ATE220564T1 - Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren - Google Patents

Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren

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Publication number
ATE220564T1
ATE220564T1 AT97810567T AT97810567T ATE220564T1 AT E220564 T1 ATE220564 T1 AT E220564T1 AT 97810567 T AT97810567 T AT 97810567T AT 97810567 T AT97810567 T AT 97810567T AT E220564 T1 ATE220564 T1 AT E220564T1
Authority
AT
Austria
Prior art keywords
factors
nanospheres
mixture
composition
loaded
Prior art date
Application number
AT97810567T
Other languages
English (en)
Inventor
Brent A Atkinson
John Ranieri
Pedro Bittmann
Marsha Lynn Whitney
James John Benedict
Donald Chickering
Original Assignee
Sulzer Innotec Ag
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Filing date
Publication date
Application filed by Sulzer Innotec Ag filed Critical Sulzer Innotec Ag
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Publication of ATE220564T1 publication Critical patent/ATE220564T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2002/30036—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in release or diffusion time
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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  • Transplantation (AREA)
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  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
AT97810567T 1997-08-14 1997-08-14 Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren ATE220564T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97810567A EP0896825B1 (de) 1997-08-14 1997-08-14 Zusammensetzung und Vorrichtung zur Reparatur von Knorpelgewebe in vivo bestehend aus Nanokapseln mit osteoinduktiven und/oder chondroinduktiven Faktoren

Publications (1)

Publication Number Publication Date
ATE220564T1 true ATE220564T1 (de) 2002-08-15

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AT97810567T ATE220564T1 (de) 1997-08-14 1997-08-14 Zusammensetzung und vorrichtung zur reparatur von knorpelgewebe in vivo bestehend aus nanokapseln mit osteoinduktiven und/oder chondroinduktiven faktoren

Country Status (8)

Country Link
US (6) US6582471B1 (de)
EP (1) EP0896825B1 (de)
JP (1) JP2001514935A (de)
AT (1) ATE220564T1 (de)
AU (1) AU746151B2 (de)
CA (1) CA2300415C (de)
DE (1) DE69714035T2 (de)
WO (1) WO1999008728A1 (de)

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US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US20070233269A1 (en) * 2001-05-25 2007-10-04 Conformis, Inc. Interpositional Joint Implant
US20110071645A1 (en) * 2009-02-25 2011-03-24 Ray Bojarski Patient-adapted and improved articular implants, designs and related guide tools
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US20110071802A1 (en) * 2009-02-25 2011-03-24 Ray Bojarski Patient-adapted and improved articular implants, designs and related guide tools
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EP0896825B1 (de) 2002-07-17
AU9260798A (en) 1999-03-08
EP0896825A1 (de) 1999-02-17
US20030236574A1 (en) 2003-12-25
US6514514B1 (en) 2003-02-04
US20090297605A1 (en) 2009-12-03
CA2300415A1 (en) 1999-02-25
DE69714035D1 (de) 2002-08-22
DE69714035T2 (de) 2003-03-06
WO1999008728A1 (en) 1999-02-25
USRE41286E1 (en) 2010-04-27
AU746151B2 (en) 2002-04-18
CA2300415C (en) 2009-10-27
JP2001514935A (ja) 2001-09-18
US20060216325A1 (en) 2006-09-28
US6582471B1 (en) 2003-06-24

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