ATE296660T1 - Vorrichtung zur lokalen verabreichung einer arznei - Google Patents

Vorrichtung zur lokalen verabreichung einer arznei

Info

Publication number
ATE296660T1
ATE296660T1 AT95910886T AT95910886T ATE296660T1 AT E296660 T1 ATE296660 T1 AT E296660T1 AT 95910886 T AT95910886 T AT 95910886T AT 95910886 T AT95910886 T AT 95910886T AT E296660 T1 ATE296660 T1 AT E296660T1
Authority
AT
Austria
Prior art keywords
substance
conduit
locally
medicine
delivery
Prior art date
Application number
AT95910886T
Other languages
English (en)
Inventor
Stephen R Hanson
Neal A Scott
Spencer B King Iii
Laurence A Harker
Original Assignee
Univ Emory
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory filed Critical Univ Emory
Application granted granted Critical
Publication of ATE296660T1 publication Critical patent/ATE296660T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/064Blood vessels with special features to facilitate anastomotic coupling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0102Insertion or introduction using an inner stiffening member, e.g. stylet or push-rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M2025/0063Catheters; Hollow probes characterised by structural features having means, e.g. stylets, mandrils, rods or wires to reinforce or adjust temporarily the stiffness, column strength or pushability of catheters which are already inserted into the human body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0041Catheters; Hollow probes characterised by the form of the tubing pre-formed, e.g. specially adapted to fit with the anatomy of body channels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0067Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Vending Machines For Individual Products (AREA)
  • External Artificial Organs (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
AT95910886T 1994-01-28 1995-01-27 Vorrichtung zur lokalen verabreichung einer arznei ATE296660T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/188,248 US5523092A (en) 1993-04-14 1994-01-28 Device for local drug delivery and methods for using the same
PCT/US1995/001080 WO1995020416A1 (en) 1994-01-28 1995-01-27 A device for local drug delivery and methods for using the same

Publications (1)

Publication Number Publication Date
ATE296660T1 true ATE296660T1 (de) 2005-06-15

Family

ID=22692364

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95910886T ATE296660T1 (de) 1994-01-28 1995-01-27 Vorrichtung zur lokalen verabreichung einer arznei

Country Status (11)

Country Link
US (2) US5523092A (de)
EP (1) EP0754072B1 (de)
JP (1) JPH10500028A (de)
AT (1) ATE296660T1 (de)
AU (1) AU682582B2 (de)
CA (1) CA2182201A1 (de)
DE (1) DE69534245T2 (de)
DK (1) DK0754072T3 (de)
ES (1) ES2243934T3 (de)
PT (1) PT754072E (de)
WO (1) WO1995020416A1 (de)

Families Citing this family (532)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5891108A (en) * 1994-09-12 1999-04-06 Cordis Corporation Drug delivery stent
US6558798B2 (en) 1995-02-22 2003-05-06 Scimed Life Systems, Inc. Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
US6264684B1 (en) 1995-03-10 2001-07-24 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Helically supported graft
US6579314B1 (en) * 1995-03-10 2003-06-17 C.R. Bard, Inc. Covered stent with encapsulated ends
US6451047B2 (en) 1995-03-10 2002-09-17 Impra, Inc. Encapsulated intraluminal stent-graft and methods of making same
US6743198B1 (en) * 1995-03-20 2004-06-01 Conticare Medical, Inc. Self-cleansing bladder drainage device
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US6322548B1 (en) 1995-05-10 2001-11-27 Eclipse Surgical Technologies Delivery catheter system for heart chamber
US5779673A (en) * 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
US6283951B1 (en) * 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6302875B1 (en) 1996-10-11 2001-10-16 Transvascular, Inc. Catheters and related devices for forming passageways between blood vessels or other anatomical structures
US5603694A (en) * 1995-10-17 1997-02-18 Brown; Joe E. Infusion coil apparatus and method for delivering fluid-based agents intravascularly
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
US6402736B1 (en) * 1996-02-16 2002-06-11 Joe E. Brown Apparatus and method for filtering intravascular fluids and for delivering diagnostic and therapeutic agents
SG64340A1 (en) * 1996-02-27 1999-04-27 Inst Of Systems Science Nation Curved surgical instruments and methods of mapping a curved path for stereotactic surgery
US6783543B2 (en) 2000-06-05 2004-08-31 Scimed Life Systems, Inc. Intravascular stent with increasing coating retaining capacity
KR20040097250A (ko) 1996-05-24 2004-11-17 유니버시티 오브 브리티시 콜롬비아 신체 통로의 질병을 치료 또는 예방하기 위한 조성물 및방법
US6190402B1 (en) * 1996-06-21 2001-02-20 Musc Foundation For Research Development Insitu formable and self-forming intravascular flow modifier (IFM) and IFM assembly for deployment of same
US5797887A (en) * 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
US5944701A (en) * 1996-10-03 1999-08-31 Dubrul; William R. Self coiling catheter
US7341598B2 (en) * 1999-01-13 2008-03-11 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US6379334B1 (en) * 1997-02-10 2002-04-30 Essex Technology, Inc. Rotate advance catheterization system
EP1007138A4 (de) * 1997-02-14 2000-06-21 Joe E Brown Spiralförmige vorrichtung sowie verfahren zum intravsakulären abgeben von diagnostischen und therapeutischen mitteln
JP3274384B2 (ja) * 1997-03-31 2002-04-15 株式会社パイオラックス 留置カテーテル及びその挿入装置
US5865815A (en) * 1997-04-25 1999-02-02 Contimed, Inc. Prostatic obstruction relief catheter
IT1293973B1 (it) * 1997-08-13 1999-03-15 Sorin Biomedica Cardio Spa Elemento per l'ancoraggio in situ di dispositivi di impianto.
US6012034A (en) * 1997-08-18 2000-01-04 Becton, Dickinson And Company System and method for selecting an intravenous device
US20020055717A1 (en) * 1997-10-20 2002-05-09 Philippe Poncet Fluid-based agent delivery device with self-expanding delivery element
US6241691B1 (en) 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
US6159165A (en) * 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6168570B1 (en) 1997-12-05 2001-01-02 Micrus Corporation Micro-strand cable with enhanced radiopacity
US6358229B1 (en) * 1998-02-17 2002-03-19 Conticare Medical, Inc. Urinary drain
US7208011B2 (en) 2001-08-20 2007-04-24 Conor Medsystems, Inc. Implantable medical device with drug filled holes
US6241762B1 (en) * 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US7208010B2 (en) 2000-10-16 2007-04-24 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US6478773B1 (en) 1998-12-21 2002-11-12 Micrus Corporation Apparatus for deployment of micro-coil using a catheter
US6296622B1 (en) 1998-12-21 2001-10-02 Micrus Corporation Endoluminal device delivery system using axially recovering shape memory material
US6500149B2 (en) 1998-08-31 2002-12-31 Deepak Gandhi Apparatus for deployment of micro-coil using a catheter
US6358276B1 (en) * 1998-09-30 2002-03-19 Impra, Inc. Fluid containing endoluminal stent
US6375648B1 (en) * 1998-10-02 2002-04-23 Misonix Incorporated Infiltration cannula with teflon coated outer surface
US6048332A (en) * 1998-10-09 2000-04-11 Ave Connaught Dimpled porous infusion balloon
US6293967B1 (en) 1998-10-29 2001-09-25 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6214042B1 (en) * 1998-11-10 2001-04-10 Precision Vascular Systems, Inc. Micro-machined stent for vessels, body ducts and the like
US6258118B1 (en) 1998-11-25 2001-07-10 Israel Aircraft Industries Ltd. Removable support device
US6348067B1 (en) * 1998-11-25 2002-02-19 Israel Aircraft Industries Ltd. Method and system with shape memory heating apparatus for temporarily supporting a tubular organ
US6413273B1 (en) 1998-11-25 2002-07-02 Israel Aircraft Industries Ltd. Method and system for temporarily supporting a tubular organ
US6835185B2 (en) * 1998-12-21 2004-12-28 Micrus Corporation Intravascular device deployment mechanism incorporating mechanical detachment
JP3524788B2 (ja) 1998-12-24 2004-05-10 株式会社パイオラックス 制癌剤投与用体内留置カテーテル
US6398803B1 (en) 1999-02-02 2002-06-04 Impra, Inc., A Subsidiary Of C.R. Bard, Inc. Partial encapsulation of stents
US6419692B1 (en) 1999-02-03 2002-07-16 Scimed Life Systems, Inc. Surface protection method for stents and balloon catheters for drug delivery
US6398758B1 (en) 1999-02-16 2002-06-04 Stephen C. Jacobsen Medicament delivery system
US20010041870A1 (en) * 1999-03-09 2001-11-15 Edward M. Gillis Implantable device for access to a treatment site
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US6595959B1 (en) 1999-04-23 2003-07-22 Alexander A. Stratienko Cardiovascular sheath/catheter
US6245045B1 (en) 1999-04-23 2001-06-12 Alexander Andrew Stratienko Combination sheath and catheter for cardiovascular use
US6514236B1 (en) 1999-04-23 2003-02-04 Alexander A. Stratienko Method for treating a cardiovascular condition
US6156373A (en) * 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6290673B1 (en) * 1999-05-20 2001-09-18 Conor Medsystems, Inc. Expandable medical device delivery system and method
US6478778B1 (en) * 1999-05-28 2002-11-12 Precision Vascular Systems, Inc. Apparatus for delivering fluids to blood vessels, body cavities, and the like
WO2000076571A1 (fr) * 1999-06-16 2000-12-21 Medi-Tech Co., Ltd. Catheter
US6368315B1 (en) * 1999-06-23 2002-04-09 Durect Corporation Composite drug delivery catheter
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6283947B1 (en) 1999-07-13 2001-09-04 Advanced Cardiovascular Systems, Inc. Local drug delivery injection catheter
US6494862B1 (en) 1999-07-13 2002-12-17 Advanced Cardiovascular Systems, Inc. Substance delivery apparatus and a method of delivering a therapeutic substance to an anatomical passageway
US6350253B1 (en) 1999-07-19 2002-02-26 I-Flow Corporation Catheter for uniform delivery of medication
US7547302B2 (en) * 1999-07-19 2009-06-16 I-Flow Corporation Anti-microbial catheter
US7004923B2 (en) * 1999-07-19 2006-02-28 I-Flow Corporation Catheter for uniform delivery of medication
US7452353B2 (en) * 1999-07-19 2008-11-18 I-Flow Corporation Catheter for uniform delivery of medication
US7510550B2 (en) * 1999-07-19 2009-03-31 I-Flow Corporation Catheter for uniform delivery of medication
JP2003507141A (ja) * 1999-08-25 2003-02-25 ジョージタウン ユニバーシティ 中空シード好ましくは金属製を含む治療用送達システム及びその用途
WO2001023027A1 (en) 1999-09-27 2001-04-05 Essex Technology, Inc. Rotate-to-advance catheterization system
AU7839900A (en) 1999-09-29 2001-04-30 Sterling Medivations, Inc. Reusable medication delivery device
US6596235B2 (en) 1999-09-30 2003-07-22 Therox, Inc. Method for blood oxygenation
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
CA2391488C (en) 1999-11-22 2012-04-03 Boston Scientific Limited Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7670327B2 (en) * 2000-01-20 2010-03-02 Regents Of The University Of Minnesota Catheter systems for delivery of agents and related method thereof
US6929633B2 (en) 2000-01-25 2005-08-16 Bacchus Vascular, Inc. Apparatus and methods for clot dissolution
US6663613B1 (en) 2000-01-25 2003-12-16 Bacchus Vascular, Inc. System and methods for clot dissolution
US7740637B2 (en) 2000-02-09 2010-06-22 Micrus Endovascular Corporation Apparatus and method for deployment of a therapeutic device using a catheter
US6379382B1 (en) 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
US6613082B2 (en) 2000-03-13 2003-09-02 Jun Yang Stent having cover with drug delivery capability
AU2001250969A1 (en) 2000-03-24 2001-10-03 Stephen Brushey Anesthesia conduction catheter
US7805188B2 (en) * 2000-03-24 2010-09-28 Micor, Inc. Anesthesia conduction catheter for delivery of electrical stimulus
AU2001253479A1 (en) * 2000-04-13 2001-10-30 Sts Biopolymers, Inc. Targeted therapeutic agent release devices and methods of making and using the same
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20040243097A1 (en) * 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
US8236048B2 (en) 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
ATE495717T1 (de) * 2000-06-05 2011-02-15 Boston Scient Ltd Intravaskulärer stent mit verbessertem haltevermögen einer beschichtung
US6685672B1 (en) * 2000-07-13 2004-02-03 Edwards Lifesciences Corporation Multi-balloon drug delivery catheter for angiogenesis
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
US7261735B2 (en) * 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
ES2275737T3 (es) 2000-09-29 2007-06-16 Cordis Corporation Dispositivos medicos revestidos.
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
AU2001294634B2 (en) 2000-10-16 2006-07-06 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US7803149B2 (en) * 2002-07-12 2010-09-28 Cook Incorporated Coated medical device
US6692458B2 (en) 2000-12-19 2004-02-17 Edwards Lifesciences Corporation Intra-pericardial drug delivery device with multiple balloons and method for angiogenesis
US6964680B2 (en) * 2001-02-05 2005-11-15 Conor Medsystems, Inc. Expandable medical device with tapered hinge
US20040073294A1 (en) * 2002-09-20 2004-04-15 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US7771468B2 (en) * 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US6719804B2 (en) 2001-04-02 2004-04-13 Scimed Life Systems, Inc. Medical stent and related methods
DE10131152B4 (de) * 2001-04-30 2004-05-27 Nutricia Healthcare S.A. Medizinisches Ballon-Button-System
EP1395241B9 (de) * 2001-05-25 2005-06-15 Medtronic, Inc. Implantierbare medizinische vorrichtung mit kontrollierter freigabe von gasförmigen mitteln
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US6629969B2 (en) * 2001-07-26 2003-10-07 Durect Corporation Catheter for modification of agent formulation
US7364565B2 (en) 2001-07-27 2008-04-29 Ramot At Tel Aviv University Ltd. Controlled enzymatic removal and retrieval of cells
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US7578841B2 (en) * 2001-09-24 2009-08-25 Boston Scientific Scimed, Inc. Stent with protruding branch portion for bifurcated vessels
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US20030065345A1 (en) * 2001-09-28 2003-04-03 Kevin Weadock Anastomosis devices and methods for treating anastomotic sites
US20030065377A1 (en) * 2001-09-28 2003-04-03 Davila Luis A. Coated medical devices
US7108701B2 (en) * 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
US6620202B2 (en) 2001-10-16 2003-09-16 Scimed Life Systems, Inc. Medical stent with variable coil and related methods
EP1446110A2 (de) * 2001-10-16 2004-08-18 Structural Bioinformatics Inc. Organoschwefel-hemmer von tyrosinphosphatasen
US6936040B2 (en) * 2001-10-29 2005-08-30 Medtronic, Inc. Method and apparatus for endovenous pacing lead
US7438710B2 (en) * 2001-11-07 2008-10-21 Anderson Kent D Distal protection device with local drug infusion by physician to maintain patency
US7041139B2 (en) 2001-12-11 2006-05-09 Boston Scientific Scimed, Inc. Ureteral stents and related methods
EP1480658B1 (de) * 2002-02-13 2017-01-25 Beth Israel Deaconess Medical Center, Inc. Verfahren zur behandlung von gefässerkrankungen
US8506647B2 (en) * 2002-02-14 2013-08-13 Boston Scientific Scimed, Inc. System for maintaining body canal patency
US8328877B2 (en) 2002-03-19 2012-12-11 Boston Scientific Scimed, Inc. Stent retention element and related methods
US20030191453A1 (en) * 2002-04-03 2003-10-09 Velez Omar E. Catheter assembly
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
AU2003226366A1 (en) 2002-04-15 2003-11-03 Beth Israel Deaconess Medical Center Use of heme oxygenase-1 and products of heme degradation
US7122048B2 (en) * 2002-05-03 2006-10-17 Scimed Life Systems, Inc. Hypotube endoluminal device
US8829198B2 (en) 2007-10-31 2014-09-09 Proteotech Inc Compounds, compositions and methods for the treatment of beta-amyloid diseases and synucleinopathies
RS110504A (en) * 2002-06-21 2007-02-05 University Of Pittsburgh Of The Commonwealth System Of Higher Education, Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
AU2003248747A1 (en) 2002-06-27 2004-01-19 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
EP1606291A2 (de) * 2002-07-02 2005-12-21 Health Research, Inc. Effiziente synthese von pyropheophorbid-a und seiner derivate
JP3887588B2 (ja) * 2002-08-30 2007-02-28 株式会社リガク X線回折による応力測定法
US20040127976A1 (en) * 2002-09-20 2004-07-01 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US20040059228A1 (en) * 2002-09-23 2004-03-25 Scimed Life Systems, Inc. Systems and methods for flushing catheters
AU2003290806A1 (en) * 2002-11-15 2004-06-15 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Variable curve catheter
WO2004087214A1 (en) 2003-03-28 2004-10-14 Conor Medsystems, Inc. Implantable medical device with beneficial agent concentration gradient
WO2004099158A1 (en) * 2003-04-30 2004-11-18 Ricerca Biosciences, Llc. Monocyclic diazodioxide based bcl-2 protein antagonists
US20040248877A1 (en) * 2003-04-30 2004-12-09 Sandeep Gupta Polycyclic diazodioxide-based Bcl-2 protein antagonists and use thereof
WO2004098565A2 (en) * 2003-05-02 2004-11-18 Surmodics, Inc. Implantable controlled release bioactive agent delivery device
CA2525547C (en) * 2003-05-14 2012-07-03 Torreypines Therapeutics, Inc. Compounds and uses thereof in modulating amyloid beta
US8916598B2 (en) 2003-05-30 2014-12-23 Proteotech Inc Compounds, compositions, and methods for the treatment of β-amyloid diseases and synucleinopathies
US20040249364A1 (en) * 2003-06-03 2004-12-09 Ilya Kaploun Device and method for dispensing medication to tissue lining a body cavity
US7169179B2 (en) * 2003-06-05 2007-01-30 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
US20040260271A1 (en) * 2003-06-18 2004-12-23 Huyser Richard F. Extended fenestration catheter with internal coil and method of making the same
US7057100B2 (en) * 2003-06-26 2006-06-06 The J.C. Robinson Seed Co. Inbred corn line W23129
US7785653B2 (en) 2003-09-22 2010-08-31 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US20050101938A1 (en) * 2003-11-06 2005-05-12 Leiboff Arnold R. Guidewire for use in colonic irrigation
WO2005090370A1 (en) 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
WO2005112913A1 (en) 2004-05-20 2005-12-01 The Scripps Research Institute Transthyretin stabilization
EP1765332A2 (de) * 2004-06-17 2007-03-28 Cengent Therapeutics, Inc. Trisubstituierte stickstoffmodulatoren von tyrosin-phosphatasen
EP1786421A2 (de) * 2004-07-09 2007-05-23 Cengent Therapeutics, Inc. Sauerstoff/stickstoff-heterozyklus-hemmer von tyrosinphosphatasen
FR2873016B1 (fr) * 2004-07-15 2006-09-29 Pierre Marcel Bourgogne Protheses vasculaires artificielles delivrant en permanence des produits actifs empechant toute stenose, thrombose, proliferation cellulaire, etc.. d'acces aise permanent pour toute intervention
US20060063930A1 (en) * 2004-08-20 2006-03-23 Agoston Gregory E Compositions and methods comprising proteinase activated receptor antagonists
WO2006028970A1 (en) * 2004-09-02 2006-03-16 Cengent Therapeutics, Inc. Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases
EP2433634A3 (de) 2004-09-17 2012-07-18 The Whitehead Institute for Biomedical Research Verbindungen, Zusammensetzungen und Verfahren zur Verhinderung einer A-Synuklein-Vergiftung
US20060067889A1 (en) * 2004-09-27 2006-03-30 Light Sciences Corporation Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted PDT agents
US20080140187A1 (en) * 2004-10-15 2008-06-12 Krause Arthur A Anti-clotting, anti-microbial, anti-inflammatory medical stent
WO2006063199A2 (en) 2004-12-09 2006-06-15 The Foundry, Inc. Aortic valve repair
US8983582B2 (en) * 2004-12-20 2015-03-17 Advanced Cardiovascular Systems, Inc. Methods and apparatuses for positioning within an internal channel
US8377041B2 (en) 2005-02-28 2013-02-19 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
US8222257B2 (en) 2005-04-01 2012-07-17 The Regents Of The University Of California Phosphono-pent-2-en-1-yl nucleosides and analogs
US20060229573A1 (en) * 2005-04-08 2006-10-12 Mckinley Medical L.L.L.P. Adjustable infusion catheter
US8343040B2 (en) 2005-05-04 2013-01-01 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US7780650B2 (en) 2005-05-04 2010-08-24 Spirus Medical, Inc. Rotate-to-advance catheterization system
US8235942B2 (en) 2005-05-04 2012-08-07 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US8317678B2 (en) 2005-05-04 2012-11-27 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US8414477B2 (en) 2005-05-04 2013-04-09 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US7396366B2 (en) 2005-05-11 2008-07-08 Boston Scientific Scimed, Inc. Ureteral stent with conforming retention structure
WO2007002109A2 (en) * 2005-06-20 2007-01-04 The Regents Of The University Of California Multidentate pyrone-derived chelators for medicinal imaging and chelation
EP1898981B1 (de) * 2005-06-27 2014-04-16 Cook Medical Technologies LLC Dilatator zur durchführung eines perkutanen medizinischen eingriffs
US9101949B2 (en) * 2005-08-04 2015-08-11 Eilaz Babaev Ultrasonic atomization and/or seperation system
US20070031611A1 (en) * 2005-08-04 2007-02-08 Babaev Eilaz P Ultrasound medical stent coating method and device
US8801694B2 (en) * 2005-08-11 2014-08-12 Massachusetts Institute Of Technology Intravesical drug delivery device
US7896539B2 (en) * 2005-08-16 2011-03-01 Bacoustics, Llc Ultrasound apparatus and methods for mixing liquids and coating stents
US8492428B2 (en) * 2005-09-20 2013-07-23 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
US7540881B2 (en) * 2005-12-22 2009-06-02 Boston Scientific Scimed, Inc. Bifurcation stent pattern
US8138361B2 (en) * 2005-12-28 2012-03-20 The Trustees Of The University Of Pennsylvania C-10 carbamates of taxanes
US8435229B2 (en) 2006-02-28 2013-05-07 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US8574220B2 (en) 2006-02-28 2013-11-05 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
KR101419554B1 (ko) * 2006-03-13 2014-07-17 교린 세이야꾸 가부시키 가이샤 Gsk­3 억제제로서 아미노퀴놀론
WO2007126841A2 (en) * 2006-03-29 2007-11-08 Foldrx Pharmaceuticals, Inc. Inhibition of alpha-synuclein toxicity
WO2007126344A1 (en) * 2006-04-27 2007-11-08 St. Jude Medical Ab Implantable medical device with releasing compound
TW201343676A (zh) 2006-08-28 2013-11-01 Kyowa Hakko Kirin Co Ltd 具拮抗性之人類light專一性人類單株抗體
US7547323B2 (en) * 2006-08-29 2009-06-16 Sinexus, Inc. Stent for irrigation and delivery of medication
DK2066662T3 (da) 2006-09-21 2013-01-07 Kyorin Seiyaku Kk Serinhydrolaseinhibitorer
WO2008042311A1 (en) * 2006-09-28 2008-04-10 Nmt Medical. Inc. Perforated expandable implant recovery sheath
US7951191B2 (en) * 2006-10-10 2011-05-31 Boston Scientific Scimed, Inc. Bifurcated stent with entire circumferential petal
US20080140176A1 (en) * 2006-10-18 2008-06-12 Krause Arthur A Medical stent and devices for localized treatment of disease
CA2666149A1 (en) 2006-10-19 2008-04-24 Auspex Pharmaceuticals, Inc. Substituted indoles
US8287519B2 (en) * 2006-10-27 2012-10-16 Smith Tech Innovations, Llc Self-cleansing bladder drainage catheter
WO2008057604A2 (en) * 2006-11-08 2008-05-15 The Regents Of The University Of California Small molecule therapeutics, syntheses of analogues and derivatives and methods of use
US7842082B2 (en) * 2006-11-16 2010-11-30 Boston Scientific Scimed, Inc. Bifurcated stent
US8419710B2 (en) * 2006-12-06 2013-04-16 Medtronic, Inc. Methods for infusing fluids via an implantable infusion system
US20080142616A1 (en) * 2006-12-15 2008-06-19 Bacoustics Llc Method of Producing a Directed Spray
CA2673566A1 (en) 2006-12-19 2008-06-26 Auspex Pharmaceuticals, Inc. Preparation and utility of ccr5 inhibitors
KR20090086115A (ko) * 2006-12-22 2009-08-10 엔싸이시브 파마슈티칼즈 인코퍼레이티드 C3a 수용체의 조정제 및 이의 사용 방법
WO2008106167A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
JP2010520200A (ja) * 2007-02-28 2010-06-10 クオナトウス ファーマシューティカルズ,インコーポレイテッド 特定のマトリックスメタロプロテイナーゼ(mmp)阻害剤を使用する肝疾患を治療する方法
AR065728A1 (es) 2007-03-15 2009-06-24 Auspex Pharmaceuticals Inc Fenetilaminas sustituidas con actividad de serotoninergico y/o norepinefrinergico
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
CN101678169A (zh) 2007-03-19 2010-03-24 茵苏莱恩医药有限公司 药物输送设备
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
WO2008122048A2 (en) * 2007-04-02 2008-10-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Removal of contrast agents from blood
US7892776B2 (en) 2007-05-04 2011-02-22 The Regents Of The University Of California Screening assay to identify modulators of protein kinase A
US20080281291A1 (en) * 2007-05-07 2008-11-13 Claude Tihon Drainage/irrigation urethral catheter
US20120149985A1 (en) * 2007-05-18 2012-06-14 Frassica James J Rotate-to-advance catheterization system
US8870755B2 (en) 2007-05-18 2014-10-28 Olympus Endo Technology America Inc. Rotate-to-advance catheterization system
US8721711B2 (en) * 2007-06-20 2014-05-13 Oregon Health & Science University Graft having microporous membrane for uniform fluid infusion
CN105943208B (zh) 2007-06-25 2019-02-15 微仙美国有限公司 自扩展假体
WO2009009367A2 (en) 2007-07-06 2009-01-15 Allievion Medical, Inc. Constrained fluid delivery device
MX2010000465A (es) * 2007-07-12 2010-08-30 Tragara Pharmaceuticals Inc Metodos y composiciones para el tratamiento de cancer, tumores y alteraciones relacionadas con tumores.
US7780095B2 (en) 2007-07-13 2010-08-24 Bacoustics, Llc Ultrasound pumping apparatus
US7753285B2 (en) 2007-07-13 2010-07-13 Bacoustics, Llc Echoing ultrasound atomization and/or mixing system
JP5426552B2 (ja) * 2007-09-11 2014-02-26 杏林製薬株式会社 Gsk−3阻害剤としてのシアノアミノキノロン及びテトラゾロアミノキノロン
US8476261B2 (en) 2007-09-12 2013-07-02 Kyorin Pharmaceutical Co., Ltd. Spirocyclic aminoquinolones as GSK-3 inhibitors
US7959669B2 (en) * 2007-09-12 2011-06-14 Boston Scientific Scimed, Inc. Bifurcated stent with open ended side branch support
US8100855B2 (en) 2007-09-17 2012-01-24 Abbott Cardiovascular Systems, Inc. Methods and devices for eluting agents to a vessel
US20090076591A1 (en) * 2007-09-19 2009-03-19 Boston Scientific Scimed, Inc. Stent Design Allowing Extended Release of Drug and/or Enhanced Adhesion of Polymer to OD Surface
US20090264421A1 (en) * 2007-10-05 2009-10-22 Bible Keith C Methods and Compositions for Treating Cancer
EP2205226B1 (de) * 2007-10-09 2020-05-13 Université Paris Descartes Vorrichtung zur verabreichung von zellen
EP2222160B1 (de) * 2007-11-21 2015-03-18 Pharmaxis Ltd. Halogenallylaminhemmer der ssao/vap-1 und ihre verwendungen
US7833266B2 (en) 2007-11-28 2010-11-16 Boston Scientific Scimed, Inc. Bifurcated stent with drug wells for specific ostial, carina, and side branch treatment
NZ585449A (en) 2007-12-11 2012-07-27 Massachusetts Inst Technology Implantable drug delivery device and methods for treatment of the bladder and other body vestcles or lumens
US8808255B2 (en) * 2007-12-14 2014-08-19 Oregon Health & Science University Drug delivery cuff
US8409133B2 (en) 2007-12-18 2013-04-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
US8277501B2 (en) * 2007-12-21 2012-10-02 Boston Scientific Scimed, Inc. Bi-stable bifurcated stent petal geometry
US8221494B2 (en) 2008-02-22 2012-07-17 Endologix, Inc. Apparatus and method of placement of a graft or graft system
US8196279B2 (en) 2008-02-27 2012-06-12 C. R. Bard, Inc. Stent-graft covering process
WO2009111611A2 (en) * 2008-03-05 2009-09-11 Proteotech Inc. Compounds, compositions and methods for the treatment of islet amyloid polypeptide (iapp) accumulation in diabetes
SI2947072T1 (sl) 2008-03-17 2017-03-31 Ambit Biosciences Corporation 1-(3-(6,7-dimetoksikinazolin-4-iloksi)fenil)-3-(5-1,1,1-trifluoro-2- metilpropan-2-il)izoksazol-3-il)urea kot modulator raf kinaze pri zdravljenju rakavih bolezni
US20090240318A1 (en) * 2008-03-19 2009-09-24 Boston Scientific Scimed, Inc. Stent expansion column, strut and connector slit design
US20090275918A1 (en) * 2008-05-01 2009-11-05 Stemcor Systems, Inc. Pancreatic delivery catheter
US8932340B2 (en) * 2008-05-29 2015-01-13 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
MX2010013282A (es) 2008-06-04 2010-12-21 Talecris Biotherapeutics Inc Composicion, metodo y kit para la preparacion de plasmina.
CA2733468C (en) 2008-08-09 2017-12-05 Massachusetts Institute Of Technology Implantable drug delivery device and methods of treating male genitourinary and surrounding tissues
US20120034156A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
CN101658533A (zh) * 2008-08-29 2010-03-03 首都医科大学宣武医院 抗肿瘤药物的干细胞递送
WO2010030728A2 (en) * 2008-09-12 2010-03-18 Boston Scientific Scimed, Inc. Devices and systems for delivery of therapeutic agents to body lumens
WO2010036541A1 (en) * 2008-09-24 2010-04-01 Cook Incorporated Catheter system having variable stiffness
EP2346559B1 (de) * 2008-10-09 2013-08-28 Nyxx Technologies Limited Medizinische vorrichtung
WO2010059364A2 (en) * 2008-10-30 2010-05-27 Epitek, Inc. Method and apparatus for sub-xiphoid delivery of therapeutic agents
RU2532893C2 (ru) 2008-11-07 2014-11-10 Инсьюлин Медикал Лтд. Устройство и способ доставки лекарственных средств
WO2010088450A2 (en) 2009-01-30 2010-08-05 Celladon Corporation Methods for treating diseases associated with the modulation of serca
US8568793B2 (en) 2009-02-11 2013-10-29 Hope Medical Enterprises, Inc. Sodium nitrite-containing pharmaceutical compositions
KR20110124787A (ko) * 2009-02-27 2011-11-17 암비트 바이오사이언시즈 코포레이션 Jak 키나아제 조절 퀴나졸린 유도체 및 이의 사용 방법
PL2403865T3 (pl) 2009-03-03 2016-01-29 Grifols Therapeutics Inc Sposoby wytwarzania plazminogenu
US8193372B2 (en) 2009-03-04 2012-06-05 Idenix Pharmaceuticals, Inc. Phosphothiophene and phosphothiazole HCV polymerase inhibitors
EP2406266B1 (de) * 2009-03-11 2013-12-25 Kyorin Pharmaceutical Co., Ltd. 7-cycloalkylaminochinolone als gsk-3-hemmer
CA2754909A1 (en) 2009-03-11 2010-09-16 Ambit Biosciences Corp. Combination of an indazolylaminopyrrolotriazine and taxane for cancer treatment
TW201038567A (en) 2009-03-27 2010-11-01 Pathway Therapeutics Ltd Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
WO2010110686A1 (en) 2009-03-27 2010-09-30 Pathway Therapeutics Limited Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
AR078120A1 (es) 2009-04-22 2011-10-19 Axikin Pharmaceuticals Inc Antagonistas de ccr3 de arilsulfonamida 2,5-disustituida y composiciones farmaceuticas
ES2474615T3 (es) 2009-04-22 2014-07-09 Axikin Pharmaceuticals, Inc. Antagonistas de CCR3 arilsulfonamidas 2,5-disustituidas
RU2539591C2 (ru) 2009-04-22 2015-01-20 Аксикин Фармасьютикалз, Инк. Антагонисты арилсульфонамида ccr3
US20110054586A1 (en) 2009-04-28 2011-03-03 Endologix, Inc. Apparatus and method of placement of a graft or graft system
US20100292641A1 (en) * 2009-05-15 2010-11-18 Bandula Wijay Targeted drug delivery device and method
SG177360A1 (en) 2009-06-26 2012-02-28 Taris Biomedical Inc Implantable drug delivery devices and methods of making the same
WO2011003870A2 (en) 2009-07-06 2011-01-13 Creabilis S.A. Mini-pegylated corticosteroids, compositions including same, and methods of making and using same
WO2011005119A1 (en) 2009-07-07 2011-01-13 Pathway Therapeutics Limited Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
AU2010270605B2 (en) 2009-07-08 2014-07-31 Hope Medical Enterprises, Inc. Dba Hope Pharmaceuticals Sodium thiosulfate-containing pharmaceutical compositions
US20110022026A1 (en) * 2009-07-21 2011-01-27 Lake Region Manufacturing, Inc. d/b/a Lake Region Medical. Inc. Methods and Devices for Delivering Drugs Using Drug-Delivery or Drug-Coated Guidewires
US8404728B2 (en) 2009-07-30 2013-03-26 Mayo Foundation For Medical Education And Research Small-molecule botulinum toxin inhibitors
EP2461811B1 (de) 2009-08-05 2016-04-20 Idenix Pharmaceuticals LLC. Makrocyclische serinproteasehemmer gegen virale infektionen, im besonderen hvc
CA2770454A1 (en) 2009-08-19 2011-02-24 Ambit Biosciences Corporation Biaryl compounds and methods of use thereof
US9017312B2 (en) 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
WO2011056566A2 (en) 2009-10-26 2011-05-12 Sunesis Pharmaceuticals, Inc. Compounds and methods for treatment of cancer
WO2011056764A1 (en) 2009-11-05 2011-05-12 Ambit Biosciences Corp. Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles
EP2499282B1 (de) 2009-11-09 2015-04-22 NeuroGenetic Pharmaceuticals, Inc. Gamma-sekretase-modulierende verbindungen, verfahren zu ihrer identifikation und verwendungen dafür
WO2011069002A1 (en) 2009-12-02 2011-06-09 Alquest Therapeutics, Inc. Organoselenium compounds and uses thereof
EP2513113B1 (de) 2009-12-18 2018-08-01 Idenix Pharmaceuticals LLC Auf 5,5-kondensiertem arylen oder heteroarylen basierende hepatitis-c-virus-hemmer
EP2515654A4 (de) * 2009-12-23 2013-04-24 Map Pharmaceuticals Inc Neue ergolinanaloga
WO2011094890A1 (en) 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
EP2542542B1 (de) 2010-03-02 2015-04-22 Axikin Pharmaceuticals, Inc. Isotopisch angereicherte arylsulfonamid-ccr3-antagonisten
WO2011112689A2 (en) 2010-03-11 2011-09-15 Ambit Biosciences Corp. Saltz of an indazolylpyrrolotriazine
TW201134820A (en) 2010-03-17 2011-10-16 Axikin Pharmaceuticals Inc Arylsulfonamide CCR3 antagonists
EP2566559B1 (de) 2010-05-05 2019-12-18 Cook Medical Technologies LLC Turbulator zur förderung der aufnahme eines therapeutikums
WO2011140177A1 (en) * 2010-05-05 2011-11-10 Cook Medical Technologies Llc Intraluminal treatment apparatus, wire guide and treatment fluid delivery method
US9265913B2 (en) 2010-09-22 2016-02-23 Vital 5, Llc Catheter assembly
WO2011150198A1 (en) 2010-05-27 2011-12-01 Ambit Biosciences Corporation Azolyl urea compounds and methods of use thereof
WO2011150201A2 (en) 2010-05-27 2011-12-01 Ambit Biosciences Corporation Azolyl amide compounds and methods of use thereof
WO2011153199A1 (en) 2010-06-01 2011-12-08 Biotheryx, Inc. Methods of treating hematologic malignancies using 6-cyclohexyl-1-hydroxy-4-methyl-2(1h)-pyridone
WO2011153197A1 (en) 2010-06-01 2011-12-08 Biotheryx, Inc. Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating proliferative diseases
JP5855095B2 (ja) 2010-06-07 2016-02-09 ノボメディックス,エルエルシーNovomedix,Llc フラニル化合物およびその使用
US9403815B2 (en) 2010-06-24 2016-08-02 The Regents Of The University Of California Compounds and uses thereof in modulating levels of various amyloid beta peptide alloforms
WO2012012370A1 (en) 2010-07-19 2012-01-26 Summa Health System Vitamin c and chromium-free vitamin k, and compositions thereof for treating an nfkb-mediated condition or disease
WO2012030924A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Azolopyridine and azolopyrimidine compounds and methods of use thereof
US20130296363A1 (en) 2010-09-01 2013-11-07 Ambit Biosciences Corporation Quinoline and isoquinoline derivatives for use as jak modulators
US20130225615A1 (en) 2010-09-01 2013-08-29 Ambit Biosciences Corporation 2-cycloquinazoline derivatives and methods of use thereof
US8703943B2 (en) 2010-09-01 2014-04-22 Ambit Biosciences Corporation Optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
US20130225614A1 (en) 2010-09-01 2013-08-29 Ambit Biosciences Corporation 4-azolylaminoquinazoline derivatives and methods of use thereof
WO2012030912A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation 7-cyclylquinazoline derivatives and methods of use thereof
ES2619850T3 (es) 2010-09-01 2017-06-27 Ambit Biosciences Corporation Sales de hidrobromuro de una pirazolilaminoquinazolina
WO2012030894A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Thienopyridine and thienopyrimidine compounds and methods of use thereof
EP2611502A1 (de) 2010-09-01 2013-07-10 Ambit Biosciences Corporation Adenosin-a3-rezeptormodulierende verbindungen und ihre verwendung
WO2012030948A1 (en) 2010-09-01 2012-03-08 Ambit Biosciences Corporation Quinazoline compounds and methods of use thereof
US9446224B2 (en) 2010-09-22 2016-09-20 Vital 5, L.L.C. Barrier catheter
IT1402059B1 (it) * 2010-09-29 2013-08-28 Rand Srl Sistema indossabile per eseguire terapie depurative di fluidi organici con l'impiego di circuiti extracorporei
WO2012044641A1 (en) 2010-09-29 2012-04-05 Pathway Therapeutics Inc. 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
MX2013003954A (es) 2010-10-11 2013-08-01 Axikin Pharmaceuticals Inc Sales de arilsulfonamida antagonistas de ccr3.
TWI556849B (zh) 2010-10-21 2016-11-11 美敦力阿福盧森堡公司 用於腎臟神經協調的導管裝置
RU2013118107A (ru) 2010-10-25 2014-12-10 Медтроник Ардиан Люксембург С.А.Р.Л. Катетерные устройства, содержащие группы из нескольких электродов, для почечной нейромодуляции и соответствующие системы и способы
JP6261339B2 (ja) 2010-11-02 2018-01-17 エンドロジックス、インク グラフトまたはグラフトシステムの配置の器具および方法
EP2648676A4 (de) 2010-12-06 2016-05-04 Follica Inc Verfahren zur behandlung von kahlköpfigkeit und zur förderung des haarwuchses
WO2012080050A1 (en) 2010-12-14 2012-06-21 F. Hoffmann-La Roche Ag Solid forms of a phenoxybenzenesulfonyl compound
RU2620032C2 (ru) 2011-01-10 2017-05-22 Аллерган, Инк. Схема приема лидокаина для применения в продолжительном лечении боли в мочевом пузыре и раздражения при мочеиспускании
AR085091A1 (es) 2011-01-26 2013-09-11 Kolltan Pharmaceuticals Inc Anticuerpos anti-kit y sus usos
US10052459B2 (en) * 2011-01-28 2018-08-21 Cook Medical Technologies Llc Catheter assembly and method
CA2825152A1 (en) 2011-01-31 2012-08-09 Celgene Corporation Pharmaceutical compositions of cytidine analogs and methods of use thereof
ES2637388T3 (es) 2011-02-04 2017-10-13 Taris Biomedical, Inc. Dispositivo implantable para la liberación controlada de un fármaco de baja solubilidad
WO2012109398A1 (en) 2011-02-10 2012-08-16 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating hcv infections
DK2691384T3 (en) 2011-03-28 2017-01-16 Mei Pharma Inc (ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEMSELVES AND THEIR SUBSTANCES CONCERNING THE USE OF THE USE
US20140088103A1 (en) 2011-03-28 2014-03-27 Mei Pharma, Inc. (fused ring arylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
JP2014509648A (ja) 2011-03-28 2014-04-21 メイ プハルマ,インコーポレーテッド (α−置換シクロアルキルアミノ及びヘテロシクリルアミノ)ピリミジニル及び1,3,5−トリアジニルベンズイミダゾール、その医薬組成物、並びに増殖性疾患の治療におけるそれらの使用
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
US11166660B2 (en) * 2011-04-05 2021-11-09 Pharmasens Ag Dermally affixed device for intravenous access
CN103517731B (zh) 2011-04-08 2016-08-31 柯惠有限合伙公司 用于去除肾交感神经和离子电渗式药物传递的离子电渗式药物传递系统和方法
JP5938095B2 (ja) * 2011-04-20 2016-06-22 キナメッド・インコーポレーテッド 手術用ケーブルまたは縫合糸のための形状付与可能なパッサー
JP2014517076A (ja) 2011-06-23 2014-07-17 マップ・ファーマシューティカルズ・インコーポレイテッド 新規のフルオロエルゴリン類似体
CN103702707B (zh) * 2011-08-08 2016-03-30 奥林巴斯株式会社 处理器具
WO2013037482A1 (en) 2011-09-15 2013-03-21 Phenex Pharmaceuticals Ag Farnesoid x receptor agonists for cancer treatment and prevention
USD679804S1 (en) 2011-09-22 2013-04-09 Vital 5, Llc Catheter
US20130085468A1 (en) * 2011-10-03 2013-04-04 Yuri Buydenok Catheter with body wall separator
MX368081B (es) 2011-10-14 2019-09-19 Ambit Biosciences Corp Compuestos heterociclicos y uso de los mismos como moduladores del receptor de tirosina cinasas tipo iii.
WO2013095707A1 (en) 2011-12-19 2013-06-27 Map Pharmaceuticals, Inc. Novel iso-ergoline derivatives
EP2793583A4 (de) 2011-12-21 2015-08-12 Map Pharmaceuticals Inc Neuartige neuromodulatorische verbindungen
WO2013130600A1 (en) 2012-02-29 2013-09-06 Ambit Biosciences Corporation Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith
AR092809A1 (es) 2012-03-16 2015-05-06 Axikin Pharmaceuticals Inc 3,5-diaminopirazol como inhibidor de quinasa
WO2013142333A1 (en) * 2012-03-19 2013-09-26 Cook Medical Technologies Llc Medical devices, methods and kits for delivering medication to a bodily passage
US10258791B2 (en) 2012-04-27 2019-04-16 Medtronic Ardian Luxembourg S.A.R.L. Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods
SG11201406948PA (en) 2012-05-02 2014-11-27 Boehringer Ingelheim Int Substituted 3-haloallylamine inhibitors of ssao and uses thereof
ES2614272T3 (es) 2012-05-11 2017-05-30 Medtronic Ardian Luxembourg S.à.r.l. Conjuntos de catéter de múltiples electrodos para neuromodulación renal y sistemas y métodos asociados
EP2861562B1 (de) 2012-06-14 2018-05-09 Mayo Foundation For Medical Education And Research Pyrazolderivate als hemmer von stat3
US9878132B2 (en) 2012-06-15 2018-01-30 W. L. Gore & Associates, Inc. Vascular occlusion and drug delivery devices, systems, and methods
US9012640B2 (en) 2012-06-22 2015-04-21 Map Pharmaceuticals, Inc. Cabergoline derivatives
DK3381943T3 (da) 2012-07-25 2022-05-16 Celldex Therapeutics Inc Anti-kit-antistoffer og anvendelser deraf
US9074186B2 (en) 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
US9156799B2 (en) 2012-09-07 2015-10-13 Axikin Pharmaceuticals, Inc. Isotopically enriched arylsulfonamide CCR3 antagonists
WO2014055647A1 (en) 2012-10-03 2014-04-10 Mei Pharma, Inc. (sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases
US9044575B2 (en) 2012-10-22 2015-06-02 Medtronic Adrian Luxembourg S.a.r.l. Catheters with enhanced flexibility and associated devices, systems, and methods
US20150272924A1 (en) 2012-11-08 2015-10-01 Summa Health System Vitamin c, vitamin k, a polyphenol, and combinations thereof for wound healing
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
WO2014085633A1 (en) 2012-11-30 2014-06-05 Novomedix, Llc Substituted biaryl sulfonamides and the use thereof
EP2928520B1 (de) 2012-12-07 2019-01-16 Cook Medical Technologies LLC System zum vermindern von lokalem unwohlsein
US9169214B2 (en) 2012-12-21 2015-10-27 The Board Of Trustees Of The Leland Stanford Junior University Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions
SG11201504931SA (en) 2012-12-21 2015-07-30 Map Pharmaceuticals Inc Novel methysergide derivatives
NZ630746A (en) 2013-01-11 2017-02-24 Summa Health System Vitamins c and k for treating polycystic diseases
CN109432543A (zh) * 2013-01-15 2019-03-08 A.V.医疗科技有限公司 具有导丝阀调的输注导管
US20140228801A1 (en) * 2013-02-12 2014-08-14 Gary Keeling Body cavity drainage device and methods for using the same
WO2014165263A1 (en) 2013-03-12 2014-10-09 The Regents Of The University Of California, A California Corporation Gamma-secretase modulators
US9179974B2 (en) 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
BR112015022433B1 (pt) 2013-03-15 2022-06-21 Taris Biomedical Llc Dispositivo de liberação de droga intravesical
US10548663B2 (en) 2013-05-18 2020-02-04 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters with shafts for enhanced flexibility and control and associated devices, systems, and methods
KR101548046B1 (ko) * 2013-06-05 2015-09-04 이근호 감염 방지구조의 소아용 요도 삽입용 카테타
WO2014197849A2 (en) 2013-06-06 2014-12-11 Igenica Biotherapeutics, Inc. Anti-c10orf54 antibodies and uses thereof
PT3035991T (pt) 2013-08-19 2020-10-06 Taris Biomedical Llc Métodos e dispositivos de unidades múltiplas para administração de fármacos
KR20160055170A (ko) 2013-08-30 2016-05-17 암비트 바이오사이언시즈 코포레이션 바이아릴 아세트아미드 화합물 및 이의 사용 방법
US20150073515A1 (en) 2013-09-09 2015-03-12 Medtronic Ardian Luxembourg S.a.r.I. Neuromodulation Catheter Devices and Systems Having Energy Delivering Thermocouple Assemblies and Associated Methods
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
EP3046924A1 (de) 2013-09-20 2016-07-27 IDENIX Pharmaceuticals, Inc. Inhibitoren des hepatitis-c-virus
US10517892B2 (en) 2013-10-22 2019-12-31 Medtronic Minimed, Inc. Methods and systems for inhibiting foreign-body responses in diabetic patients
US11116948B2 (en) 2014-01-08 2021-09-14 A.V. Medical Technologies, Ltd Devices and methods for imaging and treating blood vessels
WO2015113034A1 (en) 2014-01-27 2015-07-30 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation catheters having jacketed neuromodulation elements and related devices, systems, and methods
WO2015123320A1 (en) * 2014-02-11 2015-08-20 All Cape Gynecology Llc Endocyte cannula
EP3110974A4 (de) 2014-02-24 2018-01-24 Celgene Corporation Verfahren zur verwendung eines aktivators von cereblon für neuronale zellexpansion und behandlung von erkrankungen des zentralnervensystems
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US20170066779A1 (en) 2014-03-05 2017-03-09 Idenix Pharmaceuticals Llc Solid forms of a flaviviridae virus inhibitor compound and salts thereof
JP6568926B2 (ja) 2014-03-20 2019-08-28 カペラ セラピューティクス,インコーポレーテッド 癌の治療のためのerbbチロシンキナーゼ阻害剤としてのベンゾイミダゾール誘導体
DK3119762T3 (da) 2014-03-20 2021-08-30 Capella Therapeutics Inc Benzimidazol-derivater som erbb-tyrosin-kinase-inhibitorer til behandlingen af kræft
EP4371512A2 (de) 2014-04-24 2024-05-22 Medtronic Ardian Luxembourg S.à.r.l. Neuromodulationskatheter mit geflochtenen wellen sowie zugehörige systeme und verfahren
CN106470679A (zh) 2014-05-12 2017-03-01 科内图斯医药公司 用半胱天冬酶抑制剂治疗慢性肝脏疾病并发症
US11000658B2 (en) 2014-05-18 2021-05-11 Awair, Inc. Device to reduce discomfort in the upper airway
PT3148579T (pt) 2014-05-28 2021-03-11 Ludwig Inst For Cancer Res Ltd Anticorpos anti-gitr e métodos da sua utilização
US9527815B2 (en) 2014-06-18 2016-12-27 Biotheryx, Inc. Hydroxypyridone derivatives, pharmaceutical compositions thereof, and their therapeutic use for treating inflammatory, neurodegenerative, or immune-mediated diseases
US9499514B2 (en) 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
US20160045609A1 (en) 2014-08-14 2016-02-18 Mamoun M. Alhamadsheh Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life
US20170319548A1 (en) 2014-09-12 2017-11-09 Tobira Therapeutics, Inc. Cenicriviroc combination therapy for the treatment of fibrosis
US20170354639A1 (en) 2014-10-24 2017-12-14 Biogen Ma Inc. Diterpenoid derivatives and methods of use thereof
MX2017005715A (es) 2014-10-31 2018-02-23 Massachusetts Gen Hospital Potentes moduladores de gamma-secretasa.
EP3229838B1 (de) 2014-12-11 2020-09-09 Pierre Fabre Medicament Anti-c10orf54-antikörper und verwendungen davon
WO2016106221A1 (en) 2014-12-22 2016-06-30 The Rockefeller University Anti-mertk agonistic antibodies and uses thereof
WO2016106309A1 (en) 2014-12-23 2016-06-30 Axikin Pharmaceuticals, Inc. 3,5-diaminopyrazole kinase inhibitors
CA2974113A1 (en) 2015-01-20 2016-07-28 Xoc Pharmaceuticals, Inc. Isoergoline compounds and uses thereof
WO2016118541A1 (en) 2015-01-20 2016-07-28 Xoc Pharmaceuticals, Inc Ergoline compounds and uses thereof
JP6501896B2 (ja) 2015-01-28 2019-04-17 ジェイ・エヌ・セラピューティクスJn Therapeutics 置換イミダゾ[1,2−a]ピリジン−2−イルアミン化合物ならびにその医薬組成物および使用方法
CN114504651A (zh) 2015-03-03 2022-05-17 科马布有限公司 抗体、用途和方法
WO2016172704A1 (en) 2015-04-23 2016-10-27 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
CA2986765A1 (en) 2015-05-29 2016-12-08 Agenus Inc. Anti-ctla-4 antibodies and methods of use thereof
JP6919099B2 (ja) 2015-06-23 2021-08-18 ニューロクライン バイオサイエンシーズ,インコーポレイテッド 神経学的疾患または障害を処置するためのvmat2阻害剤
JP2018524025A (ja) 2015-06-30 2018-08-30 エンドロジックス、インク ガイドワイヤを送出システムに結合するためのロックアセンブリ
US10493232B2 (en) 2015-07-20 2019-12-03 Strataca Systems Limited Ureteral catheters, bladder catheters, systems, kits and methods for inducing negative pressure to increase renal function
US10765834B2 (en) 2015-07-20 2020-09-08 Strataca Systems Limited Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
US11541205B2 (en) 2015-07-20 2023-01-03 Roivios Limited Coated urinary catheter or ureteral stent and method
US11229771B2 (en) 2015-07-20 2022-01-25 Roivios Limited Percutaneous ureteral catheter
US11040180B2 (en) 2015-07-20 2021-06-22 Strataca Systems Limited Systems, kits and methods for inducing negative pressure to increase renal function
US10926062B2 (en) 2015-07-20 2021-02-23 Strataca Systems Limited Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
US11040172B2 (en) 2015-07-20 2021-06-22 Strataca Systems Limited Ureteral and bladder catheters and methods of inducing negative pressure to increase renal perfusion
CN108136163B (zh) 2015-07-20 2021-05-04 斯卓特凯系统有限责任公司 输尿管和膀胱导管及引入负压以增加肾灌注的方法
US10512713B2 (en) 2015-07-20 2019-12-24 Strataca Systems Limited Method of removing excess fluid from a patient with hemodilution
US10918827B2 (en) 2015-07-20 2021-02-16 Strataca Systems Limited Catheter device and method for inducing negative pressure in a patient's bladder
KR20220131277A (ko) 2015-09-01 2022-09-27 아게누스 인코포레이티드 항-pd-1 항체 및 이를 이용하는 방법
EP3875459B1 (de) 2015-10-30 2023-12-13 Neurocrine Biosciences, Inc. Valbenazin-dihydrochloridsalze und polymorphe davon
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
US10112924B2 (en) 2015-12-02 2018-10-30 Astraea Therapeutics, Inc. Piperdinyl nociceptin receptor compounds
JP6869988B2 (ja) 2015-12-23 2021-05-12 ニューロクライン バイオサイエンシーズ,インコーポレイテッド (S)−(2R,3R,11bR)−3−イソブチル−9,10−ジメトキシ−2,3,4,6,7,11b−ヘキサヒドロ−1H−ピリド[2,1−a]イソキノリン−2−イル2−アミノ−3−メチルブタノエートジ(4−メチルベンゼンスルホネート)の調製のための合成方法
KR20180101418A (ko) 2015-12-31 2018-09-12 코나터스 파마슈티칼스, 인크. 간 질환의 치료에서의 카스파제 억제제의 사용 방법
JP7071922B2 (ja) 2016-01-08 2022-05-19 セルジーン コーポレイション 2-(4-クロロフェニル)-n-((2-(2,6-ジオキソピペリジン-3-イル)-1-オキソイソインドリン-5-イル)メチル)-2,2-ジフルオロアセトアミドの固体形態、ならびにそれらの薬学的組成物及び使用
AR107321A1 (es) 2016-01-08 2018-04-18 Celgene Corp Compuestos antiproliferativos, y sus composiciones farmacéuticas y usos
WO2017151836A1 (en) 2016-03-04 2017-09-08 East Carolina University J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
US10407437B2 (en) 2016-03-08 2019-09-10 Los Gatos Pharmaceuticals, Inc. Camptothecin derivatives and uses thereof
EP3426301A4 (de) 2016-03-08 2019-11-06 Los Gatos Pharmaceuticals, Inc. Verbundnanopartikel und verwendungen davon
EP3442940A1 (de) 2016-04-11 2019-02-20 Clexio Biosciences Ltd. Deuterierte ketaminderivate
WO2017180794A1 (en) 2016-04-13 2017-10-19 Skyline Antiinfectives, Inc. Deuterated o-sulfated beta-lactam hydroxamic acids and deuterated n-sulfated beta-lactams
EP3928717B1 (de) * 2016-04-15 2023-06-07 Temple University Of The Commonwealth System Of Higher Education Infusionskatheter
US20170319818A1 (en) * 2016-05-06 2017-11-09 Cook Medical Technologies Llc Drug delivery device
EP4190357A1 (de) 2016-05-13 2023-06-07 Institut Pasteur Hemmung von beta-2-nikotin-acetylcholinrezeptoren zur behandlung von morbus-alzheimer-pathologie
TWI753910B (zh) 2016-05-16 2022-02-01 美商拜歐斯瑞克斯公司 吡啶硫酮、其醫藥組合物及其治療增生性、炎性、神經退化性或免疫介導疾病之治療用途
AU2017271588B2 (en) 2016-05-27 2022-01-20 Agenus Inc. Anti-TIM-3 antibodies and methods of use thereof
US10543006B2 (en) * 2016-06-09 2020-01-28 Boston Scientific Scimed, Inc. Infusion catheter
MA45602A (fr) 2016-07-08 2019-05-15 Staten Biotechnology B V Anticorps anti-apoc3 et leurs méthodes d'utilisation
US10919904B2 (en) 2016-08-17 2021-02-16 North Carolina State University Northern-southern route to synthesis of bacteriochlorins
US20190201409A1 (en) 2016-09-19 2019-07-04 Mei Pharma, Inc. Combination therapy
SG10201912663YA (en) 2016-10-11 2020-03-30 Agenus Inc Anti-lag-3 antibodies and methods of use thereof
WO2018083248A1 (en) 2016-11-03 2018-05-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
US11332521B2 (en) 2016-11-07 2022-05-17 Neuracle Science Co., Ltd. Anti-family with sequence similarity 19, member A5 antibodies and method of use thereof
AU2017356926B2 (en) 2016-11-09 2024-01-04 Novomedix, Llc Nitrite salts of 1, 1-dimethylbiguanide, pharmaceutical compositions, and methods of use
WO2018089692A1 (en) 2016-11-09 2018-05-17 Phloronol, Inc. Eckol derivatives, methods of synthesis and uses thereof
US10836774B2 (en) 2016-11-30 2020-11-17 North Carolina State University Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
CN110191705A (zh) 2016-12-01 2019-08-30 亚尼塔公司 治疗癌症的方法
TW202345829A (zh) 2016-12-02 2023-12-01 美商紐羅克里生物科學有限公司 戊苯那嗪(valbenazine)於治療精神分裂症或情感性精神分裂症之用途
BR112019011582A2 (pt) 2016-12-07 2019-10-22 Agenus Inc. anticorpos e métodos de utilização dos mesmos
FI3551660T3 (fi) 2016-12-07 2023-12-11 Agenus Inc Anti-ctla-4-vasta-aineita ja niiden käyttömenetelmiä
JP7199360B2 (ja) 2017-01-27 2023-01-05 ニューロクライン バイオサイエンシーズ,インコーポレイテッド 特定のvmat2インヒビターを投与するための方法
JP7307681B2 (ja) 2017-02-17 2023-07-12 カムリス インターナショナル インコーポレイテッド 汎用性抗毒素
EA201991921A1 (ru) 2017-02-17 2020-02-06 Эйдос Терапьютикс, Инк. Способы получения ag-10, его промежуточных соединений и их солей
WO2018164996A1 (en) 2017-03-06 2018-09-13 Neurocrine Biosciences, Inc. Dosing regimen for valbenazine
SG11201908678XA (en) 2017-03-27 2019-10-30 Celgene Corp Methods and compositions for reduction of immunogenicity
BR112019017241A2 (pt) 2017-04-13 2020-04-14 Agenus Inc anticorpos anti-cd137 e métodos de uso dos mesmos
AU2018255938A1 (en) 2017-04-21 2019-10-31 Staten Biotechnology B.V. Anti-ApoC3 antibodies and methods of use thereof
WO2018200605A1 (en) 2017-04-26 2018-11-01 Neurocrine Biosciences, Inc. Use of valbenazine for treating levodopa-induced dyskinesia
DK3618863T3 (da) 2017-05-01 2023-08-21 Agenus Inc Anti-tigit-antistoffer og fremgangsmåder til anvendelse deraf
JOP20190219A1 (ar) 2017-05-09 2019-09-22 Cardix Therapeutics LLC تركيبات صيدلانية وطرق لعلاج أمراض القلب والأوعية الدموية
US10085999B1 (en) 2017-05-10 2018-10-02 Arixa Pharmaceuticals, Inc. Beta-lactamase inhibitors and uses thereof
JP2020522504A (ja) 2017-06-01 2020-07-30 エックスオーシー ファーマシューティカルズ インコーポレイテッドXoc Pharmaceuticals, Inc 多環式化合物およびそれらの用途
CA3067923A1 (en) 2017-06-27 2019-01-03 Neuracle Science Co., Ltd. Anti-fam19a5 antibodies and uses thereof
EP3645044A4 (de) 2017-06-27 2021-04-28 Neuracle Science Co., Ltd Verwendung von anti-familie mit sequenzähnlichkeit 19, element-a5-antikörpern zur behandlung von glaukom
WO2019003164A1 (en) 2017-06-27 2019-01-03 Neuracle Science Co., Ltd. USE OF ANTI-FAM19A5 ANTIBODIES FOR THE TREATMENT OF CANCERS
KR102340352B1 (ko) 2017-06-27 2021-12-21 주식회사 뉴라클사이언스 섬유증의 치료를 위한 항-fam19a5 항체의 용도
US10307566B2 (en) * 2017-07-05 2019-06-04 Duke University Drainage or infusion catheter and method of use
WO2019046556A1 (en) 2017-09-01 2019-03-07 East Carolina University COMPOUNDS, COMPOSITIONS, KITS AND METHODS FOR ACTIVATING IMMUNE CELLS AND / OR AN IMMUNE SYSTEM RESPONSE
EP3684333A2 (de) 2017-09-21 2020-07-29 Neurocrine Biosciences, Inc. Hochdosierte valbenazinformulierung und zusammensetzungen, verfahren und kits dazu
US20200230127A1 (en) 2017-10-10 2020-07-23 Neurocrine Biosciences, Inc. Methods for the Administration of Certain VMAT2 Inhibitors
US10993941B2 (en) 2017-10-10 2021-05-04 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
JP7039694B2 (ja) 2017-10-31 2022-03-22 スターテン・バイオテクノロジー・ベー・フェー 抗apoc3抗体およびその使用方法
US20210060299A1 (en) * 2017-12-28 2021-03-04 Avent, Inc. Incisional Tunneler
TW201929847A (zh) 2018-01-10 2019-08-01 美商克拉治療有限責任公司 包含二羧酸之醫藥組合物及其治療應用
WO2019139869A1 (en) 2018-01-10 2019-07-18 Cura Therapeutics Llc Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications
US11116561B2 (en) 2018-01-24 2021-09-14 Medtronic Ardian Luxembourg S.A.R.L. Devices, agents, and associated methods for selective modulation of renal nerves
WO2019183463A1 (en) 2018-03-23 2019-09-26 Eidos Therapeutics, Inc. Methods of treating ttr amyloidosis using ag10
AU2019259798A1 (en) 2018-04-24 2020-11-12 Neuracle Science Co., Ltd. Use of anti-family with sequence similarity 19, member A5 antibodies for the treatment of neuropathic pain
CA3098805A1 (en) 2018-05-10 2019-11-14 Neuracle Science Co., Ltd. Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof
SG11202011544UA (en) 2018-06-14 2020-12-30 Neurocrine Biosciences Inc Vmat2 inhibitor compounds, compositions, and methods relating thereto
EP3814327A1 (de) 2018-06-29 2021-05-05 Histogen, Inc. (s)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorphenoxy)pentansäure-derivate und verwandte verbindungen als caspase-inhibitoren zur behandlung kardiovaskulärer erkrankungen
MA53160A (fr) 2018-07-20 2021-05-26 Pf Medicament Récepteur pour vista
JP2021528481A (ja) 2018-08-15 2021-10-21 ニューロクライン バイオサイエンシーズ,インコーポレイテッド 特定のvmat2阻害剤を投与するための方法
CA3104695A1 (en) 2018-08-17 2020-02-20 Eidos Therapeutics, Inc. Formulations of ag10
CA3113575A1 (en) 2018-10-03 2020-04-09 Staten Biotechnology B.V. Antibodies specific for human and cynomolgus apoc3 and methods of use thereof
CN113365650A (zh) 2018-11-16 2021-09-07 新免疫技术有限公司 用il-7蛋白和免疫检查点抑制剂的组合治疗肿瘤的方法
KR20200071198A (ko) 2018-12-10 2020-06-19 네오이뮨텍, 인코퍼레이티드 Nrf2 발현 조절 기반 T 세포 항암면역치료법
WO2020132071A1 (en) 2018-12-19 2020-06-25 Shy Therapeutics. Llc Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and f1brotic disease
US11447468B2 (en) 2019-02-06 2022-09-20 Dice Alpha, Inc. IL-17 ligands and uses thereof
MA55080A (fr) 2019-02-26 2022-01-05 Inspirna Inc Anticorps anti-mertk à affinité élevée et utilisations associées
SG11202109700PA (en) 2019-03-07 2021-10-28 Conatus Pharmaceuticals Inc Caspase inhibitors and methods of use thereof
CA3138403A1 (en) 2019-05-20 2020-11-26 Christopher J. MACNEVIN Narrow emission dyes, compositions comprising same, and methods for making and using same
AU2020311404A1 (en) 2019-07-11 2022-03-03 Cura Therapeutics, Llc Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases
US20220274921A1 (en) 2019-07-11 2022-09-01 Cura Therapeutics, Llc Phenyl compounds and pharmaceutical compositions thereof, and their therapeutic applications
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
PE20221151A1 (es) 2019-08-30 2022-07-18 Agenus Inc Anticuerpos anti-cd96 y sus metodos de uso
KR20220101075A (ko) 2019-09-16 2022-07-19 다이스 알파, 인크. Il-17a 조절인자 및 이의 용도
CN114945409A (zh) 2020-01-13 2022-08-26 新免疫技术有限公司 用il-7蛋白和双特异性抗体的组合治疗肿瘤的方法
EP4093751A1 (de) 2020-01-22 2022-11-30 Outpace Bio, Inc. Chimäre polypeptide
EP4100045A1 (de) 2020-02-05 2022-12-14 Washington University Verfahren zur behandlung eines festen tumors mit einer kombination aus einem il-7-protein und car-tragenden immunzellen
US11529331B2 (en) 2020-05-29 2022-12-20 Boulder Bioscience Llc Methods for improved endovascular thrombectomy using 3,3′-diindolylmethane
WO2021257828A1 (en) 2020-06-18 2021-12-23 Shy Therapeutics, Llc Substituted thienopyrimidines that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
TW202227427A (zh) 2020-09-16 2022-07-16 美商拜歐斯瑞克斯公司 Sos1蛋白降解劑、其醫藥組合物及其治療應用
WO2022087335A1 (en) 2020-10-23 2022-04-28 Biotheryx, Inc. Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
WO2022094475A1 (en) 2020-11-02 2022-05-05 Neoimmunetech, Inc. Use of interleukin-7 for the treatment of coronavirus
EP4240408A1 (de) 2020-11-05 2023-09-13 Neoimmunetech, Inc. Verfahren zur behandlung eines tumors mit einer kombination aus einem il-7-protein und einem nukleotidimpfstoff
CA3201965A1 (en) 2020-12-14 2022-06-23 Kyle W.H. Chan Pde4 degraders, pharmaceutical compositions, and therapeutic applications
WO2022165000A1 (en) 2021-01-27 2022-08-04 Shy Therapeutics, Llc Methods for the treatment of fibrotic disease
US20240124483A1 (en) 2021-01-27 2024-04-18 Shy Therapeutics, Llc Methods for the Treatment of Fibrotic Disease
EP4304716A1 (de) 2021-03-10 2024-01-17 Dice Molecules Sv, Inc. Alpha-v-beta-6- und alpha-v-beta-1-integrinhemmer und verwendungen davon
EP4326721A1 (de) 2021-04-22 2024-02-28 Protego Biopharma, Inc. Spirocyclische imidazolidinone und imidazolidindione zur behandlung von leichtkettiger amyloidose
WO2022251533A1 (en) 2021-05-27 2022-12-01 Protego Biopharma, Inc. Heteroaryl diamide ire1/xbp1s activators
WO2022251644A1 (en) 2021-05-28 2022-12-01 Lyell Immunopharma, Inc. Nr4a3-deficient immune cells and uses thereof
CA3177712A1 (en) 2021-06-02 2022-12-02 Lyell Immunopharma, Inc. Nr4a-deficient cells expressing c-jun and uses thereof
CA3218481A1 (en) 2021-06-14 2022-12-22 argenx BV Anti-il-9 antibodies and methods of use thereof
AU2022292649A1 (en) 2021-06-16 2024-01-04 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
WO2022266249A1 (en) 2021-06-16 2022-12-22 Biotheryx, Inc. Kras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
CN113546277B (zh) * 2021-07-23 2022-07-01 云南省阜外心血管病医院 一种刚度快速调整的医用导管结构
WO2023055045A1 (ko) 2021-09-29 2023-04-06 주식회사 엔바이오스 코일드 코일 융합 단백질
WO2023081923A1 (en) 2021-11-08 2023-05-11 Frequency Therapeutics, Inc. Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
WO2023130081A1 (en) 2021-12-30 2023-07-06 Neoimmunetech, Inc. Method of treating a tumor with a combination of il-7 protein and vegf antagonist
WO2023129577A1 (en) 2022-01-03 2023-07-06 Lilac Therapeutics, Inc. Cyclic thiol prodrugs
WO2023129576A2 (en) 2022-01-03 2023-07-06 Lilac Therapeutics, Inc. Acyclic thiol prodrugs
TW202342070A (zh) 2022-03-30 2023-11-01 美商拜奧馬林製藥公司 肌萎縮蛋白外顯子跳躍寡核苷酸
GB2619907A (en) 2022-04-01 2023-12-27 Kanna Health Ltd Novel crystalline salt forms of mesembrine
WO2023201282A1 (en) 2022-04-14 2023-10-19 Bristol-Myers Squibb Company Novel gspt1 compounds and methods of use of the novel compounds
WO2023215781A1 (en) 2022-05-05 2023-11-09 Biomarin Pharmaceutical Inc. Method of treating duchenne muscular dystrophy
WO2023220640A1 (en) 2022-05-10 2023-11-16 Biotheryx, Inc. Cdk protein degraders, pharmaceutical compositions, and therapeutic applications
WO2023225665A1 (en) 2022-05-19 2023-11-23 Lyell Immunopharma, Inc. Polynucleotides targeting nr4a3 and uses thereof
CN115253019B (zh) * 2022-08-11 2023-06-30 临沂市兴华医用器材有限公司 一种防损伤的加强型麻醉导管
US20240158370A1 (en) 2022-09-09 2024-05-16 Innovo Therapeutics, Inc. CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS
WO2024073473A1 (en) 2022-09-30 2024-04-04 Boulder Bioscience Llc Compositions comprising 3,3'-diindolylmethane for treating non-hemorrhagic closed head injury
WO2024086852A1 (en) 2022-10-21 2024-04-25 Diagonal Therapeutics Inc. Heteromeric agonistic antibodies to il-18 receptor
WO2024092037A1 (en) 2022-10-26 2024-05-02 Protego Biopharma, Inc. Spirocycle containing pyridone compounds
US20240174695A1 (en) 2022-10-26 2024-05-30 Protego Biopharma, Inc. Spirocycle Containing Bicyclic Heteroaryl Compounds
US20240174673A1 (en) 2022-10-26 2024-05-30 Protego Biopharma, Inc. Spirocycle Containing Pyridine Compounds
WO2024102722A1 (en) 2022-11-07 2024-05-16 Neoimmunetech, Inc. Methods of treating a tumor with an unmethylated mgmt promoter

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4693243A (en) * 1983-01-14 1987-09-15 Buras Sharon Y Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas
US4813925A (en) * 1987-04-21 1989-03-21 Medical Engineering Corporation Spiral ureteral stent
NZ228382A (en) * 1989-03-17 1992-08-26 Carter Holt Harvey Plastic Pro Drug administering coil-like device for insertion in body cavity of animal
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5049132A (en) * 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5221261A (en) * 1990-04-12 1993-06-22 Schneider (Usa) Inc. Radially expandable fixation member
US5102402A (en) * 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5181911A (en) * 1991-04-22 1993-01-26 Shturman Technologies, Inc. Helical balloon perfusion angioplasty catheter
US5256146A (en) * 1991-10-11 1993-10-26 W. D. Ensminger Vascular catheterization system with catheter anchoring feature

Also Published As

Publication number Publication date
EP0754072A1 (de) 1997-01-22
US5709874A (en) 1998-01-20
US5523092A (en) 1996-06-04
ES2243934T3 (es) 2005-12-01
DK0754072T3 (da) 2005-09-05
AU1868395A (en) 1995-08-15
PT754072E (pt) 2005-10-31
CA2182201A1 (en) 1995-08-03
DE69534245D1 (de) 2005-07-07
WO1995020416A1 (en) 1995-08-03
AU682582B2 (en) 1997-10-09
EP0754072A4 (de) 1998-01-14
JPH10500028A (ja) 1998-01-06
EP0754072B1 (de) 2005-06-01
DE69534245T2 (de) 2006-01-26

Similar Documents

Publication Publication Date Title
ATE296660T1 (de) Vorrichtung zur lokalen verabreichung einer arznei
ATE273024T1 (de) Vorrichtung zur erhöhung der flüssigkeitsdurchflussgeschwindigkeit in einem biologischen gewebe mit mikroporen
ATE298259T1 (de) Vorrichtung zur lokalen verabreichung einer arznei in einer körperhöhle
IL156848A0 (en) Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
DE69633411D1 (de) Vorrichtung zur umgehung von arteriellen verengungen und/oder zur ausführung anderer transvaskularer eingriffe
DE69001812T2 (de) System zur parenteralen verabreichung eines wirkstoffs.
WO1998049972A3 (en) Differential treatment of prosthetic devices
BR9807916A (pt) Conjunto de dispositivo biomédico, método para inibir substancialmente a reestenose em um vaso sanguìneo de um paciente, método para fabricar um conjunto de dispositivo biomédico.
ATE444042T1 (de) Stent und system aus stent und ballon zur verbesserung des blutflusses
SE8405227L (sv) Kateterfestanordning
DK0569552T3 (da) Intramedullær kateter
BR9610869A (pt) Cateter destinado particulamente a ser colocado numa cavidade de corpo para diálise peritoneal
ATE479458T1 (de) Medizinisches system für infusion
ATE288776T1 (de) Ausdehnbare vorrichtung zur behandlung von tumoren
DE60042213D1 (de) Kathetervorrichtung zur behandlung von verkalkten vaskulären okklusionen
ATE202272T1 (de) Vorrichtung mit mehreren strömungspfaden zur oralen verabreichung von boluseinheiten
ATE226094T1 (de) Verfahren zur arzneistoffabgabe mittels gentherapie
SE0202172L (sv) Anordning och metod för cirkulatorisk isolering och behandling av kroppsdel
DE3785213T2 (de) Vorrichtung zur retroperfusion des koerpers zum zweck der heilung einer krankheit oder einer immunschwaeche.
PT1246662E (pt) Sistema de administracao de um agente benefico ormotico
ATE383883T1 (de) Medizinische vorrichtung für die herstellung und abgabe einer mit gas angereicherten flüssigkeit
IL141117A0 (en) Means for retaining transcutaneous catheters and needles in place
CN2597004Y (zh) 前列腺电液通输治疗仪专用导管探头

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0754072

Country of ref document: EP

REN Ceased due to non-payment of the annual fee