PL1934236T3 - Heterobifunkcjonalne inhibitory pan-selektyny - Google Patents
Heterobifunkcjonalne inhibitory pan-selektynyInfo
- Publication number
- PL1934236T3 PL1934236T3 PL06814078T PL06814078T PL1934236T3 PL 1934236 T3 PL1934236 T3 PL 1934236T3 PL 06814078 T PL06814078 T PL 06814078T PL 06814078 T PL06814078 T PL 06814078T PL 1934236 T3 PL1934236 T3 PL 1934236T3
- Authority
- PL
- Poland
- Prior art keywords
- selectin inhibitors
- heterobifunctional
- pan
- heterobifunctional pan
- selectin
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71399405P | 2005-09-02 | 2005-09-02 | |
| PCT/US2006/034274 WO2007028050A1 (en) | 2005-09-02 | 2006-09-01 | Heterobifunctional pan-selectin inhibitors |
| EP06814078A EP1934236B1 (en) | 2005-09-02 | 2006-09-01 | Heterobifunctional pan-selectin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1934236T3 true PL1934236T3 (pl) | 2013-04-30 |
Family
ID=37603124
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06814078T PL1934236T3 (pl) | 2005-09-02 | 2006-09-01 | Heterobifunkcjonalne inhibitory pan-selektyny |
| PL10011660T PL2264043T3 (pl) | 2005-09-02 | 2006-09-01 | Heterobifunkcyjne inhibitory pan-selektyny |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10011660T PL2264043T3 (pl) | 2005-09-02 | 2006-09-01 | Heterobifunkcyjne inhibitory pan-selektyny |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US7728117B2 (pl) |
| EP (2) | EP1934236B1 (pl) |
| JP (2) | JP5209476B2 (pl) |
| CN (2) | CN103626813B (pl) |
| AU (1) | AU2006284578B2 (pl) |
| CA (1) | CA2670130A1 (pl) |
| CY (1) | CY1119721T1 (pl) |
| DK (2) | DK1934236T3 (pl) |
| ES (2) | ES2651929T3 (pl) |
| HU (1) | HUE038246T2 (pl) |
| LT (1) | LT2264043T (pl) |
| PL (2) | PL1934236T3 (pl) |
| PT (2) | PT1934236E (pl) |
| SI (2) | SI2264043T1 (pl) |
| WO (1) | WO2007028050A1 (pl) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7728117B2 (en) * | 2005-09-02 | 2010-06-01 | Glycomimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
| JP5298020B2 (ja) * | 2006-10-12 | 2013-09-25 | グリコミメティクス， インコーポレイテッド | ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換 |
| US8026222B2 (en) * | 2007-02-09 | 2011-09-27 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| US8039442B2 (en) | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| US9486497B2 (en) * | 2007-12-10 | 2016-11-08 | The University Of Queensland | Treatment of immunocompromised conditions |
| WO2009126556A1 (en) * | 2008-04-08 | 2009-10-15 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| AU2009257536B2 (en) * | 2008-06-13 | 2015-07-02 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
| WO2010126888A1 (en) * | 2009-05-01 | 2010-11-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| WO2012061662A1 (en) | 2010-11-03 | 2012-05-10 | Glycomimetics, Inc. | Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors |
| ES2655443T7 (es) | 2011-12-22 | 2021-03-22 | Glycomimetics Inc | Compuestos antagonistas de E-selectina |
| US20140059130A1 (en) * | 2012-08-22 | 2014-02-27 | Mainsoft R&D Ltd. | System and method for updating connections in social networks |
| LT2928476T (lt) | 2012-12-07 | 2018-05-25 | Glycomimetics, Inc. | Junginiai, kompozicijos ir būdai, naudojant e-selektino antagonistus, hemopoetinių ląstelių mobilizacijai |
| CN105683208A (zh) * | 2013-09-30 | 2016-06-15 | 糖模拟物有限公司 | 治疗和/或预防粘膜炎的方法和组合物 |
| ES2754549T3 (es) | 2014-12-03 | 2020-04-20 | Glycomimetics Inc | Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4 |
| WO2016164394A1 (en) | 2015-04-08 | 2016-10-13 | Glycomimetics, Inc. | 2-halo-galactose-containing selectin antagonists |
| US20160331775A1 (en) * | 2015-05-14 | 2016-11-17 | The Regents Of The University Of Michigan | E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk |
| WO2016196221A1 (en) | 2015-05-29 | 2016-12-08 | Nike Innovate C.V. | System for operating multiple transceiver modules concurrently |
| CA2950088A1 (en) * | 2015-12-02 | 2017-06-02 | Glycomimetics, Inc. | Heterobifunctional compounds having a triazole linker and e and/or p selectin binding affinity |
| BR112018010211A2 (pt) | 2015-12-07 | 2019-02-05 | Merck Patent Gmbh | formulação farmacêutica aquosa compreendendo anticorpo anti-pd-l1 avelumab |
| US11045485B2 (en) | 2016-01-22 | 2021-06-29 | Glycomimetics, Inc. | Glycomimetic inhibitors of PA-IL and PA-IIL lectins |
| WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
| US20200316100A1 (en) | 2016-05-24 | 2020-10-08 | GycoMimetics, Inc. | Haloalkyl fucose-containing selectin antagonists |
| WO2018031445A1 (en) | 2016-08-08 | 2018-02-15 | Glycomimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4 |
| KR20240046288A (ko) | 2016-10-07 | 2024-04-08 | 글리코미메틱스, 인크. | 매우 강력한 다량체성 e-셀렉틴 길항물질 |
| US11197877B2 (en) | 2017-03-15 | 2021-12-14 | Glycomimetics. Inc. | Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists |
| US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| US11548908B2 (en) | 2017-12-29 | 2023-01-10 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| BR112020018184A2 (pt) | 2018-03-05 | 2021-02-02 | Glycomimetics, Inc. | usos de compostos |
| WO2020123435A2 (en) | 2018-12-10 | 2020-06-18 | Glycomimetics, Inc. | Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| WO2020150263A1 (en) | 2019-01-14 | 2020-07-23 | Magnani John L | Selectin or galectin antagonists for treating cytokine release syndrome and crs-induced neurotoxicity |
| WO2020219417A1 (en) | 2019-04-24 | 2020-10-29 | Glycomimetics, Inc. | Galactose-linked multimeric glycomimetic inhibitors of e-selectins, galectin-3, and/or cxcr4 chemokine receptors |
| US20220220144A1 (en) | 2019-04-24 | 2022-07-14 | Glycomimetics, Inc. | Multimeric pan-selectin antagonists |
| EP3997247A1 (en) | 2019-07-12 | 2022-05-18 | GlycoMimetics, Inc. | Methods for use of gene expression as an indicator of e-selectin inhibitor efficacy and clinical outcome for multiple tumor types |
| US20220265693A1 (en) | 2019-07-31 | 2022-08-25 | Glycomimetics, Inc. | Use of e-selectin antagonists to enhance the survival of reconstituted, bone marrow-depleted hosts |
| US20230147312A1 (en) * | 2020-03-27 | 2023-05-11 | Glycomimetics, Inc. | Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin |
| EP4157285A1 (en) | 2020-05-31 | 2023-04-05 | GlycoMimetics, Inc. | Compounds and methods for reduction of cancer cell burden and protection of normal hematopoiesis |
| WO2021257398A1 (en) | 2020-06-14 | 2021-12-23 | Magnani John L | Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting |
| EP4214218A1 (en) * | 2020-09-17 | 2023-07-26 | GlycoMimetics, Inc. | E-selectin targeting agents |
| US20240269157A1 (en) | 2021-08-03 | 2024-08-15 | Glycomimetics, Inc. | Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting |
| CN118165054B (zh) * | 2024-04-10 | 2025-04-08 | 辽宁中医药大学 | 马齿苋中一种吡喃类新化合物及其提取分离方法与用途 |
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| US20090036386A1 (en) * | 2005-05-25 | 2009-02-05 | Glycomimetics, Inc | Heterobifunctional compounds for selectin inhibition |
| US20060287253A1 (en) | 2005-06-17 | 2006-12-21 | Kriegler Steven M | Compounds and methods for treating seizure disorders |
| US7728117B2 (en) * | 2005-09-02 | 2010-06-01 | Glycomimetics, Inc. | Heterobifunctional pan-selectin inhibitors |
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2006
- 2006-09-01 US US11/515,343 patent/US7728117B2/en not_active Ceased
- 2006-09-01 PT PT68140789T patent/PT1934236E/pt unknown
- 2006-09-01 WO PCT/US2006/034274 patent/WO2007028050A1/en not_active Ceased
- 2006-09-01 EP EP06814078A patent/EP1934236B1/en active Active
- 2006-09-01 HU HUE10011660A patent/HUE038246T2/hu unknown
- 2006-09-01 CN CN201310464420.0A patent/CN103626813B/zh active Active
- 2006-09-01 PT PT100116607T patent/PT2264043T/pt unknown
- 2006-09-01 LT LTEP10011660.7T patent/LT2264043T/lt unknown
- 2006-09-01 JP JP2008529320A patent/JP5209476B2/ja not_active Expired - Fee Related
- 2006-09-01 SI SI200632228T patent/SI2264043T1/en unknown
- 2006-09-01 SI SI200631510T patent/SI1934236T1/sl unknown
- 2006-09-01 PL PL06814078T patent/PL1934236T3/pl unknown
- 2006-09-01 PL PL10011660T patent/PL2264043T3/pl unknown
- 2006-09-01 AU AU2006284578A patent/AU2006284578B2/en active Active
- 2006-09-01 ES ES10011660.7T patent/ES2651929T3/es active Active
- 2006-09-01 DK DK06814078.9T patent/DK1934236T3/da active
- 2006-09-01 DK DK10011660.7T patent/DK2264043T3/da active
- 2006-09-01 CA CA002670130A patent/CA2670130A1/en not_active Abandoned
- 2006-09-01 ES ES06814078T patent/ES2397850T3/es active Active
- 2006-09-01 EP EP10011660.7A patent/EP2264043B1/en active Active
- 2006-09-01 CN CN200680037714.3A patent/CN101287741B/zh active Active
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2010
- 2010-04-20 US US12/764,027 patent/US7989601B2/en active Active
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2011
- 2011-06-21 US US13/165,609 patent/US8633303B2/en active Active
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2012
- 2012-05-30 US US13/484,020 patent/USRE44778E1/en active Active
- 2012-07-03 JP JP2012149401A patent/JP2012184268A/ja not_active Withdrawn
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2013
- 2013-12-13 US US14/106,662 patent/US20140178303A1/en not_active Abandoned
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2016
- 2016-06-14 US US15/181,725 patent/US20160361332A1/en not_active Abandoned
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2017
- 2017-12-27 CY CY20171101350T patent/CY1119721T1/el unknown
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