BE1002136A5 - Preparation de tetrazoles antihyperchlolesterolemiques et de leurs intermediaires. - Google Patents
Preparation de tetrazoles antihyperchlolesterolemiques et de leurs intermediaires. Download PDFInfo
- Publication number
- BE1002136A5 BE1002136A5 BE8900162A BE8900162A BE1002136A5 BE 1002136 A5 BE1002136 A5 BE 1002136A5 BE 8900162 A BE8900162 A BE 8900162A BE 8900162 A BE8900162 A BE 8900162A BE 1002136 A5 BE1002136 A5 BE 1002136A5
- Authority
- BE
- Belgium
- Prior art keywords
- preparation
- intermediates
- antihyperchlolesterolemic
- tetrazoles
- radical
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- KJUGUADJHNHALS-UHFFFAOYSA-N 1H-tetrazole Substances C=1N=NNN=1 KJUGUADJHNHALS-UHFFFAOYSA-N 0.000 title 1
- 150000003536 tetrazoles Chemical class 0.000 title 1
- -1 C1-4alkyl radical Chemical class 0.000 abstract 2
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- HXCKCCRKGXHOBK-UHFFFAOYSA-N cycloheptane Chemical compound [CH]1CCCCCC1 HXCKCCRKGXHOBK-UHFFFAOYSA-N 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyrane Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/156,865 US4824959A (en) | 1988-02-18 | 1988-02-18 | Intermediates for antihypercholesterolemic tetrazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE1002136A5 true BE1002136A5 (fr) | 1990-07-24 |
Family
ID=22561419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE8900162A BE1002136A5 (fr) | 1988-02-18 | 1989-02-17 | Preparation de tetrazoles antihyperchlolesterolemiques et de leurs intermediaires. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US4824959A (enExample) |
| JP (2) | JP2871707B2 (enExample) |
| KR (1) | KR970002233B1 (enExample) |
| CN (1) | CN1025619C (enExample) |
| AT (1) | AT401057B (enExample) |
| AU (1) | AU621586B2 (enExample) |
| BE (1) | BE1002136A5 (enExample) |
| CA (1) | CA1340430C (enExample) |
| CH (1) | CH680792A5 (enExample) |
| CY (1) | CY1874A (enExample) |
| DD (4) | DD285600A5 (enExample) |
| DE (1) | DE3904899A1 (enExample) |
| DK (1) | DK75289A (enExample) |
| EG (1) | EG19217A (enExample) |
| ES (1) | ES2017810A6 (enExample) |
| FI (1) | FI890725L (enExample) |
| FR (1) | FR2630112B1 (enExample) |
| GB (1) | GB2216121B (enExample) |
| GR (1) | GR1000664B (enExample) |
| HK (3) | HK129395A (enExample) |
| HU (2) | HU204045B (enExample) |
| IE (1) | IE65090B1 (enExample) |
| IT (1) | IT1230750B (enExample) |
| LU (1) | LU87456A1 (enExample) |
| MY (1) | MY106279A (enExample) |
| NL (1) | NL8900397A (enExample) |
| NO (1) | NO172439C (enExample) |
| NZ (1) | NZ227935A (enExample) |
| PT (1) | PT89748B (enExample) |
| SE (2) | SE503179C2 (enExample) |
| YU (1) | YU34189A (enExample) |
| ZA (1) | ZA891239B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3741509A1 (de) * | 1987-12-08 | 1989-06-22 | Hoechst Ag | Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte |
| GB2244706B (en) * | 1988-02-18 | 1992-07-15 | Bristol Myers Co | Preparation of antihypercholesterolemic tetrazole intermediates |
| US4870187A (en) * | 1988-08-23 | 1989-09-26 | Bristol-Myers Company | Antihypercholesterolemic tetrazol-1-yl compounds |
| US5010205A (en) * | 1988-08-23 | 1991-04-23 | Bristol-Myers Company | Antihypercholesterolemic tetrazol-1-yl intermediates |
| DE4128345C1 (en) * | 1991-08-27 | 1993-06-09 | Hoechst Ag, 6230 Frankfurt, De | 3R,5S 3,5,6-tri:hydroxy-hexanoic acid isopropylidene ketal derivs. prepn. - from 7-benzyl:oxy 4,6-di:hydroxy:heptene by multistage process |
| US5278313A (en) * | 1992-03-27 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors |
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| CA2137049A1 (en) * | 1993-12-15 | 1995-06-16 | John K. Thottathil | Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds |
| DE10147030A1 (de) * | 2001-09-04 | 2003-03-27 | Forschungszentrum Juelich Gmbh | Verfahren zur Trennung diastereomerer 1,3-Diol-Acetale |
| WO2005107739A1 (en) * | 2004-05-11 | 2005-11-17 | Darley Pharmaceuticals Ltd. | Spiroderivatives for the treatment of hypertension |
| US20050272808A1 (en) * | 2004-05-11 | 2005-12-08 | Nadav Zamir | Compositions and methods for the treatment of hypertension |
| CN104303915B (zh) * | 2014-08-25 | 2016-05-25 | 李世峰 | 一种机插水稻水浮式育秧技术 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0252476A2 (en) * | 1986-07-07 | 1988-01-13 | Warner-Lambert Company | Trans-6-[2-(N-heteroaryl-3,5-disubstituted) pyrazol-4-yl)-ethyl]- or ethenyl] tetrahydro-4-hydroxypyran-2-one-derivatives a process for their preparation and the use thereof |
| EP0259087A2 (en) * | 1986-09-02 | 1988-03-09 | Merck & Co. Inc. | Prodrugs of antihypercholesterolemic compounds |
| US4751229A (en) * | 1987-07-09 | 1988-06-14 | Warner-Lambert Company | Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles |
| FR2612924A1 (fr) * | 1987-02-25 | 1988-09-30 | Bristol Myers Co | Derives de tetrazole antihypercholesterolemiques |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58225085A (ja) * | 1982-06-24 | 1983-12-27 | Nippon Kayaku Co Ltd | アセタ−ルグリコ−ルジアクリレ−トおよびその製造法 |
| DE3807929A1 (de) * | 1988-03-10 | 1989-09-28 | Basf Ag | Verfahren zur herstellung von reliefformen |
-
1988
- 1988-02-18 US US07/156,865 patent/US4824959A/en not_active Expired - Lifetime
-
1989
- 1989-01-24 FR FR898900786A patent/FR2630112B1/fr not_active Expired - Lifetime
- 1989-02-10 NZ NZ227935A patent/NZ227935A/xx unknown
- 1989-02-15 EG EG7689A patent/EG19217A/xx active
- 1989-02-15 YU YU00341/89A patent/YU34189A/xx unknown
- 1989-02-15 ES ES8900538A patent/ES2017810A6/es not_active Expired - Fee Related
- 1989-02-15 FI FI890725A patent/FI890725L/fi not_active Application Discontinuation
- 1989-02-16 NO NO890661A patent/NO172439C/no not_active IP Right Cessation
- 1989-02-16 HU HU895307A patent/HU204045B/hu not_active IP Right Cessation
- 1989-02-16 CA CA000591211A patent/CA1340430C/en not_active Expired - Fee Related
- 1989-02-16 HU HU89781A patent/HU209905B/hu unknown
- 1989-02-16 MY MYPI89000188A patent/MY106279A/en unknown
- 1989-02-16 GB GB8903604A patent/GB2216121B/en not_active Expired - Lifetime
- 1989-02-17 KR KR1019890001890A patent/KR970002233B1/ko not_active Expired - Fee Related
- 1989-02-17 NL NL8900397A patent/NL8900397A/nl active Search and Examination
- 1989-02-17 AU AU30075/89A patent/AU621586B2/en not_active Expired
- 1989-02-17 DD DD89334039A patent/DD285600A5/de unknown
- 1989-02-17 DD DD89325844A patent/DD283618A5/de unknown
- 1989-02-17 IT IT8919474A patent/IT1230750B/it active
- 1989-02-17 DD DD89334043A patent/DD285603A5/de unknown
- 1989-02-17 CH CH572/89A patent/CH680792A5/de not_active IP Right Cessation
- 1989-02-17 DK DK075289A patent/DK75289A/da not_active Application Discontinuation
- 1989-02-17 BE BE8900162A patent/BE1002136A5/fr active
- 1989-02-17 ZA ZA891239A patent/ZA891239B/xx unknown
- 1989-02-17 JP JP1038142A patent/JP2871707B2/ja not_active Expired - Fee Related
- 1989-02-17 DD DD89334042A patent/DD285602A5/de unknown
- 1989-02-17 CN CN89100852A patent/CN1025619C/zh not_active Expired - Lifetime
- 1989-02-17 AT AT0036189A patent/AT401057B/de not_active IP Right Cessation
- 1989-02-17 PT PT89748A patent/PT89748B/pt not_active IP Right Cessation
- 1989-02-17 DE DE3904899A patent/DE3904899A1/de not_active Ceased
- 1989-02-17 IE IE52389A patent/IE65090B1/en not_active IP Right Cessation
- 1989-02-17 GR GR890100095A patent/GR1000664B/el not_active IP Right Cessation
- 1989-02-17 LU LU87456A patent/LU87456A1/fr unknown
- 1989-02-17 SE SE8900565A patent/SE503179C2/sv not_active IP Right Cessation
-
1993
- 1993-02-23 SE SE9300595A patent/SE9300595A0/sv not_active Application Discontinuation
-
1995
- 1995-08-17 HK HK129395A patent/HK129395A/xx not_active IP Right Cessation
- 1995-08-17 HK HK129295A patent/HK129295A/xx not_active IP Right Cessation
-
1996
- 1996-03-21 HK HK47596A patent/HK47596A/xx not_active IP Right Cessation
- 1996-04-05 CY CY187496A patent/CY1874A/en unknown
-
1998
- 1998-04-28 JP JP10118511A patent/JP2922887B2/ja not_active Expired - Lifetime
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0252476A2 (en) * | 1986-07-07 | 1988-01-13 | Warner-Lambert Company | Trans-6-[2-(N-heteroaryl-3,5-disubstituted) pyrazol-4-yl)-ethyl]- or ethenyl] tetrahydro-4-hydroxypyran-2-one-derivatives a process for their preparation and the use thereof |
| EP0259087A2 (en) * | 1986-09-02 | 1988-03-09 | Merck & Co. Inc. | Prodrugs of antihypercholesterolemic compounds |
| FR2612924A1 (fr) * | 1987-02-25 | 1988-09-30 | Bristol Myers Co | Derives de tetrazole antihypercholesterolemiques |
| US4751229A (en) * | 1987-07-09 | 1988-06-14 | Warner-Lambert Company | Treating fungal infections with substituted-(6-(tetrahydro-4-hydroxy-2-oxo-2H-pyran-2-yl)ethyl)- or ethenyl)pyrazoles |
Non-Patent Citations (1)
| Title |
|---|
| TETRAHEDRON LETTERS, vol. 27, no. 43, 1986, pages 5201-5202, Pergamon Press, GB; B. O'CONNOR et al.: "Syntheses of argentilactone 11 and goniothalamin 15" * |
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