AU2006282042B2 - Nanoparticle fabrication methods, systems, and materials - Google Patents

Nanoparticle fabrication methods, systems, and materials Download PDF

Info

Publication number
AU2006282042B2
AU2006282042B2 AU2006282042A AU2006282042A AU2006282042B2 AU 2006282042 B2 AU2006282042 B2 AU 2006282042B2 AU 2006282042 A AU2006282042 A AU 2006282042A AU 2006282042 A AU2006282042 A AU 2006282042A AU 2006282042 B2 AU2006282042 B2 AU 2006282042B2
Authority
AU
Australia
Prior art keywords
particle
particles
composition
template
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2006282042A
Other languages
English (en)
Other versions
AU2006282042A1 (en
AU2006282042A8 (en
Inventor
Joseph M. Desimone
Alex Ermoshkin
Larken E. Euliss
Ansley E. Exner
Stephanie Gratton
Benjamin W. Maynor
Andrew James Murphy
Jason P. Rolland
Ginger Denison Rothrock
Edward T. Samulski
R. Jude Samulski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of AU2006282042A1 publication Critical patent/AU2006282042A1/en
Publication of AU2006282042A8 publication Critical patent/AU2006282042A8/en
Assigned to THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, LIQUIDIA TECHNOLOGIES INC. reassignment THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL Request for Assignment Assignors: LIQUIDA TECHNOLOGIES INC., NORTH CAROLINA STATE UNIVERSITY, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Application granted granted Critical
Publication of AU2006282042B2 publication Critical patent/AU2006282042B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097—Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
    • G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
    • G03F7/0002—Lithographic processes using patterning methods other than those involving the exposure to radiation, e.g. by stamping
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Theoretical Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Mathematical Physics (AREA)
  • Manufacturing & Machinery (AREA)
  • Obesity (AREA)
AU2006282042A 2005-06-17 2006-06-19 Nanoparticle fabrication methods, systems, and materials Active AU2006282042B2 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US69160705P 2005-06-17 2005-06-17
US60/691,607 2005-06-17
US71496105P 2005-09-07 2005-09-07
US60/714,961 2005-09-07
US73422805P 2005-11-07 2005-11-07
US60/734,228 2005-11-07
US76280206P 2006-01-27 2006-01-27
US60/762,802 2006-01-27
US79987606P 2006-05-12 2006-05-12
US60/799,876 2006-05-12
PCT/US2006/023722 WO2007024323A2 (en) 2005-06-17 2006-06-19 Nanoparticle fabrication methods, systems, and materials

Publications (3)

Publication Number Publication Date
AU2006282042A1 AU2006282042A1 (en) 2007-03-01
AU2006282042A8 AU2006282042A8 (en) 2008-07-10
AU2006282042B2 true AU2006282042B2 (en) 2011-12-22

Family

ID=37772072

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006282042A Active AU2006282042B2 (en) 2005-06-17 2006-06-19 Nanoparticle fabrication methods, systems, and materials

Country Status (8)

Country Link
US (1) US20110182805A1 (https=)
EP (1) EP1904932A4 (https=)
JP (1) JP5570721B2 (https=)
CN (1) CN102016814B (https=)
AU (1) AU2006282042B2 (https=)
CA (1) CA2611985C (https=)
MX (1) MX2007016039A (https=)
WO (1) WO2007024323A2 (https=)

Families Citing this family (285)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9040090B2 (en) 2003-12-19 2015-05-26 The University Of North Carolina At Chapel Hill Isolated and fixed micro and nano structures and methods thereof
WO2011109340A1 (en) 2010-03-01 2011-09-09 Nova Southeastern University Epinephrine nanop articles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US9877921B2 (en) * 2005-09-09 2018-01-30 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US20160045457A1 (en) 2005-09-09 2016-02-18 Ousama Rachid Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine
US20100055459A1 (en) * 2006-08-30 2010-03-04 Liquidia Technologies, Inc. Nanoparticles Having Functional Additives for Self and Directed Assembly and Methods of Fabricating Same
WO2008031035A2 (en) * 2006-09-08 2008-03-13 The Regents Of The University Of California Engineering shape of polymeric micro-and nanoparticles
KR20090067174A (ko) 2006-09-14 2009-06-24 더 리전트 오브 더 유니버시티 오브 캘리포니아 뉴클레아제 활성 및 ｄｎａ 풋프린팅을 위한 나노플라즈몬 분자 계측자
EP2086767B1 (en) * 2006-11-15 2014-12-17 3M Innovative Properties Company Solvent removal assisted material transfer for flexographic printing
US20100024671A1 (en) * 2006-11-15 2010-02-04 Pekurovsky Mikhail L Solvent-assisted embossing of flexographic printing plates
BRPI0718766A2 (pt) 2006-11-15 2014-01-21 3M Innovative Properties Co Impressão flexográfica com cura durante a transferência para o substrato
US8128393B2 (en) 2006-12-04 2012-03-06 Liquidia Technologies, Inc. Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom
WO2008127455A2 (en) * 2006-12-05 2008-10-23 Liquidia Technologies, Inc. Nanoarrays and methods and materials for fabricating same
US8394483B2 (en) 2007-01-24 2013-03-12 Micron Technology, Inc. Two-dimensional arrays of holes with sub-lithographic diameters formed by block copolymer self-assembly
US8083953B2 (en) 2007-03-06 2011-12-27 Micron Technology, Inc. Registered structure formation via the application of directed thermal energy to diblock copolymer films
US8557128B2 (en) 2007-03-22 2013-10-15 Micron Technology, Inc. Sub-10 nm line features via rapid graphoepitaxial self-assembly of amphiphilic monolayers
US20100151031A1 (en) * 2007-03-23 2010-06-17 Desimone Joseph M Discrete size and shape specific organic nanoparticles designed to elicit an immune response
US7959975B2 (en) 2007-04-18 2011-06-14 Micron Technology, Inc. Methods of patterning a substrate
US8294139B2 (en) 2007-06-21 2012-10-23 Micron Technology, Inc. Multilayer antireflection coatings, structures and devices including the same and methods of making the same
US8097175B2 (en) 2008-10-28 2012-01-17 Micron Technology, Inc. Method for selectively permeating a self-assembled block copolymer, method for forming metal oxide structures, method for forming a metal oxide pattern, and method for patterning a semiconductor structure
US8372295B2 (en) 2007-04-20 2013-02-12 Micron Technology, Inc. Extensions of self-assembled structures to increased dimensions via a “bootstrap” self-templating method
US8404124B2 (en) 2007-06-12 2013-03-26 Micron Technology, Inc. Alternating self-assembling morphologies of diblock copolymers controlled by variations in surfaces
US8080615B2 (en) 2007-06-19 2011-12-20 Micron Technology, Inc. Crosslinkable graft polymer non-preferentially wetted by polystyrene and polyethylene oxide
US8283258B2 (en) 2007-08-16 2012-10-09 Micron Technology, Inc. Selective wet etching of hafnium aluminum oxide films
DE102007044146A1 (de) * 2007-09-12 2009-03-19 Bayer Materialscience Ag Thermoplast mit Metallkennzeichnungsplättchen
US8530000B2 (en) 2007-09-19 2013-09-10 Micron Technology, Inc. Methods of forming charge-trapping regions
CN103660089B (zh) 2007-10-12 2017-04-12 流体科技公司 用于生产颗粒和图案化膜的系统和方法
JPWO2009084392A1 (ja) * 2007-12-27 2011-05-19 アルプス電気株式会社 金型装置及び樹脂成型品の製造方法
US8999492B2 (en) 2008-02-05 2015-04-07 Micron Technology, Inc. Method to produce nanometer-sized features with directed assembly of block copolymers
US8101261B2 (en) 2008-02-13 2012-01-24 Micron Technology, Inc. One-dimensional arrays of block copolymer cylinders and applications thereof
WO2009111588A1 (en) 2008-03-04 2009-09-11 Liquidia Technologies, Inc. Immunomodulator particles and methods of treating
US8426313B2 (en) 2008-03-21 2013-04-23 Micron Technology, Inc. Thermal anneal of block copolymer films with top interface constrained to wet both blocks with equal preference
US8425982B2 (en) 2008-03-21 2013-04-23 Micron Technology, Inc. Methods of improving long range order in self-assembly of block copolymer films with ionic liquids
US8114300B2 (en) 2008-04-21 2012-02-14 Micron Technology, Inc. Multi-layer method for formation of registered arrays of cylindrical pores in polymer films
US8114301B2 (en) 2008-05-02 2012-02-14 Micron Technology, Inc. Graphoepitaxial self-assembly of arrays of downward facing half-cylinders
CN102056595A (zh) * 2008-06-13 2011-05-11 阿科玛股份有限公司 可生物降解的抗冲击改性的聚合物组合物
JP2012501965A (ja) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法
ES2721850T3 (es) 2008-06-16 2019-08-05 Pfizer Nanopartículas poliméricas terapéuticas que comprenden alcaloides vinca y procedimientos de fabricación y uso de las mismas
US8613951B2 (en) 2008-06-16 2013-12-24 Bind Therapeutics, Inc. Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same
US8382858B2 (en) 2008-06-25 2013-02-26 University Of Massachusetts Nanoparticle-textured surfaces and related methods for selective adhesion, sensing and separation
CN101671442A (zh) * 2008-09-12 2010-03-17 清华大学 碳纳米管阵列复合材料的制备方法
US8535644B2 (en) * 2008-10-10 2013-09-17 Massachusetts Institute Of Technology Tunable hydrogel microparticles
US8485861B2 (en) 2008-10-31 2013-07-16 The Invention Science Fund I, Llc Systems, devices, and methods for making or administering frozen particles
US8798932B2 (en) 2008-10-31 2014-08-05 The Invention Science Fund I, Llc Frozen compositions and methods for piercing a substrate
US8721583B2 (en) * 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US9072799B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8788211B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition
US9060931B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8731840B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8793075B2 (en) 2008-10-31 2014-07-29 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9072688B2 (en) 2008-10-31 2015-07-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8762067B2 (en) 2008-10-31 2014-06-24 The Invention Science Fund I, Llc Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data
US9050251B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for delivery of frozen particle adhesives
US8788212B2 (en) 2008-10-31 2014-07-22 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9050317B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US8731841B2 (en) 2008-10-31 2014-05-20 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
US9050070B2 (en) 2008-10-31 2015-06-09 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8603495B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for biological remodeling with frozen particle compositions
US9060934B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US8603494B2 (en) 2008-10-31 2013-12-10 The Invention Science Fund I, Llc Compositions and methods for administering compartmentalized frozen particles
US8725420B2 (en) 2008-10-31 2014-05-13 The Invention Science Fund I, Llc Compositions and methods for surface abrasion with frozen particles
US20100111857A1 (en) 2008-10-31 2010-05-06 Boyden Edward S Compositions and methods for surface abrasion with frozen particles
US9060926B2 (en) 2008-10-31 2015-06-23 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with frozen particles
WO2010068866A2 (en) 2008-12-12 2010-06-17 Bind Biosciences Therapeutic particles suitable for parenteral administration and methods of making and using same
US20100216804A1 (en) 2008-12-15 2010-08-26 Zale Stephen E Long Circulating Nanoparticles for Sustained Release of Therapeutic Agents
US8715981B2 (en) 2009-01-27 2014-05-06 Purdue Research Foundation Electrochemical biosensor
PL2401027T3 (pl) 2009-02-26 2018-04-30 The University Of North Carolina At Chapel Hill Układ do interwencyjnego dostarczania leku
JP5498058B2 (ja) * 2009-05-22 2014-05-21 東京エレクトロン株式会社 導電膜の製造方法及び製造装置並びに導電膜
EP3301104B1 (en) 2009-05-29 2019-10-30 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
JP2011025220A (ja) * 2009-06-24 2011-02-10 Tokyo Electron Ltd テンプレート処理装置、インプリントシステム、テンプレート処理方法、プログラム及びコンピュータ記憶媒体
US20120114554A1 (en) * 2009-07-13 2012-05-10 Liquidia Technologies, Inc. Engineered Aerosol Particles, And Associated Methods
EP2470956B1 (en) * 2009-08-26 2018-02-14 Molecular Imprints, Inc. Functional nanoparticles
EP2295480A1 (en) * 2009-09-10 2011-03-16 Occlugel Implantable bio-resorbable polymer
CN101704502B (zh) * 2009-09-11 2012-07-04 中国科学院化学研究所 一种制备阵列化有机纳米粒子的方法
WO2011040466A1 (ja) * 2009-10-01 2011-04-07 東京エレクトロン株式会社 テンプレート処理装置、インプリントシステム、テンプレート処理方法、及びコンピュータ記憶媒体
US9211519B2 (en) * 2009-10-08 2015-12-15 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods to prepare patchy microparticles
US8357401B2 (en) 2009-12-11 2013-01-22 Bind Biosciences, Inc. Stable formulations for lyophilizing therapeutic particles
ES2780156T3 (es) 2009-12-15 2020-08-24 Pfizer Composiciones terapéuticas de nanopartículas poliméricas con alta temperatura de transición vítrea o copolímeros de alto peso molecular
JP5732724B2 (ja) * 2010-02-18 2015-06-10 大日本印刷株式会社 ナノインプリント方法
US9161448B2 (en) 2010-03-29 2015-10-13 Semprius, Inc. Laser assisted transfer welding process
EP2559008A1 (en) * 2010-04-16 2013-02-20 Gojo Industries, Inc. Taggant keying system for dispensing systems
FR2959833B1 (fr) * 2010-05-07 2015-06-12 Inst Nat Sciences Appliq Procede de nano-structure topographique et electrique d'un film mince de polymere electret et film mince de polymere electret obtenu
US10170764B2 (en) 2010-06-30 2019-01-01 Semiconductor Energy Laboratory Co., Ltd. Method for manufacturing ultra small particle, positive electrode active material of second battery using the method for manufacturing ultra small particle and method for manufacturing the same, and secondary battery using the positive electrode active material and method for manufacturing the same
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US8304493B2 (en) 2010-08-20 2012-11-06 Micron Technology, Inc. Methods of forming block copolymers
US20130203675A1 (en) 2010-09-16 2013-08-08 Joseph M. DeSimone Asymmetric biofunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents
RU2013120302A (ru) 2010-10-01 2014-11-20 Модерна Терапьютикс, Инк. Сконструированные нуклеиновые кислоты и способы их применения
JP5909745B2 (ja) 2010-11-12 2016-04-27 クール ファーマシューティカルズ ディベロップメント カンパニー 炎症性疾患の治療薬、ならびにウイルスまたは細菌感染疾患の治療薬
JP2012114157A (ja) * 2010-11-22 2012-06-14 Toshiba Corp ドロップレシピ作成方法およびデータベース作成方法
ES2590983T3 (es) * 2010-12-03 2016-11-24 Xeltis B.V. Uso de un polímero fluorado como agente de contraste para formación de imágenes por resonancia magnética (IRM) 19F en estado sólido, andamiaje que comprende dicho polímero y uso del mismo
JP2012121173A (ja) * 2010-12-06 2012-06-28 Dainippon Printing Co Ltd タガント粒子群、ならびにそれを有する偽造防止用インク、偽造防止用トナー、偽造防止用シートおよび偽造防止媒体
JP5707909B2 (ja) * 2010-12-06 2015-04-30 大日本印刷株式会社 微粒子の製造方法
CN102955930B (zh) * 2011-08-21 2021-05-11 深圳兆日科技股份有限公司 一种利用物质自身物理特征识别的防伪方法和系统
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
KR20140041505A (ko) 2011-04-29 2014-04-04 셀렉타 바이오사이언시즈, 인크. 조절 b 세포 유도를 위한 관용원성 합성 나노운반체
WO2012158631A2 (en) 2011-05-13 2012-11-22 The Regents Of The University Of California Photothermal substrates for selective transfection of cells
US9605304B2 (en) * 2011-07-20 2017-03-28 The Hong Kong Polytechnic University Ultra-stable oligonucleotide-gold and-silver nanoparticle conjugates and method of their preparation
US10624847B2 (en) * 2011-08-02 2020-04-21 AnPac BioMedical Science Co., Ltd. Decomposable apparatus and methods for fabricating same
WO2013023110A2 (en) * 2011-08-11 2013-02-14 The Trustees Of The University Of Pennsylvania Uniform coatings produced by suspensions of anisotropic particles
CA2848359A1 (en) * 2011-09-11 2013-03-14 Aurasense, Llc Cellular uptake control systems
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9412727B2 (en) 2011-09-20 2016-08-09 Semprius, Inc. Printing transferable components using microstructured elastomeric surfaces with pressure modulated reversible adhesion
RU2648950C2 (ru) 2011-10-03 2018-04-02 Модерна Терапьютикс, Инк. Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
US9423392B1 (en) * 2011-10-10 2016-08-23 The Boeing Company Methods and systems for indicating and determining fuel properties
CN104094119A (zh) * 2011-10-21 2014-10-08 斯特姆詹尼克斯公司 用于胞内传递生物活性分子的官能化纳米粒子
CA2853084C (en) * 2011-10-21 2022-04-26 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
US8900963B2 (en) 2011-11-02 2014-12-02 Micron Technology, Inc. Methods of forming semiconductor device structures, and related structures
US20150037428A1 (en) 2011-11-29 2015-02-05 The University Of North Carolina At Chapel Hill Geometrically engineered particles and methods for modulating macrophage or immune responses
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
JP5584241B2 (ja) * 2012-02-27 2014-09-03 株式会社東芝 半導体製造装置及び半導体デバイスの製造方法
US20150044417A1 (en) * 2012-03-12 2015-02-12 Asahi Kasei E-Materials Corporation Mold, resist layered product, manufacturing method of the product, and concavo-convex structure product
WO2013142830A1 (en) * 2012-03-22 2013-09-26 The Regents Of The University Of Colorado, A Body Corporate Liquid deposition photolithography
CN102583235B (zh) * 2012-03-22 2015-07-22 中国科学院化学研究所 一种用液相化学反应法制备有机微纳结构及原位图案化的方法
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9254311B2 (en) 2012-04-02 2016-02-09 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
AU2013243948A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of proteins associated with human disease
CA2868391A1 (en) 2012-04-02 2013-10-10 Stephane Bancel Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
US20150336301A1 (en) 2012-05-02 2015-11-26 Rolith, Inc. Cylindrical polymer mask and method of fabrication
US9481112B2 (en) 2013-01-31 2016-11-01 Metamaterial Technologies Usa, Inc. Cylindrical master mold assembly for casting cylindrical masks
US9782917B2 (en) * 2013-01-31 2017-10-10 Metamaterial Technologies Usa, Inc. Cylindrical master mold and method of fabrication
US9522289B2 (en) 2012-05-08 2016-12-20 The Regents Of The University Of California Selective fat removal using photothermal heating
JP2015523332A (ja) 2012-05-16 2015-08-13 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 経口投与のためのポリペプチド搭載ｐｏｃａナノ粒子
WO2013184097A1 (en) * 2012-06-05 2013-12-12 Empire Technology Development, Llc Reactive tags for obtaining consumer survey responses
CA3169368A1 (en) 2012-06-15 2014-01-09 Nova Southeastern University Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine
WO2013192532A2 (en) 2012-06-21 2013-12-27 Northwestern University Peptide conjugated particles
US9780335B2 (en) * 2012-07-20 2017-10-03 3M Innovative Properties Company Structured lamination transfer films and methods
TWI643613B (zh) * 2012-08-03 2018-12-11 安派科生物醫學科技有限公司 可降解器械
MX356097B (es) 2012-09-17 2018-05-14 Pfizer Inc Star Proceso para la preparacion de nanoparticulas terapeuticas.
US9087699B2 (en) 2012-10-05 2015-07-21 Micron Technology, Inc. Methods of forming an array of openings in a substrate, and related methods of forming a semiconductor device structure
TWI524825B (zh) * 2012-10-29 2016-03-01 財團法人工業技術研究院 碳材導電膜的轉印方法
WO2014081507A1 (en) 2012-11-26 2014-05-30 Moderna Therapeutics, Inc. Terminally modified rna
US9711744B2 (en) 2012-12-21 2017-07-18 3M Innovative Properties Company Patterned structured transfer tape
US20140175707A1 (en) 2012-12-21 2014-06-26 3M Innovative Properties Company Methods of using nanostructured transfer tape and articles made therefrom
WO2014113679A1 (en) * 2013-01-18 2014-07-24 The University Of North Carolina At Chapel Hill High-throughput manufacturing of microneedles
JP6534347B2 (ja) 2013-03-04 2019-06-26 東洋合成工業株式会社 組成物、樹脂モールド、光インプリント方法、光学素子の製造方法、及び電子素子の製造方法
CN105263476A (zh) 2013-03-13 2016-01-20 库尔制药开发公司 用于治疗炎症的免疫修饰性颗粒
EP2971010B1 (en) 2013-03-14 2020-06-10 ModernaTX, Inc. Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
IL225219A (en) * 2013-03-14 2017-08-31 Micro Tag Temed Ltd A magnetic resonance facility for the detection and detection of tiny quantities of specific materials quickly and efficiently
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP2976617B1 (en) * 2013-03-18 2021-10-13 Smiths Detection Montreal Inc. Trace analyte collection swab
US8726411B1 (en) * 2013-03-21 2014-05-13 National Tsing Hua University Charged probe and electric fields measurement method thereof
CA2907770C (en) 2013-03-22 2022-02-15 Nova Southeastern University Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine
ITTO20130284A1 (it) * 2013-04-09 2014-10-10 Fond Istituto Italiano Di Tecnologia Procedimento per la produzione di microparticelle polimeriche sagomate
US9229328B2 (en) 2013-05-02 2016-01-05 Micron Technology, Inc. Methods of forming semiconductor device structures, and related semiconductor device structures
HUE052599T2 (hu) 2013-05-03 2021-05-28 Selecta Biosciences Inc CD4+ szabályozó T-sejtek fokozására szolgáló eljárások és készítmények
WO2014197904A1 (en) * 2013-06-07 2014-12-11 Akina, Inc. Device for large-scale microparticle production and method of using the same
KR101474944B1 (ko) * 2013-07-22 2014-12-22 한국기계연구원 나노채널 형성방법
IL292567B2 (en) 2013-08-13 2025-06-01 Univ Northwestern Peptide conjugated particles
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
US20160194625A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP2857350A1 (en) * 2013-09-10 2015-04-08 ESPCI Innov Use of nanoparticles for gluing gels
US9177795B2 (en) 2013-09-27 2015-11-03 Micron Technology, Inc. Methods of forming nanostructures including metal oxides
US10023626B2 (en) 2013-09-30 2018-07-17 Modernatx, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
CN103706233A (zh) * 2013-12-17 2014-04-09 杨亮月 一种环氧乙烷零排放处理体系及方法
EP3572875A1 (en) * 2013-12-19 2019-11-27 Illumina, Inc. Roll-to-roll process of preparing a patterned substrate and patterned substrate prepared by the same process
US20150202834A1 (en) 2014-01-20 2015-07-23 3M Innovative Properties Company Lamination transfer films for forming antireflective structures
US9246134B2 (en) 2014-01-20 2016-01-26 3M Innovative Properties Company Lamination transfer films for forming articles with engineered voids
WO2015108773A1 (en) 2014-01-20 2015-07-23 3M Innovative Properties Company Lamination transfer films for forming reentrant structures
JP2017511755A (ja) 2014-01-22 2017-04-27 スリーエム イノベイティブ プロパティズ カンパニー ガラス用微小光学要素
MA39734B1 (fr) 2014-03-14 2019-07-31 Pfizer Nanoparticules thérapeutiques comportant un agent thérapeutique, et leurs procédés de fabrication et d'utilisation
TW201539736A (zh) 2014-03-19 2015-10-16 ３Ｍ新設資產公司 用於藉白光成色之 oled 裝置的奈米結構
US10073424B2 (en) 2014-05-13 2018-09-11 Autodesk, Inc. Intelligent 3D printing through optimization of 3D print parameters
US9782934B2 (en) 2014-05-13 2017-10-10 Autodesk, Inc. 3D print adhesion reduction during cure process
US9841750B2 (en) 2014-05-13 2017-12-12 Autodesk, Inc. Dynamic real-time slice engine for 3D printing
US20150339569A1 (en) * 2014-05-22 2015-11-26 Smartwater Ltd Security marker systems and methods with validation protocol
ES2555790B1 (es) 2014-06-05 2016-10-13 Consejo Superior De Investigaciones Científicas (Csic) Método de obtención de un array de micropartículas planares con multiplexado molecular superficial, array obtenido y su uso
CN105294791A (zh) * 2014-06-10 2016-02-03 无锡康福特药物科技有限公司 一种大环内酯类药物的超微粉体及其制备方法
CN105198747A (zh) * 2014-06-10 2015-12-30 无锡信仁堂药物技术有限公司 一种非甾体抗炎药的超微粉体及其制备方法
CN105218370A (zh) * 2014-06-10 2016-01-06 无锡康福特药物科技有限公司 一种贝特类降脂药物的超微粉体及其制备方法
CN105198886A (zh) * 2014-06-10 2015-12-30 无锡德赛诺医药科技有限公司 一种核苷类抗病毒药物的超微粉体及其制备方法
CN105294563A (zh) * 2014-06-10 2016-02-03 苏州鑫贝瑞药业有限公司 一种cox-2抑制剂的超微粉体及其制备方法
CN105213314A (zh) * 2014-06-10 2016-01-06 无锡朗立药业有限公司 一种HMG-CoA还原酶抑制剂的超微粉体及其制备方法
CN105218458A (zh) * 2014-06-10 2016-01-06 无锡德赛诺医药科技有限公司 一种硝基咪唑类药物及其衍生物的超微粉体及其制备方法
TWI689310B (zh) 2014-07-11 2020-04-01 巨生生醫股份有限公司 治療鐵缺乏症之方法
EP3169693B1 (en) 2014-07-16 2022-03-09 ModernaTX, Inc. Chimeric polynucleotides
CN117198903A (zh) 2014-07-20 2023-12-08 艾克斯展示公司技术有限公司 用于微转贴印刷的设备及方法
US9472788B2 (en) 2014-08-27 2016-10-18 3M Innovative Properties Company Thermally-assisted self-assembly method of nanoparticles and nanowires within engineered periodic structures
KR102319347B1 (ko) * 2014-09-01 2021-10-29 삼성전자주식회사 대면적 마스터 웨이퍼, 대면적 마스터 웨이퍼의 제조 방법 및 대면적 마스터웨이퍼를 이용한 광학 소자 제조 방법
US10166725B2 (en) 2014-09-08 2019-01-01 Holo, Inc. Three dimensional printing adhesion reduction using photoinhibition
JP7009992B2 (ja) 2014-10-20 2022-01-26 スリーエム イノベイティブ プロパティズ カンパニー 断熱グレージングユニット及び微細構造化拡散部を含む微小光学層並びに方法
JP2016086117A (ja) * 2014-10-28 2016-05-19 株式会社東芝 太陽電池、太陽電池パネル及び太陽電池フィルム
WO2016098345A1 (en) * 2014-12-19 2016-06-23 Canon Kabushiki Kaisha Photocurable composition for imprint, method for producing film using the same, method for producing optical component using the same, method for producing circuit board using the same, and method for producing electronic component using the same
JP6324363B2 (ja) 2014-12-19 2018-05-16 キヤノン株式会社 インプリント用光硬化性組成物、これを用いた膜の製造方法、光学部品の製造方法、回路基板の製造方法、電子部品の製造方法
CN104593727B (zh) * 2014-12-24 2017-08-29 西安神光安瑞光电科技有限公司 一种利用aao模板制备纳米图形化衬底的方法
CA2974348A1 (en) 2015-01-19 2016-07-28 The Regents Of The University Of Michigan Multiphasic particles fabricated by wettability engendered templated self-assembly (wets) methods
US10518512B2 (en) 2015-03-31 2019-12-31 3M Innovative Properties Company Method of forming dual-cure nanostructure transfer film
US10106643B2 (en) 2015-03-31 2018-10-23 3M Innovative Properties Company Dual-cure nanostructure transfer film
US9704821B2 (en) 2015-08-11 2017-07-11 X-Celeprint Limited Stamp with structured posts
US10468363B2 (en) 2015-08-10 2019-11-05 X-Celeprint Limited Chiplets with connection posts
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
CN106706677B (zh) * 2015-11-18 2019-09-03 同方威视技术股份有限公司 检查货物的方法和系统
AU2016365412B2 (en) * 2015-12-03 2022-05-19 Amrita Vishwa Vidyapeetham Radio-wave responsive doped nanoparticles for image-guided therapeutics
US11141919B2 (en) 2015-12-09 2021-10-12 Holo, Inc. Multi-material stereolithographic three dimensional printing
RS63135B1 (sr) 2015-12-23 2022-05-31 Modernatx Inc Postupci upotrebe polinukleotida koji kodiraju ox40 ligand
US20190241658A1 (en) 2016-01-10 2019-08-08 Modernatx, Inc. Therapeutic mRNAs encoding anti CTLA-4 antibodies
US10103069B2 (en) 2016-04-01 2018-10-16 X-Celeprint Limited Pressure-activated electrical interconnection by micro-transfer printing
WO2017176762A1 (en) 2016-04-06 2017-10-12 Nanotics, Llc Particles comprising subparticles or nucleic acid scaffolds
WO2017187438A1 (en) * 2016-04-25 2017-11-02 Technion Research & Development Foundation Limited Targeted delivery of aerosols of magnetized active agents
EP3452031A4 (en) * 2016-05-05 2019-12-11 Liquidia Technologies, Inc. PRECISION-CONTROLLED LOADING AND RELEASE PARTICLES FOR POST-OPERATIONAL PAIN
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
US10603486B2 (en) 2016-06-13 2020-03-31 Galvani Bioelectronics Limited Neural interface fabrication
RU2018145364A (ru) 2016-06-27 2020-07-28 Ачиллион Фармасьютикалс, Инк. Хиназолиновые и индольные соединения для лечения медицинских нарушений
US10222698B2 (en) 2016-07-28 2019-03-05 X-Celeprint Limited Chiplets with wicking posts
US11064609B2 (en) 2016-08-04 2021-07-13 X Display Company Technology Limited Printable 3D electronic structure
KR101926625B1 (ko) * 2016-08-12 2018-12-11 엄재호 금연보조용 콘택트렌즈
US10725373B1 (en) * 2016-10-21 2020-07-28 Iowa State University Research Foundation, Inc. Nano-patterning methods including: (1) patterning of nanophotonic structures at optical fiber tip for refractive index sensing and (2) plasmonic crystal incorporating graphene oxide gas sensor for detection of volatile organic compounds
KR102095003B1 (ko) 2017-01-03 2020-03-30 주식회사 엘지화학 수지 입자의 제조 방법
CN110603252A (zh) 2017-03-01 2019-12-20 艾其林医药公司 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物
WO2018169811A1 (en) 2017-03-11 2018-09-20 Selecta Biosciences, Inc. Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
US10935891B2 (en) 2017-03-13 2021-03-02 Holo, Inc. Multi wavelength stereolithography hardware configurations
GB2564956B (en) 2017-05-15 2020-04-29 Holo Inc Viscous film three-dimensional printing systems and methods
CN106970067B (zh) * 2017-05-17 2019-12-20 佳木斯大学 一种介孔TiO2表面增强拉曼散射活性基底的制备和应用方法
JP7285220B2 (ja) 2017-05-18 2023-06-01 モデルナティエックス インコーポレイテッド 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子
FI3635009T3 (fi) 2017-06-07 2026-04-07 Regeneron Pharma Koostumuksia ja menetelmiä entsyymien internalisoimiseksi
US10245785B2 (en) 2017-06-16 2019-04-02 Holo, Inc. Methods for stereolithography three-dimensional printing
EP4717317A2 (en) 2017-06-20 2026-04-01 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
US11084222B2 (en) 2017-06-30 2021-08-10 Autodesk, Inc. Systems and methods for determining dynamic forces in a liquefier system in additive manufacturing
CN107737945B (zh) * 2017-09-12 2020-07-31 南京邮电大学 一种复合纳米金颗粒的合成方法及应用
CN109521511B (zh) * 2017-09-18 2021-01-26 京东方科技集团股份有限公司 微结构的制作方法、光调制器件、背光源、显示装置
US10895806B2 (en) 2017-09-29 2021-01-19 Canon Kabushiki Kaisha Imprinting method and apparatus
CN107855080B (zh) * 2017-10-30 2020-09-08 中国科学院过程工程研究所 高分子凝胶颗粒、其制备方法、包含其的复合凝胶颗粒及用途
CN108127580B (zh) * 2017-12-13 2019-09-13 湖北鼎汇微电子材料有限公司 一种制备抛光层的模具
WO2019133890A1 (en) * 2017-12-29 2019-07-04 University Of Kansas Nanoparticles including a glatiramoid useful in polynucleotide delivery
JP7779653B2 (ja) 2018-02-07 2025-12-03 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 治療用タンパク質送達のための方法および組成物
JP2021519337A (ja) 2018-03-26 2021-08-10 シー４ セラピューティクス， インコーポレイテッド Ｉｋａｒｏｓの分解のためのセレブロン結合剤
WO2019189246A1 (ja) * 2018-03-30 2019-10-03 日本ゼオン株式会社 樹脂薄膜の剥離片の製造方法
CN108559091B (zh) * 2018-05-08 2021-03-30 四川大学 具有聚集诱导发光及双重敏感性的聚合物药物载体、载药胶束及其制备方法
EP3793591A1 (en) 2018-05-17 2021-03-24 Regeneron Pharmaceuticals, Inc. Anti-cd63 antibodies, conjugates, and uses thereof
CN108752825A (zh) * 2018-05-30 2018-11-06 深圳市华星光电技术有限公司 量子点水凝胶、量子点图案化及转印方法
KR102142968B1 (ko) * 2018-06-01 2020-08-11 연세대학교 원주산학협력단 폐질환용 약물 전달체
CN110228153B (zh) * 2018-07-17 2021-04-30 山东科技大学 一种具有仿生自我监测功能的力致变色光子晶体材料的制备方法
JP7197886B2 (ja) * 2018-08-01 2022-12-28 国立大学法人 新潟大学 線維化コラーゲンゲル作製用鋳型材料
US10796971B2 (en) 2018-08-13 2020-10-06 X Display Company Technology Limited Pressure-activated electrical interconnection with additive repair
WO2020036173A1 (ja) * 2018-08-14 2020-02-20 Ｓｃｉｖａｘ株式会社 微細構造体製造方法
WO2020041301A1 (en) 2018-08-20 2020-02-27 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
US20200064520A1 (en) * 2018-08-22 2020-02-27 GM Global Technology Operations LLC Smart multifunctional lens coatings
WO2020051532A2 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
EP3866773B1 (en) 2018-10-16 2024-08-28 Georgia State University Research Foundation, Inc. Carbon monoxide prodrugs for the treatment of medical disorders
JP7657457B2 (ja) 2018-10-19 2025-04-07 ノバ サウスイースタン ユニバーシティー ｐＨ修飾賦形剤及び浸入促進剤を含む舌下エピネフリン組成物及びそれを使用する方法
US20200190268A1 (en) * 2018-12-14 2020-06-18 Massachusetts Institute Of Technology Systems, devices, and methods for bulk processing of highly-loaded nanocomposites
CN117067579A (zh) 2018-12-26 2023-11-17 霍洛公司 用于三维打印系统和方法的传感器
KR102194832B1 (ko) * 2019-01-03 2020-12-23 부산대학교 산학협력단 렌즈 표면 나노구조층의 제조 방법
US10748793B1 (en) 2019-02-13 2020-08-18 X Display Company Technology Limited Printing component arrays with different orientations
CN109796979B (zh) * 2019-03-07 2021-09-24 合肥工业大学 一种超强铁磁性荧光纳米胶束、制备方法及应用
CN114207440A (zh) 2019-06-04 2022-03-18 西莱克塔生物科技公司 聚乙二醇化尿酸酶的制剂和剂量
CN110441284B (zh) * 2019-07-23 2022-02-15 海南大学 一种可用于痕量检测的表面增强拉曼散射芯片的制备方法及所得产品和应用
CN112386399B (zh) * 2019-08-12 2023-05-09 湖南早晨纳米机器人有限公司 一种纳米手术机器人以及制作方法
CN110482528B (zh) * 2019-08-23 2022-02-18 哈尔滨工业大学 一种具有负巨磁阻性能的碳纳米管/四氧化三铁复合海绵制备方法
CN110845754A (zh) * 2019-12-11 2020-02-28 俞志焘 一种高分子材料的抗菌改性方法
WO2021168320A1 (en) 2020-02-20 2021-08-26 Achillion Pharmaceuticals, Inc. Heteroaryl compounds for treatment of complement factor d mediated disorders
AU2021231898A1 (en) 2020-03-05 2022-10-27 C4 Therapeutics, Inc. Compounds for targeted degradation of BRD9
US11311739B2 (en) * 2020-05-29 2022-04-26 Harvey Wayne Ko Electromagnetic method for in-vivo disruption of viral insults
CN111704894B (zh) * 2020-06-04 2021-07-20 东华大学 一种高效太阳能加热表面的组装制备方法
CN111718465B (zh) * 2020-06-17 2021-07-20 华南理工大学 一种聚二硫缩醛及其制备方法和应用
CN111840810B (zh) * 2020-07-27 2022-03-01 哈尔滨工业大学 一种基于光学相变纳米颗粒的生物组织温度场被动调控方法
CN112175439B (zh) * 2020-08-27 2022-05-13 浙江正奇世荣科技有限公司 一种纳米氧化铁防紫外线添加剂及其制备方法
KR20220033559A (ko) 2020-09-07 2022-03-17 삼성디스플레이 주식회사 교반기, 이를 포함하는 양자점 제조 장치 및 이를 이용한 양자점 제조 방법
US20250186617A1 (en) 2020-09-17 2025-06-12 Restore Vision Inc. Composition for treating or preventing diseases, disorders, or conditions associated with endoplasmic reticulum stress or all-trans-retinal, protecting retinal thickness, or suppressing reduction in retinal thickness or progress of reduction in retinal thickness
WO2022066774A1 (en) 2020-09-23 2022-03-31 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
CN112266930B (zh) * 2020-10-14 2023-03-14 中国科学院苏州生物医学工程技术研究所 超声穿孔转染细胞的方法
WO2022108922A1 (en) 2020-11-18 2022-05-27 Applied Materials, Inc. Imprint compositions with passivated nanoparticles and materials and processes for making the same
TWI803092B (zh) * 2021-04-01 2023-05-21 逢甲大學 具負載與釋放活性成分的奈米粒子、其製造方法與眼用裝置之應用
WO2022225854A1 (en) 2021-04-19 2022-10-27 Holo, Inc. Systems and methods for stereolithography three-dimensional printing
CN113536529B (zh) * 2021-05-24 2022-09-06 山西中电科新能源技术有限公司 一种用于碳碳复合材料沉积的投炉装配优化方法
CN113311042B (zh) * 2021-06-02 2023-04-25 江苏理工学院 双酚a分子印迹电化学传感器及其制备方法和应用
CN113548638B (zh) * 2021-06-03 2024-04-05 北京大学深圳研究生院 一种微凸起结构的制备方法
CN113588626B (zh) * 2021-08-24 2024-05-24 上海师范大学 一种苯丙氨酸对映体的拉曼光谱检测方法
TW202346348A (zh) 2022-01-10 2023-12-01 美商再生元醫藥公司 作為基因治療所遞送之bbb靶向的gaa在龐貝氏症小鼠模型中治療cns及肌肉
US20250302998A1 (en) 2022-05-09 2025-10-02 Regeneron Pharmaceuticals, Inc. Vectors and methods for in vivo antibody production
CN114957733B (zh) * 2022-05-12 2024-04-05 安徽工程大学 Boc-苯丙氨酸改性淀粉纳米粒子及其制备方法和在疏水药物负载的应用
IL318625A (en) 2022-07-29 2025-03-01 Regeneron Pharma Compositions and methods for transferrin receptor (TFR)-mediated delivery to brain and muscle
CN115227833B (zh) * 2022-07-29 2023-03-21 西安交通大学医学院第一附属医院 一种氟化二氧化硅载药纳米粒及其制备方法、用途
GB2637877A (en) * 2022-08-24 2025-08-06 Kimberly Clark Co Moisture absorbent films and face masks incorporating the films
CN120225677A (zh) 2022-08-31 2025-06-27 国立大学法人京都大学 光响应改造型视蛋白类
IL320016A (en) 2022-11-04 2025-06-01 Regeneron Pharma Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
AU2023379457A1 (en) 2022-11-14 2025-05-15 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
CN116440120B (zh) * 2023-03-06 2025-03-21 复旦大学 一种高效阻断巨噬细胞焦亡的纳米中药及其在抗肺纤维化方面的应用
CN116393114A (zh) * 2023-05-26 2023-07-07 西安交通大学 一种爆米花状轻质美罗培南分子印迹磁性纳米材料及其制备方法和应用
CN116555346B (zh) * 2023-07-05 2023-09-01 中山大学 一种采用碳纳米管基因载体递送系统促进草鱼生长的方法
CN117259772B (zh) * 2023-08-25 2024-05-10 江苏农林职业技术学院 一种葛根纳米银复合水溶胶及其制备方法与应用
CN117368670B (zh) * 2023-11-07 2024-03-26 东莞市一丁精密模具组件有限公司 一种模具放电特性柔性检测方法及系统
EP4570366A1 (en) * 2023-12-15 2025-06-18 Licitar, Antonijo Apparatuses and methods for producing nanoparticles from material in working liquid
CN118557720B (zh) * 2024-08-02 2024-11-22 苏州大学 一种抗体修饰的氟化纳米凝胶及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6899827B2 (en) * 2003-05-16 2005-05-31 Ut-Battelle, Llc Inorganic optical taggant and method of making

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4131064A (en) * 1977-07-15 1978-12-26 Westinghouse Electric Corp. Tagging particles which are easily detected by luminescent response, or magnetic pickup, or both
US5147763A (en) * 1988-10-19 1992-09-15 Canon Kabushiki Kaisha Process for producing molding stamper for data recording medium substrate
JPH0580530A (ja) * 1991-09-24 1993-04-02 Hitachi Ltd 薄膜パターン製造方法
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
US20030114366A1 (en) * 1999-01-11 2003-06-19 Francis J. Martin Microfabricated particles and method for treating solid tumors
FR2808704B1 (fr) * 2000-05-10 2002-08-16 Rhodia Chimie Sa Agents tensioactifs formes par des particules minerales de dimension nanometrique de surface modifiee
JP4524943B2 (ja) * 2001-03-27 2010-08-18 ダイキン工業株式会社 半導体素子のパターン形成方法及びインプリント加工用モールドの製造方法
US20040115279A1 (en) * 2002-09-06 2004-06-17 The Ohio State University Microfabrication of polymer microparticles
US20040115239A1 (en) * 2002-09-20 2004-06-17 Shastri Venkatram P. Engineering of material surfaces
JP4022571B2 (ja) * 2002-11-11 2007-12-19 国立大学法人東京農工大学 高分子微粒子の製造方法
KR100486730B1 (ko) * 2003-01-21 2005-05-03 삼성전자주식회사 교류 전압과 ｔ 채널을 이용하여 제타 포텐셜을 측정하는방법
JP4450596B2 (ja) * 2003-09-22 2010-04-14 独立行政法人科学技術振興機構 微粒子の製造方法
CN1997691B (zh) * 2003-09-23 2011-07-20 北卡罗来纳大学查珀尔希尔分校 光固化的全氟聚醚用作微流体器件中的新材料
DK1704585T3 (en) * 2003-12-19 2017-05-22 Univ North Carolina Chapel Hill Methods for preparing isolated micro- and nanostructures using soft lithography or printing lithography

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6899827B2 (en) * 2003-05-16 2005-05-31 Ut-Battelle, Llc Inorganic optical taggant and method of making

Also Published As

Publication number Publication date
JP2008546715A (ja) 2008-12-25
EP1904932A2 (en) 2008-04-02
EP1904932A4 (en) 2013-02-27
MX2007016039A (es) 2008-10-27
JP5570721B2 (ja) 2014-08-13
AU2006282042A1 (en) 2007-03-01
AU2006282042A8 (en) 2008-07-10
WO2007024323A3 (en) 2010-12-16
CN102016814A (zh) 2011-04-13
US20110182805A1 (en) 2011-07-28
CA2611985A1 (en) 2007-03-01
CA2611985C (en) 2016-08-16
CN102016814B (zh) 2013-10-23
WO2007024323A2 (en) 2007-03-01

Similar Documents

Publication Publication Date Title
AU2006282042B2 (en) Nanoparticle fabrication methods, systems, and materials
US9902818B2 (en) Isolated and fixed micro and nano structures and methods thereof
US20230248651A1 (en) Methods for fabricating isolated micro- or nano-structures using soft or imprint lithography
US20160038418A1 (en) Nanoparticle fabrication methods, systems, and materials
WO2007094829A2 (en) Isolated and fixed micro and nano structures and methods thereof
WO2007030698A2 (en) Materials and methods for fabricating isolated micro-and nano-structures having chemical functionality
JP6232352B6 (ja) ソフトリソグラフィー又はインプリントリソグラフィーを用いる分離微小構造及び分離ナノ構造の作製方法
HK1095921B (en) Methods for fabricating isolated micro-and nano-structures using soft or imprint lithography

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; L

Free format text: FORMER APPLICANT(S): THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; LIQUIDA TECHNOLOGIES INC.; NORTH CAROLINA STATE UNIVERSITY

TH Corrigenda

Free format text: IN VOL 22, NO 5, PAGE(S) 537 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE -NAME INDEX UNDER THE NAME LIQUIDA TECHNOLOGIES INC. AND THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL, APPLICATION NO. 2006282042, UNDER INID (71) ADD APPLICANT NORTH CAROLINA STATE UNIVERSITY

DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ SAMULSKI, R. JUDE; MURPHY, ANDREW JAMES; DESIMONE, JOSEPH M.; SAMULSKI, EDWARD T.; GRATTON, STEPHANIE; ERMOSHKIN, ALEX; ROLLAND, JASON P.; EU- LISS, LARKEN E.; MAYNOR, BENJAMIN W.; EXNER, ANSLEY E.; ROTHROCK, GINGER DENISON.

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ ROLLAND, JASON P.; GRATTON, STEPHANIE; SAMULSKI, R. JUDE; EXNER, ANSLEY E.; ROTHROCK, GINGER DENISON; SAMULSKI, EDWARD T.; EULISS, LARKEN E.; MURPHY, ANDREW JAMES; DESIMONE, JOSEPH M.; ERMOSHKIN, ALEX AND MAYNOR, BENJAMIN W.

FGA Letters patent sealed or granted (standard patent)