ATE387429T1 - Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin - Google Patents
Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotoninInfo
- Publication number
- ATE387429T1 ATE387429T1 AT00976885T AT00976885T ATE387429T1 AT E387429 T1 ATE387429 T1 AT E387429T1 AT 00976885 T AT00976885 T AT 00976885T AT 00976885 T AT00976885 T AT 00976885T AT E387429 T1 ATE387429 T1 AT E387429T1
- Authority
- AT
- Austria
- Prior art keywords
- norepinephrine
- serotonin
- dopamine
- heteroaryl
- reuppost
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16326999P | 1999-11-03 | 1999-11-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE387429T1 true ATE387429T1 (de) | 2008-03-15 |
Family
ID=22589226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00976885T ATE387429T1 (de) | 1999-11-03 | 2000-11-03 | Arly- und heteroaryl-substituierte tetrahydroisoquinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin |
Country Status (17)
Country | Link |
---|---|
US (3) | US6579885B2 (de) |
EP (1) | EP1246806B1 (de) |
JP (1) | JP4907818B2 (de) |
KR (1) | KR100885986B1 (de) |
CN (1) | CN1414953A (de) |
AT (1) | ATE387429T1 (de) |
AU (1) | AU781179B2 (de) |
BR (1) | BR0015320A (de) |
CA (1) | CA2389306C (de) |
CY (1) | CY1108081T1 (de) |
DE (1) | DE60038185T2 (de) |
DK (1) | DK1246806T3 (de) |
ES (1) | ES2304984T3 (de) |
MX (1) | MXPA02004330A (de) |
PT (1) | PT1246806E (de) |
RU (1) | RU2309953C2 (de) |
WO (1) | WO2001032625A1 (de) |
Families Citing this family (35)
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CN100436420C (zh) * | 1999-11-03 | 2008-11-26 | Amr科技公司 | 4-苯基取代的四氢异喹啉及其用于制备药物的用途 |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
RU2309953C2 (ru) * | 1999-11-03 | 2007-11-10 | Эймр Текнолоджи, Инк. | Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе |
CA2415532C (en) * | 2000-07-11 | 2010-05-11 | Albany Molecular Research, Inc. | Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof |
PT1453810E (pt) * | 2001-12-05 | 2009-05-27 | Sanofi Aventis Deutschland | 4-feniltetra-hidroisoquinolinas substituídas, processo para a sua preparação, sua utilização como medicamento, bem como medicamento contendo as mesmas |
US6911453B2 (en) | 2001-12-05 | 2005-06-28 | Aventis Pharma Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them |
US6703405B2 (en) | 2001-12-22 | 2004-03-09 | Aventis Pharma Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them |
MXPA05005586A (es) * | 2002-12-02 | 2005-07-27 | Pharmacia & Up John Company Ll | El uso de tetrahidroisoquinolinas 4-fenilsustituidas en el tratamiento del dolor, migrana e incontinencia urinaria. |
WO2004050630A1 (en) * | 2002-12-02 | 2004-06-17 | Pharmacia & Upjohn Company Llc | The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence |
MXPA05005829A (es) * | 2002-12-02 | 2005-08-29 | Pharmacia & Upjohn Co Llc | El uso de tetrahidroisoquinolinas 4-fenil-sustituidas en el tratamiento del dolor, dolores de cabeza migranosos e incontinencia urinaria. |
DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
EP1740558A1 (de) * | 2004-04-21 | 2007-01-10 | Sosei R&D Ltd. | Benzoxazocine und deren therapeutische verwendung als monoamin-wiederaufnahmehemmer |
KR101412339B1 (ko) * | 2004-07-15 | 2014-06-25 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를차단하기 위한 용도 |
US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US20060111385A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
US20060111394A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
KR20060059728A (ko) * | 2004-11-29 | 2006-06-02 | 삼성에스디아이 주식회사 | 액정 표시 장치 및 그 제조 방법 |
WO2006077846A1 (ja) * | 2005-01-18 | 2006-07-27 | Mitsubishi Pharma Corporation | 注意欠陥/多動性障害治療薬 |
FR2884251B1 (fr) * | 2005-04-08 | 2007-07-13 | Servier Lab | Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CN101495184A (zh) * | 2005-07-15 | 2009-07-29 | Amr科技公司 | 芳基和杂芳基取代的四氢苯并氮杂及其在阻断去甲肾上腺素多巴胺和血清素的重摄取中的应用 |
KR100698800B1 (ko) * | 2005-08-05 | 2007-03-23 | 미미라이팅주식회사 | 공기청정기능을 구비한 천장직착식 조명등기구 |
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WO2008090117A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1 |
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AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
WO2010088414A2 (en) * | 2009-01-28 | 2010-08-05 | Emory University | Subunit selective nmda receptor potentiators for the treatment of neurological conditions |
CA2760837C (en) | 2009-05-12 | 2018-04-03 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
US8815894B2 (en) | 2009-05-12 | 2014-08-26 | Bristol-Myers Squibb Company | Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof |
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US9045468B2 (en) | 2010-08-17 | 2015-06-02 | Albany Molecular Research, Inc. | 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
CN106003947A (zh) * | 2016-06-30 | 2016-10-12 | 广东新视野薄膜有限公司 | 一种安全膜及其制备方法 |
WO2021241982A1 (ko) | 2020-05-29 | 2021-12-02 | 재단법인 대구경북첨단의료산업진흥재단 | N을 하나 이상 포함하는 5원자의 헤테로아릴 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물 |
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EP4159725A4 (de) | 2020-05-29 | 2023-12-20 | Daegu-Gyeongbuk Medical Innovation Foundation | Carboxamidderivat und pharmazeutische zusammensetzung damit als wirkstoff zur vorbeugung oder behandlung von geisteskrankheiten |
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- 2000-11-03 EP EP00976885A patent/EP1246806B1/de not_active Expired - Lifetime
- 2000-11-03 CA CA2389306A patent/CA2389306C/en not_active Expired - Fee Related
- 2000-11-03 PT PT00976885T patent/PT1246806E/pt unknown
- 2000-11-03 DK DK00976885T patent/DK1246806T3/da active
- 2000-11-03 JP JP2001534777A patent/JP4907818B2/ja not_active Expired - Fee Related
- 2000-11-03 DE DE60038185T patent/DE60038185T2/de not_active Expired - Lifetime
- 2000-11-03 CN CN00818078A patent/CN1414953A/zh active Pending
- 2000-11-03 AU AU14597/01A patent/AU781179B2/en not_active Ceased
- 2000-11-03 KR KR1020027005744A patent/KR100885986B1/ko not_active IP Right Cessation
- 2000-11-03 WO PCT/US2000/030329 patent/WO2001032625A1/en active IP Right Grant
- 2000-11-03 MX MXPA02004330A patent/MXPA02004330A/es active IP Right Grant
- 2000-11-03 AT AT00976885T patent/ATE387429T1/de active
- 2000-11-03 ES ES00976885T patent/ES2304984T3/es not_active Expired - Lifetime
- 2000-11-03 BR BR0015320-6A patent/BR0015320A/pt not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
ES2304984T3 (es) | 2008-11-01 |
EP1246806B1 (de) | 2008-02-27 |
DK1246806T3 (da) | 2008-06-16 |
MXPA02004330A (es) | 2004-07-30 |
AU1459701A (en) | 2001-05-14 |
DE60038185D1 (de) | 2008-04-10 |
US7612090B2 (en) | 2009-11-03 |
BR0015320A (pt) | 2002-07-09 |
JP4907818B2 (ja) | 2012-04-04 |
KR20020079730A (ko) | 2002-10-19 |
CA2389306C (en) | 2010-03-30 |
DE60038185T2 (de) | 2009-02-19 |
AU781179B2 (en) | 2005-05-12 |
KR100885986B1 (ko) | 2009-03-03 |
WO2001032625A1 (en) | 2001-05-10 |
US7265116B2 (en) | 2007-09-04 |
RU2309953C2 (ru) | 2007-11-10 |
CY1108081T1 (el) | 2014-02-12 |
CA2389306A1 (en) | 2001-05-10 |
US20030203920A1 (en) | 2003-10-30 |
EP1246806A1 (de) | 2002-10-09 |
JP2003513074A (ja) | 2003-04-08 |
CN1414953A (zh) | 2003-04-30 |
PT1246806E (pt) | 2008-04-03 |
US20020143014A1 (en) | 2002-10-03 |
US20050020597A1 (en) | 2005-01-27 |
US6579885B2 (en) | 2003-06-17 |
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