AU2014384434B2 - Charged linkers and their uses for conjugation - Google Patents

Charged linkers and their uses for conjugation Download PDF

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Publication number
AU2014384434B2
AU2014384434B2 AU2014384434A AU2014384434A AU2014384434B2 AU 2014384434 B2 AU2014384434 B2 AU 2014384434B2 AU 2014384434 A AU2014384434 A AU 2014384434A AU 2014384434 A AU2014384434 A AU 2014384434A AU 2014384434 B2 AU2014384434 B2 AU 2014384434B2
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cell
drug
inhibitors
antibody
acid
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AU2014384434A1 (en
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Yuangyuang HUANG
Xing Li
Qingliang YANG
Robert Yongxin Zhao
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Hangzhou Dac Biotech Co Ltd
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Hangzhou Dac Biotech Co Ltd
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    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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AU2014384434A 2014-02-28 2014-02-28 Charged linkers and their uses for conjugation Active AU2014384434B2 (en)

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US11873281B2 (en) 2012-07-12 2024-01-16 Hangzhou Dac Biotech Co., Ltd. Conjugates of cell binding molecules with cytotoxic agents
PL2872157T3 (pl) 2012-07-12 2020-07-13 Hangzhou Dac Biotech Co., Ltd Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi
JP6417421B2 (ja) 2014-02-28 2018-11-07 ハンジョウ ディーエーシー バイオテック シーオー．，エルティディ．Ｈａｎｇｚｈｏｕ Ｄａｃ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 荷電連結体及び共役体のためのその使用
WO2015138638A1 (en) 2014-03-11 2015-09-17 Theraly Pharmaceuticals, Inc. Long acting trail receptor agonists for treatment of autoimmune diseases
WO2017019559A1 (en) * 2015-07-24 2017-02-02 University Of Utah Research Foundation Hpma-drug conjugates for the treatment of acute myeloid leukemia
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US20190127399A1 (en) 2019-05-02
CN114262344A (zh) 2022-04-01
US10696699B2 (en) 2020-06-30

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