ATE495746T1 - Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats - Google Patents

Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats

Info

Publication number
ATE495746T1
ATE495746T1 AT04818537T AT04818537T ATE495746T1 AT E495746 T1 ATE495746 T1 AT E495746T1 AT 04818537 T AT04818537 T AT 04818537T AT 04818537 T AT04818537 T AT 04818537T AT E495746 T1 ATE495746 T1 AT E495746T1
Authority
AT
Austria
Prior art keywords
solid dispersion
pharmaceutical preparations
represent
formula
hydrogen atom
Prior art date
Application number
AT04818537T
Other languages
English (en)
Inventor
Hiroyuki Higuchi
Hirokazu Hagio
Kenichi Ogawa
Akira Yabuki
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Application granted granted Critical
Publication of ATE495746T1 publication Critical patent/ATE495746T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT04818537T 2003-11-14 2004-11-15 Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats ATE495746T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003385501 2003-11-14
PCT/JP2004/016942 WO2005046696A1 (ja) 2003-11-14 2004-11-15 フェニルアラニン誘導体の固体分散体または固体分散体医薬製剤

Publications (1)

Publication Number Publication Date
ATE495746T1 true ATE495746T1 (de) 2011-02-15

Family

ID=34587365

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04818537T ATE495746T1 (de) 2003-11-14 2004-11-15 Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats

Country Status (12)

Country Link
US (1) US8518441B2 (de)
EP (1) EP1683524B1 (de)
JP (1) JP4780522B2 (de)
KR (2) KR101138219B1 (de)
CN (2) CN100563658C (de)
AT (1) ATE495746T1 (de)
CA (1) CA2546115C (de)
DE (1) DE602004031144D1 (de)
DK (1) DK1683524T3 (de)
ES (1) ES2360064T3 (de)
PL (1) PL1683524T3 (de)
WO (1) WO2005046696A1 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
WO2003070709A1 (fr) * 2002-02-20 2003-08-28 Ajinomoto Co.,Inc. Nouveau derive de phenylalanine
WO2005051925A1 (ja) 2003-11-27 2005-06-09 Ajinomoto Co., Inc. フェニルアラニン誘導体の結晶及びその製造方法
JP4703959B2 (ja) * 2003-12-03 2011-06-15 株式会社日立製作所 記憶装置システムおよびそのレプリケーション作成方法
PL1773816T3 (pl) 2004-06-24 2015-06-30 Vertex Pharma Modulatory transporterów posiadających kasetę wiążącą ATP
CN101360736A (zh) * 2005-11-23 2009-02-04 阿斯利康(瑞典)有限公司 L-丙氨酸衍生物
HUE049976T2 (hu) 2005-12-28 2020-11-30 Vertex Pharma N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói
JP2007308479A (ja) 2006-04-20 2007-11-29 Shin Etsu Chem Co Ltd 固体分散体製剤
CN101057833A (zh) * 2006-04-20 2007-10-24 信越化学工业株式会社 固体分散体制剂
WO2007141473A1 (en) * 2006-06-09 2007-12-13 Astrazeneca Ab N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl] -l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors
JP5140585B2 (ja) 2006-06-22 2013-02-06 株式会社カネカ 還元型補酵素ｑ１０含有組成物およびその製造方法
US8343547B2 (en) 2006-08-08 2013-01-01 Shin-Etsu Chemical Co., Ltd. Solid dosage form comprising solid dispersion
JP5258224B2 (ja) * 2006-08-08 2013-08-07 信越化学工業株式会社 固体分散体の固形製剤及びその製造方法
US8343548B2 (en) 2006-08-08 2013-01-01 Shin-Etsu Chemical Co., Ltd. Solid dosage form comprising solid dispersion
US8519120B2 (en) 2006-08-08 2013-08-27 Shin-Etsu Chemical Co., Ltd. Methods for producing a low-substituted hydroxypropylcellulose powder
EP2103601B1 (de) 2006-11-22 2012-03-14 Ajinomoto Co., Inc. Verfahren zur herstellung von phenylalaninderivaten mit chinazolindiongerüsten, und zwischenprodukte für die herstellung
WO2008073958A2 (en) 2006-12-12 2008-06-19 Wyeth Substituted benzothiadiazinedioxide derivatives and methods of their use
CA2673536A1 (en) * 2006-12-22 2008-07-03 Yuhan Corporation Revaprazan-containing solid dispersion and process for the preparation thereof
WO2008093065A1 (en) * 2007-01-29 2008-08-07 Astrazeneca Ab L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS
WO2008125811A1 (en) * 2007-04-11 2008-10-23 Astrazeneca Ab N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS
CN101835492B (zh) 2007-08-21 2012-11-21 德克萨斯州立大学董事会 用于制药应用的热动力学混合
EP2251005B1 (de) * 2008-02-13 2012-10-10 Dainippon Sumitomo Pharma Co., Ltd. Oral zerfallende tabletten
ES2607814T3 (es) * 2008-02-28 2017-04-04 Abbvie Inc. Preparación de tabletas
NO2328618T3 (de) * 2008-08-13 2018-04-28
KR101565621B1 (ko) * 2009-01-26 2015-11-03 신에쓰 가가꾸 고교 가부시끼가이샤 저치환도 히드록시프로필셀룰로오스 수분산액을 이용한 습식 조립 타정법
KR101852173B1 (ko) 2009-03-20 2018-04-27 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
WO2011019043A1 (ja) * 2009-08-11 2011-02-17 大日本住友製薬株式会社 ２種以上の粒子を含有する口腔内速崩壊錠
EP2554169B1 (de) * 2010-03-29 2019-11-20 EA Pharma Co., Ltd. Pharmazeutisches präparat mit einem phenylalaninderivat
EP2993173A1 (de) 2010-03-29 2016-03-09 Ajinomoto Co., Inc. Kristalle von Salzen von Phenylalaninderivaten
KR101739818B1 (ko) * 2011-05-20 2017-05-26 주식회사유한양행 레바프라잔 또는 그의 염을 함유하는 현탁액 형태의 경구투여용 약학 조성물
BR112014021090B1 (pt) 2012-02-27 2023-01-24 Vertex Pharmaceuticals Incorporated Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma
WO2016051828A1 (ja) 2014-09-29 2016-04-07 味の素株式会社 潰瘍性大腸炎の治療用医薬組成物
KR20170063954A (ko) 2014-10-07 2017-06-08 버텍스 파마슈티칼스 인코포레이티드 낭성 섬유증 막횡단 전도도 조절자의 조정제의 공-결정
US20180344646A1 (en) * 2015-11-25 2018-12-06 Patheon Development Services Inc. Amorphous dispersion granules and oral dosage forms
EP3810085A1 (de) 2018-06-20 2021-04-28 Progenity, Inc. Behandlung der erkrankung des gastrointestinaltraktes mit einem integrin-inhibitor
CA3115820A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
CA3114240C (en) 2018-10-30 2023-09-05 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
CN112969504B (zh) 2018-10-30 2024-04-09 吉利德科学公司 用于抑制α4β7整合素的化合物
CA3148613A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Phenylalanine derived compounds and their use as inhinitors of alpha 4 beta 7 integrin

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6038322A (ja) * 1983-08-11 1985-02-27 Fujisawa Pharmaceut Co Ltd ジヒドロピリジンａ物質含有易溶性固形製剤
JPH054919A (ja) * 1990-07-25 1993-01-14 Sankyo Co Ltd チアゾリジン誘導体の固体分散体
JPH05310571A (ja) * 1991-07-01 1993-11-22 Ishihara Sangyo Kaisha Ltd 非晶質性ベンゾイルウレア系化合物の抗ガン性医薬組成物
IT1256386B (it) * 1992-11-13 1995-12-04 Luigi Boltri Composizioni farmaceutiche comprendenti un farmaco,una sostanza polimerica reticolata,un olio ed un agente tensioattivo
JPH07324086A (ja) 1994-05-31 1995-12-12 Sankyo Co Ltd チアゾリジン誘導体の固体分散体または固体分散体製剤
WO1996019239A1 (fr) * 1994-12-21 1996-06-27 Yamanouchi Pharmaceutical Co., Ltd. Composition solide a solubilite et absorbabilite ameliorees
TW487582B (en) 1995-08-11 2002-05-21 Nissan Chemical Ind Ltd Method for converting sparingly water-soluble medical substance to amorphous state
US6005069A (en) 1996-12-18 1999-12-21 Donlar Corporation Production of polysuccinimide and derivatives thereof in a sulfur-containing solvent
TW486370B (en) * 1996-12-25 2002-05-11 Yamanouchi Pharma Co Ltd Rapidly disintegrable pharmaceutical composition
KR20010022405A (ko) * 1997-07-31 2001-03-15 진 엠. 듀발 Ｖｌａ-4에 의해 매개된 백혈구 유착을 억제하는설포닐화된 디펩타이드 화합물
EE200000186A (et) 1997-11-03 2001-04-16 Janssen Pharmaceutica N.V. Osake, selliste osakeste valmistamismeetod ja kasutamine, farmatseutiline doosivorm ja selle valmistamismeetod, tahke dispersioon ja farmatseutiline pakend
US6329372B1 (en) * 1998-01-27 2001-12-11 Celltech Therapeutics Limited Phenylalanine derivatives
JPH11246404A (ja) 1998-03-04 1999-09-14 Taiho Yakuhin Kogyo Kk 吸収を改善した医薬組成物
DK1561458T3 (da) * 1998-07-28 2010-10-25 Takeda Pharmaceutical Hurtigt henfaldende fast middel
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
JP2000191518A (ja) * 1998-10-19 2000-07-11 Eisai Co Ltd 溶解性の改善された口腔内速崩壊性錠剤
US6407278B2 (en) * 1998-11-16 2002-06-18 Medimmune Oncology, Inc. Stable amorphous amifostine compositions and methods for the preparation and use of the same
US6331646B1 (en) * 1998-11-20 2001-12-18 The Nutrasweet Co. Amorphous N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester
US6291503B1 (en) 1999-01-15 2001-09-18 Bayer Aktiengesellschaft β-phenylalanine derivatives as integrin antagonists
JP4748839B2 (ja) * 1999-03-25 2011-08-17 大塚製薬株式会社 シロスタゾール製剤
JP2000281561A (ja) 1999-03-26 2000-10-10 Ajinomoto Co Inc 新規溶媒法固体分散体製剤
JPWO2001078716A1 (ja) 2000-04-19 2004-07-22 藤沢薬品工業株式会社 吸収性が改善された固体分散体
JP2001335483A (ja) 2000-05-30 2001-12-04 Nichiko Pharmaceutical Co Ltd ニルバジピン含有製剤
SI1288205T1 (sl) * 2000-08-18 2011-05-31 Ajinomoto Kk Novi derivati fenilalanina
JP4895067B2 (ja) 2000-09-29 2012-03-14 味の素株式会社 新規フェニルアラニン誘導体
WO2002069932A1 (fr) 2001-03-05 2002-09-12 Nippon Shinyaku Co., Ltd. Compositions moussantes
WO2003024426A1 (en) * 2001-09-21 2003-03-27 Egalet A/S Controlled release solid dispersions
JP4135373B2 (ja) 2002-02-15 2008-08-20 味の素株式会社 光学活性β−フェニルアラニン誘導体の製造方法
CN101386600B (zh) 2003-02-20 2011-07-06 味之素株式会社 具有喹唑二酮骨架的苯丙氨酸衍生物的制造方法及制造中间体
WO2005046697A1 (ja) 2003-11-14 2005-05-26 Ajinomoto Co., Inc. フェニルアラニン誘導体の徐放性経口投与製剤
WO2005051925A1 (ja) 2003-11-27 2005-06-09 Ajinomoto Co., Inc. フェニルアラニン誘導体の結晶及びその製造方法
BRPI0418026A (pt) 2003-12-22 2007-04-17 Ajinomoto Kk derivados de fenilalanina ou sais farmaceuticamente aceitáveis destes, composição farmacêutica, antagonista de alfa4 integrina, e, agente terapêutico ou agente preventivo para doenças

Also Published As

Publication number Publication date
PL1683524T3 (pl) 2011-06-30
CN1882346A (zh) 2006-12-20
ES2360064T3 (es) 2011-05-31
DK1683524T3 (da) 2011-03-14
CA2546115C (en) 2013-01-08
WO2005046696A1 (ja) 2005-05-26
CN101664411A (zh) 2010-03-10
EP1683524B1 (de) 2011-01-19
US20060204572A1 (en) 2006-09-14
KR20110086886A (ko) 2011-08-01
KR101138219B1 (ko) 2012-04-24
CN100563658C (zh) 2009-12-02
US8518441B2 (en) 2013-08-27
DE602004031144D1 (de) 2011-03-03
EP1683524A1 (de) 2006-07-26
KR101118930B1 (ko) 2012-03-14
EP1683524A4 (de) 2010-04-14
CA2546115A1 (en) 2005-05-26
JP4780522B2 (ja) 2011-09-28
KR20060125766A (ko) 2006-12-06
JPWO2005046696A1 (ja) 2007-05-24

Similar Documents

Publication Publication Date Title
ATE495746T1 (de) Feste dispersion oder medizinisches festes dispersionspräparat eines phenylalanin-derivats
TR200100300T2 (tr) Sitokinlerin üretiminde engelleyici olarak kullanışlı amid türevleri
HUP0400710A2 (hu) Tioéter helyettesítővel helyettesített imidazokinolinszármazékok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
EP1156045A4 (de) Amid-derivate und drogen-zusammensetzungen
AU2001293233A1 (en) Aza heterocyclic derivatives and their therapeutic use
AU2003225617A1 (en) Thiadiazolylpiperazine derivatives useful for treating or preventing pain
DK0590919T3 (da) Terapeutiske midler mod Parkinsons sygdom
ATE226574T1 (de) 4,6-diarylpyrimidin-derivate und deren salze
DE60142934D1 (de) Pharmazeutische dopamin-glykokonjugat-zusammensetzungen und verfahren zu deren herstellung
DE69313051T2 (de) Ethanolamin-derivate mit sympathomimetischer und anti-pollakiuria wirkung
RU2002100058A (ru) Кристаллические производные 1-метилкарбапенема
DE60035429D1 (de) Verwendung von sulfodehydroabietinsäure zur behandlung entzündlicher darmerkrankungen
SE0302570D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
FI933719A (fi) 4-((2-bensotiazolyl)metylamino)-a-((3,4-difluorfenoxi)metyl)-1-piperidinetanol
RU2227799C2 (ru) Производные капурамицина, фармацевтическая композиция на их основе и способы лечения или профилактики бактериальной инфекции
GEP20063759B (en) Novel Benzothiazine and Benzothiadiazine Derivatives, Method for Preparing Same and Pharmaceutical Compositions Containing Same
WO2000024389A3 (en) Benzoquinoline derivatives useful as antibacterial agents
FR2793248B1 (fr) Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TW200509941A (en) Pharmaceutical solution composition
DE60238847D1 (de) Pyrimidinderivate enthaltendes medikament
NO20013480L (no) Legemiddel for torr hud
AR011136A1 (es) Compuesto derivado 4-aminoalcoxi-1h-benzoimidazoles, composicion farmaceutica que lo contiene y el uso del mismo para la fabricacion de unmedicamento
GEP20063757B (en) Novel Benzothiazine and Benzothiadiazine Derivatives, Method for Preparing Same and Pharmaceutical Compositions Containing Same
RU94038051A (ru) Гетероциклические производные, способ их получения, фармацевтическая композиция и способ лечения
HUP0202237A2 (hu) Amin, módosított pszeudomicin vegyületek, azokat tartalmazó gyógyászati készítmény és alkalmazásuk

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties