PL1934236T3 - Heterobifunkcjonalne inhibitory pan-selektyny - Google Patents
Heterobifunkcjonalne inhibitory pan-selektynyInfo
- Publication number
- PL1934236T3 PL1934236T3 PL06814078T PL06814078T PL1934236T3 PL 1934236 T3 PL1934236 T3 PL 1934236T3 PL 06814078 T PL06814078 T PL 06814078T PL 06814078 T PL06814078 T PL 06814078T PL 1934236 T3 PL1934236 T3 PL 1934236T3
- Authority
- PL
- Poland
- Prior art keywords
- selectin inhibitors
- heterobifunctional
- pan
- heterobifunctional pan
- selectin
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71399405P | 2005-09-02 | 2005-09-02 | |
| EP06814078A EP1934236B1 (en) | 2005-09-02 | 2006-09-01 | Heterobifunctional pan-selectin inhibitors |
| PCT/US2006/034274 WO2007028050A1 (en) | 2005-09-02 | 2006-09-01 | Heterobifunctional pan-selectin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1934236T3 true PL1934236T3 (pl) | 2013-04-30 |
Family
ID=37603124
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10011660T PL2264043T3 (pl) | 2005-09-02 | 2006-09-01 | Heterobifunkcyjne inhibitory pan-selektyny |
| PL06814078T PL1934236T3 (pl) | 2005-09-02 | 2006-09-01 | Heterobifunkcjonalne inhibitory pan-selektyny |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10011660T PL2264043T3 (pl) | 2005-09-02 | 2006-09-01 | Heterobifunkcyjne inhibitory pan-selektyny |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US7728117B2 (pl) |
| EP (2) | EP2264043B1 (pl) |
| JP (2) | JP5209476B2 (pl) |
| CN (2) | CN103626813B (pl) |
| AU (1) | AU2006284578B2 (pl) |
| CA (1) | CA2670130A1 (pl) |
| CY (1) | CY1119721T1 (pl) |
| DK (2) | DK1934236T3 (pl) |
| ES (2) | ES2397850T3 (pl) |
| HU (1) | HUE038246T2 (pl) |
| LT (1) | LT2264043T (pl) |
| PL (2) | PL2264043T3 (pl) |
| PT (2) | PT2264043T (pl) |
| SI (2) | SI2264043T1 (pl) |
| WO (1) | WO2007028050A1 (pl) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2264043T1 (en) * | 2005-09-02 | 2018-01-31 | Glycomimetics, Inc. | HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS |
| US7964569B2 (en) * | 2006-10-12 | 2011-06-21 | Glycomimetics, Inc. | Glycomimetic replacements for hexoses and N-acetyl hexosamines |
| WO2008100453A1 (en) * | 2007-02-09 | 2008-08-21 | Glycomimetics, Inc. | Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines |
| US8039442B2 (en) * | 2007-07-18 | 2011-10-18 | Glycomimetics, Inc. | Compounds and methods for treatment of sickle cell disease or complications associated therewith |
| AU2008336249B2 (en) | 2007-12-10 | 2015-01-29 | The University Of Queensland | Treatment and prophylaxis |
| US8895510B2 (en) | 2008-04-08 | 2014-11-25 | Glycomimetics, Inc. | Pan-selectin inhibitor with enhanced pharmacokinetic activity |
| US8518896B2 (en) * | 2008-06-13 | 2013-08-27 | Glycomimetics, Inc. | Treatment of cancers of the blood using selected glycomimetic compounds |
| AU2010241807B2 (en) * | 2009-05-01 | 2014-08-14 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors |
| US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
| WO2012061662A1 (en) * | 2010-11-03 | 2012-05-10 | Glycomimetics, Inc. | Glycomimetic-peptidomimetic inhibitors of e-selectins and cxcr4 chemokine receptors |
| EP2794626B3 (en) * | 2011-12-22 | 2020-08-05 | GlycoMimetics, Inc. | E-selectin antagonist compounds |
| US20140059130A1 (en) * | 2012-08-22 | 2014-02-27 | Mainsoft R&D Ltd. | System and method for updating connections in social networks |
| HUE038423T2 (hu) * | 2012-12-07 | 2018-10-29 | Glycomimetics Inc | E-szelektin antagonistákat felhasználó vegyületek, készítmények és eljárások vérképzõ sejtek mobilizációjára |
| WO2015048616A1 (en) * | 2013-09-30 | 2015-04-02 | Glycomimetics, Inc. | Methods and compositions for treating and/or preventing mucositis |
| CN107108679B (zh) | 2014-12-03 | 2020-10-23 | 糖模拟物有限公司 | E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂 |
| WO2016164394A1 (en) | 2015-04-08 | 2016-10-13 | Glycomimetics, Inc. | 2-halo-galactose-containing selectin antagonists |
| US20160331775A1 (en) * | 2015-05-14 | 2016-11-17 | The Regents Of The University Of Michigan | E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk |
| US10924177B2 (en) | 2015-05-29 | 2021-02-16 | Nike, Inc. | System for operating multiple transceiver modules concurrently |
| EP3383882A1 (en) * | 2015-12-02 | 2018-10-10 | GlycoMimetics, Inc. | Heterobifunctional pan-selectin antagonists having a triazole linker |
| DK3386541T3 (da) | 2015-12-07 | 2020-09-28 | Merck Patent Gmbh | Vandig farmaceutisk formulering omfattende anti-pd-1-antistof avelumab |
| WO2017127422A1 (en) | 2016-01-22 | 2017-07-27 | Glycomimetics, Inc. | Glycomimetic inhibitors of pa-il and pa-iil lectins |
| US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
| US20200316100A1 (en) | 2016-05-24 | 2020-10-08 | GycoMimetics, Inc. | Haloalkyl fucose-containing selectin antagonists |
| US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
| BR112019006642A2 (pt) | 2016-10-07 | 2019-07-02 | Glycomimetics Inc | antagonistas multiméricos de e-selectina altamente potentes |
| CA3054605A1 (en) | 2017-03-15 | 2018-09-20 | Glycomimetics, Inc. | Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists |
| EP3717013A1 (en) | 2017-11-30 | 2020-10-07 | GlycoMimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
| US11548908B2 (en) | 2017-12-29 | 2023-01-10 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| AU2019230013A1 (en) | 2018-03-05 | 2020-09-10 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
| WO2020123435A2 (en) | 2018-12-10 | 2020-06-18 | Glycomimetics, Inc. | Methods of treating hiv and aids and the elimination of latent reservoirs of hiv infection using selectin, galectin, and siglec antagonists |
| US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
| WO2020150263A1 (en) | 2019-01-14 | 2020-07-23 | Magnani John L | Selectin or galectin antagonists for treating cytokine release syndrome and crs-induced neurotoxicity |
| CA3136661A1 (en) | 2019-04-24 | 2020-10-29 | Glycomimetics, Inc. | Galactose-linked multimeric glycomimetic inhibitors of e-selectins, galectin-3, and/or cxcr4 chemokine receptors |
| US20220220144A1 (en) | 2019-04-24 | 2022-07-14 | Glycomimetics, Inc. | Multimeric pan-selectin antagonists |
| CN114341368A (zh) | 2019-07-12 | 2022-04-12 | 糖模拟物有限公司 | 使用基因表达作为多种肿瘤类型的e-选择素抑制剂功效和临床结果的指标的方法 |
| ES3063748T3 (en) | 2019-07-31 | 2026-04-20 | Crescent Biopharma Inc | E-selectin antagonists for use in enhancing the survival of reconstituted, bone marrow-depleted hosts |
| US20230147312A1 (en) * | 2020-03-27 | 2023-05-11 | Glycomimetics, Inc. | Treatment of acute respiratory distress syndrome and related conditions with antagonists of e-selectin |
| WO2021247396A1 (en) | 2020-05-31 | 2021-12-09 | Magnani John L | Compounds and methods for reduction of cancer cell burden and protection of normal hematopoiesis |
| JP2023529485A (ja) | 2020-06-14 | 2023-07-10 | グリコミメティクス， インコーポレイテッド | Ｅ－セレクチン標的化を介して微小環境媒介耐性を克服するための組成物および方法 |
| JP2023543168A (ja) * | 2020-09-17 | 2023-10-13 | グリコミメティクス， インコーポレイテッド | Ｅ－セレクチン標的化剤 |
| WO2023014690A1 (en) | 2021-08-03 | 2023-02-09 | Glycomimetics, Inc. | Compositions and methods for overcoming microenvironment-mediated resistance via e-selectin targeting |
| CN118165054B (zh) * | 2024-04-10 | 2025-04-08 | 辽宁中医药大学 | 马齿苋中一种吡喃类新化合物及其提取分离方法与用途 |
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| SI2264043T1 (en) | 2005-09-02 | 2018-01-31 | Glycomimetics, Inc. | HETEROBIFUNCTIONAL PAN-SELECTINE INHIBITORS |
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2006
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- 2006-09-01 AU AU2006284578A patent/AU2006284578B2/en not_active Ceased
- 2006-09-01 CN CN201310464420.0A patent/CN103626813B/zh active Active
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- 2006-09-01 DK DK06814078.9T patent/DK1934236T3/da active
- 2006-09-01 CA CA002670130A patent/CA2670130A1/en not_active Abandoned
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- 2006-09-01 JP JP2008529320A patent/JP5209476B2/ja not_active Expired - Fee Related
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- 2006-09-01 WO PCT/US2006/034274 patent/WO2007028050A1/en not_active Ceased
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