MXPA02004330A - Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina.. - Google Patents
Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina..Info
- Publication number
- MXPA02004330A MXPA02004330A MXPA02004330A MXPA02004330A MXPA02004330A MX PA02004330 A MXPA02004330 A MX PA02004330A MX PA02004330 A MXPA02004330 A MX PA02004330A MX PA02004330 A MXPA02004330 A MX PA02004330A MX PA02004330 A MXPA02004330 A MX PA02004330A
- Authority
- MX
- Mexico
- Prior art keywords
- norepinephrine
- serotonin
- dopamine
- aryl
- heteroaryl substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Se proporcionan en la presente compuestos de la formula (I) (ver formula) en donde R1-R8 son como se describio en la presente, R4 siendo arilo o heteroarilo. Estos compuestos son particularmente utiles en el tratamiento de un trastorno que se crea por, o depende de disponibilidad disminuida de serotonina, norepinefrina o dopamina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16326999P | 1999-11-03 | 1999-11-03 | |
PCT/US2000/030329 WO2001032625A1 (en) | 1999-11-03 | 2000-11-03 | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02004330A true MXPA02004330A (es) | 2004-07-30 |
Family
ID=22589226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02004330A MXPA02004330A (es) | 1999-11-03 | 2000-11-03 | Tetrahidroisoquinolinas aril-y heteroaril-sustituidas y uso de las mismas para bloquear la recaptacion de norepinefrina, dopamina y serotonina.. |
Country Status (17)
Country | Link |
---|---|
US (3) | US6579885B2 (es) |
EP (1) | EP1246806B1 (es) |
JP (1) | JP4907818B2 (es) |
KR (1) | KR100885986B1 (es) |
CN (1) | CN1414953A (es) |
AT (1) | ATE387429T1 (es) |
AU (1) | AU781179B2 (es) |
BR (1) | BR0015320A (es) |
CA (1) | CA2389306C (es) |
CY (1) | CY1108081T1 (es) |
DE (1) | DE60038185T2 (es) |
DK (1) | DK1246806T3 (es) |
ES (1) | ES2304984T3 (es) |
MX (1) | MXPA02004330A (es) |
PT (1) | PT1246806E (es) |
RU (1) | RU2309953C2 (es) |
WO (1) | WO2001032625A1 (es) |
Families Citing this family (35)
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EP1246805A1 (en) * | 1999-11-03 | 2002-10-09 | Albany Molecular Research, Inc. | 4-phenyl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
DK1246806T3 (da) * | 1999-11-03 | 2008-06-16 | Amr Technology Inc | Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin |
US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
BR0112350A (pt) * | 2000-07-11 | 2003-06-24 | Albany Molecular Res Inc | Composto, composição farmacêutica, e, método de tratar um animal afligido por um distúrbio neurológico ou psicológico |
US6911453B2 (en) | 2001-12-05 | 2005-06-28 | Aventis Pharma Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them |
EP1453810B1 (de) * | 2001-12-05 | 2009-03-18 | Sanofi-Aventis Deutschland GmbH | Substituierte 4-phenyltetrahydroisochinoline, verfahren zu ihrer herstellung, ihre verwendung als medikament, sowie sie enthaltendes medikament |
US6703405B2 (en) | 2001-12-22 | 2004-03-09 | Aventis Pharma Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them |
MXPA05005586A (es) * | 2002-12-02 | 2005-07-27 | Pharmacia & Up John Company Ll | El uso de tetrahidroisoquinolinas 4-fenilsustituidas en el tratamiento del dolor, migrana e incontinencia urinaria. |
WO2004050630A1 (en) * | 2002-12-02 | 2004-06-17 | Pharmacia & Upjohn Company Llc | The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence |
CA2505783A1 (en) * | 2002-12-02 | 2004-06-17 | Pharmacia & Upjohn Company Llc | The use of 4-phenyl-substituted tetrahydroisoquinolines in the treatment of pain, migraine headaches and urinary incontinence |
DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
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-
2000
- 2000-11-03 DK DK00976885T patent/DK1246806T3/da active
- 2000-11-03 EP EP00976885A patent/EP1246806B1/en not_active Expired - Lifetime
- 2000-11-03 PT PT00976885T patent/PT1246806E/pt unknown
- 2000-11-03 AT AT00976885T patent/ATE387429T1/de active
- 2000-11-03 ES ES00976885T patent/ES2304984T3/es not_active Expired - Lifetime
- 2000-11-03 RU RU2002114338/04A patent/RU2309953C2/ru not_active IP Right Cessation
- 2000-11-03 BR BR0015320-6A patent/BR0015320A/pt not_active IP Right Cessation
- 2000-11-03 DE DE60038185T patent/DE60038185T2/de not_active Expired - Lifetime
- 2000-11-03 CA CA2389306A patent/CA2389306C/en not_active Expired - Fee Related
- 2000-11-03 JP JP2001534777A patent/JP4907818B2/ja not_active Expired - Fee Related
- 2000-11-03 CN CN00818078A patent/CN1414953A/zh active Pending
- 2000-11-03 WO PCT/US2000/030329 patent/WO2001032625A1/en active IP Right Grant
- 2000-11-03 MX MXPA02004330A patent/MXPA02004330A/es active IP Right Grant
- 2000-11-03 AU AU14597/01A patent/AU781179B2/en not_active Ceased
- 2000-11-03 KR KR1020027005744A patent/KR100885986B1/ko not_active IP Right Cessation
-
2002
- 2002-03-06 US US10/091,949 patent/US6579885B2/en not_active Expired - Fee Related
-
2003
- 2003-04-29 US US10/426,097 patent/US7612090B2/en not_active Expired - Fee Related
-
2004
- 2004-08-13 US US10/917,801 patent/US7265116B2/en not_active Expired - Fee Related
-
2008
- 2008-05-26 CY CY20081100547T patent/CY1108081T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2389306C (en) | 2010-03-30 |
PT1246806E (pt) | 2008-04-03 |
AU781179B2 (en) | 2005-05-12 |
US7265116B2 (en) | 2007-09-04 |
KR100885986B1 (ko) | 2009-03-03 |
DE60038185T2 (de) | 2009-02-19 |
ATE387429T1 (de) | 2008-03-15 |
CY1108081T1 (el) | 2014-02-12 |
EP1246806A1 (en) | 2002-10-09 |
US20050020597A1 (en) | 2005-01-27 |
RU2309953C2 (ru) | 2007-11-10 |
WO2001032625A1 (en) | 2001-05-10 |
CN1414953A (zh) | 2003-04-30 |
US6579885B2 (en) | 2003-06-17 |
ES2304984T3 (es) | 2008-11-01 |
US20020143014A1 (en) | 2002-10-03 |
JP2003513074A (ja) | 2003-04-08 |
EP1246806B1 (en) | 2008-02-27 |
BR0015320A (pt) | 2002-07-09 |
DE60038185D1 (de) | 2008-04-10 |
AU1459701A (en) | 2001-05-14 |
DK1246806T3 (da) | 2008-06-16 |
KR20020079730A (ko) | 2002-10-19 |
US20030203920A1 (en) | 2003-10-30 |
CA2389306A1 (en) | 2001-05-10 |
JP4907818B2 (ja) | 2012-04-04 |
US7612090B2 (en) | 2009-11-03 |
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