LT2794626T - E selektino antagonisto junginiai - Google Patents

E selektino antagonisto junginiai

Info

Publication number
LT2794626T
LT2794626T LTEP12813711.4T LT12813711T LT2794626T LT 2794626 T LT2794626 T LT 2794626T LT 12813711 T LT12813711 T LT 12813711T LT 2794626 T LT2794626 T LT 2794626T
Authority
LT
Lithuania
Prior art keywords
antagonist compounds
selectin antagonist
selectin
compounds
antagonist
Prior art date
Application number
LTEP12813711.4T
Other languages
English (en)
Inventor
John L. Magnani
Arun K. Sarkar
Myung-Gi Baek
Frank E. ANDERSON, III
Yanhong Li
Original Assignee
Glycomimetics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics, Inc. filed Critical Glycomimetics, Inc.
Publication of LT2794626T publication Critical patent/LT2794626T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09C—TREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES ; PREPARATION OF CARBON BLACK  ; PREPARATION OF INORGANIC MATERIALS WHICH ARE NO SINGLE CHEMICAL COMPOUNDS AND WHICH ARE MAINLY USED AS PIGMENTS OR FILLERS
    • C09C1/00—Treatment of specific inorganic materials other than fibrous fillers; Preparation of carbon black
    • C09C1/62—Metallic pigments or fillers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LTEP12813711.4T 2011-12-22 2012-12-21 E selektino antagonisto junginiai LT2794626T (lt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161579646P 2011-12-22 2011-12-22
US201261583547P 2012-01-05 2012-01-05
US201261704424P 2012-09-21 2012-09-21
US201261704399P 2012-09-21 2012-09-21
US201261734924P 2012-12-07 2012-12-07
PCT/US2012/071519 WO2013096926A1 (en) 2011-12-22 2012-12-21 E-selectin antagonist compounds, compositions, and methods of use

Publications (1)

Publication Number Publication Date
LT2794626T true LT2794626T (lt) 2018-02-12

Family

ID=48669591

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP12813711.4T LT2794626T (lt) 2011-12-22 2012-12-21 E selektino antagonisto junginiai

Country Status (18)

Country Link
US (6) US9109002B2 (lt)
EP (2) EP2794626B3 (lt)
JP (5) JP2015500887A (lt)
KR (1) KR102055958B1 (lt)
CN (1) CN104039805B (lt)
AU (1) AU2012358150B2 (lt)
BR (1) BR112014014547B1 (lt)
CA (1) CA2858099C (lt)
CY (1) CY1119794T1 (lt)
DK (1) DK2794626T6 (lt)
ES (1) ES2655443T7 (lt)
HK (1) HK1201842A1 (lt)
HU (1) HUE036253T2 (lt)
LT (1) LT2794626T (lt)
PL (1) PL2794626T6 (lt)
PT (1) PT2794626T (lt)
SI (1) SI2794626T1 (lt)
WO (1) WO2013096926A1 (lt)

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WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
US9109002B2 (en) * 2011-12-22 2015-08-18 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
JP2016501840A (ja) * 2012-10-31 2016-01-21 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンアンタゴニスト化合物および使用方法
ES2668045T3 (es) * 2012-12-07 2018-05-16 Glycomimetics, Inc. Compuestos, composiciones y métodos que usan antagonistas de la E-selectina para la movilización de las células hematopoyéticas
US20170296566A9 (en) * 2013-09-30 2017-10-19 Glycomimetics, Inc. Methods and compositions for treating and/or preventing mucositis
DE102013112915A1 (de) 2013-11-22 2015-05-28 Universitätsklinikum Hamburg-Eppendorf (UKE) DNA-Aptamere, die E- und P-Selektine spezifisch binden
WO2015109049A1 (en) * 2014-01-17 2015-07-23 Glycomimetics, Inc. E-selectin antagonists modified by macrocycle formation to the galactose
ES2754549T3 (es) * 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
WO2016164394A1 (en) * 2015-04-08 2016-10-13 Glycomimetics, Inc. 2-halo-galactose-containing selectin antagonists
US20160331775A1 (en) * 2015-05-14 2016-11-17 The Regents Of The University Of Michigan E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk
US9891811B2 (en) * 2015-06-07 2018-02-13 Apple Inc. Devices and methods for navigating between user interfaces
BR112018008962A8 (pt) * 2015-11-03 2019-02-26 Glycomimetics Inc anticorpos para direcionar células tronco cancerígenas e tratar cânceres agressivos
WO2017151708A1 (en) * 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
EP3522931A1 (en) 2016-10-07 2019-08-14 GlycoMimetics, Inc. Highly potent multimeric e-selectin antagonists
JP7272956B2 (ja) * 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体
JP7275131B2 (ja) * 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
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WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
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AU2020263266A1 (en) 2019-04-24 2021-12-16 Glycomimetics, Inc. Galactose-linked multimeric glycomimetic inhibitors of E-selectins, galectin-3, and/or CXCR4 chemokine receptors
US20220220144A1 (en) 2019-04-24 2022-07-14 Glycomimetics, Inc. Multimeric pan-selectin antagonists
EP3997247A1 (en) 2019-07-12 2022-05-18 GlycoMimetics, Inc. Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types
US20220257775A1 (en) 2019-07-31 2022-08-18 Glycomimetics, Inc. Use of highly potent multimeric e-selectin antagonists for treating sickle cell disease
WO2021022132A1 (en) 2019-07-31 2021-02-04 Magnani John L Use of e-selectin antagonists to enhance the survival of reconstituted, bone marrow-depleted hosts
WO2021034796A1 (en) 2019-08-20 2021-02-25 Glycomimetics, Inc. Process for preparing an e-selectin inhibitor intermediate
WO2021195465A1 (en) * 2020-03-27 2021-09-30 Magnani John L Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin
CN115666584A (zh) 2020-05-31 2023-01-31 糖模拟物有限公司 用于减少癌细胞负荷和保护正常血细胞生成的化合物和方法
KR20230024402A (ko) * 2020-06-14 2023-02-20 글리코미메틱스, 인크. E-셀렉틴 표적화를 통해 미세환경 매개 내성을 극복하기 위한 조성물 및 방법
WO2022061168A1 (en) * 2020-09-17 2022-03-24 Glycomimetics, Inc. E-selectin targeting agents
MX2023009127A (es) 2021-02-18 2023-08-16 Glycomimetics Inc Proceso para preparar un compuesto intermedio inhibidor de la selectina e.
WO2023014690A1 (en) 2021-08-03 2023-02-09 Glycomimetics, Inc. Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting

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