BG61916B1 - Нови производни на еритромицина и метод за получаването иизползването им като лекарствени средства - Google Patents

Нови производни на еритромицина и метод за получаването иизползването им като лекарствени средства Download PDF

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Publication number
BG61916B1
BG61916B1 BG100150A BG10015095A BG61916B1 BG 61916 B1 BG61916 B1 BG 61916B1 BG 100150 A BG100150 A BG 100150A BG 10015095 A BG10015095 A BG 10015095A BG 61916 B1 BG61916 B1 BG 61916B1
Authority
BG
Bulgaria
Prior art keywords
formula
compounds
methyl
radical
optionally
Prior art date
Application number
BG100150A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG100150A (bg
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of BG100150A publication Critical patent/BG100150A/bg
Publication of BG61916B1 publication Critical patent/BG61916B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BG100150A 1994-04-08 1995-11-20 Нови производни на еритромицина и метод за получаването иизползването им като лекарствени средства BG61916B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
BG100150A BG100150A (bg) 1996-06-28
BG61916B1 true BG61916B1 (bg) 1998-09-30

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100150A BG61916B1 (bg) 1994-04-08 1995-11-20 Нови производни на еритромицина и метод за получаването иизползването им като лекарствени средства

Country Status (49)

Country Link
US (2) US5656607A (no)
EP (1) EP0676409B1 (no)
JP (1) JP3000023B2 (no)
KR (1) KR100317148B1 (no)
CN (1) CN1059445C (no)
AP (1) AP587A (no)
AT (1) ATE234853T1 (no)
AU (1) AU684939B2 (no)
BG (1) BG61916B1 (no)
BR (1) BR9506147A (no)
CA (1) CA2164638C (no)
CO (1) CO4370097A1 (no)
CZ (1) CZ296005B6 (no)
DE (1) DE69529934T2 (no)
DK (1) DK0676409T3 (no)
DZ (1) DZ1869A1 (no)
EE (1) EE04498B1 (no)
ES (1) ES2189820T3 (no)
FI (1) FI111264B (no)
FR (1) FR2718450B1 (no)
GB (1) GB2288174A (no)
GE (1) GEP19991836B (no)
HR (1) HRP950217B1 (no)
HU (1) HU215396B (no)
IL (1) IL112954A (no)
IS (1) IS1865B (no)
JO (1) JO1850B1 (no)
LV (1) LV11182B (no)
MA (1) MA23501A1 (no)
MD (1) MD663G2 (no)
MY (1) MY114672A (no)
NO (1) NO308361B1 (no)
NZ (1) NZ284498A (no)
OA (1) OA10200A (no)
PE (1) PE2896A1 (no)
PL (1) PL180837B1 (no)
PT (1) PT676409E (no)
RO (1) RO115634B1 (no)
RU (1) RU2141965C1 (no)
SA (1) SA97170757A (no)
SI (1) SI0676409T1 (no)
SK (1) SK284079B6 (no)
SV (1) SV1995000018A (no)
TN (1) TNSN95026A1 (no)
TW (1) TW316908B (no)
UA (1) UA44705C2 (no)
WO (1) WO1995027720A1 (no)
YU (1) YU49221B (no)
ZA (1) ZA952059B (no)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
KR20000011071A (ko) * 1996-05-07 2000-02-25 스티븐 에프. 웨인스톡 3-데스클라디노스-2,3-안하이드로에리트로마이신 유도체
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
NZ334274A (en) * 1996-09-04 2001-02-23 Abbott Lab 6-o-substituted ketolides having antibacterial activity
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6421398A (en) * 1997-03-24 1998-10-20 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
PL337606A1 (en) * 1997-06-11 2000-08-28 Pfizer Prod Inc Derivatives of erythromycin 9-oxime
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
WO2000017218A1 (en) 1998-09-22 2000-03-30 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1137654A1 (en) 1998-12-10 2001-10-04 Pfizer Products Inc. Carbamate and carbazate ketolide antibiotics
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
EP1749832A3 (en) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Carbamate and carbazate ketolide antibiotics
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6458771B1 (en) 1999-04-16 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
WO2000063224A2 (en) * 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Macrolide antiinfective agents
IL145739A0 (en) * 1999-05-24 2002-07-25 Pfizer Prod Inc 13-methyl-erythromycin derivatives
CA2451391A1 (en) 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
MXPA04012978A (es) 2002-07-01 2005-09-12 Arkion Life Sciences Llc D B A Proceso y material para la produccion de glucosamina y n-acetilglucosamina.
US7601695B2 (en) 2003-03-10 2009-10-13 Optimer Pharmaceuticals, Inc. Antibacterial agents
JP2006524702A (ja) * 2003-04-25 2006-11-02 カイロン コーポレイション ピリジル置換ケトライド抗体
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
CA2703475A1 (en) * 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN102245195B (zh) * 2008-10-24 2016-01-13 森普拉制药公司 使用含三唑的大环内酯的生物防御
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
WO2011119604A1 (en) 2010-03-22 2011-09-29 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
AU2011255464C1 (en) 2010-05-20 2017-02-23 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc FLUOROCETOLIDES FORMING HYDROGEN LINKS TO TREAT DISEASES
EP2830632A4 (en) 2012-03-27 2015-10-21 Cempra Pharmaceuticals Inc PARENTERAL FORMULATIONS FOR THE ADMINISTRATION OF MACROLIDE ANTIBIOTICS
AU2014239959A1 (en) 2013-03-14 2015-10-01 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CN105246334A (zh) 2013-04-04 2016-01-13 哈佛大学的校长及成员们 大环内酯及其制备和使用方法
US10633407B2 (en) * 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
HRP950217B1 (en) 2004-06-30
MD663G2 (ro) 1997-07-31
DE69529934D1 (de) 2003-04-24
HU215396B (hu) 1998-12-28
MA23501A1 (fr) 1995-12-31
CN1126997A (zh) 1996-07-17
MD663F1 (ro) 1997-01-31
EP0676409B1 (fr) 2003-03-19
JO1850B1 (en) 1995-12-27
JP3000023B2 (ja) 2000-01-17
FI955913A (fi) 1995-12-08
CZ296005B6 (cs) 2005-12-14
IL112954A (en) 2000-07-16
SK154695A3 (en) 1996-10-02
NO954942L (no) 1996-02-07
US5760233A (en) 1998-06-02
CO4370097A1 (es) 1996-10-07
TNSN95026A1 (fr) 1996-02-06
SV1995000018A (es) 1997-10-24
ES2189820T3 (es) 2003-07-16
FR2718450A1 (fr) 1995-10-13
LV11182B (en) 1997-04-20
AP9500743A0 (en) 1995-07-31
ATE234853T1 (de) 2003-04-15
EP0676409A1 (fr) 1995-10-11
HRP950217A2 (en) 1997-08-31
PL311871A1 (en) 1996-03-18
EE9500080A (et) 1996-12-16
IS4309A (is) 1995-11-17
RU2141965C1 (ru) 1999-11-27
HU9503505D0 (en) 1996-02-28
EE04498B1 (et) 2005-06-15
YU49221B (sh) 2004-11-25
PE2896A1 (es) 1996-02-12
TW316908B (no) 1997-10-01
GB9506856D0 (en) 1995-05-24
BR9506147A (pt) 1996-04-16
OA10200A (fr) 1996-12-18
SK284079B6 (sk) 2004-09-08
SA97170757A (ar) 2005-12-03
FI111264B (fi) 2003-06-30
NO954942D0 (no) 1995-12-06
DZ1869A1 (fr) 2002-02-17
SI0676409T1 (en) 2003-06-30
CN1059445C (zh) 2000-12-13
AU2310795A (en) 1995-10-30
YU21695A (sh) 1997-12-05
KR100317148B1 (ko) 2002-06-22
BG100150A (bg) 1996-06-28
WO1995027720A1 (fr) 1995-10-19
JPH07278177A (ja) 1995-10-24
DE69529934T2 (de) 2003-09-04
US5656607A (en) 1997-08-12
GB2288174A (en) 1995-10-11
NZ284498A (en) 1997-07-27
ZA952059B (en) 1996-03-13
LV11182A (lv) 1996-04-20
PT676409E (pt) 2003-08-29
DK0676409T3 (da) 2003-06-23
AU684939B2 (en) 1998-01-08
GEP19991836B (en) 1999-11-05
FR2718450B1 (fr) 1997-01-10
CA2164638A1 (fr) 1995-10-19
FI955913A0 (fi) 1995-12-08
PL180837B1 (pl) 2001-04-30
CZ322395A3 (en) 1996-08-14
AP587A (en) 1997-04-29
CA2164638C (fr) 2003-12-30
HUT73772A (en) 1996-09-30
UA44705C2 (uk) 2002-03-15
IL112954A0 (en) 1995-06-29
NO308361B1 (no) 2000-09-04
RO115634B1 (ro) 2000-04-28
IS1865B (is) 2003-05-02
MY114672A (en) 2002-12-31

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