DK1246806T3 - Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin - Google Patents
Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotoninInfo
- Publication number
- DK1246806T3 DK1246806T3 DK00976885T DK00976885T DK1246806T3 DK 1246806 T3 DK1246806 T3 DK 1246806T3 DK 00976885 T DK00976885 T DK 00976885T DK 00976885 T DK00976885 T DK 00976885T DK 1246806 T3 DK1246806 T3 DK 1246806T3
- Authority
- DK
- Denmark
- Prior art keywords
- norepinephrine
- serotonin
- heteroaryl
- aryl
- dopsmin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16326999P | 1999-11-03 | 1999-11-03 | |
PCT/US2000/030329 WO2001032625A1 (en) | 1999-11-03 | 2000-11-03 | Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1246806T3 true DK1246806T3 (da) | 2008-06-16 |
Family
ID=22589226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00976885T DK1246806T3 (da) | 1999-11-03 | 2000-11-03 | Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin |
Country Status (17)
Country | Link |
---|---|
US (3) | US6579885B2 (de) |
EP (1) | EP1246806B1 (de) |
JP (1) | JP4907818B2 (de) |
KR (1) | KR100885986B1 (de) |
CN (1) | CN1414953A (de) |
AT (1) | ATE387429T1 (de) |
AU (1) | AU781179B2 (de) |
BR (1) | BR0015320A (de) |
CA (1) | CA2389306C (de) |
CY (1) | CY1108081T1 (de) |
DE (1) | DE60038185T2 (de) |
DK (1) | DK1246806T3 (de) |
ES (1) | ES2304984T3 (de) |
MX (1) | MXPA02004330A (de) |
PT (1) | PT1246806E (de) |
RU (1) | RU2309953C2 (de) |
WO (1) | WO2001032625A1 (de) |
Families Citing this family (35)
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US7163949B1 (en) | 1999-11-03 | 2007-01-16 | Amr Technology, Inc. | 4-phenyl substituted tetrahydroisoquinolines and use thereof |
CN1414953A (zh) * | 1999-11-03 | 2003-04-30 | 阿尔巴尼分子研究公司 | 芳基和杂芳基取代的四氢异喹啉及其阻断去甲肾上腺素、多巴胺和5-羟色胺重摄取的用途 |
EP1246805A1 (de) * | 1999-11-03 | 2002-10-09 | Albany Molecular Research, Inc. | 4-phenyl-substituierte tetrahydroisochinoline und ihre verwendung als hemmer der wiederaufnahme von norepinephrin, dopamin und serotonin |
AU7334901A (en) * | 2000-07-11 | 2002-01-21 | Du Pont Pharm Co | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
UA77042C2 (en) * | 2001-12-05 | 2006-10-16 | Sanofi Aventis Deutschland | Substituted 4-tetrahydroquinolines, use thereof as medicament, a medicament containing them |
US6911453B2 (en) | 2001-12-05 | 2005-06-28 | Aventis Pharma Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolinium, process for their preparation, their use as a medicament, and medicament containing them |
US6703405B2 (en) | 2001-12-22 | 2004-03-09 | Aventis Pharma Deutschland Gmbh | Substituted 4-phenyltetrahydroisoquinolinium salts, process for their preparation, their use as a medicament, and medicament containing them |
MXPA05005829A (es) * | 2002-12-02 | 2005-08-29 | Pharmacia & Upjohn Co Llc | El uso de tetrahidroisoquinolinas 4-fenil-sustituidas en el tratamiento del dolor, dolores de cabeza migranosos e incontinencia urinaria. |
WO2004050629A2 (en) * | 2002-12-02 | 2004-06-17 | Pharmacia & Upjohn Company Llc | The use of 4-phenyl substituted tetrahydroisoquinolines in the treatment of pain, migraine and urinary incontinence |
AU2003283646A1 (en) * | 2002-12-02 | 2004-06-23 | Pharmacia & Upjohn Company Llc | The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence |
DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
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MX2007000428A (es) | 2004-07-15 | 2008-03-05 | Amr Technology Inc | Tetrahidroisoquinolinas sustituidas con arilo y heteroarilo y uso de las mismas para bloquear la captacion de norepinefrina, dopamina y serotonina. |
US20060111394A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US20060111393A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | 4-Phenyl substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin |
US20060111385A1 (en) * | 2004-11-22 | 2006-05-25 | Molino Bruce F | Novel 4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof |
KR20060059728A (ko) * | 2004-11-29 | 2006-06-02 | 삼성에스디아이 주식회사 | 액정 표시 장치 및 그 제조 방법 |
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FR2884251B1 (fr) * | 2005-04-08 | 2007-07-13 | Servier Lab | Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CA2615403C (en) * | 2005-07-15 | 2015-06-16 | Amr Technology, Inc. | Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
KR100698800B1 (ko) * | 2005-08-05 | 2007-03-23 | 미미라이팅주식회사 | 공기청정기능을 구비한 천장직착식 조명등기구 |
DE102005044815A1 (de) * | 2005-09-20 | 2007-03-22 | Sanofi-Aventis Deutschland Gmbh | Verwendung von Inhibitoren des Na+/H+ Austauschers, Subtyp 5 (NHE5) zur Gedächtnisverbesserung |
CN101641099A (zh) | 2007-01-24 | 2010-02-03 | 葛兰素集团有限公司 | 包含3,5-二氨基-6-(2,3-二氯苯基)-1,2,4-三嗪或r(-)-2,4-二氨基-5-(2,3-二氯苯基)-6-氟甲基嘧啶和nk1的药物组合物 |
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US9156812B2 (en) | 2008-06-04 | 2015-10-13 | Bristol-Myers Squibb Company | Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine |
AR071997A1 (es) * | 2008-06-04 | 2010-07-28 | Bristol Myers Squibb Co | Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina |
WO2010088408A2 (en) | 2009-01-28 | 2010-08-05 | Emory University | Subunit selective nmda receptor antagonists for the treatment of neurological conditions |
ES2662072T3 (es) | 2009-05-12 | 2018-04-05 | Albany Molecular Research, Inc. | 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina y uso de la misma |
KR20120034644A (ko) | 2009-05-12 | 2012-04-12 | 알바니 몰레큘라 리써치, 인크. | 아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도 |
EP2429293B1 (de) * | 2009-05-12 | 2014-10-29 | Bristol-Myers Squibb Company | KRISTALLINE FORMEN VON (S)-7-([1,2,4]TRIAZOL[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLORPHENYL)-1,2,3,4-TETRAHYDROISOCHINOLIN UND IHRE VERWENDUNG |
EP2606049A4 (de) | 2010-08-17 | 2014-01-08 | Albany Molecular Res Inc | 2,5-methan- und 2,5-ethan-tetrahydrobenzazepin-derivate und ihre verwendung zur hemmung der wiederaufnahme von norepinephrin, dopamin und serotonin |
CN106003947A (zh) * | 2016-06-30 | 2016-10-12 | 广东新视野薄膜有限公司 | 一种安全膜及其制备方法 |
CN116057049A (zh) | 2020-05-29 | 2023-05-02 | 大邱庆北尖端医疗产业振兴财团 | 甲酰胺衍生物和含其作为活性成分的用于预防或治疗精神疾病的药物组合物 |
WO2021241982A1 (ko) | 2020-05-29 | 2021-12-02 | 재단법인 대구경북첨단의료산업진흥재단 | N을 하나 이상 포함하는 5원자의 헤테로아릴 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물 |
WO2021241875A1 (ko) | 2020-05-29 | 2021-12-02 | 재단법인 대구경북첨단의료산업진흥재단 | 설폰아미드 유도체 및 이를 유효성분으로 함유하는 정신질환의 예방 또는 치료용 약학적 조성물 |
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-
2000
- 2000-11-03 CN CN00818078A patent/CN1414953A/zh active Pending
- 2000-11-03 EP EP00976885A patent/EP1246806B1/de not_active Expired - Lifetime
- 2000-11-03 KR KR1020027005744A patent/KR100885986B1/ko not_active IP Right Cessation
- 2000-11-03 MX MXPA02004330A patent/MXPA02004330A/es active IP Right Grant
- 2000-11-03 WO PCT/US2000/030329 patent/WO2001032625A1/en active IP Right Grant
- 2000-11-03 AT AT00976885T patent/ATE387429T1/de active
- 2000-11-03 JP JP2001534777A patent/JP4907818B2/ja not_active Expired - Fee Related
- 2000-11-03 DE DE60038185T patent/DE60038185T2/de not_active Expired - Lifetime
- 2000-11-03 ES ES00976885T patent/ES2304984T3/es not_active Expired - Lifetime
- 2000-11-03 CA CA2389306A patent/CA2389306C/en not_active Expired - Fee Related
- 2000-11-03 RU RU2002114338/04A patent/RU2309953C2/ru not_active IP Right Cessation
- 2000-11-03 AU AU14597/01A patent/AU781179B2/en not_active Ceased
- 2000-11-03 PT PT00976885T patent/PT1246806E/pt unknown
- 2000-11-03 DK DK00976885T patent/DK1246806T3/da active
- 2000-11-03 BR BR0015320-6A patent/BR0015320A/pt not_active IP Right Cessation
-
2002
- 2002-03-06 US US10/091,949 patent/US6579885B2/en not_active Expired - Fee Related
-
2003
- 2003-04-29 US US10/426,097 patent/US7612090B2/en not_active Expired - Fee Related
-
2004
- 2004-08-13 US US10/917,801 patent/US7265116B2/en not_active Expired - Fee Related
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2008
- 2008-05-26 CY CY20081100547T patent/CY1108081T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US7265116B2 (en) | 2007-09-04 |
US7612090B2 (en) | 2009-11-03 |
KR100885986B1 (ko) | 2009-03-03 |
ES2304984T3 (es) | 2008-11-01 |
JP2003513074A (ja) | 2003-04-08 |
EP1246806B1 (de) | 2008-02-27 |
PT1246806E (pt) | 2008-04-03 |
AU781179B2 (en) | 2005-05-12 |
CY1108081T1 (el) | 2014-02-12 |
DE60038185D1 (de) | 2008-04-10 |
MXPA02004330A (es) | 2004-07-30 |
CA2389306C (en) | 2010-03-30 |
US6579885B2 (en) | 2003-06-17 |
WO2001032625A1 (en) | 2001-05-10 |
US20030203920A1 (en) | 2003-10-30 |
CN1414953A (zh) | 2003-04-30 |
ATE387429T1 (de) | 2008-03-15 |
JP4907818B2 (ja) | 2012-04-04 |
DE60038185T2 (de) | 2009-02-19 |
US20020143014A1 (en) | 2002-10-03 |
RU2309953C2 (ru) | 2007-11-10 |
KR20020079730A (ko) | 2002-10-19 |
EP1246806A1 (de) | 2002-10-09 |
AU1459701A (en) | 2001-05-14 |
BR0015320A (pt) | 2002-07-09 |
US20050020597A1 (en) | 2005-01-27 |
CA2389306A1 (en) | 2001-05-10 |
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