DE602004031144D1 - Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats - Google Patents

Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats

Info

Publication number
DE602004031144D1
DE602004031144D1 DE602004031144T DE602004031144T DE602004031144D1 DE 602004031144 D1 DE602004031144 D1 DE 602004031144D1 DE 602004031144 T DE602004031144 T DE 602004031144T DE 602004031144 T DE602004031144 T DE 602004031144T DE 602004031144 D1 DE602004031144 D1 DE 602004031144D1
Authority
DE
Germany
Prior art keywords
solid dispersion
pharmaceutical preparations
represent
formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004031144T
Other languages
English (en)
Inventor
Hiroyuki Higuchi
Hirokazu Hagio
Kenichi Ogawa
Akira Yabuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE602004031144D1 publication Critical patent/DE602004031144D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE602004031144T 2003-11-14 2004-11-15 Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats Active DE602004031144D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003385501 2003-11-14
PCT/JP2004/016942 WO2005046696A1 (ja) 2003-11-14 2004-11-15 フェニルアラニン誘導体の固体分散体または固体分散体医薬製剤

Publications (1)

Publication Number Publication Date
DE602004031144D1 true DE602004031144D1 (de) 2011-03-03

Family

ID=34587365

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004031144T Active DE602004031144D1 (de) 2003-11-14 2004-11-15 Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats

Country Status (12)

Country Link
US (1) US8518441B2 (de)
EP (1) EP1683524B1 (de)
JP (1) JP4780522B2 (de)
KR (2) KR101138219B1 (de)
CN (2) CN101664411A (de)
AT (1) ATE495746T1 (de)
CA (1) CA2546115C (de)
DE (1) DE602004031144D1 (de)
DK (1) DK1683524T3 (de)
ES (1) ES2360064T3 (de)
PL (1) PL1683524T3 (de)
WO (1) WO2005046696A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
ATE464299T1 (de) * 2002-02-20 2010-04-15 Ajinomoto Kk Neues phenylalaninderivat
CN1886385B (zh) 2003-11-27 2013-02-27 味之素株式会社 苯丙氨酸衍生物的结晶及其制造方法
JP4703959B2 (ja) * 2003-12-03 2011-06-15 株式会社日立製作所 記憶装置システムおよびそのレプリケーション作成方法
NZ587551A (en) 2004-06-24 2012-01-12 Vertex Pharma 5-Amino-phenol derivatives such as 5-amino-2,4-di-tert-butyl-phenol
WO2007060409A1 (en) * 2005-11-23 2007-05-31 Astrazeneca Ab L-alanine derivatives
PL3219705T3 (pl) 2005-12-28 2020-08-10 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne amorficznych postaci n-[2,4-bis(1,1-dimetyloetylo)-5-hydroksyfenylo]-1,4-dihydro-4-oksochinolino-3-karboksyamidu
JP2007308479A (ja) 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd 固体分散体製剤
CN101057833A (zh) * 2006-04-20 2007-10-24 信越化学工业株式会社 固体分散体制剂
EP2049490A1 (de) * 2006-06-09 2009-04-22 Astra Zeneca AB N-(benzoyl)-0-[2-(pyridin-2-ylamino)ethyl]-l-tyrosinderivate und verwandte verbindungen als a5b1-antagonisten zur behandlung fester tumore
AU2007261943B2 (en) 2006-06-22 2012-11-01 Kaneka Corporation Reduced coenzyme Q10-containing composition and method for producing the same
US8519120B2 (en) 2006-08-08 2013-08-27 Shin-Etsu Chemical Co., Ltd. Methods for producing a low-substituted hydroxypropylcellulose powder
US8343547B2 (en) 2006-08-08 2013-01-01 Shin-Etsu Chemical Co., Ltd. Solid dosage form comprising solid dispersion
JP5258224B2 (ja) * 2006-08-08 2013-08-07 信越化学工業株式会社 固体分散体の固形製剤及びその製造方法
US8343548B2 (en) 2006-08-08 2013-01-01 Shin-Etsu Chemical Co., Ltd. Solid dosage form comprising solid dispersion
WO2008062859A1 (fr) 2006-11-22 2008-05-29 Ajinomoto Co., Inc. Procédé de fabrication de dérivés de phénylalanine ayant des squelettes de quinazolinedione et intermédiaires pour la fabrication
WO2008073958A2 (en) 2006-12-12 2008-06-19 Wyeth Substituted benzothiadiazinedioxide derivatives and methods of their use
EP2101737B1 (de) * 2006-12-22 2014-06-18 Yuhan Corporation Revaprazan enthaltende feste dispersion und verfahren zu ihrer herstellung
US20090062267A1 (en) * 2007-01-29 2009-03-05 Astrazeneca Ab L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS
WO2008125811A1 (en) * 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
JP6073043B2 (ja) 2007-08-21 2017-02-01 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 医薬品適用のための熱−動力学的混合
EP2251005B1 (de) 2008-02-13 2012-10-10 Dainippon Sumitomo Pharma Co., Ltd. Oral zerfallende tabletten
CA2714190C (en) * 2008-02-28 2018-01-16 Nishanth Gopinathan Tablets and preparation thereof
EP3345625B1 (de) * 2008-08-13 2020-12-09 Vertex Pharmaceuticals Incorporated Pharmazeutische zusammensetzung und verabreichung davon
US8303868B2 (en) * 2009-01-26 2012-11-06 Shin-Etsu Chemical Co., Ltd. Wet granulation tableting method using aqueous dispersion of low-substituted hydroxypropyl cellulose
KR101852173B1 (ko) 2009-03-20 2018-04-27 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
US8591955B2 (en) * 2009-08-11 2013-11-26 Dainippon Sumitomo Pharma Co., Ltd. Orally rapidly disintegrating tablet that contains two or more types of particles
WO2011122620A1 (ja) 2010-03-29 2011-10-06 味の素株式会社 フェニルアラニン誘導体を含有する医薬製剤
EP2993173A1 (de) 2010-03-29 2016-03-09 Ajinomoto Co., Inc. Kristalle von Salzen von Phenylalaninderivaten
KR101739818B1 (ko) * 2011-05-20 2017-05-26 주식회사유한양행 레바프라잔 또는 그의 염을 함유하는 현탁액 형태의 경구투여용 약학 조성물
CN109966264A (zh) 2012-02-27 2019-07-05 沃泰克斯药物股份有限公司 药物组合物及其施用
CA2961311C (en) 2014-09-29 2022-12-06 Ea Pharma Co., Ltd. Pharmaceutical composition for treating ulcerative colitis
US9701639B2 (en) 2014-10-07 2017-07-11 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
US20180344646A1 (en) * 2015-11-25 2018-12-06 Patheon Development Services Inc. Amorphous dispersion granules and oral dosage forms
WO2019246455A1 (en) 2018-06-20 2019-12-26 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an integrin inhibitor
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
KR102652797B1 (ko) 2018-10-30 2024-04-02 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린의 억제를 위한 화합물
KR102630416B1 (ko) 2018-10-30 2024-02-01 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체
AU2019373245C1 (en) 2018-10-30 2022-10-27 Gilead Sciences, Inc. Compounds for inhibition of alpha 4β7 integrin
JP7491996B2 (ja) 2019-08-14 2024-05-28 ギリアード サイエンシーズ， インコーポレイテッド α４β７インテグリンの阻害のための化合物

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6038322A (ja) 1983-08-11 1985-02-27 Fujisawa Pharmaceut Co Ltd ジヒドロピリジンａ物質含有易溶性固形製剤
JPH054919A (ja) * 1990-07-25 1993-01-14 Sankyo Co Ltd チアゾリジン誘導体の固体分散体
JPH05310571A (ja) * 1991-07-01 1993-11-22 Ishihara Sangyo Kaisha Ltd 非晶質性ベンゾイルウレア系化合物の抗ガン性医薬組成物
IT1256386B (it) * 1992-11-13 1995-12-04 Luigi Boltri Composizioni farmaceutiche comprendenti un farmaco,una sostanza polimerica reticolata,un olio ed un agente tensioattivo
JPH07324086A (ja) * 1994-05-31 1995-12-12 Sankyo Co Ltd チアゾリジン誘導体の固体分散体または固体分散体製剤
WO1996019239A1 (fr) * 1994-12-21 1996-06-27 Yamanouchi Pharmaceutical Co., Ltd. Composition solide a solubilite et absorbabilite ameliorees
TW487582B (en) 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
US6005069A (en) 1996-12-18 1999-12-21 Donlar Corporation Production of polysuccinimide and derivatives thereof in a sulfur-containing solvent
TW486370B (en) 1996-12-25 2002-05-11 Yamanouchi Pharma Co Ltd Rapidly disintegrable pharmaceutical composition
PL338457A1 (en) * 1997-07-31 2000-11-06 Elan Pharm Inc Sulphonylated dipeptidic compounds capable to inhibit adhesion of leucocytes through the mediation of vla-4
DE69804994D1 (de) 1997-11-03 2002-05-23 Janssen Pharmaceutica Nv Arzneimittel enthaltend lipidsenkende verbindungen
US6329372B1 (en) * 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
JPH11246404A (ja) 1998-03-04 1999-09-14 Taiho Yakuhin Kogyo Kk 吸収を改善した医薬組成物
JP3404648B2 (ja) * 1998-07-28 2003-05-12 武田薬品工業株式会社 速崩壊性固形製剤
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
JP2000191518A (ja) * 1998-10-19 2000-07-11 Eisai Co Ltd 溶解性の改善された口腔内速崩壊性錠剤
US6407278B2 (en) * 1998-11-16 2002-06-18 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and methods for the preparation and use of the same
US6331646B1 (en) * 1998-11-20 2001-12-18 The Nutrasweet Co. Amorphous N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6291503B1 (en) * 1999-01-15 2001-09-18 Bayer Aktiengesellschaft β-phenylalanine derivatives as integrin antagonists
JP4748839B2 (ja) * 1999-03-25 2011-08-17 大塚製薬株式会社 シロスタゾール製剤
JP2000281561A (ja) 1999-03-26 2000-10-10 Ajinomoto Co Inc 新規溶媒法固体分散体製剤
HUP0300429A2 (hu) 2000-04-19 2003-07-28 Fujisawa Pharmaceutical Co., Ltd. Javított felszívódási képességű szilárd diszperzió és eljárás az előállítására
JP2001335483A (ja) 2000-05-30 2001-12-04 Nichiko Pharmaceutical Co Ltd ニルバジピン含有製剤
BRPI0113331B8 (pt) * 2000-08-18 2021-05-25 Ajinomoto Kk derivados de fenilalanina ou seus sais parmaceuticamente aceitáveis, antagonista de integrina alfa 4, agente terapêutico ou agente preventivo para doenças inflamatórias, e, composição farmacêutica
ATE345127T1 (de) 2000-09-29 2006-12-15 Ajinomoto Kk Neue phenylalanin-derivate
JP4165224B2 (ja) 2001-03-05 2008-10-15 日本新薬株式会社 発泡性組成物
DE60224293T2 (de) * 2001-09-21 2008-12-11 Egalet A/S Feste dispersionen mit kontrollierter freisetzung von carvedilol
JP4135373B2 (ja) * 2002-02-15 2008-08-20 味の素株式会社 光学活性β−フェニルアラニン誘導体の製造方法
CN101386600B (zh) 2003-02-20 2011-07-06 味之素株式会社 具有喹唑二酮骨架的苯丙氨酸衍生物的制造方法及制造中间体
EP3216449A1 (de) 2003-11-14 2017-09-13 EA Pharma Co., Ltd. Präparat zur oralen verabreichung aus phenylalaninderivaten
CN1886385B (zh) 2003-11-27 2013-02-27 味之素株式会社 苯丙氨酸衍生物的结晶及其制造方法
RU2390520C2 (ru) 2003-12-22 2010-05-27 Адзиномото Ко., Инк. Новые производные фенилаланина

Also Published As

Publication number Publication date
WO2005046696A1 (ja) 2005-05-26
KR20060125766A (ko) 2006-12-06
KR20110086886A (ko) 2011-08-01
ATE495746T1 (de) 2011-02-15
CN1882346A (zh) 2006-12-20
KR101118930B1 (ko) 2012-03-14
PL1683524T3 (pl) 2011-06-30
EP1683524A4 (de) 2010-04-14
US8518441B2 (en) 2013-08-27
EP1683524A1 (de) 2006-07-26
CN101664411A (zh) 2010-03-10
EP1683524B1 (de) 2011-01-19
CN100563658C (zh) 2009-12-02
JP4780522B2 (ja) 2011-09-28
CA2546115C (en) 2013-01-08
DK1683524T3 (da) 2011-03-14
US20060204572A1 (en) 2006-09-14
ES2360064T3 (es) 2011-05-31
KR101138219B1 (ko) 2012-04-24
JPWO2005046696A1 (ja) 2007-05-24
CA2546115A1 (en) 2005-05-26

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