DE69232259D1 - Verfahren zur Herstellung von Interleukin-6 Zusammensetzungen - Google Patents

Verfahren zur Herstellung von Interleukin-6 Zusammensetzungen

Info

Publication number
DE69232259D1
DE69232259D1 DE69232259T DE69232259T DE69232259D1 DE 69232259 D1 DE69232259 D1 DE 69232259D1 DE 69232259 T DE69232259 T DE 69232259T DE 69232259 T DE69232259 T DE 69232259T DE 69232259 D1 DE69232259 D1 DE 69232259D1
Authority
DE
Germany
Prior art keywords
human interleukin
interleukin
compositions
preparation
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232259T
Other languages
English (en)
Other versions
DE69232259T2 (de
Inventor
Shingou Sakurai
Masanobu Naruto
Makoto Kihara
Keizo Hanada
Emiko Sano
Shigeru Ichikura
Jun Utsumi
Kazuo Hosoi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of DE69232259D1 publication Critical patent/DE69232259D1/de
Application granted granted Critical
Publication of DE69232259T2 publication Critical patent/DE69232259T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/204IL-6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5412IL-6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/20Partition-, reverse-phase or hydrophobic interaction chromatography
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656Adult fibroblasts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69232259T 1991-04-18 1992-04-17 Verfahren zur Herstellung von Interleukin-6 Zusammensetzungen Expired - Fee Related DE69232259T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8660291 1991-04-18
JP8828491 1991-04-19
PCT/JP1992/000487 WO1992018537A1 (fr) 1991-04-18 1992-04-17 Composition a base d'interleukine 6 et procede de production

Publications (2)

Publication Number Publication Date
DE69232259D1 true DE69232259D1 (de) 2002-01-17
DE69232259T2 DE69232259T2 (de) 2002-06-13

Family

ID=26427716

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232259T Expired - Fee Related DE69232259T2 (de) 1991-04-18 1992-04-17 Verfahren zur Herstellung von Interleukin-6 Zusammensetzungen

Country Status (10)

Country Link
EP (1) EP0550756B1 (de)
KR (1) KR930700550A (de)
AT (1) ATE210150T1 (de)
AU (1) AU1554592A (de)
CA (1) CA2085744A1 (de)
DE (1) DE69232259T2 (de)
ES (1) ES2164050T3 (de)
FI (1) FI925745A0 (de)
TW (1) TW221379B (de)
WO (1) WO1992018537A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
ATE309350T1 (de) 1997-12-03 2005-11-15 Roche Diagnostics Gmbh Verfahren zur herstellung von polypeptiden mit geeigneter glykosilierung
ES2350063T3 (es) 1998-12-09 2011-01-17 Phyton Holdings, Llc Método para fabricación de glicoproteínas que tienen glicosilación de tipo humano.
DK1228231T3 (da) 1999-10-26 2007-10-29 Plant Res Int Bv Mammal-type glycosylering i planter
JP2005505234A (ja) 2001-01-19 2005-02-24 ザ ダウ ケミカル カンパニー 植物細胞によるヒト型糖鎖をもつ糖タンパク質の分泌生産方法
US7897842B2 (en) 2002-03-19 2011-03-01 Plant Research International B.V. GnTIII expression in plants
AU2003219418B2 (en) 2002-03-19 2008-02-28 Stichting Dienst Landbouwkundig Onderzoek Optimizing glycan processing in plants
AR042145A1 (es) 2002-11-27 2005-06-08 Dow Agrociences Llc Produccion de inmunoglobulinas en plantas con una fucocilacion reducida
BRPI0810443A2 (pt) 2007-04-17 2016-09-27 Plant Res Int Bv glicosilação do tipo em mamífero em plantas através da expressão de glicosiltransferases de não mamíferos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6062997A (ja) * 1983-09-17 1985-04-11 Mochida Pharmaceut Co Ltd インタ−フエロンの生産方法
DE3519011A1 (de) * 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
JPS62153755A (ja) * 1985-12-27 1987-07-08 Showa Denko Kk クロマトグラフイ−用吸着担体
JP2648860B2 (ja) * 1986-05-08 1997-09-03 イエダ リサーチ アンド デベロップメント コンパニー リミテッド ヒトインターフエロン−β2A及びヒトインターフエロン−β2B、該インターフエロンをコードする遺伝子を含むベクター、該インターフエロンを産生するセルライン及び該インターフエロンの医薬品としての用途
IE67035B1 (en) * 1986-07-08 1996-02-21 Genetics Inst Production and use of non-glycosylated IL-6
JP2676336B2 (ja) * 1986-08-06 1997-11-12 忠三 岸本 ヒトb細胞分化因子の遺伝子
JPS63150297A (ja) * 1986-12-12 1988-06-22 Ajinomoto Co Inc 新規b細胞分化因子蛋白標品
EP0315782B1 (de) * 1987-10-13 1994-09-28 Dr. Karl Thomae GmbH Verfahren zur Herstellung von Proteinen
JPH03133935A (ja) * 1989-10-19 1991-06-07 Toray Ind Inc ヒト天然型インターロイキン6組成物

Also Published As

Publication number Publication date
CA2085744A1 (en) 1992-10-19
EP0550756B1 (de) 2001-12-05
FI925745A (fi) 1992-12-17
ATE210150T1 (de) 2001-12-15
ES2164050T3 (es) 2002-02-16
EP0550756A4 (de) 1994-04-27
EP0550756A1 (de) 1993-07-14
AU1554592A (en) 1992-11-17
TW221379B (de) 1994-03-01
FI925745A0 (fi) 1992-12-17
KR930700550A (ko) 1993-03-15
DE69232259T2 (de) 2002-06-13
WO1992018537A1 (fr) 1992-10-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee