AU2006235329B2 - Spiroheterocyclic compounds and their uses as therapeutic agents - Google Patents

Spiroheterocyclic compounds and their uses as therapeutic agents Download PDF

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Publication number
AU2006235329B2
AU2006235329B2 AU2006235329A AU2006235329A AU2006235329B2 AU 2006235329 B2 AU2006235329 B2 AU 2006235329B2 AU 2006235329 A AU2006235329 A AU 2006235329A AU 2006235329 A AU2006235329 A AU 2006235329A AU 2006235329 B2 AU2006235329 B2 AU 2006235329B2
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Australia
Prior art keywords
aryl
heteroaryl
aralkyl
heterocyclyl
alkyl
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Expired - Fee Related
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AU2006235329A
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AU2006235329A1 (en
Inventor
Mehran Seid Bagherzadeh
Mikhail Chafeev
Sultan Chowdhury
Robert Fraser
Jianmin Fu
Rajender Kamboj
Shifeng Liu
Jianyu Sun
Serguei Sviridov
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Xenon Pharmaceuticals Inc
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Xenon Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
AU2006235329A 2005-04-11 2006-04-11 Spiroheterocyclic compounds and their uses as therapeutic agents Expired - Fee Related AU2006235329B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67096205P 2005-04-11 2005-04-11
US60/670,962 2005-04-11
PCT/US2006/013318 WO2006110654A1 (en) 2005-04-11 2006-04-11 Spiroheterocyclic compounds and their uses as therapeutic agents

Publications (2)

Publication Number Publication Date
AU2006235329A1 AU2006235329A1 (en) 2006-10-19
AU2006235329B2 true AU2006235329B2 (en) 2011-12-15

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AU2006235329A Expired - Fee Related AU2006235329B2 (en) 2005-04-11 2006-04-11 Spiroheterocyclic compounds and their uses as therapeutic agents

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US (2) US7799798B2 (enExample)
EP (1) EP1888592B1 (enExample)
JP (1) JP2008535916A (enExample)
KR (1) KR20080007250A (enExample)
CN (2) CN101967150A (enExample)
AR (1) AR053710A1 (enExample)
AT (1) ATE504587T1 (enExample)
AU (1) AU2006235329B2 (enExample)
BR (1) BRPI0608995A2 (enExample)
CA (1) CA2604010A1 (enExample)
DE (1) DE602006021169D1 (enExample)
EC (1) ECSP077848A (enExample)
ES (1) ES2362908T3 (enExample)
HR (1) HRP20070499A2 (enExample)
IL (1) IL186615A0 (enExample)
MA (1) MA29685B1 (enExample)
MX (1) MX2007012637A (enExample)
MY (1) MY145694A (enExample)
NO (1) NO20074620L (enExample)
NZ (1) NZ561204A (enExample)
PL (1) PL1888592T3 (enExample)
RU (1) RU2428424C2 (enExample)
SG (1) SG161264A1 (enExample)
TN (1) TNSN07384A1 (enExample)
TW (1) TW200720278A (enExample)
WO (1) WO2006110654A1 (enExample)
ZA (1) ZA200709004B (enExample)

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AR053710A1 (es) 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
WO2008046082A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Use of heterocyclic compounds as therapeutic agents
MX2009003876A (es) 2006-10-12 2009-05-11 Xenon Pharmaceuticals Inc Uso de compuestos de espiro-oxindol como agentes terapeuticos.
WO2008046087A2 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiro compounds and their uses as therapeutic agents
WO2008046065A1 (en) * 2006-10-12 2008-04-17 Xenon Pharmaceuticals Inc. Spiroheterocyclic compounds and their uses as therapeutic agents
JP2010522690A (ja) * 2006-10-12 2010-07-08 ゼノン・ファーマシューティカルズ・インコーポレイテッド 三環式スピロオキシインドール誘導体および治療薬としてのその使用
MX2009003875A (es) * 2006-10-12 2009-04-22 Xenon Pharmaceuticals Inc Derivados y compuestos relacionados de espiro(furo[3,2-c]piridina- 3,3'-indol)-2' (1'h)ona para el tratamiento de enfermedades mediadas por los canales de sodio, tal como dolor.
US20100010092A1 (en) * 2006-12-19 2010-01-14 Arless Ltd. Use of modafinil to treat restless leg syndrome
US7795228B2 (en) * 2006-12-28 2010-09-14 Theracos, Inc. Spiroheterocyclic glycosides and methods of use
US8309544B2 (en) * 2007-05-16 2012-11-13 Merck Sharp & Dohme Corp. Spiroindalones
JP2010540628A (ja) 2007-10-04 2010-12-24 メルク・シャープ・エンド・ドーム・コーポレイション カルシウムチャネル遮断薬としてのｎ−置換されたオキシインドリン誘導体
CA2701203A1 (en) * 2007-10-04 2009-04-09 Merck Sharp & Dohme Corp. N-substituted oxindoline derivatives as calcium channel blockers
UA101004C2 (en) 2007-12-13 2013-02-25 Теракос, Инк. Derivatives of benzylphenylcyclohexane and use thereof
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