | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
| US6992066B2 (en) | 1998-10-16 | 2006-01-31 | Zimmer Orthobiologics, Inc. | Povidone-containing carriers for polypeptide growth factors |
| US7087577B2 (en) | 1998-10-16 | 2006-08-08 | Zimmer Orthobiologies, Inc. | Method of promoting natural bypass |
| ES2146552B1 (es) * | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
| EP1142908A4 (de) * | 1999-01-07 | 2002-05-22 | Takeda Chemical Industries Ltd | Methode zum herstellen von aktivierten proteinen |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
| WO2000065521A2 (en) | 1999-04-23 | 2000-11-02 | Massachusetts Institute Of Technology | System and method for polymer notation |
| DE19944626A1 (de) * | 1999-09-17 | 2001-03-22 | Knoell Hans Forschung Ev | Verfahren zur Herstellung von dimeren, biologisch aktiven knochenmorphogenetischen Proteinen |
| EP2286847A1 (de) | 1999-10-15 | 2011-02-23 | Genetics Institute, LLC | Hyaluronsäure enthaltende Zusammensetzungen zur Abgabe osteogener Proteine |
| AU2001243512C1 (en) | 2000-03-08 | 2008-04-17 | Massachusetts Institute Of Technology | Heparinase III and uses thereof |
| DE10026713A1 (de) * | 2000-05-30 | 2001-12-06 | Walter Sebald | Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta |
| US7081240B1 (en) * | 2000-06-28 | 2006-07-25 | Zimmer Orthobiologics, Inc. | Protein mixtures for wound healing |
| DK1319183T3 (da) | 2000-09-12 | 2009-05-18 | Massachusetts Inst Technology | Fremgangsmåder og produkter relateret til heparin med lav molekylvægt |
| EP1328260A2 (de) | 2000-10-18 | 2003-07-23 | Massachusetts Institute Of Technology | Verfahren und produkte zur pulmonalen verabreichung von polysacchariden |
| US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
| RU2316563C2 (ru) | 2001-02-23 | 2008-02-10 | Иммьюнекс Корпорейшн | Способ промотирования активной конформации гликозилированного рекомбинантного белка, способ получения активного гликозилированного белка и способ получения композиции указанного белка для введения потребителю и/или пациенту или потребления потребителем и/или пациентом |
| US7276580B2 (en) | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
| US7226587B2 (en) | 2001-06-01 | 2007-06-05 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| FI117667B (fi) | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
| EP1432431B1 (de) | 2001-10-04 | 2017-05-10 | Genetics Institute LLC | Verfahren und zusammensetzungen zur modulierung der wirkung des interleukin-21 |
| US7232802B2 (en) | 2001-12-21 | 2007-06-19 | Zimmer Orthobiologics, Inc. | Compositions and methods for promoting myocardial and peripheral angiogenesis |
| SK287965B6 (sk) * | 2002-02-05 | 2012-07-03 | Geymonat S. P. A. | Process for extracting and purifying the recombinant Placental Growth Factor and Placental Growth Factor in active form |
| RU2295535C2 (ru) * | 2002-02-05 | 2007-03-20 | Джимонат С.П.А. | Рекомбинантный плацентарный фактор роста и способ его получения |
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| EP1542711A4 (de) | 2002-08-13 | 2009-07-01 | Wyeth Corp | Peptide als solubilisierende hilfsstoffe zur umwandlung von wachstumsfaktor-proteinen |
| JP4571776B2 (ja) * | 2002-11-05 | 2010-10-27 | Ｊｘ日鉱日石エネルギー株式会社 | 潤滑油組成物 |
| US7074412B2 (en) | 2003-01-30 | 2006-07-11 | The University Of Zurich | Pharmaceutical composition |
| JP4742030B2 (ja) | 2003-04-18 | 2011-08-10 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | ポリマーが結合したグリコシル化ニューブラスチン |
| ES2282904T3 (es) | 2003-09-12 | 2007-10-16 | Wyeth | Barras solidas de fosfato calcico inyectables para el suministro de proteinas osteogenicas. |
| ES2404682T3 (es) | 2003-12-11 | 2013-05-28 | Isto Technologies Inc. | Sistema de cartílago particulado |
| JP4852545B2 (ja) * | 2004-08-19 | 2012-01-11 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | ニューブラスチン（Ｎｅｕｂｌａｓｔｉｎ）変異体 |
| ATE472333T1 (de) | 2004-08-19 | 2010-07-15 | Biogen Idec Inc | Rückfaltung von proteinen der transforming-growth-factor-beta-familie |
| US20060166251A1 (en) * | 2005-01-26 | 2006-07-27 | Archambault Joanne M | Use of sFRPs as markers of BMP activity |
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1989
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- 1990-11-27 EP EP90810922A patent/EP0433225B1/de not_active Expired - Lifetime
- 1990-11-27 DK DK90810922T patent/DK0433225T3/da active
- 1990-11-27 DE DE69033040T patent/DE69033040T2/de not_active Expired - Lifetime
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