ATE5001T1 - Verfahren zur herstellung eines ausgewaehlten proteins. - Google Patents

Verfahren zur herstellung eines ausgewaehlten proteins.

Info

Publication number
ATE5001T1
ATE5001T1 AT79301054T AT79301054T ATE5001T1 AT E5001 T1 ATE5001 T1 AT E5001T1 AT 79301054 T AT79301054 T AT 79301054T AT 79301054 T AT79301054 T AT 79301054T AT E5001 T1 ATE5001 T1 AT E5001T1
Authority
AT
Austria
Prior art keywords
selected protein
production
cleaved
protein
gene
Prior art date
Application number
AT79301054T
Other languages
English (en)
Inventor
Walter Gilbert
Stephanie A. Broome
Lydia J. Villa-Komaroff
Argiris A. Efstratiadis
Original Assignee
President And Fellows Of Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25433372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE5001(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by President And Fellows Of Harvard College filed Critical President And Fellows Of Harvard College
Application granted granted Critical
Publication of ATE5001T1 publication Critical patent/ATE5001T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/30—Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT79301054T 1978-06-08 1979-06-04 Verfahren zur herstellung eines ausgewaehlten proteins. ATE5001T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/913,533 US4411994A (en) 1978-06-08 1978-06-08 Protein synthesis
EP79301054A EP0006694B2 (de) 1978-06-08 1979-06-04 Verfahren zur Herstellung eines ausgewählten Proteins

Publications (1)

Publication Number Publication Date
ATE5001T1 true ATE5001T1 (de) 1983-10-15

Family

ID=25433372

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79301054T ATE5001T1 (de) 1978-06-08 1979-06-04 Verfahren zur herstellung eines ausgewaehlten proteins.

Country Status (20)

Country Link
US (1) US4411994A (de)
EP (1) EP0006694B2 (de)
JP (2) JPS5519092A (de)
AT (1) ATE5001T1 (de)
AU (1) AU524856B2 (de)
BG (1) BG60444B2 (de)
CA (1) CA1215920A (de)
DD (1) DD148235A5 (de)
DE (1) DE2966291D1 (de)
DK (1) DK237979A (de)
ES (1) ES481362A1 (de)
FI (1) FI791841A (de)
GR (1) GR72953B (de)
IE (1) IE48156B1 (de)
IL (1) IL57491A (de)
MX (1) MX6339E (de)
NZ (1) NZ190524A (de)
PT (1) PT69737A (de)
WO (1) WO1980000030A1 (de)
ZA (1) ZA792486B (de)

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Also Published As

Publication number Publication date
IL57491A0 (en) 1979-10-31
EP0006694B1 (de) 1983-10-12
NZ190524A (en) 1982-09-14
US4411994A (en) 1983-10-25
PT69737A (en) 1979-07-01
DE2966291D1 (en) 1983-11-17
JPS61227598A (ja) 1986-10-09
EP0006694A2 (de) 1980-01-09
DD148235A5 (de) 1981-05-13
EP0006694B2 (de) 1992-01-22
ES481362A1 (es) 1980-03-01
IE48156B1 (en) 1984-10-17
AU524856B2 (en) 1982-10-07
CA1215920A (en) 1986-12-30
JPS5519092A (en) 1980-02-09
AU4775279A (en) 1979-12-13
IL57491A (en) 1983-09-30
BG60444B2 (bg) 1995-03-31
FI791841A (fi) 1979-12-09
DK237979A (da) 1979-12-09
WO1980000030A1 (en) 1980-01-10
EP0006694A3 (en) 1980-01-23
JPS6246160B2 (de) 1987-09-30
ZA792486B (en) 1981-01-28
GR72953B (de) 1984-01-18
JPH0755151B2 (ja) 1995-06-14
MX6339E (es) 1985-04-23
IE791115L (en) 1979-12-08

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