AU2010229490B2 - Slip chip device and methods - Google Patents

Slip chip device and methods Download PDF

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Publication number
AU2010229490B2
AU2010229490B2 AU2010229490A AU2010229490A AU2010229490B2 AU 2010229490 B2 AU2010229490 B2 AU 2010229490B2 AU 2010229490 A AU2010229490 A AU 2010229490A AU 2010229490 A AU2010229490 A AU 2010229490A AU 2010229490 B2 AU2010229490 B2 AU 2010229490B2
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AU
Australia
Prior art keywords
areas
area
substance
exposed
slipchip
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Ceased
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AU2010229490A
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English (en)
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AU2010229490A1 (en
Inventor
Delai Chen
Wenbin Du
Rustem F. Ismagilov
Jason Eugene Kreutz
Liang Li
Kevin Paul Flood Nichols
Feng Shen
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University of Chicago
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University of Chicago
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Application filed by University of Chicago filed Critical University of Chicago
Publication of AU2010229490A1 publication Critical patent/AU2010229490A1/en
Priority to AU2015200465A priority Critical patent/AU2015200465A1/en
Application granted granted Critical
Publication of AU2010229490B2 publication Critical patent/AU2010229490B2/en
Priority to AU2017202597A priority patent/AU2017202597B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10W—GENERIC PACKAGES, INTERCONNECTIONS, CONNECTORS OR OTHER CONSTRUCTIONAL DETAILS OF DEVICES COVERED BY CLASS H10
    • H10W70/00—Package substrates; Interposers; Redistribution layers [RDL]
    • H10W70/60—Insulating or insulated package substrates; Interposers; Redistribution layers
    • H10W70/62—Insulating or insulated package substrates; Interposers; Redistribution layers characterised by their interconnections
    • H10W70/65—Shapes or dispositions of interconnections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/304—Micromixers the mixing being performed in a mixing chamber where the products are brought into contact
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Fluid Mechanics (AREA)
  • AIDS & HIV (AREA)
  • Plasma & Fusion (AREA)
  • Toxicology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2010229490A 2009-03-24 2010-03-23 Slip chip device and methods Ceased AU2010229490B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2015200465A AU2015200465A1 (en) 2009-03-24 2015-01-30 Slip chip device and methods
AU2017202597A AU2017202597B2 (en) 2009-03-24 2017-04-19 Slip chip device and methods

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16292209P 2009-03-24 2009-03-24
US61/162,922 2009-03-24
US26237509P 2009-11-18 2009-11-18
US61/262,375 2009-11-18
US34087210P 2010-03-22 2010-03-22
US61/340,872 2010-03-22
PCT/US2010/028316 WO2010111265A1 (en) 2009-03-24 2010-03-23 Slip chip device and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015200465A Division AU2015200465A1 (en) 2009-03-24 2015-01-30 Slip chip device and methods

Publications (2)

Publication Number Publication Date
AU2010229490A1 AU2010229490A1 (en) 2011-10-20
AU2010229490B2 true AU2010229490B2 (en) 2015-02-12

Family

ID=42781435

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010229490A Ceased AU2010229490B2 (en) 2009-03-24 2010-03-23 Slip chip device and methods

Country Status (9)

Country Link
US (3) US9415392B2 (https=)
EP (1) EP2412020B1 (https=)
JP (4) JP5766178B2 (https=)
KR (2) KR101796906B1 (https=)
CN (2) CN104722342B (https=)
AU (1) AU2010229490B2 (https=)
CA (1) CA2756463C (https=)
IL (2) IL215160A (https=)
WO (1) WO2010111265A1 (https=)

Families Citing this family (296)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2661168T3 (es) 2003-07-12 2018-03-27 Accelerate Diagnostics, Inc. Biodetección sensible y rápida
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US8741158B2 (en) 2010-10-08 2014-06-03 Ut-Battelle, Llc Superhydrophobic transparent glass (STG) thin film articles
WO2009114709A2 (en) 2008-03-12 2009-09-17 Uva Patent Foundation Detection of polymeric analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9415392B2 (en) 2009-03-24 2016-08-16 The University Of Chicago Slip chip device and methods
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
IT1393855B1 (it) * 2009-04-22 2012-05-11 Consiglio Nazionale Ricerche Dispensatore elettrodinamico di liquidi in quantita' micro/nano-litriche basato sull'effetto piroelettrico in materiali funzionalizzati, senza l'impiego di sorgenti elettriche esterne.
US9063136B2 (en) * 2009-08-02 2015-06-23 Qvella Corporation Cell concentration, capture and lysis devices and methods of use thereof
US12405280B2 (en) * 2009-12-18 2025-09-02 Entegrion, Inc. Portable coagulation monitoring devices, systems, and methods
US10739358B2 (en) * 2009-12-18 2020-08-11 Entegrion, Inc. Portable coagulation monitoring devices, systems, and methods
EP2528687B1 (en) 2010-01-29 2018-08-22 Micronics, Inc. System comprising a host instrument and a microfluidic cartridge for assays
CA2791862A1 (en) * 2010-03-03 2011-09-09 Nippon Kayaku Kabushiki Kaisha Detection device
US20140297397A1 (en) * 2010-04-25 2014-10-02 Tomer Bakalash Use of neural activation in the superior temporal sulcus as a predictor for memorability of audio and/or visual content and emotional engagement
US20150359431A1 (en) * 2010-04-25 2015-12-17 Tomer Bakalash Brand-self perceptual neural model utilizing the superior temporal sulcus
US10232374B2 (en) 2010-05-05 2019-03-19 Miroculus Inc. Method of processing dried samples using digital microfluidic device
JP5893620B2 (ja) * 2010-07-22 2016-03-23 ジェンセル バイオシステムズ リミテッド 合成液体セル
US9476811B2 (en) 2010-10-01 2016-10-25 The Governing Council Of The University Of Toronto Digital microfluidic devices and methods incorporating a solid phase
JP5756611B2 (ja) * 2010-10-07 2015-07-29 株式会社 資生堂 分析方法
US11292919B2 (en) 2010-10-08 2022-04-05 Ut-Battelle, Llc Anti-fingerprint coatings
CN107502660B (zh) * 2011-01-20 2021-08-10 华盛顿大学商业中心 进行数字测量的方法和系统
WO2012122314A2 (en) 2011-03-07 2012-09-13 Accelr8 Technology Corporation Rapid cell purification systems
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
EP2686154B1 (en) * 2011-03-15 2018-11-14 National Research Council of Canada Microfluidic system having monolithic nanoplasmonic structures
CN103998932B (zh) 2011-06-29 2017-06-06 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
US20140349298A1 (en) * 2011-07-14 2014-11-27 William Eugene Stanchina Portable, low power instrument for the optoelectronic detection of pathogens using isothermal nucleic acid amplification protocols
EP2740788A4 (en) * 2011-08-05 2015-08-19 Toshiba Kk TOOL FOR MULTIPLE NUCLEIC ACID AMPLIFICATION REACTIONS
EP2747859A4 (en) * 2011-08-22 2015-04-22 Waters Technologies Corp MICROFLUIDIC DEVICE WITH INTERFACE FOR DBS CARD
WO2013029155A1 (en) * 2011-08-30 2013-03-07 The Royal Institute For The Advancement Of Learning/Mcgill University Methods and devices for multiplexed microarray microfluidic analysis of biomolecules
JP2014533240A (ja) * 2011-10-31 2014-12-11 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 生物材料の凍結乾燥球形ペレットを調製する方法
US8824768B1 (en) * 2011-11-10 2014-09-02 Blair K. Simon Fertilization test method and apparatus
JP6057251B2 (ja) * 2011-11-11 2017-01-11 国立研究開発法人産業技術総合研究所 粒子分別装置および粒子分別方法
ES2656022T3 (es) 2011-12-21 2018-02-22 Huawei Technologies Co., Ltd. Detección y codificación de altura tonal muy débil
DE102012100824A1 (de) * 2012-02-01 2013-09-05 Albert-Ludwigs-Universität Freiburg Gemultiplexte Digital PCR
KR20150010939A (ko) * 2012-03-16 2015-01-29 라이프 테크놀로지스 코포레이션 생물학적 샘플을 평가하기 위한 시스템 및 방법
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
CA2868391A1 (en) 2012-04-02 2013-10-10 Stephane Bancel Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
US9808798B2 (en) 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
EP2839260B1 (en) * 2012-04-20 2018-07-18 Talis Biomedical Corporation Fluidic devices and systems for sample preparation or autonomous analysis
US9803237B2 (en) * 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
WO2013159189A1 (en) * 2012-04-24 2013-10-31 Transfert Plus, S.E.C. Methods and apparatuses for evaluating water pollution
US9044738B2 (en) * 2012-04-30 2015-06-02 General Electric Company Methods and compositions for extraction and storage of nucleic acids
US9480966B2 (en) 2012-04-30 2016-11-01 General Electric Company Substrates and methods for collection, stabilization and elution of biomolecules
US9283559B2 (en) * 2012-05-09 2016-03-15 Wisconsin Alumni Research Foundation Lid for functionalized microfluidic platform and method
US9186670B2 (en) * 2012-05-09 2015-11-17 Wisconsin Alumni Research Foundation Functionalized microfluidic device and method
US9410171B2 (en) * 2012-06-20 2016-08-09 The Regents Of The University Of California Non-thermal cycling for polymerase chain reaction
BR112014032911A2 (pt) 2012-06-28 2017-06-27 Fluoresentric Inc dispositivo indicador químico
EP2867663B1 (en) 2012-06-29 2022-12-07 Koninklijke Philips N.V. Processing of bound and unbound magnetic particles
US9136099B2 (en) * 2012-07-04 2015-09-15 Sony Dadc Austria Ag Method and substrates for forming crystals
US9771656B2 (en) 2012-08-28 2017-09-26 Ut-Battelle, Llc Superhydrophobic films and methods for making superhydrophobic films
US9766166B2 (en) * 2013-01-09 2017-09-19 Wisconsin Alumni Research Foundation Device and method incorporating a slideable lid for extracting a targeted fraction from a sample
CN104870652A (zh) * 2012-10-05 2015-08-26 加州理工学院 用于微流体成像和分析的方法和系统
WO2016154113A1 (en) * 2015-03-20 2016-09-29 The Methodist Hospital Multiplexed volumetric bar chart chip for point of care biomarker and/or analyte quantitation, including competitive control
US9097710B2 (en) 2012-10-16 2015-08-04 The Methodist Hospital Research Institute Multiplexed volumetric bar chart chip for point of care biomarker and analyte quantitation
CA2888042A1 (en) 2012-11-27 2014-06-05 Gencell Biosystems Ltd. Handling liquid samples
CN104919035B (zh) 2012-12-21 2017-08-11 精密公司 便携式荧光检测系统和微测定盒
EP3549674B1 (en) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Low elasticity films for microfluidic use
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
US20140206007A1 (en) * 2013-01-18 2014-07-24 The Johns Hopkins University Electromagnetically actuated droplet microfluidic chip and system
US9888283B2 (en) 2013-03-13 2018-02-06 Nagrastar Llc Systems and methods for performing transport I/O
USD758372S1 (en) * 2013-03-13 2016-06-07 Nagrastar Llc Smart card interface
WO2014152825A1 (en) * 2013-03-14 2014-09-25 Diagnostics For All, Inc. Molecular diagnostic devices with magnetic components
US11029310B2 (en) * 2013-03-14 2021-06-08 Wisconsin Alumni Research Foundation Device and method for extracting a targeted fraction from a sample
GB201304797D0 (en) * 2013-03-15 2013-05-01 Diagnostics For The Real World Ltd Apparatus and method for automated sample preparation and adaptor for use in the apparatus
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
WO2014172688A1 (en) * 2013-04-19 2014-10-23 California Institute Of Technology Parallelized sample handling
JP6472788B2 (ja) 2013-05-07 2019-02-20 マイクロニクス， インコーポレイテッド 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法
JP6484222B2 (ja) * 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
EP2994750B1 (en) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP6244589B2 (ja) * 2013-05-21 2017-12-13 国立大学法人名古屋大学 微粒子分離用マイクロ流路チップ、移流集積ユニット、微粒子分離用システム及び微粒子分離方法
GB201311679D0 (en) 2013-06-28 2013-08-14 Ibm Microfluidic chip with dielectrophoretic electrodes extending in hydrophilic flow path
WO2015009967A1 (en) * 2013-07-19 2015-01-22 California Institute Of Technology Digital assay for quantifying and concentrating analytes
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
US20160194625A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Chimeric polynucleotides
WO2015084458A2 (en) * 2013-09-18 2015-06-11 California Institute Of Technology System and method for movement and timing control
JP2015068708A (ja) * 2013-09-27 2015-04-13 株式会社東芝 表面状態評価装置及び表面状態評価方法
US10220389B2 (en) * 2013-09-30 2019-03-05 Capitainer Ab Microfluidic device, use and methods
TWI581861B (zh) * 2013-09-30 2017-05-11 新加坡科技研究局 微流體裝置、用於檢測之系統、使用該系統之檢測方法及該系統之用途
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
EP3058100A4 (en) * 2013-10-18 2017-04-19 California Institute of Technology Enhanced nucleic acid identification and detection
US10823743B1 (en) * 2013-10-28 2020-11-03 Ifirst Medical Technologies, Inc. Methods of measuring coagulation of a biological sample
US10168271B2 (en) 2013-11-01 2019-01-01 The General Hospital Corporation Microparticles having reference markers arranged in different concentrations
EP3102329B1 (en) 2014-02-05 2018-10-10 Talis Biomedical Corporation Sample preparation module with stepwise pressurization mechanism
EP3105326A4 (en) 2014-02-10 2018-01-10 Gencell Biosystems Limited Composite liquid cell (clc) mediated nucleic acid library preparation device, and methods for using the same
US20150239773A1 (en) 2014-02-21 2015-08-27 Ut-Battelle, Llc Transparent omniphobic thin film articles
WO2015134984A1 (en) 2014-03-07 2015-09-11 Bio-Rad Laboratories, Inc. Automated blotting using sliding devices
US10195610B2 (en) * 2014-03-10 2019-02-05 Click Diagnostics, Inc. Cartridge-based thermocycler
US9595430B2 (en) * 2014-03-26 2017-03-14 Li-Cor, Inc. Laser desorption ionization mass spectrometry using a particulate separation bed
WO2015153816A2 (en) 2014-04-01 2015-10-08 Academia Sinica Methods and systems for cancer diagnosis and prognosis
WO2015157369A1 (en) 2014-04-08 2015-10-15 University Of Washington Through Its Center For Commercialization Methods and apparatus for performing digital assays using polydisperse droplets
EP3594360B1 (en) 2014-04-24 2021-06-23 Lucira Health, Inc. Colorimetric detection of nucleic acid amplification
KR101596131B1 (ko) * 2014-04-25 2016-02-22 한국과학기술원 소수성 표면을 이용한 칩 패키징 방법 및 칩 패키지
EP3169693B1 (en) 2014-07-16 2022-03-09 ModernaTX, Inc. Chimeric polynucleotides
WO2016014846A1 (en) 2014-07-23 2016-01-28 Moderna Therapeutics, Inc. Modified polynucleotides for the production of intrabodies
US10073091B2 (en) 2014-08-08 2018-09-11 Ortho-Clinical Diagnostics, Inc. Lateral flow assay device
US10112198B2 (en) 2014-08-26 2018-10-30 Academia Sinica Collector architecture layout design
WO2016044578A1 (en) * 2014-09-18 2016-03-24 Cedars-Sinai Medical Center Antifungal therapy for the treatment of hirschsprung-associated enterocolitis
US10094767B2 (en) * 2014-09-19 2018-10-09 Konica Minolta, Inc. Image processor, image processing method, and program
US10418527B2 (en) * 2014-10-31 2019-09-17 eLux, Inc. System and method for the fluidic assembly of emissive displays
JP6914192B2 (ja) 2014-10-31 2021-08-04 マサチューセッツ インスティテュート オブ テクノロジー 乳剤形成のための組成および方法
US10446728B2 (en) * 2014-10-31 2019-10-15 eLux, Inc. Pick-and remove system and method for emissive display repair
HK1243466A1 (zh) 2014-11-05 2018-07-13 加州理工学院 生物体对药物的响应的微流体测量
FR3028318B1 (fr) * 2014-11-12 2025-10-03 Phuong Lan Tran Procede et dispositif de tri selectif, specifique et simultane de cellules rares cibles dans un echantillon biologique
EP4029606A1 (en) 2014-12-31 2022-07-20 Visby Medical, Inc. Molecular diagnostic testing
WO2016115441A1 (en) * 2015-01-16 2016-07-21 Kansas State University Research Foundation Co-detection and association of multiple genes from the same genome in a sample
GB2536650A (en) 2015-03-24 2016-09-28 Augmedics Ltd Method and system for combining video-based and optic-based augmented reality in a near eye display
KR101656181B1 (ko) 2015-03-30 2016-09-08 경희대학교 산학협력단 마이크로 패드 플랫폼
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
AU2016243656A1 (en) 2015-03-30 2017-11-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
CN104774747B (zh) * 2015-04-14 2017-03-01 浙江大学 用于细胞迁移分析实验的微流控液滴芯片装置及方法
WO2016172388A2 (en) * 2015-04-21 2016-10-27 Joseph Paul Robinson Culture detection and measurement over time
EP3250919A4 (en) * 2015-04-29 2019-03-06 Ixcela, Inc. METHOD AND DEVICE FOR QUANTIZING BLOOD SAMPLES
USD864968S1 (en) 2015-04-30 2019-10-29 Echostar Technologies L.L.C. Smart card interface
CN106268392B (zh) * 2015-05-27 2019-12-13 艾博生物医药(杭州)有限公司 一种混合至少两种物质的方法
US10695762B2 (en) 2015-06-05 2020-06-30 Miroculus Inc. Evaporation management in digital microfluidic devices
CN108026494A (zh) 2015-06-05 2018-05-11 米罗库鲁斯公司 限制蒸发和表面结垢的空气基质数字微流控装置和方法
GB201511342D0 (en) * 2015-06-29 2015-08-12 Rolls Royce Plc Vortex identification methods and tools
EP3120928A1 (en) 2015-07-24 2017-01-25 Centre National De La Recherche Scientifique Fluidic devices with at least one actionnable fiber
WO2017033070A1 (en) * 2015-08-26 2017-03-02 Gencell Biosystems Ltd. Composite liquid cell (clc) supports, and methods of making and using the same
US10125342B2 (en) * 2015-08-26 2018-11-13 EMULATE, Inc. Droplet fluid connections
CN108473932B (zh) 2015-09-09 2022-07-15 集联健康有限公司 用于样品收集、稳定化和保存的系统、方法和装置
US10300485B2 (en) 2015-10-23 2019-05-28 The Royal Institution For The Advancement Of Learning/Mcgill University Nanoarray-in-microarray multiplexed analysis methods and systems
FR3044685B1 (fr) * 2015-12-02 2020-11-27 Univ Grenoble 1 Puce microfluidique pour la cristallisation de molecules, procede de preparation, dispositif la comprenant et procede de cristallisation de molecules
CN105400693B (zh) * 2015-12-15 2017-06-06 上海海洋大学 平板等温核酸扩增芯片
CN105400692B (zh) * 2015-12-15 2017-06-27 上海海洋大学 等温核酸扩增装置及等温核酸扩增实验方法
TWI579030B (zh) * 2015-12-15 2017-04-21 Ｃｇ生物技術有限公司 分離細胞之容器、系統及方法
EP3402595A4 (en) * 2016-01-11 2019-10-02 Fluoresentric, Inc. SYSTEMS, DEVICES AND METHOD FOR INLINE SAMPLE PREPARATION
KR20170099738A (ko) * 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 패치 및 그 제조 방법
JP7064665B2 (ja) 2016-03-07 2022-05-11 ファーザー フラナガンズ ボーイズ ホーム ドゥーイング ビジネス アズ ボーイズ タウン ナショナル リサーチ ホスピタル 非侵襲的分子対照
EP3429543B1 (en) 2016-03-14 2024-11-20 Pfizer Inc. Selectively vented biological assay devices and associated methods
AU2017232340B2 (en) 2016-03-14 2022-04-28 Pfizer Inc. Systems and methods for performing biological assays
ES2927062T3 (es) 2016-03-14 2022-11-02 Lucira Health Inc Dispositivos y procedimientos para modificar propiedades ópticas
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
CN105861309B (zh) * 2016-04-14 2018-05-11 清华大学 一种超疏水微坑阵列芯片及其制备方法与应用
US10987674B2 (en) 2016-04-22 2021-04-27 Visby Medical, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
CN106031889B (zh) * 2016-05-17 2018-04-17 西安交通大学 一种基于离心平台的蛋白质快速检测系统
CN106513062B (zh) * 2016-05-30 2019-02-22 苏州汶颢芯片科技有限公司 酶联免疫快速检测的微流控芯片及其预处理和检测方法
US10255524B2 (en) * 2016-06-03 2019-04-09 Becton Dickinson Rowa Germany Gmbh Method for providing a singling device of a storage and dispensing container
SG11201811781XA (en) * 2016-06-30 2019-01-30 General Automation Lab Technologies Inc High resolution systems, kits, apparatus, and methods using magnetic beads for high throughput microbiology applications
US10150115B2 (en) * 2016-07-21 2018-12-11 Spacepharma SA System and method for rehydrating powder and delivering the rehydrated powder to a reactor
CN106268990B (zh) * 2016-07-26 2018-07-24 林捷琳 一种基于点阵热压法的纸微流控芯片制备方法
CN109715781A (zh) 2016-08-22 2019-05-03 米罗库鲁斯公司 用于数字微流控设备中的并行液滴控制的反馈系统
US20190170737A1 (en) 2016-09-19 2019-06-06 Massachusetts Institute Of Technology Systems including janus droplets
US11168347B2 (en) 2016-09-23 2021-11-09 California Institute Of Technology Digital quantification of DNA replication and/or chromosome segregation based determination of antimicrobial susceptibility
CA3042036A1 (en) * 2016-10-26 2018-05-03 Integrated Nano-Technologies, Inc. Systems and methods for optical sensing of biomolecular targets
CN106370832B (zh) * 2016-11-09 2024-02-27 苏州一呼医疗科技有限公司 智能呼气分子诊断系统
CN106754335B (zh) * 2016-11-22 2019-05-17 上海海洋大学 一种等温核酸扩增芯片
CN110383061A (zh) 2016-12-28 2019-10-25 米罗库鲁斯公司 数字微流控设备和方法
TWI882519B (zh) 2017-01-10 2025-05-01 美商集聯健康有限公司 用於收集和儲存來自受試者之血液的裝置
US10470841B2 (en) * 2017-03-28 2019-11-12 Steris Inc. Robot-based rack processing system
US11623219B2 (en) 2017-04-04 2023-04-11 Miroculus Inc. Digital microfluidics apparatuses and methods for manipulating and processing encapsulated droplets
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
CN106916728B (zh) * 2017-04-18 2023-10-27 朱红 一种磁力搅拌式药敏分析仪器以及配套试剂盒
WO2018217778A1 (en) * 2017-05-22 2018-11-29 Beckman Coulter, Inc. Integrated sample processing system with multiple detection capability
US10787695B2 (en) * 2017-06-01 2020-09-29 General Electric Company Systems and methods for rapidly sensing microbial metabolism
EP3658908B1 (en) 2017-07-24 2025-11-12 Integra Biosciences AG Digital microfluidics systems and methods with integrated plasma collection device
JP2019024366A (ja) * 2017-07-27 2019-02-21 キヤノン株式会社 分析システム、分析方法、プログラム、および記憶媒体
CN107365685A (zh) * 2017-08-03 2017-11-21 甘肃出入境检验检疫局检验检疫综合技术中心 数字pcr扩增仪及其工作方法
CN107287112A (zh) * 2017-08-03 2017-10-24 甘肃出入境检验检疫局检验检疫综合技术中心 一种阵列式数字pcr芯片及其使用方法
JP2019030273A (ja) * 2017-08-09 2019-02-28 キヤノン株式会社 分析システム、分析方法、プログラム、および記憶媒体
US11243167B2 (en) 2017-08-18 2022-02-08 Somadetect Inc. Methods and systems for assessing a health state of a lactating mammal
KR102192651B1 (ko) * 2017-08-23 2020-12-17 노을 주식회사 시약을 저장하는 저장 매체 및 이를 이용한 검사 방법 및 검사 모듈
CA3073058A1 (en) 2017-09-01 2019-03-07 Miroculus Inc. Digital microfluidics devices and methods of using them
WO2019048645A1 (en) 2017-09-08 2019-03-14 Mina Therapeutics Limited STABILIZED COMPOSITIONS OF SMALL ACTIVATOR RNA (PARNA) FROM CEBPA AND METHODS OF USE
KR101977963B1 (ko) * 2017-09-13 2019-08-28 건국대학교 산학협력단 미세 유체 제어 장치 및 이를 이용하는 미세 유체의 제어 방법
US11149265B2 (en) 2017-09-14 2021-10-19 California Institute Of Technology Purification and detection of analytes
CN113777011B (zh) 2017-09-14 2024-11-19 辉瑞公司 具有电子读出的复用生物测定装置
US11624062B2 (en) 2017-09-25 2023-04-11 California Institute Of Technology Methods and systems for performing single cell analysis of molecules and molecular complexes
CN107886496A (zh) * 2017-09-30 2018-04-06 北京得华机器人技术研究院有限公司 一种基于形状匹配的汽车零配件的质量检测方法
WO2019075264A1 (en) 2017-10-11 2019-04-18 California Institute Of Technology ANTIBIOSENSITIVITY OF MICROORGANISMS AND COMPOSITIONS, METHODS AND ASSOCIATED SYSTEMS
US12448655B2 (en) 2017-10-11 2025-10-21 California Institute Of Technology Antibiotic susceptibility of microorganisms and related methods and systems
US11890620B2 (en) 2017-10-13 2024-02-06 The Charles Stark Draper Laboratory, Inc. Miniaturized DNA microarray for small-volume sample processing
CN108004129A (zh) * 2017-10-28 2018-05-08 深圳职业技术学院 一种核酸一体化多重检测盒体及检测方法
JP7098096B2 (ja) * 2017-11-07 2022-07-11 株式会社リコー 検出精度特定方法、検出精度特定装置、及び検出精度特定プログラム
SG11202002931VA (en) 2017-11-09 2020-04-29 Visby Medical Inc Portable molecular diagnostic device and methods for the detection of target viruses
WO2019108954A1 (en) 2017-12-01 2019-06-06 Arizona Board Of Regents On Behalf Of Arizona State University Materials and methods relating to single molecule arrays
EP3495865A1 (en) * 2017-12-07 2019-06-12 European Molecular Biology Laboratory A sample holder for imaging a plurality of samples
US12458411B2 (en) 2017-12-07 2025-11-04 Augmedics Ltd. Spinous process clamp
US12521201B2 (en) 2017-12-07 2026-01-13 Augmedics Ltd. Spinous process clamp
US11707736B2 (en) * 2017-12-08 2023-07-25 Enuvio Inc. Microfluidic chip and method for making the same
WO2019126388A1 (en) * 2017-12-19 2019-06-27 Biological Dynamics, Inc. Methods and devices for detection of multiple analytes from a biological sample
CN108153955A (zh) * 2017-12-20 2018-06-12 湖州师范学院 基于遗传算法的柴油机硅油减振器多目标动态匹配方法
WO2019155488A1 (en) * 2018-02-07 2019-08-15 Jaydeep Bhattacharya A low cost microfluidic device for dna/rna isolation, purification and amplification using chip based pcr/ rt- pcr for biosensing applications
CN108660068B (zh) * 2018-02-13 2022-04-05 臻准生物工程(山西)有限公司 生物反应芯片及其制备方法
WO2019165363A1 (en) * 2018-02-23 2019-08-29 University Of Virginia Patent Foundation Slipchip device for on-chip dilution and size-based extraction of protein labeling reagents
CN108121981A (zh) * 2018-02-26 2018-06-05 深圳市生强科技有限公司 指纹检测装置
WO2019195196A1 (en) 2018-04-02 2019-10-10 Biological Dynamics, Inc. Dielectric materials
EP3775211B1 (en) 2018-04-12 2023-04-05 MiNA Therapeutics Limited Sirt1-sarna compositions and methods of use
CN114345261B (zh) * 2018-04-17 2023-03-14 上海交通大学 一种制备微颗粒的方法
US11980507B2 (en) 2018-05-02 2024-05-14 Augmedics Ltd. Registration of a fiducial marker for an augmented reality system
CA3100580A1 (en) * 2018-05-18 2019-11-21 Enersoft Inc. Geological analysis system and methods using x-ray flurescence and spectroscopy
WO2019226919A1 (en) 2018-05-23 2019-11-28 Miroculus Inc. Control of evaporation in digital microfluidics
CN108837718A (zh) * 2018-06-11 2018-11-20 上海交通大学 一种高通量微液滴梯度稀释装置和方法
CN108896754A (zh) * 2018-07-05 2018-11-27 南京优芯生物科技有限公司 一种快速检测生物标志物的滑动微流控芯片
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
EP3830301B1 (en) * 2018-08-01 2024-05-22 Mammoth Biosciences, Inc. Programmable nuclease compositions and methods of use thereof
CN110760571B (zh) * 2018-08-27 2024-10-01 浙江达普生物科技有限公司 数字化定量的多靶标共同、生物检测
JP2020031606A (ja) * 2018-08-31 2020-03-05 シスメックス株式会社 核酸検出装置および核酸検出方法
JP2020034496A (ja) * 2018-08-31 2020-03-05 シスメックス株式会社 試料処理方法、試料処理装置、プログラムおよび試料処理カートリッジ
KR20210081335A (ko) 2018-09-03 2021-07-01 비스비 메디컬, 인코포레이티드 항생제 감수성 시험을 위한 장치 및 방법
CN109046484B (zh) * 2018-09-12 2021-03-30 上海交通大学 一种位移式微流控芯片由表面张力生成液滴的方法
CN112823276A (zh) * 2018-10-09 2021-05-18 卢西拉健康公司 基于消费者的疾病诊断
WO2020086674A1 (en) * 2018-10-23 2020-04-30 Myriad Applied Technologies, Inc. Kits and methods for real-time multiplex detection and identification of pathogens
CN109092022B (zh) * 2018-11-06 2023-11-24 王东杰 一种内外循环风道切换结构及其控湿装置
US11766296B2 (en) 2018-11-26 2023-09-26 Augmedics Ltd. Tracking system for image-guided surgery
CN109612853B (zh) * 2018-11-26 2021-08-03 Tcl华星光电技术有限公司 抗压测试装置及其测试方法
IL284830B2 (en) * 2019-01-14 2025-09-01 Zeev Russak Multi-test kit
EP3917670A4 (en) 2019-01-31 2022-11-02 Miroculus Inc. ANTIFOULING COMPOSITIONS AND METHODS FOR HANDLING AND TREATING ENCAPSULATED DROPLET
AU2020215103B2 (en) * 2019-01-31 2025-07-17 Samplix Aps A microfluidic device and a method for provision of emulsion droplets
CN109540860B (zh) * 2019-02-19 2021-03-02 济南大学 一种检测卡那霉素的荧光生物传感器及其制备方法和应用
CN112435975B (zh) * 2019-02-22 2022-07-19 西安航思半导体有限公司 散热dfn半导体器件封装结构
US12582991B2 (en) 2019-02-28 2026-03-24 Integra Biosciences Ag Digital microfluidics devices and methods of using them
US11976269B2 (en) * 2019-03-18 2024-05-07 Cellular Research, Inc. Precise delivery of components into fluids
JP7553963B2 (ja) * 2019-04-03 2024-09-19 グラディエンテク エービー カセットアセンブリ
CN114206499B (zh) 2019-04-08 2024-10-08 米罗库鲁斯公司 多盒式数字微流控装置和使用方法
EP3953473A1 (en) 2019-04-12 2022-02-16 MiNA Therapeutics Limited Sirt1-sarna compositions and methods of use
JP2022530323A (ja) 2019-04-28 2022-06-29 ビスビュー メディカル，インコーポレイテッド デジタル検出能力および無線接続性を有する分子診断デバイス
CN110071031B (zh) * 2019-05-05 2020-05-05 东北大学 一种蛇形线式质谱仪连续性变压取样装置及方法
CA3139147A1 (en) 2019-05-06 2020-11-12 University Of Prince Edward Island Portable field testing apparatus and method
CN110082346B (zh) * 2019-05-12 2020-11-03 武汉生之源生物科技股份有限公司 一种载脂蛋白e检测试剂盒
WO2020239874A1 (en) * 2019-05-27 2020-12-03 Centre National De La Recherche Scientifique (Cnrs) Digital biomolecules detection and/or quantification using isothermal amplification
CN110272822B (zh) * 2019-06-06 2021-10-26 上海交通大学 一种基因扩增实时荧光定量检测装置及检测方法
US11524298B2 (en) 2019-07-25 2022-12-13 Miroculus Inc. Digital microfluidics devices and methods of use thereof
US11980506B2 (en) 2019-07-29 2024-05-14 Augmedics Ltd. Fiducial marker
WO2021021906A1 (en) * 2019-07-29 2021-02-04 The Regents Of The University Of California Early detection of e. coli and total coliform using an automated, colorimetric and fluorometric fiber optics-based device
US12178666B2 (en) 2019-07-29 2024-12-31 Augmedics Ltd. Fiducial marker
CN110643483B (zh) * 2019-09-06 2023-04-14 上海交通大学 一种在微流控芯片上生成液滴阵列的方法
US12274993B2 (en) 2019-09-18 2025-04-15 Massachusetts Institute Of Technology Systems and methods for affecting interactions of electromagnetic radiation with janus droplets for sensitive detection of species
US20210116338A1 (en) * 2019-10-19 2021-04-22 Cfd Research Corporation Fluidic bead trap and methods of use
US11382712B2 (en) 2019-12-22 2022-07-12 Augmedics Ltd. Mirroring in image guided surgery
US11866695B2 (en) 2019-12-23 2024-01-09 California Institute Of Technology Methods and systems and related compositions for mixtures separation with a solid matrix
US11352675B2 (en) 2020-01-03 2022-06-07 Visby Medical, Inc. Devices and methods for antibiotic susceptability testing
US20230051263A1 (en) * 2020-01-09 2023-02-16 The Regents Of The University Of Michigan Device for rapid and quantitative detection of drugs of abuse in sweat
US12277814B2 (en) 2020-01-29 2025-04-15 Ifirst Medical Technologies, Inc. Medical analyzer and diagnostic sample profiler
CN111250182B (zh) * 2020-02-11 2021-03-19 北京理工大学 一种高通量微流控电泳筛分芯片及其制备方法、应用方法
KR102375816B1 (ko) * 2020-02-14 2022-03-18 주식회사 디앤에이보이 검체 분석 디바이스 및 이의 제조 방법
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
US11389252B2 (en) 2020-06-15 2022-07-19 Augmedics Ltd. Rotating marker for image guided surgery
CN111676131A (zh) * 2020-06-17 2020-09-18 清华大学 用于活体单细胞局部微区原位自由基刺激的微流控装置
US20230228654A1 (en) * 2020-07-02 2023-07-20 Capitainer Ab Blood Sampling Device and Method for PEth Measurement
US12239385B2 (en) 2020-09-09 2025-03-04 Augmedics Ltd. Universal tool adapter
US12502163B2 (en) 2020-09-09 2025-12-23 Augmedics Ltd. Universal tool adapter for image-guided surgery
CA3192988A1 (en) 2020-09-16 2022-03-24 Grant I. Sanden Multiple-sensor analysis of geological samples
WO2022081564A1 (en) 2020-10-13 2022-04-21 Bio-Rad Europe Gmbh System and method for target detection with applications in characterizing food quality and improving food safety
CN116635534A (zh) 2020-10-19 2023-08-22 生物辐射实验室股份有限公司 用于快速多路复用样品处理的系统和方法及其核酸扩增试验的应用
TWI776559B (zh) * 2020-11-12 2022-09-01 邑流微測股份有限公司 顯微鏡觀測載台
EP4249508A4 (en) * 2020-11-17 2024-07-17 FUJIFILM Corporation Sars-cov-2 detection kit and sars-cov-2 detection method
US20240002832A1 (en) * 2020-12-07 2024-01-04 Centre National De La Recherche Scientifique A method for isolating molecules and/or molecular complexes
GB2603454A (en) 2020-12-09 2022-08-10 Ucl Business Ltd Novel therapeutics for the treatment of neurodegenerative disorders
JP2022102386A (ja) * 2020-12-25 2022-07-07 国立大学法人旭川医科大学 遺伝子解析用サンプルの製造方法
CN117242188A (zh) * 2021-01-12 2023-12-15 权威生物技术有限责任公司 用于检测生物样品中的核酸的装置和方法
CN114798013A (zh) * 2021-01-29 2022-07-29 中国科学院长春光学精密机械与物理研究所 一种微流控芯片及其制造方法
CN114836291B (zh) * 2021-02-01 2025-11-21 深圳拜尔洛克生物技术有限公司 生物材料解冻复苏的系统及其方法
JP7235064B2 (ja) * 2021-02-26 2023-03-08 横河電機株式会社 測定方法及び測定システム
EP4314292A1 (en) 2021-03-26 2024-02-07 MiNA Therapeutics Limited Tmem173 sarna compositions and methods of use
KR102577768B1 (ko) * 2021-04-06 2023-09-12 연세대학교 산학협력단 세포포획이 가능한 미세유체 디바이스
KR20230158601A (ko) * 2021-06-21 2023-11-20 가부시키가이샤 타카이세이사쿠쇼 두부류 제조 장치
CA3223962A1 (en) 2021-06-25 2022-12-29 Grant I. Sanden Laser induced breakdown spectroscopy for geological analysis
US11896445B2 (en) 2021-07-07 2024-02-13 Augmedics Ltd. Iliac pin and adapter
US12150821B2 (en) 2021-07-29 2024-11-26 Augmedics Ltd. Rotating marker and adapter for image-guided surgery
CN113699033B (zh) * 2021-08-10 2024-12-03 上海交通大学 一种基于熔解曲线的多重数字核酸分析装置和分析方法
EP4387552A4 (en) 2021-08-18 2025-04-30 Augmedics Ltd. AUGMENTED REALITY SURGICAL SYSTEM USING DEPTH SENSING
RU209656U1 (ru) * 2021-09-22 2022-03-17 Федеральное государственное бюджетное образовательное учреждение высшего образования "Брянский государственный аграрный университет" Цилиндрический триер
CA3233168A1 (en) * 2021-09-27 2023-03-30 Richard D. Oleschuk Method and apparatus for rapid mass spectrometric calibration
CN114062632B (zh) * 2021-11-17 2023-12-29 扬州大学 一种基于纳米颗粒酶联增敏的镉离子微流控检测方法
WO2023099884A1 (en) 2021-12-01 2023-06-08 Mina Therapeutics Limited Pax6 sarna compositions and methods of use
GB202117758D0 (en) 2021-12-09 2022-01-26 Ucl Business Ltd Therapeutics for the treatment of neurodegenerative disorders
CN114113023B (zh) * 2021-12-16 2024-04-26 郑州轻工业大学 基于单核增生李斯特菌来源的氮掺杂碳点的制备方法和应用
US11772093B2 (en) 2022-01-12 2023-10-03 Miroculus Inc. Methods of mechanical microfluidic manipulation
WO2023170435A1 (en) 2022-03-07 2023-09-14 Mina Therapeutics Limited Il10 sarna compositions and methods of use
EP4511809A4 (en) 2022-04-21 2026-03-11 Augmedics Ltd Systems and methods for medical image visualization
CN114591812B (zh) * 2022-05-10 2022-07-22 博奥生物集团有限公司 生物反应芯片及离心式微流控系统
CN114608891B (zh) * 2022-05-12 2022-07-15 潍坊优特检测服务有限公司 一种全自动水质检测仪器
CN115178199B (zh) * 2022-05-31 2024-04-30 清华大学 无源微流控微反应器以及微流控芯片
EP4587881A1 (en) 2022-09-13 2025-07-23 Augmedics Ltd. Augmented reality eyewear for image-guided medical intervention
US20240175008A1 (en) * 2022-11-30 2024-05-30 FemtoFluidics, Inc. Synthesizing chemical libraries using digital microfluidics
WO2024125597A1 (en) 2022-12-14 2024-06-20 Providence Therapeutics Holdings Inc. Compositions and methods for infectious diseases
WO2024134199A1 (en) 2022-12-22 2024-06-27 Mina Therapeutics Limited Chemically modified sarna compositions and methods of use
CN116083207B (zh) * 2023-02-08 2025-06-24 中国科学院苏州生物医学工程技术研究所 微生物富集液流控制系统及方法
CN116606727B (zh) * 2023-04-17 2024-03-12 长庚大学 核酸检测装置及核酸检测方法
CN116870976A (zh) * 2023-06-07 2023-10-13 祥符实验室 一种微流控滑动芯片结构及其制备方法和应用
WO2025019586A1 (en) * 2023-07-18 2025-01-23 Twist Bioscience Corporation Spatially controlled data transfer
WO2025059024A1 (en) * 2023-09-12 2025-03-20 Andson Biotech Inc. Systems and methods for sample processing
US20250101487A1 (en) * 2023-09-22 2025-03-27 The University Of Hong Kong Self-diluting microfluidic device for rapid antimicrobial susceptibility tests
CN117168612B (zh) * 2023-09-27 2024-01-02 华安钢宝利高新汽车板加工(常熟)有限公司 一种激光器发光功率监测装置
KR20250059304A (ko) * 2023-10-23 2025-05-02 명지대학교 산학협력단 광중합 기술 기반 디지털 중합효소연쇄반응용 용액을 제조하기 위한 키트 및 이의 용도
CN117772302A (zh) * 2023-12-27 2024-03-29 上海前瞻创新研究院有限公司 一种用于片上梯度稀释的滑动微流控芯片和应用
WO2025174552A1 (en) * 2024-02-13 2025-08-21 Board Of Regents, The University Of Texas System Examining latent fingerprints using atomic force microscopy
CN117970855B (zh) * 2024-03-28 2024-05-28 睢宁县泰宁建材有限公司 一种混凝土制备生产线运行智能监控控制系统
WO2026035181A1 (en) 2024-08-07 2026-02-12 Tenje Maria Monitoring device
CN119555927B (zh) * 2024-12-04 2025-11-21 湖北美顺和医学科技有限公司 一种应用于免疫层析试剂条大板的组装工装
CN119875805A (zh) * 2024-12-27 2025-04-25 上海交通大学 一种微生物药敏检测装置和方法
TWI901561B (zh) * 2025-06-02 2025-10-11 國立屏東科技大學 核酸檢測系統及其使用方法
CN120919843B (zh) * 2025-10-13 2025-12-09 天津师范大学 具有超憎液层和致密筛分层的复合膜及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020125197A1 (en) * 2001-03-08 2002-09-12 Hager David C. Multi-well apparatus
US20040119070A1 (en) * 2002-08-02 2004-06-24 Roach David John Integrated microchip design
US20070026439A1 (en) * 2005-07-15 2007-02-01 Applera Corporation Fluid processing device and method
US20090021728A1 (en) * 2007-06-21 2009-01-22 Gen-Probe Incorporated Multi-Channel Optical Measurement Instrument

Family Cites Families (278)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2541413A (en) 1947-04-01 1951-02-13 Graflex Inc Photographic camera and shutter therefor
US3787290A (en) 1972-04-10 1974-01-22 S Kaye Method and means for assaying biological factors demonstrating quantal response
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4071409A (en) 1976-05-20 1978-01-31 Corning Glass Works Immobilization of proteins on inorganic support materials
GB2097692B (en) 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
US4853336A (en) 1982-11-15 1989-08-01 Technicon Instruments Corporation Single channel continuous flow system
US5656493A (en) 1985-03-28 1997-08-12 The Perkin-Elmer Corporation System for automated performance of the polymerase chain reaction
US4963498A (en) 1985-08-05 1990-10-16 Biotrack Capillary flow device
JPS62106000A (ja) 1985-10-30 1987-05-16 Fujitsu Ltd 生体高分子結晶自動作製装置
US5077017A (en) 1987-11-05 1991-12-31 Biotrack, Inc. Integrated serial dilution and mixing cartridge
US5185099A (en) 1988-04-20 1993-02-09 Institut National De Recherche Chimique Appliquee Visco-elastic, isotropic materials based on water, fluorinate sufactants and fluorinated oils, process for their preparation, and their use in various fields, such as optics, pharmacology and electrodynamics
US5026113A (en) 1988-09-09 1991-06-25 Sky-Top Sunroofs Ltd. Sliding and venting sunroof
US5237016A (en) 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5114208A (en) 1989-08-04 1992-05-19 Aisin Seiki Kabushiki Kaisha Sliding mechanism for sunroof
US6503707B1 (en) 1990-06-27 2003-01-07 The Blood Center Research Foundation, Inc. Method for genetic typing
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
WO1992019960A1 (en) 1991-05-09 1992-11-12 Nanophore, Inc. Methods for the electrophoretic separation of nucleic acids and other linear macromolecules in gel media with restrictive pore diameters
US5686315A (en) 1991-06-14 1997-11-11 Quidel Corporation Assay device for one step detection of analyte
US5251670A (en) 1991-06-25 1993-10-12 Bates Lyle D Flush valve
US5169942A (en) 1991-11-21 1992-12-08 General Electric Company Method for making 2-(18F)fluoro-2-deoxy-D-glucose
DE4139664A1 (de) 1991-12-02 1993-06-03 Diagen Inst Molekularbio Vorrichtung und verfahren zur isolierung und reinigung von nukleinsaeuren
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5264570A (en) 1992-08-05 1993-11-23 General Electric Company Method for making 2-[18 F]fluoro-2-deoxy-D-glucose
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5795714A (en) 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
GB9301122D0 (en) 1993-01-21 1993-03-10 Scient Generics Ltd Method of analysis/separation
US5518892A (en) * 1994-02-23 1996-05-21 Idexx Laboratories, Inc. Apparatus and method for quantification of biological material in a liquid sample
US5986076A (en) 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
DE4420732A1 (de) 1994-06-15 1995-12-21 Boehringer Mannheim Gmbh Vorrichtung zur Behandlung von Nukleinsäuren aus einer Probe
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
CA2181190C (en) 1994-11-14 2001-02-06 Peter Wilding Mesoscale sample preparation device and systems for determination and processing of analytes
US5688651A (en) 1994-12-16 1997-11-18 Ramot University Authority For Applied Research And Development Ltd. Prevention of protein aggregation
US20020022261A1 (en) 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5872010A (en) 1995-07-21 1999-02-16 Northeastern University Microscale fluid handling system
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US6146854A (en) 1995-08-31 2000-11-14 Sequenom, Inc. Filtration processes, kits and devices for isolating plasmids
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5707850A (en) 1995-11-09 1998-01-13 Cole; Kenneth D. Concentration and size-fractionation of nucleic acids and viruses in porous media
US5772889A (en) 1995-11-13 1998-06-30 Transgenomic, Inc. System and method for performing nucleic acid separations using liquid chromatography
US5805947A (en) 1995-12-08 1998-09-08 Nikon Corporation Camera provided with a sliding cover
US5917184A (en) 1996-02-08 1999-06-29 Perseptive Biosystems Interface between liquid flow and mass spectrometer
US6126899A (en) * 1996-04-03 2000-10-03 The Perkins-Elmer Corporation Device for multiple analyte detection
WO1997039359A1 (en) 1996-04-15 1997-10-23 Dade International Inc. Apparatus and method for analysis
CN1329729C (zh) 1996-06-28 2007-08-01 卡钳生命科学股份有限公司 微流体系统
US6429025B1 (en) 1996-06-28 2002-08-06 Caliper Technologies Corp. High-throughput screening assay systems in microscale fluidic devices
US5800690A (en) 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
AU4114397A (en) 1996-07-15 1998-02-09 Kemgas Limited Production of powders
US5718509A (en) * 1996-10-03 1998-02-17 Instrumentation Technology Associates, Inc. Materials dispersion apparatus with relatively slidable blocks
US6140053A (en) 1996-11-06 2000-10-31 Sequenom, Inc. DNA sequencing by mass spectrometry via exonuclease degradation
EP0946749A1 (en) 1996-11-20 1999-10-06 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
US5725017A (en) 1997-01-27 1998-03-10 Medtronic, Inc. In-line pressure check valve for drug-delivery systems
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
DE19717085C2 (de) 1997-04-23 1999-06-17 Bruker Daltonik Gmbh Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR)
US6558901B1 (en) 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
DE69823347T2 (de) 1997-05-16 2005-05-12 Alberta Research Council, Edmonton Mikrofluidisches system und verfahren zu dessen betrieb
US20050070005A1 (en) 1997-06-16 2005-03-31 Martin Keller High throughput or capillary-based screening for a bioactivity or biomolecule
GB9715101D0 (en) 1997-07-18 1997-09-24 Environmental Sensors Ltd The production of microstructures for analysis of fluids
US6300138B1 (en) 1997-08-01 2001-10-09 Qualigen, Inc. Methods for conducting tests
US6426230B1 (en) 1997-08-01 2002-07-30 Qualigen, Inc. Disposable diagnostic device and method
US6111096A (en) 1997-10-31 2000-08-29 Bbi Bioseq, Inc. Nucleic acid isolation and purification
WO1999029703A2 (en) 1997-12-06 1999-06-17 Dna Research Instruments Limited Isolation of nucleic acids
US6632653B1 (en) 1997-12-08 2003-10-14 Thomas W. Astle Continuous polymerase chain reaction apparatus with multiple temperature stations
US6565813B1 (en) 1998-02-04 2003-05-20 Merck & Co., Inc. Virtual wells for use in high throughput screening assays
NZ507591A (en) 1998-05-01 2002-03-28 Maxygen Inc Optimization of pest resistance genes using DNA shuffling
US5997636A (en) 1998-05-01 1999-12-07 Instrumentation Technology Associates, Inc. Method and apparatus for growing crystals
GB2337261B (en) 1998-05-15 2002-09-18 Fsm Technologies Ltd Separation of nucleic acids
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
FR2782729B1 (fr) 1998-09-01 2002-10-25 Bio Merieux Carte de denombrement et de caracterisation de micro-organismes
US6804663B1 (en) 1998-09-21 2004-10-12 Microsoft Corporation Methods for optimizing the installation of a software product onto a target computer system
US6203989B1 (en) 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6569631B1 (en) 1998-11-12 2003-05-27 3-Dimensional Pharmaceuticals, Inc. Microplate thermal shift assay for ligand development using 5-(4″dimethylaminophenyl)-2-(4′-phenyl)oxazole derivative fluorescent dyes
US20030069601A1 (en) 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
US7790865B1 (en) 1999-02-02 2010-09-07 Qiagen North American Holdings, Inc Eluting reagents, methods and kits for isolating DNA
CA2299119C (en) 1999-02-23 2013-02-05 Qiagen Gmbh A method of stabilizing and/or isolating nucleic acids
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
EP1173744A4 (en) 1999-03-02 2002-10-16 Qualigen Inc METHODS AND APPARATUS FOR SEPARATING BIOLOGICAL FLUIDS
US6749814B1 (en) 1999-03-03 2004-06-15 Symyx Technologies, Inc. Chemical processing microsystems comprising parallel flow microreactors and methods for using same
AU6048199A (en) 1999-03-11 2000-09-28 Whatman, Inc. Solid medium and process for the storage and rapid purification of nucleic acid
TW496775B (en) 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
US6858439B1 (en) 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
US6436292B1 (en) 1999-04-02 2002-08-20 Symyx Technologies, Inc. Parallel high-performance liquid chromatography with post-separation treatment
US6451610B1 (en) 1999-04-14 2002-09-17 International Technidyne Corporation Method and apparatus for coagulation based assays
US7011940B1 (en) 1999-04-14 2006-03-14 Medical Discovery Partners Llc Quality control for cytochemical assays
AU778230B2 (en) 1999-05-03 2004-11-25 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
EP1925678B1 (en) 1999-05-03 2009-07-22 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
US6821770B1 (en) 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
US6391624B1 (en) 1999-06-03 2002-05-21 Lockheed Martin Corporation Highly sensitive biological agent probe
DE19926181C1 (de) 1999-06-09 2000-12-14 Inst Mikrotechnik Mainz Gmbh Magazin für mikrostrukturierte Formteile und Verfahren zu dessen Herstellung
US6630006B2 (en) 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US7139592B2 (en) 1999-06-21 2006-11-21 Arraycomm Llc Null deepening for an adaptive antenna based communication station
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
US6372895B1 (en) 2000-07-07 2002-04-16 3M Innovative Properties Company Fluorogenic compounds
US6524456B1 (en) 1999-08-12 2003-02-25 Ut-Battelle, Llc Microfluidic devices for the controlled manipulation of small volumes
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
AU2001234997B2 (en) 2000-02-11 2006-07-27 Monogram Biosciences, Inc. Microfluid device with sample injector and method of use
US20020012971A1 (en) 2000-03-20 2002-01-31 Mehta Tammy Burd PCR compatible nucleic acid sieving medium
AU5121801A (en) 2000-03-31 2001-10-15 Micronics Inc Protein crystallization in microfluidic structures
US6638408B1 (en) 2000-04-03 2003-10-28 The Wistar Institute Method and device for separation of charged molecules by solution isoelectric focusing
US20020001856A1 (en) 2000-04-06 2002-01-03 Chow Andrea W. Methods and devices for achieving long incubation times in high-throughput systems
US6949575B2 (en) 2000-05-04 2005-09-27 Pfizer Inc. Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives
GB0011443D0 (en) 2000-05-13 2000-06-28 Dna Research Instr Limited Separation device
WO2001090614A2 (en) 2000-05-24 2001-11-29 Micronics, Inc. Surface tension valves for microfluidic applications
DE10030584A1 (de) 2000-06-21 2002-01-03 Gneuss Kunststofftechnik Gmbh Mehrweg-Drehschieber-Ventil zur Verteilung von hochmolekularen Polymer-Kunststoff-Schmelzen
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6548256B2 (en) 2000-07-14 2003-04-15 Eppendorf 5 Prime, Inc. DNA isolation method and kit
AU8306901A (en) 2000-08-04 2002-02-18 Caliper Techn Corp Control of operation conditions within fluidic systems
US20040005582A1 (en) 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
WO2002023163A1 (en) 2000-09-15 2002-03-21 California Institute Of Technology Microfabricated crossflow devices and methods
CA2422110A1 (en) 2000-09-18 2002-03-21 President And Fellows Of Harvard College Method and apparatus for gradient generation
EP1327132A4 (en) 2000-09-21 2004-03-31 Dna Sciences Inc METHOD AND SYSTEM FOR INJECTING A SPECIMEN
US6808934B2 (en) 2000-09-25 2004-10-26 Picoliter Inc. High-throughput biomolecular crystallization and biomolecular crystal screening
EP1328342A4 (en) 2000-10-10 2006-03-15 Aviva Biosciences Corp INTEGRATED BIOCHIP SYSTEM FOR SAMPLE PREPARATION AND ANALYSIS
GB0030929D0 (en) 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
US6770434B2 (en) 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
CN2482070Y (zh) 2001-01-02 2002-03-13 大连市临床检验中心 血液促凝球
WO2002064253A2 (en) * 2001-02-09 2002-08-22 Microchem Solutions Method and apparatus for sample injection in microfabricated devices
US20020110835A1 (en) 2001-02-13 2002-08-15 Rajan Kumar Microfluidic devices and methods
NL1017374C2 (nl) 2001-02-15 2002-08-16 Univ Delft Tech Inrichting voor het uitvoeren van een reactie, alsmede een werkwijze voor het uitvoeren van een reactie in de inrichting.
CN100523216C (zh) 2001-03-02 2009-08-05 匹兹堡大学 Pcr方法
ATE340029T1 (de) 2001-03-09 2006-10-15 Gen Probe Inc Durchdringbarer verschluss
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US6575188B2 (en) 2001-07-26 2003-06-10 Handylab, Inc. Methods and systems for fluid control in microfluidic devices
US20030064414A1 (en) 2001-03-30 2003-04-03 Benecky Michael J. Rapid assessment of coagulation activity in whole blood
US20040137458A1 (en) 2001-05-03 2004-07-15 Christian Archambault Molecular tag code for monitoring a product and process using same
US6797056B2 (en) 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6994749B2 (en) 2001-06-08 2006-02-07 Syrrx, Inc. Microfluidic device for parallel delivery and mixing of fluids
US6567492B2 (en) 2001-06-11 2003-05-20 Eastern Isotopes, Inc. Process and apparatus for production of F-18 fluoride
US7025774B2 (en) 2001-06-12 2006-04-11 Pelikan Technologies, Inc. Tissue penetration device
WO2003000853A2 (en) 2001-06-20 2003-01-03 Caprion Pharmaceuticals Inc. Protein aggregation assays and uses thereof
US20030003962A1 (en) 2001-06-29 2003-01-02 Tan Vooi-Kia Automatic sliding machanism for portable electronic product, particularly for a sliding front cover of a mobile phone
US6702256B2 (en) 2001-07-17 2004-03-09 Agilent Technologies, Inc. Flow-switching microdevice
WO2003015890A1 (en) 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
DE60237531D1 (de) 2001-10-11 2010-10-14 Aviva Biosciences Corp Verfahren zum trennen von seltenen zellen von fluidproben
US7297485B2 (en) 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
AU2002360282A1 (en) 2001-10-19 2003-06-10 West Virginia University Research Corporation Microflludic system for proteome analysis
NL1019378C2 (nl) 2001-11-16 2003-05-20 Univ Delft Tech Werkwijze voor het vullen van een putje in een substraat.
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
AU2002356341A1 (en) 2001-12-28 2003-07-30 Norchip As Fluid manipulation in a microfabricated reaction chamber system
ATE429482T1 (de) 2001-12-31 2009-05-15 Trinity College Dublin Vorrichtung zur durchführung von auf zellen basierende analyseverfahren
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
FR2838066B1 (fr) 2002-04-09 2004-06-25 Genesystems Procede et automate d'extraction d'acides nucleiques a partir d'un melange complexe
US7135180B2 (en) 2002-04-11 2006-11-14 Medimmune Vaccines, Inc. Preservation of bioactive materials by freeze dried foam
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
EP2302389B1 (en) 2002-05-09 2018-01-24 The University of Chicago Device and method for pressure-driven plug transport and reaction
US7122640B2 (en) 2002-06-10 2006-10-17 Phynexus, Inc. Open channel solid phase extraction systems and methods
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US20040005247A1 (en) 2002-07-03 2004-01-08 Nanostream, Inc. Microfluidic closed-end metering systems and methods
DE60331879D1 (de) 2002-07-10 2010-05-12 Fujifilm Corp Methode zur Trennung und Aufreinigung von Nukleinsäuren
JP3983125B2 (ja) 2002-07-19 2007-09-26 富士フイルム株式会社 核酸の分離精製方法
JP3890360B2 (ja) 2002-07-19 2007-03-07 富士フイルム株式会社 核酸の分離精製方法
US7244961B2 (en) 2002-08-02 2007-07-17 Silicon Valley Scientific Integrated system with modular microfluidic components
US7351303B2 (en) 2002-10-09 2008-04-01 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
WO2004040314A1 (en) 2002-10-31 2004-05-13 Chemometec A/S A method for assessment of particles
EP1608952B1 (en) 2002-12-20 2016-08-10 Life Technologies Corporation Assay apparatus and method using microfluidic arrays
US20050042639A1 (en) * 2002-12-20 2005-02-24 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA length
CN101613660B (zh) * 2002-12-30 2013-05-15 加州大学评议会 检测和分析病原体的方法和设备
KR20050088476A (ko) 2002-12-30 2005-09-06 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
WO2004075734A2 (en) 2003-02-25 2004-09-10 Inlight Solutions, Inc. DETERMINATION OF pH INCLUDING HEMOGLOBIN CORRECTION
JP4053444B2 (ja) 2003-03-07 2008-02-27 シャープ株式会社 携帯可能な多機能電子機器
US7713485B2 (en) 2003-03-19 2010-05-11 Industrial Technology Research Institute Microfluidics switch with moving planes
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
US20040223874A1 (en) 2003-03-31 2004-11-11 Canon Kabushiki Kaisha Biochemical reaction cartridge
FI118669B (fi) 2003-04-01 2008-01-31 Samsung Electro Mech Liukutyyppinen matkapuhelin ja liukumismenetelmä siihen
EP2127736A1 (en) 2003-04-10 2009-12-02 The President and Fellows of Harvard College Formation and control of fluidic species
US7262059B2 (en) 2003-05-06 2007-08-28 Thrombodyne, Inc. Systems and methods for measuring fluid properties
US8362219B2 (en) 2003-05-08 2013-01-29 Phynexus, Inc. Open channel solid phase extraction systems and methods
US6916113B2 (en) * 2003-05-16 2005-07-12 Agilent Technologies, Inc. Devices and methods for fluid mixing
CA2526409A1 (en) 2003-05-19 2004-12-02 Brandeis University Nucleic acid processing methods, kits and devices
US7648835B2 (en) 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
ATE376882T1 (de) 2003-07-04 2007-11-15 November Ag Molekulare Medizin Verwendung eines einwegbehälters, mikrofluidische vorrichtung und verfahren zur bearbeitung von molekülen
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
DE10336849A1 (de) 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
CN104069784B (zh) 2003-08-27 2017-01-11 哈佛大学 流体物种的电子控制
JP2005083505A (ja) * 2003-09-09 2005-03-31 Olympus Corp スライド式バルブ装置
JP2005083510A (ja) * 2003-09-09 2005-03-31 Toshiba Corp バルブ装置、化学分析装置及び化学分析システム
US7003104B2 (en) 2003-10-13 2006-02-21 Hanbit Precision Co., Ltd. Apparatus for opening and closing cover of cellular phone
US7846333B2 (en) 2003-11-24 2010-12-07 Effendorf AG Porous media
SE526330C2 (sv) * 2003-11-26 2005-08-23 Boule Medical Ab Förfarande och anordning för bestämning av en liten volym av ett flytnade prov
WO2005056186A1 (en) 2003-12-10 2005-06-23 The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin A modular biochip assembly
US20050130177A1 (en) 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7939249B2 (en) 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7629165B2 (en) 2004-01-22 2009-12-08 Qualigen, Inc Diagnostic device and method
GB2416030B (en) 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
DE102004021780B4 (de) 2004-04-30 2008-10-02 Siemens Ag Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien
ES2553097T3 (es) 2004-05-03 2015-12-04 Handylab, Inc. Procesamiento de muestras que contienen polinucleótidos
ES2527426T3 (es) 2004-05-07 2015-01-23 Cepheid Detección combinada de agentes biológicos
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
WO2006018044A1 (en) * 2004-08-18 2006-02-23 Agilent Technologies, Inc. Microfluidic assembly with coupled microfluidic devices
EP1630228B1 (en) 2004-08-25 2012-01-11 FUJIFILM Corporation Method for separation and purification of nucleic acid
JP4511596B2 (ja) 2004-09-15 2010-07-28 レイアード テクノロジーズ マップ カンパニー リミテッド 携帯電話の開閉に対する摺動機構
US7955504B1 (en) 2004-10-06 2011-06-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Microfluidic devices, particularly filtration devices comprising polymeric membranes, and method for their manufacture and use
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US20060183261A1 (en) 2005-02-15 2006-08-17 Dudenhoefer Christie L Method of forming a biological sensor
JP4829509B2 (ja) 2005-02-18 2011-12-07 シスメックス株式会社 遺伝子検査方法
EP2248578B1 (en) 2005-03-04 2012-06-06 President and Fellows of Harvard College Method for forming multiple emulsions
US7964413B2 (en) 2005-03-10 2011-06-21 Gen-Probe Incorporated Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay
US7731907B2 (en) 2005-04-09 2010-06-08 Boehringer Ingelheim Microparts Gmbh Device and process for testing a sample liquid
WO2006116616A2 (en) 2005-04-26 2006-11-02 Applera Corporation Systems and methods for multiple analyte detection
DK1885880T3 (da) 2005-04-29 2010-11-08 Synthetic Genomics Inc Amplifikation og kloning af enkelte DNA-molekyler ved anvendelse af rolling circle-amplifikation
US7235216B2 (en) 2005-05-01 2007-06-26 Iba Molecular North America, Inc. Apparatus and method for producing radiopharmaceuticals
WO2006120221A1 (en) 2005-05-12 2006-11-16 Stmicroelectronics S.R.L. Microfluidic device with integrated micropump, in particular biochemical microreactor, and manufacturing method thereof
JP2008539787A (ja) 2005-05-18 2008-11-20 コーネル・リサーチ・ファンデーション・インコーポレイテッド 生物学的な障壁を有する薬物動態学ベース培養システム
ES2373686T3 (es) 2005-06-23 2012-02-07 Biocartis Sa Cartucho, sistema y procedimiento para diagnósticos médicos automatizados.
JP2009501522A (ja) 2005-07-12 2009-01-22 コドン デバイシズ インコーポレイテッド 生体触媒工学のための組成物及び方法
ES2390354T3 (es) 2005-07-22 2012-11-12 Amgen, Inc Liofilizados de proteínas concentrados, procedimientos y usos
US7915030B2 (en) 2005-09-01 2011-03-29 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic DNA
US7556776B2 (en) 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
US7329485B2 (en) 2005-10-12 2008-02-12 The Board Of Regents Of The University Of Oklahoma Methods for detecting compounds that interfere with protein aggregation utilizing an in vitro fluorescence-based assay
WO2007044974A2 (en) 2005-10-12 2007-04-19 The Research Foundation Of State University Of New York Absolute pcr quantification
WO2007050565A2 (en) 2005-10-25 2007-05-03 Baylor College Of Medicine Incorporation of antimicrobial combinations onto devices to reduce infection
US20070134739A1 (en) 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
US20090221096A1 (en) 2005-12-13 2009-09-03 Great Basin Scientific Thin film biosensor and method and device for detection of analytes
JP2009536313A (ja) 2006-01-11 2009-10-08 レインダンス テクノロジーズ， インコーポレイテッド ナノリアクターの形成および制御において使用するマイクロ流体デバイスおよび方法
WO2007089541A2 (en) 2006-01-27 2007-08-09 President And Fellows Of Harvard College Fluidic droplet coalescence
EP1983889A4 (en) 2006-01-31 2009-09-16 Univ Chicago METHOD AND DEVICE FOR ANALYZING BLOOD COAGULATION
TR201910868T4 (tr) 2006-02-02 2019-08-21 Univ Leland Stanford Junior Dijital analizle invazif olmayan fetal genetik tarama.
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
GB0604973D0 (en) 2006-03-11 2006-04-19 Central Science Lab Csl Of San Purification method and kit
JP5254949B2 (ja) 2006-03-15 2013-08-07 マイクロニクス， インコーポレイテッド 一体型の核酸アッセイ
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
ATE540750T1 (de) 2006-05-11 2012-01-15 Raindance Technologies Inc Mikrofluidische vorrichtung und verfahren
WO2007146923A2 (en) 2006-06-12 2007-12-21 Great Basin Scientific Methods and materials for detecting frameshift mutations
EP2041318A2 (en) 2006-06-26 2009-04-01 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
EP2041556A1 (en) 2006-06-28 2009-04-01 RGB Technologies AB A sensor kit and a system for detecting an analyte in a test environment
US7465597B2 (en) 2006-06-29 2008-12-16 Home Diagnostics, Inc. Method of manufacturing a diagnostic test strip
US8187557B2 (en) 2006-07-13 2012-05-29 Cepheid Reagent reservoir system for analytical instruments
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
KR101422572B1 (ko) 2006-09-05 2014-07-30 삼성전자주식회사 핵산 검출을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
US7375190B2 (en) 2006-09-19 2008-05-20 National Yang-Ming University Recombinant protein and method of screening for agents that modulate polypeptide aggregation
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
WO2008043041A1 (en) 2006-10-04 2008-04-10 University Of Washington Method and device for rapid parallel microfluidic molecular affinity assays
CN101578520B (zh) 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
US7709203B2 (en) 2006-10-20 2010-05-04 E.I. Du Pont De Nemours And Company Sequences diagnostic for shrimp pathogens
EP2080025A4 (en) 2006-10-27 2011-12-07 Montecito Bio Sciences Ltd PORTABLE DEVICE FOR IMPROVED SAMPLE ANALYSIS
WO2008067552A2 (en) 2006-11-30 2008-06-05 Fluidigm Corporation Method and apparatus for biological sample analysis
US7615351B2 (en) 2006-12-01 2009-11-10 Panomics, Inc. Two stage nucleic acid amplification using an amplification oligomer
WO2008079274A1 (en) 2006-12-19 2008-07-03 University Of Chicago Spacers for microfludic channels
US8338166B2 (en) 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US7851207B1 (en) 2007-02-07 2010-12-14 The United States Of America As Represented By The Secretary Of The Army Multiplex field device to detect and identify a variety of microbial agents simultaneously
EP2164541A2 (en) 2007-06-22 2010-03-24 Circle Biologics, LLC. Fluid concentrator, autologous concentrated body fluids, and uses thereof
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
DK2172566T4 (da) 2007-07-17 2022-06-13 Somalogic Inc Fremgangsmåde til generering af aptamerer med forbedrede off-rates
EP2017618A1 (en) 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Methods and systems for detecting
US9090885B2 (en) 2007-07-26 2015-07-28 The University Of Chicago Co-incubating confined microbial communities
WO2009018348A1 (en) 2007-07-30 2009-02-05 Cornell Research Foundation, Inc. Microchannel detection device and use thereof
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
CA2698545C (en) 2007-09-07 2014-07-08 Fluidigm Corporation Copy number variation determination, methods and systems
US7736891B2 (en) 2007-09-11 2010-06-15 University Of Washington Microfluidic assay system with dispersion monitoring
US20100311616A1 (en) * 2007-10-26 2010-12-09 Tomoyuki Ozawa Reaction chip and method of manufacturing the same
US8222048B2 (en) 2007-11-05 2012-07-17 Abbott Laboratories Automated analyzer for clinical laboratory
EP2225561A4 (en) 2007-11-28 2011-09-14 Great Basin Scient METHODS AND COMPOSITIONS FOR REINFORCING SIGNALS USING MULTIVALENT INTERACTIONS
DE102007059533A1 (de) 2007-12-06 2009-06-10 Thinxxs Microtechnology Ag Mikrofluidische Speichervorrichtung
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
GB0808557D0 (en) 2008-05-13 2008-06-18 3M Innovative Properties Co Sampling devices and methods of use
US8622987B2 (en) 2008-06-04 2014-01-07 The University Of Chicago Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution
EP2315629B1 (en) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Droplet libraries
DE102008042581B4 (de) 2008-10-02 2012-02-02 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Mikrofluidische Extraktions- und Reaktionsvorrichtung
EP2384438A2 (en) 2008-12-30 2011-11-09 Redhorse Fluidics Systems, devices, methods and kits for fluid handling
DE102009005874A1 (de) 2009-01-21 2010-07-22 Thinxxs Microtechnology Ag Ventil, insbesondere für ein Bauelement der Mikrofluidtechnik
DE102009009728A1 (de) 2009-02-19 2010-09-02 Thinxxs Microtechnology Ag Flusszelle mit integriertem Fluidspeicher
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9415392B2 (en) 2009-03-24 2016-08-16 The University Of Chicago Slip chip device and methods
US9458489B2 (en) 2010-03-04 2016-10-04 Massachusetts Institute Of Technology Microfluidics sorter for cell detection and isolation
CA2881200A1 (en) 2012-02-14 2013-08-22 Great Basin Scientific Methods of isothermal amplification using blocked primers
US20130331298A1 (en) 2012-06-06 2013-12-12 Great Basin Scientific Analyzer and disposable cartridge for molecular in vitro diagnostics
US9097710B2 (en) * 2012-10-16 2015-08-04 The Methodist Hospital Research Institute Multiplexed volumetric bar chart chip for point of care biomarker and analyte quantitation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020125197A1 (en) * 2001-03-08 2002-09-12 Hager David C. Multi-well apparatus
US20040119070A1 (en) * 2002-08-02 2004-06-24 Roach David John Integrated microchip design
US20070026439A1 (en) * 2005-07-15 2007-02-01 Applera Corporation Fluid processing device and method
US20090021728A1 (en) * 2007-06-21 2009-01-22 Gen-Probe Incorporated Multi-Channel Optical Measurement Instrument

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CN104722342A (zh) 2015-06-24
CA2756463A1 (en) 2010-09-30
CN102439717B (zh) 2015-01-21
AU2010229490A1 (en) 2011-10-20
CN104722342B (zh) 2017-01-11
JP2016163590A (ja) 2016-09-08
JP6141822B2 (ja) 2017-06-07
EP2412020A1 (en) 2012-02-01
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JP6263577B2 (ja) 2018-01-17
CA2756463C (en) 2019-01-22
CN102439717A (zh) 2012-05-02
US20160256870A1 (en) 2016-09-08
JP6227059B2 (ja) 2017-11-08
JP2016165306A (ja) 2016-09-15

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