ATE337019T1 - Geladene lipide und deren verwendung - Google Patents

Geladene lipide und deren verwendung

Info

Publication number
ATE337019T1
ATE337019T1 AT98906695T AT98906695T ATE337019T1 AT E337019 T1 ATE337019 T1 AT E337019T1 AT 98906695 T AT98906695 T AT 98906695T AT 98906695 T AT98906695 T AT 98906695T AT E337019 T1 ATE337019 T1 AT E337019T1
Authority
AT
Austria
Prior art keywords
charged lipids
compositions
drug delivery
imaging
lipids
Prior art date
Application number
AT98906695T
Other languages
English (en)
Inventor
Evan C Unger
Original Assignee
Imarx Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/823,791 external-priority patent/US6143276A/en
Priority claimed from US08/851,780 external-priority patent/US6090800A/en
Priority claimed from US08/877,826 external-priority patent/US6537246B1/en
Application filed by Imarx Pharmaceutical Corp filed Critical Imarx Pharmaceutical Corp
Application granted granted Critical
Publication of ATE337019T1 publication Critical patent/ATE337019T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
AT98906695T 1997-03-21 1998-02-25 Geladene lipide und deren verwendung ATE337019T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/823,791 US6143276A (en) 1997-03-21 1997-03-21 Methods for delivering bioactive agents to regions of elevated temperatures
US08/851,780 US6090800A (en) 1997-05-06 1997-05-06 Lipid soluble steroid prodrugs
US08/877,826 US6537246B1 (en) 1997-06-18 1997-06-18 Oxygen delivery agents and uses for the same
US08/887,215 US6028066A (en) 1997-05-06 1997-07-02 Prodrugs comprising fluorinated amphiphiles
US08/925,353 US6120751A (en) 1997-03-21 1997-09-08 Charged lipids and uses for the same

Publications (1)

Publication Number Publication Date
ATE337019T1 true ATE337019T1 (de) 2006-09-15

Family

ID=27542238

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98906695T ATE337019T1 (de) 1997-03-21 1998-02-25 Geladene lipide und deren verwendung

Country Status (6)

Country Link
US (3) US6120751A (de)
EP (1) EP1037673B1 (de)
AT (1) ATE337019T1 (de)
AU (1) AU6185398A (de)
DE (1) DE69835692D1 (de)
WO (1) WO1998042383A1 (de)

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US6808720B2 (en) 2004-10-26
AU6185398A (en) 1998-10-20
EP1037673B1 (de) 2006-08-23
US6120751A (en) 2000-09-19
EP1037673A4 (de) 2002-05-02
US20030054027A1 (en) 2003-03-20
EP1037673A1 (de) 2000-09-27
WO1998042383A1 (en) 1998-10-01
US6403056B1 (en) 2002-06-11
DE69835692D1 (de) 2006-10-05

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