AU770745B2 - Stable complexes of poorly soluble compounds - Google Patents

Stable complexes of poorly soluble compounds Download PDF

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Publication number
AU770745B2
AU770745B2 AU48807/99A AU4880799A AU770745B2 AU 770745 B2 AU770745 B2 AU 770745B2 AU 48807/99 A AU48807/99 A AU 48807/99A AU 4880799 A AU4880799 A AU 4880799A AU 770745 B2 AU770745 B2 AU 770745B2
Authority
AU
Australia
Prior art keywords
compound
polymer
therapeutically active
ionic polymer
insoluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU48807/99A
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English (en)
Other versions
AU4880799A (en
Inventor
Antonio A. Albano
Wantanee Phuapradit
Harpreet K. Sandhu
Navnit Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26798138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU770745(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU4880799A publication Critical patent/AU4880799A/en
Application granted granted Critical
Publication of AU770745B2 publication Critical patent/AU770745B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU48807/99A 1998-09-22 1999-09-20 Stable complexes of poorly soluble compounds Expired AU770745B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10133698P 1998-09-22 1998-09-22
US60/101336 1998-09-22
US13653199P 1999-05-28 1999-05-28
US60/136531 1999-05-28

Publications (2)

Publication Number Publication Date
AU4880799A AU4880799A (en) 2000-03-23
AU770745B2 true AU770745B2 (en) 2004-03-04

Family

ID=26798138

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48807/99A Expired AU770745B2 (en) 1998-09-22 1999-09-20 Stable complexes of poorly soluble compounds

Country Status (32)

Country Link
US (1) US6350786B1 (enExample)
EP (1) EP0988863B2 (enExample)
JP (5) JP2000095708A (enExample)
KR (1) KR100362019B1 (enExample)
CN (1) CN1201821C (enExample)
AR (2) AR022096A1 (enExample)
AT (1) ATE265232T1 (enExample)
AU (1) AU770745B2 (enExample)
BR (1) BR9904283A (enExample)
CA (1) CA2282906C (enExample)
CO (1) CO5140077A1 (enExample)
CZ (1) CZ300215B6 (enExample)
DE (1) DE69916733T3 (enExample)
DK (1) DK0988863T4 (enExample)
ES (1) ES2218918T5 (enExample)
HR (1) HRP990287B1 (enExample)
HU (1) HU228341B1 (enExample)
ID (1) ID24034A (enExample)
IL (1) IL131957A (enExample)
MA (1) MA26692A1 (enExample)
MY (1) MY124377A (enExample)
NO (1) NO326928B1 (enExample)
NZ (1) NZ337884A (enExample)
PE (1) PE20001049A1 (enExample)
PL (1) PL202757B1 (enExample)
PT (1) PT988863E (enExample)
RS (1) RS50193B (enExample)
RU (1) RU2240827C2 (enExample)
SG (1) SG97131A1 (enExample)
SI (1) SI0988863T2 (enExample)
TR (1) TR199902324A2 (enExample)
TW (1) TWI234465B (enExample)

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