US9044575B2 - Catheters with enhanced flexibility and associated devices, systems, and methods - Google Patents

Catheters with enhanced flexibility and associated devices, systems, and methods Download PDF

Info

Publication number
US9044575B2
US9044575B2 US14/060,564 US201314060564A US9044575B2 US 9044575 B2 US9044575 B2 US 9044575B2 US 201314060564 A US201314060564 A US 201314060564A US 9044575 B2 US9044575 B2 US 9044575B2
Authority
US
United States
Prior art keywords
shaft
shape
neuromodulation
neuromodulation catheter
segment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
US14/060,564
Other versions
US20140114287A1 (en
Inventor
Rudy Beasley
Justin Goshgarian
Vincent Ku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Ardian Luxembourg SARL
Original Assignee
Medtronic Ardian Luxembourg SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261717067P priority Critical
Priority to US201361800195P priority
Priority to US201361793144P priority
Application filed by Medtronic Ardian Luxembourg SARL filed Critical Medtronic Ardian Luxembourg SARL
Priority to US14/060,564 priority patent/US9044575B2/en
Assigned to MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. reassignment MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BEASLEY, RUDY, GOSHGARIAN, JUSTIN, KU, VINCENT
Publication of US20140114287A1 publication Critical patent/US20140114287A1/en
Application granted granted Critical
Publication of US9044575B2 publication Critical patent/US9044575B2/en
Application status is Active legal-status Critical
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M25/005Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids
    • A61M25/0053Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids having a variable stiffness along the longitudinal axis, e.g. by varying the pitch of the coil or braid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B17/320068Surgical cutting instruments using mechanical vibrations, e.g. ultrasonic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/06Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating caused by chemical reaction, e.g. moxaburners
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1492Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/0085Devices for generating hot or cold treatment fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M25/005Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids
    • A61M25/0051Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids made from fenestrated or weakened tubing layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M25/0054Catheters; Hollow probes characterised by structural features with regions for increasing flexibility
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056Transvascular endocardial electrode systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/06Electrodes for high-frequency therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • A61B2018/00386Coronary vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00404Blood vessels other than those in or around the heart
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00434Neural system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00505Urinary tract
    • A61B2018/00511Kidney
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577Ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0212Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0231Characteristics of handpieces or probes
    • A61B2018/0262Characteristics of handpieces or probes using a circulating cryogenic fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A61F2007/0056Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • A61F2007/126Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N2007/0004Applications of ultrasound therapy
    • A61N2007/0021Neural system treatment

Abstract

A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of the following applications:

  • (a) U.S. Provisional Application No. 61/717,067, filed Oct. 22, 2012;
  • (b) U.S. Provisional Application No. 61/793,144, filed Mar. 15, 2013; and
  • (c) U.S. Provisional Application No. 61/800,195, filed Mar. 15, 2013.

The foregoing applications are incorporated herein by reference in their entireties.

TECHNICAL FIELD

The present technology is related to catheters. In particular, at least some embodiments are related to neuromodulation catheters having one or more cuts and/or other features that enhance flexibility, such as to facilitate intravascular delivery via transradial or other suitable percutaneous transluminal approaches.

BACKGROUND

The sympathetic nervous system (SNS) is a primarily involuntary bodily control system typically associated with stress responses. Fibers of the SNS extend through tissue in almost every organ system of the human body and can affect characteristics such as pupil diameter, gut motility, and urinary output. Such regulation can have adaptive utility in maintaining homeostasis or in preparing the body for rapid response to environmental factors. Chronic activation of the SNS, however, is a common maladaptive response that can drive the progression of many disease states. Excessive activation of the renal SNS in particular has been identified experimentally and in humans as a likely contributor to the complex pathophysiology of hypertension, states of volume overload (e.g., heart failure), and progressive renal disease.

Sympathetic nerves of the kidneys terminate in the renal blood vessels, the juxtaglomerular apparatus, and the renal tubules, among other structures. Stimulation of the renal sympathetic nerves can cause, for example, increased renin release, increased sodium reabsorption, and reduced renal blood flow. These and other neural-regulated components of renal function are considerably stimulated in disease states characterized by heightened sympathetic tone. For example, reduced renal blood flow and glomerular filtration rate as a result of renal sympathetic efferent stimulation is likely a cornerstone of the loss of renal function in cardio-renal syndrome, (i.e., renal dysfunction as a progressive complication of chronic heart failure). Pharmacologic strategies to thwart the consequences of renal sympathetic stimulation include centrally-acting sympatholytic drugs, beta blockers (e.g., to reduce renin release), angiotensin-converting enzyme inhibitors and receptor blockers (e.g., to block the action of angiotensin II and aldosterone activation consequent to renin release), and diuretics (e.g., to counter the renal sympathetic mediated sodium and water retention). These pharmacologic strategies, however, have significant limitations including limited efficacy, compliance issues, side effects, and others.

BRIEF DESCRIPTION OF THE DRAWINGS

Many aspects of the present technology can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale. Instead, emphasis is placed on illustrating clearly the principles of the present technology. For ease of reference, throughout this disclosure identical reference numbers may be used to identify identical or at least generally similar or analogous components or features.

FIG. 1 is a partially schematic perspective view illustrating a therapeutic system including a neuromodulation catheter configured in accordance with an embodiment of the present technology.

FIG. 2 is an enlarged partially cut-away side view of a shaft of the neuromodulation catheter shown in FIG. 1 illustrating a hypotube of the shaft and a cut extending along a helical path having varying pitch along the length of the shaft.

FIG. 3 is a two-dimensional representation of the helical path shown in FIG. 2 and a portion of the shaft shown in FIG. 1.

FIG. 4 is a two-dimensional representation of the cut shown in FIG. 2 along a first portion of the helical path shown in FIG. 3.

FIG. 5 is a two-dimensional representation of the cut shown in FIG. 2 along a second portion of the helical path shown in FIG. 3.

FIGS. 6-9B are two-dimensional representations of cuts along portions of helical paths configured in accordance with embodiments of the present technology.

FIGS. 10-12 are perspective views of shaft segments having guide wire exit openings with different positions relative to cuts configured in accordance with embodiments of the present technology.

FIGS. 13 and 14 are perspective views of shaft segments including helically wound elongate members configured in accordance with embodiments of the present technology.

FIGS. 15 and 16 are side profile views of helically wound elongate members having windings with different average helix angles configured in accordance with embodiments of the present technology.

FIG. 17 is a side profile view of a helically wound elongate member having windings with different average helix angles on either side of a transition region configured in accordance with an embodiment of the present technology.

DETAILED DESCRIPTION

Neuromodulation catheters configured in accordance with at least some embodiments of the present technology include elongate shafts having one or more cuts and/or other features that enhance flexibility without unduly compromising desirable axial stiffness (e.g., pushability or other responsiveness to axial force) and/or desirable torsional stiffness (e.g., torqueability or other responsiveness to torsional force). For example, a neuromodulation catheter configured in accordance with a particular embodiment of the present technology is sufficiently flexible in some respects to facilitate deployment via a relatively long and/or tortuous intravascular path without excessive resistance, while still being sufficiently stiff in other respects so as to allow intravascular navigation or other suitable manipulation via an extracorporeal handle. Desirable axial stiffness can include, for example, the capability of the shaft to be advanced or withdrawn along the length of an intravascular path without significantly buckling or elongating. Desirable torsional stiffness can include, for example, the capability of the shaft to distally transfer rotational motion (e.g., from a handle at a proximal end portion of the shaft to a neuromodulation element operably connected to the shaft via a distal end portion of the shaft) with close correspondence (e.g., at least about one-to-one correspondence). In addition or alternatively, desirable torsional stiffness can include the capability of the shaft to distally transfer rotational motion without causing whipping and/or diametrical deformation of the shaft. Desirable axial and torsional stiffness together can facilitate predictable and controlled transmission of axial and torsional force from the proximal end portion of the shaft toward the distal end portion of the shaft while a neuromodulation catheter is in use.

Metal hypodermic (needle) tubing, aka hypotubing, is commonly incorporated into small-diameter shafts of medical catheters to utilize the wire-like physical properties of such material along with the useable lumen extending therethrough. However, solid-walled metal tubing also has known limitations regarding flexibility and kink resistance, and various designs have utilized slits, slots or other openings in the tubing wall to achieve improvements in flexibility. Such modifications to the wall structure have always brought about compromises in physical properties in tension, compression, and torsion. Thus, in at least some conventional neuromodulation catheters, imparting flexibility can require unduly sacrificing axial stiffness and/or torsional stiffness. For example, creating a continuous helical cut in a relatively rigid hypotube of a shaft tends to increase the flexibility of the shaft, but, in some instances, the resulting coils between turns of the cut may also tend to separate to an undesirable degree in response to tension on the shaft and/or torsion on the shaft in at least one circumferential direction. In some cases, this separation can cause a permanent or temporary change in the length of the shaft (e.g., undesirable elongation of the shaft), a permanent or temporary diametrical deformation of the shaft (e.g., undesirable flattening of a cross-section of the shaft), and/or torsional whipping. Such shaft behavior can interfere with intravascular navigation and/or have other undesirable effects on neuromodulation procedures.

Due, at least in part, to enhanced flexibility in combination with desirable axial and torsional stiffness, neuromodulation catheters configured in accordance with at least some embodiments of the present technology can be well-suited for intravascular delivery to treatment locations (e.g., treatment locations within or otherwise proximate to a renal artery of a human patient) via transradial approaches (e.g., approaches that include the radial artery, the subclavian artery, and the descending aorta). Transradial approaches are typically more tortuous and longer than femoral approaches and at least some other commonly used approaches. Transradial approaches can be desirable for accessing certain anatomy, but other types of approaches (e.g., femoral approaches) may be desirable in particularly tortuous anatomy or vessels having relatively small diameters. In some instances, however, use of transradial approaches can provide certain advantages over use of femoral approaches. In some cases, for example, use of transradial approaches can be associated with increased patient comfort, decreased bleeding, and/or faster sealing of the percutaneous puncture site relative to use of femoral approaches.

In addition to or instead of facilitating intravascular delivery via transradial approaches, neuromodulation catheters configured in accordance with at least some embodiments of the present technology can be well suited for intravascular delivery via one or more other suitable approaches, such as other suitable approaches that are shorter or longer than transradial approaches and other suitable approaches that are less tortuous or more tortuous than transradial approaches. For example, neuromodulation catheters configured in accordance with at least some embodiments of the present technology can be well suited for intravascular delivery via brachial approaches and/or femoral approaches. Even when used with approaches that are generally shorter and/or less tortuous than transradial approaches, the combination of flexibility and desirable axial and torsional stiffness associated with neuromodulation catheters configured in accordance with at least some embodiments of the present technology can be beneficial, such as to accommodate anatomical differences between patients and/or to reduce vessel trauma during delivery, among other potential benefits.

Specific details of several embodiments of the present technology are described herein with reference to FIGS. 1-17. Although many of the embodiments are described herein with respect to devices, systems, and methods for intravascular renal neuromodulation, other applications and other embodiments in addition to those described herein are within the scope of the present technology. For example, at least some embodiments may be useful for intraluminal neuromodulation, for extravascular neuromodulation, for non-renal neuromodulation, and/or for use in therapies other than neuromodulation. It should be noted that other embodiments in addition to those disclosed herein are within the scope of the present technology. For example, in still other embodiments, the technology described herein may be used in devices, systems and methods for stent delivery and balloon angioplasty. Further, embodiments of the present technology can have different configurations, components, and/or procedures than those shown or described herein. Moreover, a person of ordinary skill in the art will understand that embodiments of the present technology can have configurations, components, and/or procedures in addition to those shown or described herein and that these and other embodiments can be without several of the configurations, components, and/or procedures shown or described herein without deviating from the present technology.

As used herein, the terms “distal” and “proximal” define a position or direction with respect to a clinician or a clinician's control device (e.g., a handle of a neuromodulation catheter). The terms, “distal” and “distally” refer to a position distant from or in a direction away from a clinician or a clinician's control device. The terms “proximal” and “proximally” refer to a position near or in a direction toward a clinician or a clinician's control device. The headings provided herein are for convenience only and should not be construed as limiting the subject matter disclosed.

Selected Examples of Neuromodulation Catheters and Related Devices

FIG. 1 is a partially schematic perspective view illustrating a therapeutic system 100 configured in accordance with an embodiment of the present technology. The system 100 can include a neuromodulation catheter 102, a console 104, and a cable 106 extending therebetween. The neuromodulation catheter 102 can include an elongate shaft 108 having a proximal end portion 108 a and a distal end portion 108 b. A handle 110 of the neuromodulation catheter 102 can be operably connected to the shaft 108 via the proximal end portion 108 a, and a neuromodulation element 112 of the neuromodulation catheter 102 can be operably connected to the shaft 108 via the distal end portion 108 b. The shaft 108 can be configured to locate the neuromodulation element 112 intravascularly at a treatment location within or otherwise proximate to a body lumen (e.g., a blood vessel, a duct, an airway, or another naturally occurring lumen within the human body), and the neuromodulation element 112 can be configured to provide or support a neuromodulation treatment at the treatment location. The shaft 108 and the neuromodulation element 112 can be 2, 3, 4, 5, 6, or 7 French or one or more other suitable sizes.

In some embodiments, intravascular delivery of the neuromodulation catheter 102 includes percutaneously inserting a guide wire (not shown) into a body lumen of a patient and moving the shaft 108 and the neuromodulation element 112 along the guide wire until the neuromodulation element 112 reaches a suitable treatment location. In other embodiments, the neuromodulation catheter 102 can be a steerable or non-steerable device configured for use without a guide wire. In still other embodiments, the neuromodulation catheter 102 can be configured for delivery via a guide catheter or sheath (not shown).

The console 104 can be configured to control, monitor, supply, and/or otherwise support operation of the neuromodulation catheter 102. Alternatively, the neuromodulation catheter 102 can be self-contained or otherwise configured for operation without connection to the console 104. When present, the console 104 can be configured to generate a selected form and/or magnitude of energy for delivery to tissue at the treatment location via the neuromodulation element 112 (e.g., via one or more energy delivery elements (not shown) of the neuromodulation element 112). The console 104 can have different configurations depending on the treatment modality of the neuromodulation catheter 102. When the neuromodulation catheter 102 is configured for electrode-based, heat-element-based, or transducer-based treatment, for example, the console 104 can include an energy generator (not shown) configured to generate radio frequency (RF) energy (e.g., monopolar and/or bipolar RF energy), pulsed energy, microwave energy, optical energy, ultrasound energy (e.g., intravascularly delivered ultrasound, extracorporeal ultrasound, and/or high-intensity focused ultrasound (HIFU)), cryotherapeutic energy, direct heat energy, chemicals (e.g., drugs and/or other agents), radiation (e.g., infrared, visible, and/or gamma radiation), and/or another suitable type of energy. When the neuromodulation catheter 102 is configured for cryotherapeutic treatment, for example, the console 104 can include a refrigerant reservoir (not shown) and can be configured to supply the neuromodulation catheter 102 with refrigerant. Similarly, when the neuromodulation catheter 102 is configured for chemical-based treatment (e.g., drug infusion), the console 104 can include a chemical reservoir (not shown) and can be configured to supply the neuromodulation catheter 102 with one or more chemicals.

In some embodiments, the system 100 includes a control device 114 along the cable 106. The control device 114 can be configured to initiate, terminate, and/or adjust operation of one or more components of the neuromodulation catheter 102 directly and/or via the console 104. In other embodiments, the control device 114 can be absent or have another suitable location (e.g., within the handle 110). The console 104 can be configured to execute an automated control algorithm 116 and/or to receive control instructions from an operator. Furthermore, the console 104 can be configured to provide feedback to an operator before, during, and/or after a treatment procedure via an evaluation/feedback algorithm 118.

FIG. 2 is an enlarged partially cut-away side view of the shaft 108 illustrating a hypotube 120 concentrically disposed within an outside wall 121. The hypotube 120 can be configured to reinforce the shaft 108 against collapsing from lateral compression. For example, the hypotube 120 can be made of a relatively strong material (e.g., nitinol, stainless steel, or another suitable metal). The hypotube 120 may be disposed within all or a portion of the shaft 108. In some embodiments, for example, the hypotube 120 may only be disposed at a distal section of the shaft 108, and a proximal section of the shaft 108 may have a different arrangement and/or configuration. Tubes made of relatively strong materials tend to be relatively stiff (e.g., resistant to bending) when unmodified. To increase the flexibility of the neuromodulation catheter 102, the shaft 108 can include a cut 122 extending at least partially through a wall thickness of the hypotube 120, the outside wall 121, or another suitable portion of the shaft 108. For example, the shaft 108 can have a longitudinal axis 124 and the cut 122 can follow a helical path 126 that extends about the longitudinal axis 124 (e.g., a coiled, spiral, or other similar form having two or more turns consistently or variably spaced along the longitudinal axis 124). The cut 122 can be continuous or discontinuous along the helical path 126. Furthermore, the shaft 108 can be cut along more than one helical path 126 (e.g., a double helix having two or more helical paths 126 having the same “hand” or chirality and spaced apart along the longitudinal axis 124). The cut 122 can be formed, for example, using laser etching, electrical discharge machining, chemical etching, or other suitable techniques.

FIG. 3 is a two-dimensional representation of the helical path 126. In particular, FIG. 3 is a representation of the helical path 126 and a portion of the shaft 108 with the x-axis in FIG. 3 corresponding to the longitudinal axis 124 along at least a portion of the length of the shaft 108 and the y-axis in FIG. 3 corresponding to the circumference of the shaft 108. In other words, FIG. 3 illustrates the helical path 126 as though at least a portion of the shaft 108 were aligned with the x-axis and rolled along the y-axis with the helical path 126 unwinding to a flat ribbon or making an imprinted image as the shaft 108 is rolled. The helical path 126 can include a first portion 126 a, a second portion 126 b, and a third portion 126 c therebetween. The first portion 126 a, the second portion 126 b, and the third portion 126 c can extend around portions of the longitudinal axis 124 corresponding to a first segment 127 a, a second segment 127 b, and a third segment 127 c of the shaft 108, respectively. In some embodiments, the first segment 127 a is distal to the second and third segments 127 b, 127 c, and the third segment 127 c is between the first and second segments 127 a, 127 b. In other embodiments, the first, second, and third segments 127 a-c can be reversed or have another suitable arrangement. The first, second, and third segments 127 a-c can be directly adjacent to one another or spaced apart from one another along the longitudinal axis 124. Furthermore, the first segment 127 a can be directly adjacent to or spaced apart from a distalmost portion of the shaft 108 (e.g., a junction between the shaft 108 and the neuromodulation element 112), and the second segment 127 b can be directly adjacent to or spaced apart from a proximalmost portion of the shaft 108 (e.g., a junction between the shaft 108 and the handle 110).

As shown in FIG. 3, the first, second, and third portions 126 a-126 c of the helical path 126 can have different slopes when transposed two-dimensionally. These slopes can correspond to the axial density (e.g., frequency or pitch angle) of turns, shapes, or other suitable features of the cut 122 along the longitudinal axis 124. For example, the first portion 126 a of the helical path 126 can have a greater slope than the second portion 126 b, and the third portion 126 c can be curved with a slope that gradually transitions between the slopes of the first and second portions 126 a, 126 b. Accordingly, the cut 122 can have a greater axial density of turns, shapes, or other suitable features along a portion of the longitudinal axis 124 corresponding to the first segment 127 a than along a portion of the longitudinal axis 124 corresponding to the second segment 127 b. Similarly, the axial density of turns, shapes, or other suitable features of the cut 122 along the longitudinal axis 124 can increase gradually or in another suitable manner along the third segment 127 c from the second segment 127 b toward the first segment 127 a. For example, gradually increasing or otherwise transitioning the axial density of turns, shapes, slope, type, size/dimension, or other suitable features of the cut 122 may reduce focused stress on the shaft 108, which can reduce or eliminate kinking or other undesirable behavior of the shaft 108 when it bends.

By varying the axial density of turns, shapes, or other suitable features of the cut 122, different segments of the shaft 108 can have different levels of flexibility. For example, with reference to FIGS. 1-3 together, a greater axial density of turns, shapes, or other suitable features can correspond to greater flexibility than a lesser axial density of turns, shapes, or other suitable features. In some cases, a distance along the longitudinal axis 124 between the neuromodulation element 112 and a cut segment of the shaft 108 (e.g., the first, second, or third segment 127 a-c) can be selected such that the cut segment tends to be disposed in or near a particular anatomical location when the neuromodulation catheter 102 is in use. For example, the distance along the longitudinal axis 124 between the neuromodulation element 112 and the cut segment can be selected such that the cut segment tends to be at least proximate to a relatively sharply angled or otherwise relatively tortuous anatomic region of an approach (e.g., a transradial or other suitable approach) when the neuromodulation element 112 is at a selected treatment location (e.g., a treatment location within or otherwise proximate to a renal artery of a human patient). The relatively sharply angled or otherwise relatively tortuous region, for example, can be a region within or otherwise proximate to a subclavian artery (e.g., a portion of a subclavian artery adjacent to the descending aorta), an ostium of a renal artery, or another suitable anatomical feature. The axial density of turns, shapes, or other suitable features of the cut 122 along different segments of the shaft 108 and the relative flexibilities of the different segments can be selected to facilitate transradial catheterization or deployment of the neuromodulation catheter 102 via another suitable approach. In some embodiments, an axial density of turns, shapes, or other suitable features of the cut 122 along the longitudinal axis 124 varies along the length of the shaft 108 (e.g., to tailor the shaft 108 to the tortuosity or other geometry of different portions of a transradial or other suitable approach). In other embodiments, the axial density of turns, shapes, or other suitable features of the cut 122 along the longitudinal axis 124 can be consistent along the length of the shaft 108 (e.g., to increase the overall flexibility of the shaft 108).

FIG. 4 is a two-dimensional representation of the cut 122 along the first portion 126 a of the helical path 126. Such a two-dimensional representation is as if the shaft were rolled over a flat surface to leave an imprint of the cut shape therein. In some instances, these two dimensional representations can be used as input for an automated manufacturing process used to form cut shapes along a path in a tubular workpiece. With reference to FIGS. 2-4 together, the shaft 108 can include two or more first cut shapes 128 and two or more second cut shapes 130 interspersed along the helical path 126, with the first and second cut shapes 128, 130 forming portions of the cut 122. The first cut shapes 128 can be configured to at least partially interlock to thereby resist deformation in response to a set of three types of force acting on the shaft 108, and the second cut shapes 130 can be configured to at least partially interlock to thereby resist deformation in response to a different, complementary set of three types of force acting on the shaft 108. The sets can be different combinations of (a) compression along the longitudinal axis 124, (b) tension along the longitudinal axis 124, (c) torsion in a first circumferential direction perpendicular to the longitudinal axis 124, and (d) torsion in a second, opposite circumferential direction perpendicular to the longitudinal axis 124. For example, the first cut shapes 128 can be configured to at least partially resist deformation in response to compression on the shaft 108, tension on the shaft 108, and torsion on the shaft 108 in the first circumferential direction, and the second cut shapes 130 can be configured to at least partially resist deformation in response to compression on the shaft 108, torsion on the shaft 108 in the first circumferential direction, and torsion on the shaft 108 in a second circumferential direction opposite to the first circumferential direction. The first cut shapes 128 can be less resistant to deformation in response to torsion on the shaft 108 in the second circumferential direction than the second cut shapes 130. Similarly, the second cut shapes 130 can be less resistant to deformation in response to tension on the shaft 108 than the first cut shapes 128. Working together, the first and second cut shapes 128, 130 can provide the shaft 108 with sufficient resistance to deformation in response to all types of axial and torsional force that may act on the shaft 108 during use of the neuromodulation catheter 102.

In some embodiments, the first and second cut shapes 128, 130 are sinusoidal and have amplitudes with different (e.g., perpendicular) orientations relative to the longitudinal axis 124. In other embodiments, the first and second cut shapes 128, 130 can have other suitable forms. For example, as shown in FIG. 4, the first cut shapes 128 can individually include a first peak 132 (e.g., a first finger) and a second peak 134 (e.g., a second finger) with a first interface 136 therebetween. The first interface 136 can be perpendicular to the longitudinal axis 124 (FIG. 2). The second cut shapes 130 can individually include a third peak 138 (e.g., a third finger) and a fourth peak 140 (e.g., a fourth finger) with a second interface 142 therebetween. The second interface 142 can be parallel to the longitudinal axis 124. Alternatively, the first and second interfaces 136, 142 can have other suitable angles relative to the longitudinal axis 124, such as other suitable angles in which an angle between the first interface 136 and the longitudinal axis 124 is greater than an angle between the second interface 142 and the longitudinal axis 124. The first and second cut shapes 128, 130 can be configured to at least partially resist deformation in response to forces perpendicular to the first and second interfaces 136, 142, respectively. For example, such forces can cause the first and second peaks 132, 134 or the third and fourth peaks 138, 140 to at least partially interlock and thereby prevent or reduce widening of the cut 122.

FIG. 5 is a two-dimensional representation of the cut 122 along the second portion 126 b of the helical path 126. With reference to FIGS. 2, 3 and 5 together, an average length of the first interfaces 136, an average length of the second interfaces 142, or both can be different at different portions of the helical path 126. For example, the average length of the second interfaces 142 can be greater among the second cut shapes 130 along the second portion 126 b of the helical path 126 and the second segment 127 b of the shaft 108 than among the second cut shapes 130 along the first portion 126 a of the helical path 126 and the first segment 127 a of the shaft 108. In some cases, the average length of the first interfaces 136, the second interfaces 142, or both are selected based on different axial densities of turns, shapes, or other suitable features of the cut 122 at different segments of the shaft 108. For example, when the axial density is greater, the lengths of the first and second interfaces 136, 142 can be more restricted than when the axial density is lower (e.g., so as to avoid overlapping at adjacent turns).

FIGS. 6-9B are two-dimensional representations of cuts along portions of helical paths configured in accordance with further embodiments of the present technology. As shown in FIG. 6, for example, in some embodiments a shaft 108 includes an uncut region 144 with the first and second cut shapes 128, 130 positioned along portions of a helical path on either side of the uncut region 144. For example, the uncut region 144 can be one of many uncut regions 144 interspersed among the first and second cut shapes 128, 130 along the helical path. In other embodiments, the first and second cut shapes 128, 130 can be portions of a continuous cut. For example, as shown in FIG. 7, the first and second cut shapes 128, 130 can be in suitable patterns along the helical path other than one-to-one alternating patterns. Suitable patterns can include, for example, random patterns, non-random patterns, two-to-one alternating patterns, two-to-two alternating patterns, and three-to-two alternating patterns, among others. Furthermore, the spacing between adjacent first and second cut shapes 128, 130 can be consistent or variable.

Referring next to FIG. 8, a shaft can include two or more third cut shapes 146 and two or more fourth cut shapes 148 interspersed along a helical path. The individual third cut shapes 146 can be configured to fully interlock rather than partially interlock. For example, the individual third cut shapes 146 can be configured to at least partially resist deformation in response to compression on the shaft, tension on the shaft, torsion on the shaft in the first circumferential direction, and torsion on the shaft in the second circumferential direction. The shaft, for example, can include tabs 149 (e.g., protrusions, lobes, or other suitable structures) adjacent to the third cut shapes 146, with the third cut shapes 146 forming recesses complementary to the tabs 149. The individual tabs 149 can include a flared portion 149 a (e.g., a rounded head portion) and a restricted portion 149 b (e.g., a rounded neck portion), or other suitable structures. The fourth cut shapes 148 can be sinusoidal and have amplitudes oriented perpendicularly to the helical path. For example, the individual fourth cut shapes 148 can include a first peak 150 and a second peak 152 with an interface 154 therebetween that is diagonal relative to a longitudinal axis of the shaft and perpendicular to the helical path.

As shown in FIGS. 9A and 9B, in some embodiments a shaft includes the third cut shapes 146 without the fourth cut shapes 148. Referring to FIG. 9B, for example, the shaft includes tabs 302 adjacent to respective third cut shapes 300. The individual tabs 302 and corresponding third cut shapes 300, for example, can comprise a wedge-shaped arrangement with the tabs 302 including a wedge-shaped portion 304 (i.e., a “tail”) and a restricted neck portion 306, while the complementary third cut shapes 300 form recesses or sockets (i.e., “tail sockets”) complementary to the tabs 302. In some embodiments, the tabs 302 and third cut shapes 300 may fit snugly with very little room between the respective portions of the two components. In other embodiments, however, there may be some space between at least a portion of each wedge-shaped portion 304 and the complementary socket portion to allow some amount of relative movement between the components.

In other embodiments, the shaft can include the fourth cut shapes 148 without the third cut shapes 146. Although the third and fourth cut shapes 146, 148 are potentially useful alone or in combination with other cut shapes, it is expected that combinations of the first and second cut shapes 128, 130 may be more stable than the third and fourth cut shapes 146, 148 alone or in combination during use of a neuromodulation catheter. For example, is it expected that combinations of cut shapes that impart resistance to complementary sets of fewer than all types of axial and torsional force that may act on a shaft during use of a neuromodulation catheter may facilitate dissipation of localized stresses along a cut. It will further be appreciated that catheters configured in accordance with embodiments of the present technology can include various combinations of cut shapes tailored to provide a desired level of flexibility and/or control for different applications.

FIGS. 10-12 are perspective views of shaft segments having guide wire exit openings with different positions relative to cuts. For example, with reference to FIGS. 5 and 10, in some embodiments a shaft segment 156 having the first and second cut shapes 128, 130 has a guide wire exit opening 158 in place of a third peak 138 of one of the second cut shapes 130. In other embodiments, the guide wire exit opening 158 can be in place of the first peak 132, the second peak 134, the fourth peak 140, or a combination thereof including or not including the third peak 138. As another example, with reference to FIGS. 5 and 11, a shaft segment 160 having the first and second cut shapes 128, 130 can have a guide wire exit opening 162 between (e.g., about evenly between) adjacent turns of a helical path along which the first and second cut shapes 128, 130 are distributed. As yet another example, with reference to FIGS. 5, 6 and 12, a shaft segment 164 having the first and second cut shapes 128, 130 and the uncut region 146 (e.g., as described above with reference to FIG. 6) can have a guide wire exit opening 166 at the uncut region 146. In other examples, the guide wire exit openings may have other suitable positions relative to the cuts. Furthermore, although the guide wire exit openings 158, 162, 166 are illustrated in FIGS. 10-12 as generally oval with their longitudinal axes aligned with longitudinal axes of the corresponding shaft segments 156, 160, 164, the guide wire exit openings 158, 162, 166 can have other suitable shapes and/or orientations.

Instead of or in addition to a cut tube, neuromodulation catheters configured in accordance with at least some embodiments of the present technology can include one or more elongate members (e.g., filaments, wires, ribbons, or other suitable structures) helically wound into one or more tubular shapes. Similar to the axial density of turns, shapes, or other suitable features of a cut along a longitudinal axis of a shaft (e.g., as discussed above with reference to FIG. 3), the axial density of windings of a helically wound elongate member along a longitudinal axis of a shaft can be selected to change the flexibility of the shaft. For example, an axial density of windings along a longitudinal axis of a shaft can be selected to facilitate intravascular delivery of a neuromodulation element to a treatment location within or otherwise proximate to a renal artery of a human patient via a transradial or other suitable approach. In some embodiments, an axial density of windings along a longitudinal axis of a shaft varies along the length of the shaft (e.g., to tailor the shaft to the tortuosity or other geometry of different portions of a transradial or other suitable approach). In other embodiments, the axial density of windings along a longitudinal axis of a shaft can be consistent along the length of the shaft (e.g., to increase the overall flexibility of the shaft).

FIGS. 13 and 14 are perspective views of shaft segments including helically wound elongate members configured in accordance with embodiments of the present technology. With reference to FIG. 13, a shaft 168 can include a first helically wound elongate member 170 having a series of first windings 172 at least partially forming a first tubular structure 174. The shaft 168 can further include a second helically wound elongate member 176 having a series of second windings 178 at least partially forming a second tubular structure 180. The first tubular structure 174 can be disposed within the second tubular structure 180, and the first and second tubular structures 174, 180 can be concentric.

In some embodiments, at least one of the first and second helically wound elongate members 170, 176 is multifilar. For example, in the embodiment shown in FIG. 13, the second helically wound elongate member 176 is multifilar with five parallel filaments (individually identified in FIG. 13 as 176 a-e), and the first helically wound elongate member 170 is monofilar. In other embodiments, the second helically wound elongate member 176 can be monofilar and the first helically wound elongate member 170 can be multifilar. In still other embodiments, both the first and second helically wound elongate members 170, 176 can be monofilar or multifilar. Furthermore, in some embodiments, the first windings 172, the second windings 178, or both are “openly wound” or spaced apart along a longitudinal axis of the shaft 168. For example, in the embodiment shown in FIG. 13, the second windings 178 are shown spaced apart along the longitudinal axis of the shaft 168 with gaps 181 between adjacent second windings 178, and the first windings 172 are shown not spaced apart along the longitudinal axis of the shaft 168. In other embodiments, the second windings 178 can be not spaced apart along the longitudinal axis of the shaft 168 and the first windings 172 can be spaced apart along the longitudinal axis of the shaft 168. In still other embodiments, both the first and second windings 172, 178 can be spaced apart or not spaced apart along the longitudinal axis of the shaft 168.

With reference to FIG. 14, a shaft 182 can include a third helically wound elongate member 183 having a series of third windings 184 at least partially forming a third tubular structure 186. The first and second tubular structures 174, 180 can be disposed within the third tubular structure 186, and the first, second, and third tubular structures 174, 180, 186 can be concentric. In the embodiment shown in FIG. 14, the third helically wound elongate member 183 is multifilar with parallel filaments (individually identified in FIG. 14 as 183 a-e). In other embodiments, the third helically wound elongate member 183 can be monofilar. Furthermore, in embodiments having more than one helically wound layer, the layers may be counter-wound, e.g. a right-hand helical layer may surround a left-hand helical layer. The shaft 182 can further include biocompatible jacket 188 at least partially encasing the first, second, and third tubular structures 174, 180, 186. The biocompatible jacket 188, for example, can be at least partially made of a smooth polymer or other suitable material well suited for sliding contact with an inner wall of a body lumen.

FIG. 15 is a side profile view of a helically wound elongate member 190 having a series of windings 192 with an average helix angle A1. FIG. 16 is a side profile view of a helically wound elongate member 194 having a series of windings 196 with an average helix angle A2. With reference to FIGS. 14-16 together, the first windings 172, the second windings 178, the third windings 184, or a subset thereof, can have different average helix angles. For example, a first average helix angle of the first windings 172 can be different than a second average helix angle of the second windings 178 by an angle within a range from about 10 degrees to about 140 degrees (e.g., a range from about 30 degrees to about 120 degrees, or another suitable range). Similarly, the first average helix angle of the first windings 172 can be different than a third average helix angle of the third windings 184 by an angle within a range from about 10 degrees to about 140 degrees (e.g., a range from about 30 degrees to about 120 degrees, or another suitable range) and the second average helix angle of the second windings 178 can be between (e.g., about midway between) the first and third average helix angles of the first and third windings 172, 184, respectively.

FIG. 17 is a side profile view of a helically wound elongate member 198 having a series of windings 200 with different average helix angles and opposite chirality on either side of a transition region 202. Although an abrupt change in average helix angle at the transition region 202 is shown in FIG. 17, the change at the transition region 202 can alternatively be gradual or incremental. With reference to FIGS. 14, 15 and 17 together, in some embodiments the first windings 172, the second windings 178, and/or the third windings 184 include one or more transition regions 202. In other embodiments, the first windings 172, the second windings 178, and the third windings 184 can have consistent helix angles along the length of the shaft 168. Including one or more transition regions 202 can be useful, for example, to allow a difference between average helix angles of windings within concentric tubular structures to vary (e.g., to change at least once) along the length of the shaft 168. For example, this difference can decrease (e.g., abruptly, gradually, or incrementally) distally along the length of the shaft 168. It is expected that increasing a difference between average helix angles of windings within concentric tubular structures may reduce flexibility and increase axial and torsional stiffness of a shaft, and that decreasing a difference between average helix angles of windings within concentric tubular structures may increase flexibility and decrease axial and torsional stiffness of a shaft. Accordingly, the positions of the transition regions 202 can be selected to change the flexibility of the shaft relative to the axial and torsional stiffness of the shaft along the length of a shaft (e.g., to facilitate intravascular delivery of a neuromodulation element to a treatment location within or otherwise proximate to a renal artery of a human patient via a transradial or other suitable approach).

Instead of or in addition to a cut tube and/or a helically wound elongate member, neuromodulation catheters configured in accordance with at least some embodiments of the present technology can include shafts having one or more segments with different shape memory properties. With reference to FIG. 3, for example, the first segment 127 a can be made at least partially of a first shape-memory alloy, the second segment 127 b can be made at least partially of a second shape-memory alloy, and the third segment 127 c can be made at least partially of a third shape-memory alloy. The first, second, and third shape-memory alloys can be different or the same. In some embodiments, the first, second, and third shape-memory alloys are nitinol. In other embodiments, the first, second, and third shape-memory alloys can be other suitable materials. The first, second, and third shape-memory alloys can have first, second, and third shape-memory transformation temperature ranges, respectively. For example, when the first, second, and third shape-memory alloys are nitinol, the first, second, and third shape-memory transformation temperature ranges can include Af temperatures.

The second shape-memory transformation temperature range and/or an Af temperature of the second shape-memory transformation temperature range can be lower than the first shape-memory transformation temperature range and/or an Af temperature of the first shape-memory transformation temperature range. For example, the first shape-memory transformation temperature range can include an Af temperature greater than body temperature and the second shape-memory transformation temperature range includes an Af temperature less than body temperature. A shape-memory transformation temperature range and/or an Af temperature of a shape-memory transformation temperature range of the shaft 108 can increase (e.g., abruptly, gradually, or incrementally) along the third segment 127 c from the second segment 127 b toward the first segment 127 a. In some embodiments, to vary the shape-memory transformation temperature ranges and/or Af temperatures along the length of the shaft 108, the first, second, and third segments 127 a-c are formed separately and then joined. In other embodiments, the shape-memory transformation temperature ranges and/or the Af temperatures along the length of the shaft 108 can be achieved by processing the first, second, and third segments 127 a-c differently while they are joined. For example, one of the first, second, and third segments 127 a-c can be subjected to a heat treatment to change its shape-memory transformation temperature range and/or Af temperature while the others of the first, second, and third segments 127 a-c are thermally insulated.

It is expected that greater shape-memory transformation temperature ranges and/or Af temperatures of shape-memory transformation temperature ranges may increase flexibility and decrease axial and torsional stiffness of a shaft (e.g., by causing nitinol to tend to assume a austenite phase at body temperature), and that lower shape-memory transformation temperature ranges and/or Af temperatures of shape-memory transformation temperature ranges may decrease flexibility and increase axial and torsional stiffness of a shaft (e.g., by causing nitinol to tend to assume a martensite phase at body temperature). Accordingly, the positions of segments of a shaft having different shape-memory transformation temperature ranges and/or Af temperatures of shape-memory transformation temperature ranges can be selected to change the flexibility of the shaft relative to the axial and torsional stiffness of the shaft along the length of a shaft (e.g., to facilitate intravascular delivery of a neuromodulation element to a treatment location within or otherwise proximate to a renal artery of a human patient via a transradial or other suitable approach).

Renal Neuromodulation

Renal neuromodulation is the partial or complete incapacitation or other effective disruption of nerves of the kidneys (e.g., nerves terminating in the kidneys or in structures closely associated with the kidneys). In particular, renal neuromodulation can include inhibiting, reducing, and/or blocking neural communication along neural fibers (e.g., efferent and/or afferent neural fibers) of the kidneys. Such incapacitation can be long-term (e.g., permanent or for periods of months, years, or decades) or short-term (e.g., for periods of minutes, hours, days, or weeks). Renal neuromodulation is expected to contribute to the systemic reduction of sympathetic tone or drive and/or to benefit at least some specific organs and/or other bodily structures innervated by sympathetic nerves. Accordingly, renal neuromodulation is expected to be useful in treating clinical conditions associated with systemic sympathetic overactivity or hyperactivity, particularly conditions associated with central sympathetic overstimulation. For example, renal neuromodulation is expected to efficaciously treat hypertension, heart failure, acute myocardial infarction, metabolic syndrome, insulin resistance, diabetes, left ventricular hypertrophy, chronic and end stage renal disease, inappropriate fluid retention in heart failure, cardio-renal syndrome, polycystic kidney disease, polycystic ovary syndrome, osteoporosis, erectile dysfunction, and sudden death, among other conditions.

Renal neuromodulation can be electrically-induced, thermally-induced, chemically-induced, or induced in another suitable manner or combination of manners at one or more suitable treatment locations during a treatment procedure. The treatment location can be within or otherwise proximate to a renal lumen (e.g., a renal artery, a ureter, a renal pelvis, a major renal calyx, a minor renal calyx, or another suitable structure), and the treated tissue can include tissue at least proximate to a wall of the renal lumen. For example, with regard to a renal artery, a treatment procedure can include modulating nerves in the renal plexus, which lay intimately within or adjacent to the adventitia of the renal artery.

Renal neuromodulation can include a cryotherapeutic treatment modality alone or in combination with another treatment modality. Cryotherapeutic treatment can include cooling tissue at a treatment location in a manner that modulates neural function. For example, sufficiently cooling at least a portion of a sympathetic renal nerve can slow or potentially block conduction of neural signals to produce a prolonged or permanent reduction in renal sympathetic activity. This effect can occur as a result of cryotherapeutic tissue damage, which can include, for example, direct cell injury (e.g., necrosis), vascular or luminal injury (e.g., starving cells from nutrients by damaging supplying blood vessels), and/or sublethal hypothermia with subsequent apoptosis. Exposure to cryotherapeutic cooling can cause acute cell death (e.g., immediately after exposure) and/or delayed cell death (e.g., during tissue thawing and subsequent hyperperfusion). Neuromodulation using a cryotherapeutic treatment in accordance with embodiments of the present technology can include cooling a structure proximate an inner surface of a body lumen wall such that tissue is effectively cooled to a depth where sympathetic renal nerves reside. For example, in some embodiments, a cooling assembly of a cryotherapeutic device can be cooled to the extent that it causes therapeutically-effective, cryogenic renal neuromodulation. In other embodiments, a cryotherapeutic treatment modality can include cooling that is not configured to cause neuromodulation. For example, the cooling can be at or above cryogenic temperatures and can be used to control neuromodulation via another treatment modality (e.g., to protect tissue from neuromodulating energy).

Renal neuromodulation can include an electrode-based or transducer-based treatment modality alone or in combination with another treatment modality. Electrode-based or transducer-based treatment can include delivering electricity and/or another form of energy to tissue at a treatment location to stimulate and/or heat the tissue in a manner that modulates neural function. For example, sufficiently stimulating and/or heating at least a portion of a sympathetic renal nerve can slow or potentially block conduction of neural signals to produce a prolonged or permanent reduction in renal sympathetic activity. A variety of suitable types of energy can be used to stimulate and/or heat tissue at a treatment location. For example, neuromodulation in accordance with embodiments of the present technology can include delivering RF energy, pulsed energy, microwave energy, optical energy, focused ultrasound energy (e.g., high-intensity focused ultrasound energy), or another suitable type of energy alone or in combination. An electrode or transducer used to deliver this energy can be used alone or with other electrodes or transducers in a multi-electrode or multi-transducer array. Furthermore, the energy can be applied from within the body (e.g., within the vasculature or other body lumens in a catheter-based approach) and/or from outside the body (e.g., via an applicator positioned outside the body). Furthermore, energy can be used to reduce damage to non-targeted tissue when targeted tissue adjacent to the non-targeted tissue is subjected to neuromodulating cooling.

Neuromodulation using focused ultrasound energy (e.g., high-intensity focused ultrasound energy) can be beneficial relative to neuromodulation using other treatment modalities. Focused ultrasound is an example of a transducer-based treatment modality that can be delivered from outside the body. Focused ultrasound treatment can be performed in close association with imaging (e.g., magnetic resonance, computed tomography, fluoroscopy, ultrasound (e.g., intravascular or intraluminal), optical coherence tomography, or another suitable imaging modality). For example, imaging can be used to identify an anatomical position of a treatment location (e.g., as a set of coordinates relative to a reference point). The coordinates can then entered into a focused ultrasound device configured to change the power, angle, phase, or other suitable parameters to generate an ultrasound focal zone at the location corresponding to the coordinates. The focal zone can be small enough to localize therapeutically-effective heating at the treatment location while partially or fully avoiding potentially harmful disruption of nearby structures. To generate the focal zone, the ultrasound device can be configured to pass ultrasound energy through a lens, and/or the ultrasound energy can be generated by a curved transducer or by multiple transducers in a phased array (curved or straight).

Heating effects of electrode-based or transducer-based treatment can include ablation and/or non-ablative alteration or damage (e.g., via sustained heating and/or resistive heating). For example, a treatment procedure can include raising the temperature of target neural fibers to a target temperature above a first threshold to achieve non-ablative alteration, or above a second, higher threshold to achieve ablation. The target temperature can be higher than about body temperature (e.g., about 37° C.) but less than about 45° C. for non-ablative alteration, and the target temperature can be higher than about 45° C. for ablation. Heating tissue to a temperature between about body temperature and about 45° C. can induce non-ablative alteration, for example, via moderate heating of target neural fibers or of vascular or luminal structures that perfuse the target neural fibers. In cases where vascular structures are affected, the target neural fibers can be denied perfusion resulting in necrosis of the neural tissue. Heating tissue to a target temperature higher than about 45° C. (e.g., higher than about 60° C.) can induce ablation, for example, via substantial heating of target neural fibers or of vascular or luminal structures that perfuse the target fibers. In some patients, it can be desirable to heat tissue to temperatures that are sufficient to ablate the target neural fibers or the vascular or luminal structures, but that are less than about 90° C. (e.g., less than about 85° C., less than about 80° C., or less than about 75° C.).

Renal neuromodulation can include a chemical-based treatment modality alone or in combination with another treatment modality. Neuromodulation using chemical-based treatment can include delivering one or more chemicals (e.g., drugs or other agents) to tissue at a treatment location in a manner that modulates neural function. The chemical, for example, can be selected to affect the treatment location generally or to selectively affect some structures at the treatment location over other structures. The chemical, for example, can be guanethidine, ethanol, phenol, a neurotoxin, or another suitable agent selected to alter, damage, or disrupt nerves. A variety of suitable techniques can be used to deliver chemicals to tissue at a treatment location. For example, chemicals can be delivered via one or more needles originating outside the body or within the vasculature or other body lumens. In an intravascular example, a catheter can be used to intravascularly position a therapeutic element including a plurality of needles (e.g., micro-needles) that can be retracted or otherwise blocked prior to deployment. In other embodiments, a chemical can be introduced into tissue at a treatment location via simple diffusion through a body lumen wall, electrophoresis, or another suitable mechanism. Similar techniques can be used to introduce chemicals that are not configured to cause neuromodulation, but rather to facilitate neuromodulation via another treatment modality.

Returning to FIG. 1, in another embodiment the system 100 may comprise a stent delivery system. In this embodiment, stent delivery catheter 102 includes stent delivery element 112. In one embodiment, stent delivery element 112 includes a dilatation balloon with a balloon expandable stent disposed thereon. The stent delivery catheter 102 also includes handle 110 operably connected to shaft 108 via proximal end portion 108 a. The shaft 108 can be configured to locate the stent delivery element 112 intravascularly at a treatment location within or otherwise proximate to a body lumen (e.g., coronary artery). The handle 110 is configured to aid in the delivery and deployment of the stent (not shown) to the treatment location. The stent delivery system 100 does not include the console 104 or cable 106.

The stent of stent delivery element 112 may be any balloon expandable stent as known to one of ordinary skill in the art. In one embodiment, for example, the stent is formed from a single wire forming a continuous sinusoid. The stent may include a coating disposed on the surface of the stent. The coating may include a polymer and/or a therapeutic agent. In one embodiment, the coating includes a Biolinx™ polymer blended with a limus drug. In another embodiment, the stent is a drug filled stent having a lumen filled with a therapeutic agent. In still another embodiment, element 112 does not include a stent disposed on the dilatation balloon.

CONCLUSION

This disclosure is not intended to be exhaustive or to limit the present technology to the precise forms disclosed herein. Although specific embodiments are disclosed herein for illustrative purposes, various equivalent modifications are possible without deviating from the present technology, as those of ordinary skill in the relevant art will recognize. In some cases, well-known structures and functions have not been shown and/or described in detail to avoid unnecessarily obscuring the description of the embodiments of the present technology. Although steps of methods may be presented herein in a particular order, in alternative embodiments the steps may have another suitable order. Similarly, certain aspects of the present technology disclosed in the context of particular embodiments can be combined or eliminated in other embodiments. Furthermore, while advantages associated with certain embodiments may have been disclosed in the context of those embodiments, other embodiments can also exhibit such advantages, and not all embodiments need necessarily exhibit such advantages or other advantages disclosed herein to fall within the scope of the present technology. Accordingly, this disclosure and associated technology can encompass other embodiments not expressly shown and/or described herein.

Throughout this disclosure, the singular terms “a,” “an,” and “the” include plural referents unless the context clearly indicates otherwise. Similarly, unless the word “or” is expressly limited to mean only a single item exclusive from the other items in reference to a list of two or more items, then the use of “or” in such a list is to be interpreted as including (a) any single item in the list, (b) all of the items in the list, or (c) any combination of the items in the list. Additionally, the terms “comprising” and the like are used throughout this disclosure to mean including at least the recited feature(s) such that any greater number of the same feature(s) and/or one or more additional types of features are not precluded. Directional terms, such as “upper,” “lower,” “front,” “back,” “vertical,” and “horizontal,” may be used herein to express and clarify the relationship between various elements. It should be understood that such terms do not denote absolute orientation. Reference herein to “one embodiment,” “an embodiment,” or similar formulations means that a particular feature, structure, operation, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present technology. Thus, the appearances of such phrases or formulations herein are not necessarily all referring to the same embodiment. Furthermore, various particular features, structures, operations, or characteristics may be combined in any suitable manner in one or more embodiments.

Claims (13)

We claim:
1. A neuromodulation catheter, comprising:
an elongate shaft including
a tubular wall,
a first hypotube segment concentrically disposed within the tubular wall, the first hypotube segment being made at least partially of a first shape-memory alloy having a first shape-memory transformation temperature range, and
a second hypotube segment concentrically disposed within the tubular wall proximal to the first hypotube segment along a longitudinal axis of the shaft, the second hypotube segment being made at least partially of a second shape-memory alloy having a second shape-memory transformation temperature range lower than the first shape-memory transformation temperature range; and
a neuromodulation element operably connected to the shaft via a distal end portion of the shaft.
2. The neuromodulation catheter of claim 1 wherein:
the elongate shaft includes a third hypotube segment concentrically disposed within the tubular wall between the first and second hypotube segments along the longitudinal axis, the third hypotube segment being made at least partially of a third shape-memory alloy having a third shape-memory transformation temperature range;
the first, second, and third shape-memory alloys are the same; and
the third shape-memory transformation temperature range gradually increases along the third segment from the second segment toward the first segment.
3. The neuromodulation catheter of claim 2 wherein the first, second, and third shape-memory alloys are nitinol.
4. A neuromodulation catheter, comprising:
an elongate shaft including
a first segment made at least partially of nitinol having a first shape-memory transformation temperature range, and
a second segment made at least partially of nitinol having a second shape-memory transformation temperature range lower than the first shape-memory transformation temperature range, the second segment being proximal to the first segment along a longitudinal axis of the shaft; and
a neuromodulation element operably connected to the shaft via a distal end portion of the shaft,
wherein
the first shape-memory transformation temperature range includes an Af temperature greater than body temperature; and
the second shape-memory transformation temperature range includes an Af temperature less than body temperature.
5. The neuromodulation catheter of claim 1 wherein the neuromodulation element comprises one or more energy delivery elements.
6. The neuromodulation catheter of claim 1 wherein the neuromodulation catheter is configured for electrode-based treatment.
7. The neuromodulation catheter of claim 1 wherein the neuromodulation catheter is configured for heat-element-based treatment.
8. The neuromodulation catheter of claim 1 wherein the neuromodulation catheter is configured for transducer-based treatment.
9. The neuromodulation catheter of claim 1 wherein the neuromodulation catheter is configured for chemical-based treatment.
10. The neuromodulation catheter of claim 9 wherein the neuromodulation catheter is configured for drug infusion.
11. The neuromodulation catheter of claim 9, further comprising a therapeutic element including a plurality of needles.
12. The neuromodulation catheter of claim 1 wherein the neuromodulation catheter is configured for intravascular delivery via a transradial approach.
13. The neuromodulation catheter of claim 1 wherein the neuromodulation catheter is configured for intravascular delivery to a renal artery of a human patient.
US14/060,564 2012-10-22 2013-10-22 Catheters with enhanced flexibility and associated devices, systems, and methods Active US9044575B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US201261717067P true 2012-10-22 2012-10-22
US201361800195P true 2013-03-15 2013-03-15
US201361793144P true 2013-03-15 2013-03-15
US14/060,564 US9044575B2 (en) 2012-10-22 2013-10-22 Catheters with enhanced flexibility and associated devices, systems, and methods

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14/060,564 US9044575B2 (en) 2012-10-22 2013-10-22 Catheters with enhanced flexibility and associated devices, systems, and methods
US14/716,631 US9492635B2 (en) 2012-10-22 2015-05-19 Catheters with enhanced flexibility and associated devices, systems, and methods
US15/227,691 US9844643B2 (en) 2012-10-22 2016-08-03 Catheters with enhanced flexibility and associated devices, systems, and methods
US15/811,351 US10188829B2 (en) 2012-10-22 2017-11-13 Catheters with enhanced flexibility and associated devices, systems, and methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/716,631 Division US9492635B2 (en) 2012-10-22 2015-05-19 Catheters with enhanced flexibility and associated devices, systems, and methods

Publications (2)

Publication Number Publication Date
US20140114287A1 US20140114287A1 (en) 2014-04-24
US9044575B2 true US9044575B2 (en) 2015-06-02

Family

ID=50485989

Family Applications (4)

Application Number Title Priority Date Filing Date
US14/060,564 Active US9044575B2 (en) 2012-10-22 2013-10-22 Catheters with enhanced flexibility and associated devices, systems, and methods
US14/716,631 Active US9492635B2 (en) 2012-10-22 2015-05-19 Catheters with enhanced flexibility and associated devices, systems, and methods
US15/227,691 Active US9844643B2 (en) 2012-10-22 2016-08-03 Catheters with enhanced flexibility and associated devices, systems, and methods
US15/811,351 Active US10188829B2 (en) 2012-10-22 2017-11-13 Catheters with enhanced flexibility and associated devices, systems, and methods

Family Applications After (3)

Application Number Title Priority Date Filing Date
US14/716,631 Active US9492635B2 (en) 2012-10-22 2015-05-19 Catheters with enhanced flexibility and associated devices, systems, and methods
US15/227,691 Active US9844643B2 (en) 2012-10-22 2016-08-03 Catheters with enhanced flexibility and associated devices, systems, and methods
US15/811,351 Active US10188829B2 (en) 2012-10-22 2017-11-13 Catheters with enhanced flexibility and associated devices, systems, and methods

Country Status (1)

Country Link
US (4) US9044575B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9399115B2 (en) 2012-10-22 2016-07-26 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US9492635B2 (en) 2012-10-22 2016-11-15 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners
US9775627B2 (en) 2012-11-05 2017-10-03 Relievant Medsystems, Inc. Systems and methods for creating curved paths through bone and modulating nerves within the bone
US10028753B2 (en) 2008-09-26 2018-07-24 Relievant Medsystems, Inc. Spine treatment kits
US10111704B2 (en) 2002-09-30 2018-10-30 Relievant Medsystems, Inc. Intraosseous nerve treatment

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9265512B2 (en) 2013-12-23 2016-02-23 Silk Road Medical, Inc. Transcarotid neurovascular catheter
JP5954747B2 (en) * 2014-03-20 2016-07-20 朝日インテック株式会社 catheter
US10183145B2 (en) 2016-02-24 2019-01-22 Incept, Llc Enhanced flexibility neurovascular catheter
US9918705B2 (en) 2016-07-07 2018-03-20 Brian Giles Medical devices with distal control
US20180185193A1 (en) * 2016-12-30 2018-07-05 Zoll Circulation, Inc. High efficiency heat exchange catheters for control of patient body temperature

Citations (192)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602624A (en) 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
US4764504A (en) 1984-04-19 1988-08-16 Biotechnology Research Associates J.V. Novel atrial natriuretic/vasodilator polypeptides
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US4998923A (en) 1988-08-11 1991-03-12 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
EP0348136B1 (en) 1988-06-22 1993-08-04 EVANS, John Martin Catheters and methods of manufacture
US5300068A (en) 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
US5322505A (en) 1990-02-07 1994-06-21 Smith & Nephew Dyonics, Inc. Surgical instrument
US5358514A (en) 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US5368591A (en) 1988-10-28 1994-11-29 Prutech Research And Development Partnership Ii Heated balloon catheters
US5399164A (en) 1992-11-02 1995-03-21 Catheter Imaging Systems Catheter having a multiple durometer
US5423744A (en) 1992-12-22 1995-06-13 Gencheff; Nelson Catheter system for the deployment of biological material
US5425364A (en) 1991-02-15 1995-06-20 Cardiac Pathways Corporation Flexible strip assembly without feedthrough holes and device utilizing the same
US5437288A (en) 1992-09-04 1995-08-01 Mayo Foundation For Medical Education And Research Flexible catheter guidewire
WO1995025472A1 (en) 1994-03-23 1995-09-28 Vidamed, Inc. Dual-channel rf power delivery system
US5477856A (en) 1991-02-15 1995-12-26 Lundquist; Ingemar H. Torquable catheter and torquable tubular member for use therewith
US5484400A (en) 1992-08-12 1996-01-16 Vidamed, Inc. Dual channel RF delivery system
US5558643A (en) 1985-07-30 1996-09-24 Advanced Cardiovascular Systems, Inc. Catheter with NiTi tubular shaft
US5571147A (en) 1993-11-02 1996-11-05 Sluijter; Menno E. Thermal denervation of an intervertebral disc for relief of back pain
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
US5599319A (en) 1994-09-01 1997-02-04 Cordis Corporation Soft flexible catheter tip for use in angiography
WO1997003611A1 (en) 1995-07-18 1997-02-06 Edwards, Garland, U. Flexible shaft
US5626576A (en) 1989-01-06 1997-05-06 Advanced Coronary Intervention, Inc. Electrosurgical catheter for resolving atherosclerotic plaque by radio frequency sparking
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
US5685868A (en) 1991-02-15 1997-11-11 Lundquist; Ingemar H. Torquable tubular assembly and torquable catheter utilizing the same
US5688266A (en) 1991-11-08 1997-11-18 Ep Technologies, Inc. Electrode and associated systems using thermally insulated temperature sensing elements
US5700282A (en) 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US5772590A (en) 1992-06-30 1998-06-30 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
WO1999000060A1 (en) 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
US5865787A (en) 1992-10-06 1999-02-02 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery
US5871444A (en) 1996-03-25 1999-02-16 Terumo Kabushiki Kaisha Electrode catheter
WO1999011313A1 (en) 1997-09-04 1999-03-11 Alcon Laboratories, Inc. Flexible tube with circular grooves of varying width and depth
US5891110A (en) 1997-10-15 1999-04-06 Scimed Life Systems, Inc. Over-the-wire catheter with improved trackability
US5893885A (en) 1996-11-01 1999-04-13 Cordis Webster, Inc. Multi-electrode ablation catheter
EP0521595B1 (en) 1991-02-15 1999-05-12 Ingemar H. Lundquist Torquable catheter
US5916178A (en) 1995-03-30 1999-06-29 Medtronic, Inc. Steerable high support guidewire with thin wall nitinol tube
US5931830A (en) 1995-12-07 1999-08-03 Sarcos L.C. Hollow coil guide wire apparatus for catheters
US5935102A (en) 1993-05-14 1999-08-10 C. R. Bard Steerable electrode catheter
EP0937481A1 (en) 1998-02-19 1999-08-25 Precision Vascular Systems, Inc. Catheter or guidewire with varying flexibility
US5944710A (en) 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US5954719A (en) 1996-12-11 1999-09-21 Irvine Biomedical, Inc. System for operating a RF ablation generator
US5983141A (en) 1996-06-27 1999-11-09 Radionics, Inc. Method and apparatus for altering neural tissue function
US6004269A (en) 1993-07-01 1999-12-21 Boston Scientific Corporation Catheters for imaging, sensing electrical potentials, and ablating tissue
US6009877A (en) 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US6024730A (en) 1996-11-08 2000-02-15 Smiths Industries Plc Catheter assemblies and inner cannulae
US6048338A (en) 1997-10-15 2000-04-11 Scimed Life Systems, Inc. Catheter with spiral cut transition member
US6059769A (en) 1998-10-02 2000-05-09 Medtronic, Inc. Medical catheter with grooved soft distal segment
US6066134A (en) 1992-01-07 2000-05-23 Arthrocare Corporation Method for electrosurgical cutting and ablation
US6099524A (en) 1994-01-28 2000-08-08 Cardiac Pacemakers, Inc. Electrophysiological mapping and ablation catheter and method
US6102890A (en) 1998-10-23 2000-08-15 Scimed Life Systems, Inc. Catheter having improved proximal shaft design
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US6135999A (en) 1997-02-12 2000-10-24 Oratec Internationals, Inc. Concave probe for arthroscopic surgery
US6149620A (en) 1995-11-22 2000-11-21 Arthrocare Corporation System and methods for electrosurgical tissue treatment in the presence of electrically conductive fluid
US6161048A (en) 1997-06-26 2000-12-12 Radionics, Inc. Method and system for neural tissue modification
WO2001022897A1 (en) 1999-09-28 2001-04-05 Novasys Medical, Inc. Treatment of tissue by application of energy and drugs
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6246914B1 (en) 1999-08-12 2001-06-12 Irvine Biomedical, Inc. High torque catheter and methods thereof
US6246912B1 (en) 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US6251092B1 (en) 1997-12-30 2001-06-26 Medtronic, Inc. Deflectable guiding catheter
US6254588B1 (en) 1995-11-13 2001-07-03 Micro Therapeutics, Inc. Microcatheter
US6273876B1 (en) 1997-12-05 2001-08-14 Intratherapeutics, Inc. Catheter segments having circumferential supports with axial projection
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6292695B1 (en) 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
WO2001070114A1 (en) 2000-03-17 2001-09-27 Rita Medical Systems Inc. Lung treatment apparatus
US6314325B1 (en) 1998-04-07 2001-11-06 William R. Fitz Nerve hyperpolarization method and apparatus for pain relief
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
US6322558B1 (en) 1995-06-09 2001-11-27 Engineering & Research Associates, Inc. Apparatus and method for predicting ablation depth
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US6413255B1 (en) 1999-03-09 2002-07-02 Thermage, Inc. Apparatus and method for treatment of tissue
US20020165532A1 (en) 2001-05-01 2002-11-07 Cardima, Inc. Helically shaped electrophysiology catheter
US6488679B1 (en) 1998-09-10 2002-12-03 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US20020183682A1 (en) 1999-06-04 2002-12-05 Nissim Darvish Drug delivery device
US6506189B1 (en) 1995-05-04 2003-01-14 Sherwood Services Ag Cool-tip electrode thermosurgery system
US6514226B1 (en) 2000-02-10 2003-02-04 Chf Solutions, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US20030050681A1 (en) 1998-11-20 2003-03-13 Pianca Anne M. Self-anchoring coronary sinus lead
US20030060858A1 (en) 2000-09-27 2003-03-27 Kieval Robert S. Stimulus regimens for cardiovascular reflex control
US6562034B2 (en) 1998-02-19 2003-05-13 Curon Medical, Inc. Electrodes for creating lesions in tissue regions at or near a sphincter
US6585718B2 (en) 2001-05-02 2003-07-01 Cardiac Pacemakers, Inc. Steerable catheter with shaft support system for resisting axial compressive loads
US20030125790A1 (en) 2001-12-27 2003-07-03 Vitaly Fastovsky Deployment device, system and method for medical implantation
US6611720B2 (en) 1999-08-12 2003-08-26 Irvine Biomedical Inc. High torque catheter possessing multi-directional deflectability and methods thereof
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US6622731B2 (en) 2001-01-11 2003-09-23 Rita Medical Systems, Inc. Bone-treatment instrument and method
US20030181897A1 (en) 2000-10-02 2003-09-25 Thomas Simon W.H. Apparatus and methods for treating female urinary incontinence
US6635054B2 (en) 2000-07-13 2003-10-21 Transurgical, Inc. Thermal treatment methods and apparatus with focused energy application
US20030216792A1 (en) 2002-04-08 2003-11-20 Levin Howard R. Renal nerve stimulation method and apparatus for treatment of patients
US6656195B2 (en) 2000-09-22 2003-12-02 Medtronic Xomed, Inc. Flexible inner tubular members and rotary tissue cutting instruments having flexible inner tubular members
US6669670B1 (en) 1997-03-06 2003-12-30 Medtronic Ave, Inc. Catheter core wire
US20040010289A1 (en) 2000-10-17 2004-01-15 Broncus Technologies, Inc. Control system and process for application of energy to airway walls and other mediums
US6716207B2 (en) 2001-05-22 2004-04-06 Scimed Life Systems, Inc. Torqueable and deflectable medical device shaft
US6736835B2 (en) 2002-03-21 2004-05-18 Depuy Acromed, Inc. Early intervention spinal treatment methods and devices for use therein
US6749560B1 (en) 1999-10-26 2004-06-15 Circon Corporation Endoscope shaft with slotted tube
US20040215186A1 (en) 2003-03-03 2004-10-28 Sinus Rhythm Technologies, Inc. Electrical block positioning devices and methods of use therefor
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US6850801B2 (en) 2001-09-26 2005-02-01 Cvrx, Inc. Mapping methods for cardiovascular reflex control devices
US20050080400A1 (en) 2003-05-27 2005-04-14 Cardia, Inc. Flexible medical device
US20050080409A1 (en) 2003-10-10 2005-04-14 Scimed Life Systems, Inc. Multi-zone bipolar ablation probe assembly
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6893436B2 (en) 2002-01-03 2005-05-17 Afx, Inc. Ablation instrument having a flexible distal portion
US20050187579A1 (en) 1997-04-07 2005-08-25 Asthmatx, Inc. Method for treating an asthma attack
US6939346B2 (en) 1999-04-21 2005-09-06 Oratec Interventions, Inc. Method and apparatus for controlling a temperature-controlled probe
US20050251094A1 (en) * 2003-01-27 2005-11-10 Cardiac Pacemakers, Inc. System and method for accessing the coronary sinus to facilitate insertion of pacing leads
US20050253680A1 (en) * 2002-04-04 2005-11-17 Mathews Eric D Temperature-controlled actuator
WO2005110528A1 (en) 2004-05-06 2005-11-24 Boston Scientific Limited Intravascular self-anchoring electrode body
US20060004346A1 (en) 2004-06-17 2006-01-05 Begg John D Bend relief
WO2005041748A3 (en) 2003-09-12 2006-02-23 Minnow Medical Llc Selectable eccentric remodeling and/or ablation of atherosclerotic material
US20060064055A1 (en) * 2004-05-24 2006-03-23 John Pile-Spellman Steerable devices
US20060064123A1 (en) 1998-02-06 2006-03-23 Possis Medical, Inc. Rapid exchange fluid jet thrombectomy device and method
US20060095029A1 (en) 2004-10-28 2006-05-04 Scimed Life Systems, Inc. Ablation probe with flared electrodes
US20060100687A1 (en) 2004-11-10 2006-05-11 Creganna Technologies Limited Elongate tubular member for use in medical device shafts
US20060100618A1 (en) 2004-11-08 2006-05-11 Cardima, Inc. System and method for performing ablation and other medical procedures using an electrode array with flex circuit
US7058456B2 (en) 2002-08-09 2006-06-06 Concentric Medical, Inc. Methods and devices for changing the shape of a medical device
US20060206150A1 (en) 2002-04-08 2006-09-14 Ardian, Inc. Methods and apparatus for treating acute myocardial infarction
US20060224112A1 (en) 2005-04-04 2006-10-05 Cook Incorporated Scored catheter device
US7119183B2 (en) 1988-02-25 2006-10-10 The General Hospital Corporation Rapid immunoselection cloning method
US7128718B2 (en) 2002-03-22 2006-10-31 Cordis Corporation Guidewire with deflectable tip
US7149574B2 (en) 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
US7171275B2 (en) 1999-08-12 2007-01-30 Irvine Biomedical Inc. High torque balloon catheter possessing multi-directional deflectability and methods thereof
US20070049999A1 (en) * 2005-07-21 2007-03-01 Esch Brady D Apparatus and method for ensuring safe operation of a thermal treatment catheter
WO2006041881B1 (en) 2004-10-05 2007-05-10 Ardian Inc Methods and apparatus for renal neuromodulation
WO2007008954A3 (en) 2005-07-11 2007-05-10 Ablation Frontiers Low power tissue ablation system
US7221979B2 (en) 2003-04-30 2007-05-22 Medtronic, Inc. Methods and apparatus for the regulation of hormone release
US20070129720A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US20070213687A1 (en) 2006-03-07 2007-09-13 Barlow David E Cannulation device with segmented tip
US7276062B2 (en) 2003-03-12 2007-10-02 Biosence Webster, Inc. Deflectable catheter with hinge
US20070287955A1 (en) 2002-07-25 2007-12-13 Boston Scientific Scimed, Inc. Tubular member having tapered transition for use in a medical device
US20080077119A1 (en) 2001-07-05 2008-03-27 Precision Vascular Systems, Inc. Torqueable soft tip medical device and method of usage
US20080097397A1 (en) 2006-06-08 2008-04-24 Vrba Anthony C Vascular introducer sheath
US7381200B2 (en) 2003-05-06 2008-06-03 Asahi Intecc Co., Ltd. Infusion device
US20080147001A1 (en) 2002-03-22 2008-06-19 Laila Al-Marashi Rapid-exchange balloon catheter shaft and method
US7390894B2 (en) 2005-07-07 2008-06-24 Mayo Foundation For Medical Education And Research Glutathione S-transferase sequence variants
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
US20080319513A1 (en) 2007-06-25 2008-12-25 Cardiac Pacemakers, Inc. Neural stimulation with respiratory rhythm management
US20080319418A1 (en) 2004-03-30 2008-12-25 Cathrx Pty Ltd Catheter Steering Device
US7520863B2 (en) 2002-03-22 2009-04-21 Cordis Corporation Guidewire with deflectable tip having improved torque characteristics
US20090125001A1 (en) 2007-06-15 2009-05-14 Anderson Neil L Deflectable stylet
US20090157048A1 (en) 2007-12-18 2009-06-18 Boston Scientific Scimed, Inc. Spiral cut hypotube
WO2009108997A1 (en) 2008-03-03 2009-09-11 Mk International Pty Ltd Catheter with friction reducing surface shaping
EP2106821A1 (en) 2008-03-31 2009-10-07 Astra Tech AB Catheter assembly comprising a tubular member having pleated regions, and a method of activating the same
WO2009125575A1 (en) 2008-04-11 2009-10-15 日本ライフライン株式会社 Catheter
US7615067B2 (en) 2006-06-05 2009-11-10 Cambridge Endoscopic Devices, Inc. Surgical instrument
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20090312606A1 (en) 2006-03-31 2009-12-17 Boston Scientific Scimed, Inc. Flexible device shaft with angled spiral wrap
US7637903B2 (en) 2004-02-09 2009-12-29 Cryocor, Inc. Catheter articulation segment with alternating cuts
US20100010526A1 (en) 2008-07-10 2010-01-14 B&M Precislon, Inc. Flexible Inner Member Having a Flexible Region Comprising a Labyrinthine Cut
US20100030217A1 (en) 2008-08-01 2010-02-04 Miroslav Mitusina Flexible Inner Member Having a Flexible Region Comprising a Cut with Convoluted Path Areas
US20100057037A1 (en) 2008-09-02 2010-03-04 Abbott Cardiovascular Systems Inc. Agent Delivery Catheters
US20100069882A1 (en) 2008-09-18 2010-03-18 Boston Scientific Scimed, Inc. Medical device with preferential bending
US7682319B2 (en) 1999-04-09 2010-03-23 Evalve, Inc. Steerable access sheath and methods of use
US7702397B2 (en) 2000-09-07 2010-04-20 Covidien Ag Apparatus and method for treatment of an intervertebral disc
US20100099952A1 (en) 2008-10-22 2010-04-22 Boston Scientific Scimed, Inc. Steerable Shaft Having Micromachined Tube
US7708704B2 (en) 2006-07-31 2010-05-04 Codman & Shurtleff, Pc Interventional medical device component having an interrupted spiral section and method of making the same
EP1982741B1 (en) 2007-04-18 2010-06-23 Medical Service GmbH Catheter set
US7744856B2 (en) 2005-10-03 2010-06-29 Biotech Research And Development Corporation Formulations with feruloyl glycerides and methods of preparation
US7771410B2 (en) 2002-11-25 2010-08-10 Invatec S.R.L. Pipe having at least a portion with a variable flexibility
US7771421B2 (en) 1999-04-05 2010-08-10 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US7778703B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
US20100217184A1 (en) 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Steerable catheter having intermediate stiffness transition zone
EP1839697B1 (en) 2006-03-29 2010-09-08 Cordis Development Corporation Joined metal tubing
US20100228112A1 (en) 2007-10-26 2010-09-09 St. Jude Medical Systems Ab Sensor guide wire with micro-cable winding
US7815637B2 (en) 2001-11-29 2010-10-19 Ormsby Theodore C Radio-frequency-based catheter system with improved deflection and steering mechanisms
US7833191B2 (en) 2008-04-19 2010-11-16 Biotronik Crm Patent Ag Controllable electrode for deep brain stimulation
US20100305682A1 (en) * 2006-09-21 2010-12-02 Cleveny Technologies Specially configured and surface modified medical device with certain design features that utilize the intrinsic properties of tungsten, zirconium, tantalum and/or niobium
US20100331776A1 (en) 2009-06-24 2010-12-30 Amr Salahieh Steerable Medical Delivery Devices and Methods of Use
US20100331618A1 (en) 2009-06-24 2010-12-30 Gyrus Acmi, Inc. Endoscope shaft frame member with wavy slot
US20110054464A1 (en) 2009-08-25 2011-03-03 Randell Werneth Bi-modal linear and loop ablation catheter, and method
US20110066105A1 (en) 2002-11-15 2011-03-17 Applied Medical Resources Corporation Steerable kink-resistant sheath
EP2332607A1 (en) 2009-12-14 2011-06-15 The Royal College of Surgeons in Ireland A urethral catheter
US7989042B2 (en) 2004-11-24 2011-08-02 Boston Scientific Scimed, Inc. Medical devices with highly flexible coated hypotube
EP2351593A2 (en) 2010-01-29 2011-08-03 Cordis Corporation Highly flexible tubular device for medical use
US20110245808A1 (en) 2010-03-31 2011-10-06 Boston Scientific Scimed, Inc. Guidewire with an improved flexural rigidity profile
US8043279B2 (en) 2002-06-26 2011-10-25 Terumo Kabushiki Kaisha Catheter and medical tube
US20110276034A1 (en) 2009-01-15 2011-11-10 Cathrx Ltd Steerable stylet
US20110288392A1 (en) 2009-12-31 2011-11-24 De La Rama Alan Kit for Non-Invasive Electrophysiology Procedures and Method of its Use
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20120101413A1 (en) 2010-10-20 2012-04-26 Medtronic Ardian Luxembourg S.a.r.I. Catheter apparatuses having expandable mesh structures for renal neuromodulation and associated systems and methods
US20120123328A1 (en) * 2010-11-17 2012-05-17 Micrus Endovascular Llc Guide catheter composed of shape memory polymer
US20120136350A1 (en) * 2010-10-21 2012-05-31 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US20120143293A1 (en) 2010-10-25 2012-06-07 Medtronic Ardian Luxembourg S.a.r.I. Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods
US20120204387A1 (en) * 2007-03-12 2012-08-16 Cook Medical Technologies Llc Woven fabric with shape memory element strands
US20120232529A1 (en) * 2004-03-26 2012-09-13 Lawrence Livermore National Security, Llc Shape memory system with integrated actuation using embedded particles
US20130006238A1 (en) * 2011-06-30 2013-01-03 Tom Allen Ditter Catheter with variable arcuate distal section
US8376865B2 (en) 2006-06-20 2013-02-19 Cardiacmd, Inc. Torque shaft and torque shaft drive
US20140114288A1 (en) 2012-10-22 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US20140135736A1 (en) * 2012-11-10 2014-05-15 Stephen J. Hebert Coaxial bi-directional catheter
US20140142509A1 (en) * 2012-11-21 2014-05-22 P Tech, Llc Expandable access systems and methods

Family Cites Families (344)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020829A (en) * 1975-10-23 1977-05-03 Willson James K V Spring guide wire with torque control for catheterization of blood vessels and method of using same
US5007896A (en) * 1988-12-19 1991-04-16 Surgical Systems & Instruments, Inc. Rotary-catheter for atherectomy
US4890623A (en) 1988-03-14 1990-01-02 C. R. Bard, Inc. Biopotential sensing device and method for making
EP0352955A3 (en) 1988-07-22 1990-05-09 Baxter International Inc. Metal hot tip catheter with fused tip and temperature feedback loop
US5779698A (en) 1989-01-18 1998-07-14 Applied Medical Resources Corporation Angioplasty catheter system and method for making same
SE8902630L (en) 1989-07-31 1991-02-01 Radi Medical Systems Catheter control device and combination daerav
US5158564A (en) 1990-02-14 1992-10-27 Angiomed Ag Atherectomy apparatus
WO1992015356A1 (en) 1991-03-01 1992-09-17 Baxter International Inc. Cardiovascular catheter having discrete regions of varying flexibility
US5454788A (en) 1991-04-24 1995-10-03 Baxter International Inc. Exchangeable integrated-wire balloon catheter
IT1245528B (en) 1991-05-06 1994-09-29 Mini Ricerca Scient Tecnolog Angioplasty catheter and method for obtaining it.
US5741429A (en) 1991-09-05 1998-04-21 Cardia Catheter Company Flexible tubular device for use in medical applications
EP0680351B1 (en) 1991-09-05 1998-08-05 Mayo Foundation For Medical Education And Research Flexible tubular device for use in medical applications
US6915806B2 (en) 1993-05-10 2005-07-12 Arthrocare Corporation Method for harvesting graft vessel
US6632193B1 (en) 1995-06-07 2003-10-14 Arthrocare Corporation Systems and methods for electrosurgical tissue treatment
US5628775A (en) 1991-11-08 1997-05-13 Ep Technologies, Inc. Flexible bond for sleeves enclosing a bendable electrode tip assembly
CA2082315C (en) 1991-11-13 1997-03-18 Harold I. Pearsall Catheter
AU3472593A (en) 1992-01-22 1993-09-01 Thomas R. Winston Medical catheter using ultrasound mapping with external transducers
EP0634907B1 (en) 1992-04-10 1997-01-29 Cardiorhythm Intracardiac electrical potential reference catheter
WO1993020886A1 (en) 1992-04-13 1993-10-28 Ep Technologies, Inc. Articulated systems for cardiac ablation
WO1994007446A1 (en) 1992-10-05 1994-04-14 Boston Scientific Corporation Device and method for heating tissue
CA2107741C (en) 1992-10-07 2000-06-27 Peter T. Keith Ablation devices and methods of use
WO1994010922A1 (en) 1992-11-13 1994-05-26 Ep Technologies, Inc. Cardial ablation systems using temperature monitoring
US5441483A (en) 1992-11-16 1995-08-15 Avitall; Boaz Catheter deflection control
US5690666A (en) * 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
CA2109980A1 (en) 1992-12-01 1994-06-02 Mir A. Imran Steerable catheter with adjustable bend location and/or radius and method
US5509411A (en) 1993-01-29 1996-04-23 Cardima, Inc. Intravascular sensing device
US5358493A (en) 1993-02-18 1994-10-25 Scimed Life Systems, Inc. Vascular access catheter and methods for manufacture thereof
US6346074B1 (en) 1993-02-22 2002-02-12 Heartport, Inc. Devices for less invasive intracardiac interventions
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
EP0703756B1 (en) 1993-06-10 2004-12-15 IMRAN, Mir, A. Transurethral radio frequency ablation apparatus
US5860974A (en) 1993-07-01 1999-01-19 Boston Scientific Corporation Heart ablation catheter with expandable electrode and method of coupling energy to an electrode on a catheter shaft
US5545200A (en) 1993-07-20 1996-08-13 Medtronic Cardiorhythm Steerable electrophysiology catheter
US5417208A (en) 1993-10-12 1995-05-23 Arrow International Investment Corp. Electrode-carrying catheter and method of making same
US5582609A (en) 1993-10-14 1996-12-10 Ep Technologies, Inc. Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
CA2102250A1 (en) 1993-11-02 1995-05-03 Robert S. Schwartz Flexible catheter guidewire
US6283960B1 (en) 1995-10-24 2001-09-04 Oratec Interventions, Inc. Apparatus for delivery of energy to a surgical site
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US5554114A (en) 1994-10-20 1996-09-10 Micro Therapeutics, Inc. Infusion device with preformed shape
IT1278372B1 (en) 1995-02-15 1997-11-20 Sorin Biomedica Cardio Spa Catheter, particularly for the treatment of cardiac arrhythmias.
US5904697A (en) 1995-02-24 1999-05-18 Heartport, Inc. Devices and methods for performing a vascular anastomosis
US6110187A (en) 1995-02-24 2000-08-29 Heartport, Inc. Device and method for minimizing heart displacements during a beating heart surgical procedure
WO1996034646A1 (en) 1995-05-01 1996-11-07 Medtronic Cardiorhythm Dual curve ablation catheter and method
US6830568B1 (en) 1995-05-10 2004-12-14 Randy J. Kesten Guiding catheter system for ablating heart tissue
US5899892A (en) 1996-05-31 1999-05-04 Scimed Life Systems, Inc. Catheter having distal fiber braid
US6293943B1 (en) 1995-06-07 2001-09-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods which predict maximum tissue temperature
US6705323B1 (en) * 1995-06-07 2004-03-16 Conceptus, Inc. Contraceptive transcervical fallopian tube occlusion devices and methods
US6090104A (en) 1995-06-07 2000-07-18 Cordis Webster, Inc. Catheter with a spirally wound flat ribbon electrode
US8241217B2 (en) 1995-06-29 2012-08-14 Teratech Corporation Portable ultrasound imaging data
US5827272A (en) 1995-08-07 1998-10-27 Medtronic Cardiorhythm Simplified torquing electrode catheter
US5823955A (en) 1995-11-20 1998-10-20 Medtronic Cardiorhythm Atrioventricular valve tissue ablation catheter and method
CN1216930A (en) 1996-02-02 1999-05-19 血管转换公司 Device, system and method for interstitial transvascular intervention
US5695506A (en) 1996-02-06 1997-12-09 Devices For Vascular Intervention Catheter device with a flexible housing
WO1997029800A1 (en) 1996-02-13 1997-08-21 Cardiovascular Dynamics, Inc. Hybrid catheter shaft
US5807249A (en) 1996-02-16 1998-09-15 Medtronic, Inc. Reduced stiffness, bidirectionally deflecting catheter assembly
US6036687A (en) 1996-03-05 2000-03-14 Vnus Medical Technologies, Inc. Method and apparatus for treating venous insufficiency
WO1997036541A1 (en) 1996-04-02 1997-10-09 Cordis Webster, Inc. Electrophysiology catheter with a bullseye electrode
EP1171032A4 (en) 1999-04-15 2008-10-29 Surgi Vision Methods for in vivo magnetic resonance imaging
GB9612993D0 (en) 1996-06-20 1996-08-21 Gyrus Medical Ltd Electrosurgical instrument
US5899890A (en) 1996-06-21 1999-05-04 Medtronic, Inc. Flow-directed catheter system and method of use
US5826576A (en) 1996-08-08 1998-10-27 Medtronic, Inc. Electrophysiology catheter with multifunction wire and method for making
US5697928A (en) 1996-09-23 1997-12-16 Uab Research Foundation Cardic electrode catheter
NL1004160C2 (en) 1996-10-01 1998-04-02 Cordis Europ An ablation catheter with inductively heated heating member.
US5971975A (en) 1996-10-09 1999-10-26 Target Therapeutics, Inc. Guide catheter with enhanced guidewire tracking
US6091995A (en) 1996-11-08 2000-07-18 Surx, Inc. Devices, methods, and systems for shrinking tissues
US6159187A (en) 1996-12-06 2000-12-12 Target Therapeutics, Inc. Reinforced catheter with a formable distal tip
US5904667A (en) 1997-03-17 1999-05-18 C.R. Bard, Inc. Rotatable control mechanism for steerable catheter
US5954761A (en) 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
WO1998043530A1 (en) 1997-03-31 1998-10-08 Biosense Inc. Deflectable catheter
AU7277598A (en) 1997-04-30 1998-11-24 Kenton W. Gregory Energy delivery of catheter and method for the use thereof
WO1998050098A1 (en) 1997-05-08 1998-11-12 Microvena Corporation Improved multi-durometer catheter
US5952671A (en) 1997-05-09 1999-09-14 Micron Technology, Inc. Small electrode for a chalcogenide switching device and method for fabricating same
JP2002515813A (en) 1997-05-23 2002-05-28 バイオセンス・インコーポレイテッド Catheter having a lumen extending diagonally
US5895378A (en) 1997-05-29 1999-04-20 Target Therapeutics, Inc. Flow-directed catheter having multiple tapers and radio-opaque markers
US5951539A (en) 1997-06-10 1999-09-14 Target Therpeutics, Inc. Optimized high performance multiple coil spiral-wound vascular catheter
US6869431B2 (en) 1997-07-08 2005-03-22 Atrionix, Inc. Medical device with sensor cooperating with expandable member
US6024740A (en) 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US6966908B2 (en) 1997-07-08 2005-11-22 Atrionix, Inc. Tissue ablation device assembly and method for electrically isolating a pulmonary vein ostium from an atrial wall
AU8507698A (en) 1997-07-29 1999-02-22 Ep Technologies Inc Improved catheter distal end assemblies
EP0900547B1 (en) 1997-09-05 2007-05-30 Biosense Webster, Inc. Steerable catheter for detecting and revascularizing ischemic myocardial tissue
US5891114A (en) 1997-09-30 1999-04-06 Target Therapeutics, Inc. Soft-tip high performance braided catheter
CN1274294A (en) 1997-10-08 2000-11-22 钟渊化学工业株式会社 Balloon catheter and method of prodn. thereof
US5935124A (en) 1997-12-02 1999-08-10 Cordis Webster, Inc. Tip electrode with multiple temperature sensors
US6917834B2 (en) 1997-12-03 2005-07-12 Boston Scientific Scimed, Inc. Devices and methods for creating lesions in endocardial and surrounding tissue to isolate focal arrhythmia substrates
US6267679B1 (en) * 1997-12-31 2001-07-31 Jack W. Romano Method and apparatus for transferring drilling energy to a cutting member
US6245020B1 (en) 1998-01-26 2001-06-12 Scimed Life System, Inc. Catheter assembly with distal end inductive coupler and embedded transmission line
US5935145A (en) * 1998-02-13 1999-08-10 Target Therapeutics, Inc. Vaso-occlusive device with attached polymeric materials
US6142993A (en) 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
US6666874B2 (en) 1998-04-10 2003-12-23 Endicor Medical, Inc. Rotational atherectomy system with serrated cutting tip
US7494488B2 (en) 1998-05-28 2009-02-24 Pearl Technology Holdings, Llc Facial tissue strengthening and tightening device and methods
US20060167498A1 (en) 2001-07-23 2006-07-27 Dilorenzo Daniel J Method, apparatus, and surgical technique for autonomic neuromodulation for the treatment of disease
US5980563A (en) 1998-08-31 1999-11-09 Tu; Lily Chen Ablation apparatus and methods for treating atherosclerosis
US6796981B2 (en) 1999-09-30 2004-09-28 Sherwood Services Ag Vessel sealing system
US6210406B1 (en) 1998-12-03 2001-04-03 Cordis Webster, Inc. Split tip electrode catheter and signal processing RF ablation system
US6113615A (en) 1999-02-03 2000-09-05 Scimed Life Systems, Inc. Atherectomy burr including a bias wire
US6427089B1 (en) 1999-02-19 2002-07-30 Edward W. Knowlton Stomach treatment apparatus and method
US6179857B1 (en) * 1999-02-22 2001-01-30 Cordis Corporation Stretch resistant embolic coil with variable stiffness
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US20050010095A1 (en) 1999-04-05 2005-01-13 Medtronic, Inc. Multi-purpose catheter apparatus and method of use
US6514236B1 (en) 1999-04-23 2003-02-04 Alexander A. Stratienko Method for treating a cardiovascular condition
US6245045B1 (en) 1999-04-23 2001-06-12 Alexander Andrew Stratienko Combination sheath and catheter for cardiovascular use
WO2000066211A1 (en) 1999-04-30 2000-11-09 Usaminanotechnology, Inc. Catheter and guide wire
US6648854B1 (en) 1999-05-14 2003-11-18 Scimed Life Systems, Inc. Single lumen balloon-tipped micro catheter with reinforced shaft
US6890329B2 (en) 1999-06-15 2005-05-10 Cryocath Technologies Inc. Defined deflection structure
SE519023C2 (en) 1999-06-21 2002-12-23 Micromuscle Ab Catheter-borne micro-surgical tool set
EP1198271A4 (en) 1999-06-25 2009-01-21 Univ Emory Devices and methods for vagus nerve stimulation
US6508804B2 (en) 1999-07-28 2003-01-21 Scimed Life Systems, Inc. Catheter having continuous lattice and coil reinforcement
US9078660B2 (en) 2000-08-09 2015-07-14 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US6298256B1 (en) 1999-09-10 2001-10-02 Frank-Egbert Meyer Device and method for the location and catheterization of the surroundings of a nerve
US6829497B2 (en) 1999-09-21 2004-12-07 Jamil Mogul Steerable diagnostic catheters
US6711444B2 (en) 1999-11-22 2004-03-23 Scimed Life Systems, Inc. Methods of deploying helical diagnostic and therapeutic element supporting structures within the body
US6542781B1 (en) 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
CA2391488C (en) 1999-11-22 2012-04-03 Boston Scientific Limited Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6613046B1 (en) 1999-11-22 2003-09-02 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6529756B1 (en) 1999-11-22 2003-03-04 Scimed Life Systems, Inc. Apparatus for mapping and coagulating soft tissue in or around body orifices
US6745080B2 (en) 1999-11-22 2004-06-01 Scimed Life Systems, Inc. Helical and pre-oriented loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6454775B1 (en) 1999-12-06 2002-09-24 Bacchus Vascular Inc. Systems and methods for clot disruption and retrieval
US6800075B2 (en) 1999-12-10 2004-10-05 Sprite Solutions Method to inject and extract fluid at a treatment site to remove debris
US6440125B1 (en) 2000-01-04 2002-08-27 Peter Rentrop Excimer laser catheter
US6628976B1 (en) 2000-01-27 2003-09-30 Biosense Webster, Inc. Catheter having mapping assembly
US6663622B1 (en) 2000-02-11 2003-12-16 Iotek, Inc. Surgical devices and methods for use in tissue ablation procedures
JP2004500207A (en) 2000-03-06 2004-01-08 ティシューリンク・メディカル・インコーポレーテッドTissuelink Medical,Inc. Fluid delivery system and electrosurgical instrument controller
US20020107514A1 (en) 2000-04-27 2002-08-08 Hooven Michael D. Transmural ablation device with parallel jaws
US20020022864A1 (en) 2000-06-07 2002-02-21 Mahvi David M. Multipolar electrode system for radiofrequency ablation
WO2001095820A1 (en) 2000-06-13 2001-12-20 Atrionix, Inc. Surgical ablation probe for forming a circumferential lesion
US6497711B1 (en) 2000-08-16 2002-12-24 Scimed Life Systems, Inc. Therectomy device having a light weight drive shaft and an imaging device
US6669692B1 (en) 2000-08-21 2003-12-30 Biosense Webster, Inc. Ablation catheter with cooled linear electrode
US6482221B1 (en) 2000-08-21 2002-11-19 Counter Clockwise, Inc. Manipulatable delivery catheter for occlusive devices (II)
US6584362B1 (en) 2000-08-30 2003-06-24 Cardiac Pacemakers, Inc. Leads for pacing and/or sensing the heart from within the coronary veins
US6640120B1 (en) 2000-10-05 2003-10-28 Scimed Life Systems, Inc. Probe assembly for mapping and ablating pulmonary vein tissue and method of using same
US6926669B1 (en) 2000-10-10 2005-08-09 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US7198635B2 (en) 2000-10-17 2007-04-03 Asthmatx, Inc. Modification of airways by application of energy
EA005391B1 (en) 2000-11-24 2005-02-24 Инноваселл Биотехнологи Гмбх Ultrasonic probe comprising a positioning device for examination devices and operation devices
US6659981B2 (en) 2000-12-08 2003-12-09 Medtronic, Inc. Medical device delivery catheter with distal locator
US6569177B1 (en) 2001-01-19 2003-05-27 Scimed Life Systems, Inc. Ablation atherectomy burr
AU2002309117A1 (en) 2001-03-08 2002-11-05 Avtandil Koridze Alkane and alkane group dehydrogenation with organometallic catalysts
DE10114725A1 (en) 2001-03-21 2002-09-26 Biotronik Mess & Therapieg Intravascular electrode line
US20020147480A1 (en) 2001-04-04 2002-10-10 Mamayek Donald S. Treatment of lipid pool
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US6648883B2 (en) 2001-04-26 2003-11-18 Medtronic, Inc. Ablation system and method of use
US6663627B2 (en) 2001-04-26 2003-12-16 Medtronic, Inc. Ablation system and method of use
US6645223B2 (en) 2001-04-30 2003-11-11 Advanced Cardiovascular Systems, Inc. Deployment and recovery control systems for embolic protection devices
WO2002089908A1 (en) 2001-05-10 2002-11-14 Super Dimension Ltd. Steerable multiple electrode catheter and method
CA2446920A1 (en) 2001-05-21 2002-11-28 Medtronic, Inc. Trans-septal catheter with retention mechanism
US20030050635A1 (en) 2001-08-22 2003-03-13 Csaba Truckai Embolization systems and techniques for treating tumors
WO2003024309A2 (en) 2001-09-19 2003-03-27 Urologix, Inc. Microwave ablation device
US6723043B2 (en) 2001-09-25 2004-04-20 Sdgi Holdings, Inc. Methods and devices for inserting and manipulating surgical instruments
US7517349B2 (en) 2001-10-22 2009-04-14 Vnus Medical Technologies, Inc. Electrosurgical instrument and method
US6652508B2 (en) 2001-11-09 2003-11-25 Scimed Life Systems, Inc. Intravascular microcatheter having hypotube proximal shaft with transition
US20030092995A1 (en) 2001-11-13 2003-05-15 Medtronic, Inc. System and method of positioning implantable medical devices
WO2003043685A2 (en) 2001-11-19 2003-05-30 Cardiovascular Systems, Inc High torque, low profile intravascular guidewire system
US6849075B2 (en) 2001-12-04 2005-02-01 Estech, Inc. Cardiac ablation devices and methods
US6945970B2 (en) * 2001-12-27 2005-09-20 Scimed Life Systems, Inc. Catheter incorporating a curable polymer layer to control flexibility and method of manufacture
US7488338B2 (en) 2001-12-27 2009-02-10 Boston Scientific Scimed, Inc. Catheter having an improved torque transmitting shaft
US6817999B2 (en) 2002-01-03 2004-11-16 Afx, Inc. Flexible device for ablation of biological tissue
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US6790206B2 (en) 2002-01-31 2004-09-14 Scimed Life Systems, Inc. Compensation for power variation along patient cables
US7311705B2 (en) 2002-02-05 2007-12-25 Medtronic, Inc. Catheter apparatus for treatment of heart arrhythmia
US7192427B2 (en) 2002-02-19 2007-03-20 Afx, Inc. Apparatus and method for assessing transmurality of a tissue ablation
US7294127B2 (en) 2002-03-05 2007-11-13 Baylis Medical Company Inc. Electrosurgical tissue treatment method
US7846157B2 (en) 2002-03-15 2010-12-07 C.R. Bard, Inc. Method and apparatus for control of ablation energy and electrogram acquisition through multiple common electrodes in an electrophysiology catheter
WO2003082403A2 (en) 2002-03-27 2003-10-09 Cvrx, Inc. Devices and methods for cardiovascular reflex control via coupled electrodes
US20030191451A1 (en) * 2002-04-05 2003-10-09 Kevin Gilmartin Reinforced catheter system
US20040147903A1 (en) 2002-04-05 2004-07-29 Lucas Latini Microcatheter having tip relief region
DE10217559B4 (en) 2002-04-19 2004-02-19 Universitätsklinikum Freiburg A device for minimally invasive, intravascular Aortenklappenextraktion
US6748953B2 (en) 2002-06-11 2004-06-15 Scimed Life Systems, Inc. Method for thermal treatment of type II endoleaks in arterial aneurysms
US7153315B2 (en) 2002-06-11 2006-12-26 Boston Scientific Scimed, Inc. Catheter balloon with ultrasonic microscalpel blades
US6773447B2 (en) 2002-07-02 2004-08-10 Sentient Engineering & Technology, Llc Balloon catheter and treatment apparatus
US8273100B2 (en) * 2002-07-31 2012-09-25 Microvention, Inc. Three element coaxial vaso-occlusive device
US20050171572A1 (en) * 2002-07-31 2005-08-04 Microvention, Inc. Multi-layer coaxial vaso-occlusive device
US6855123B2 (en) 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
US7063679B2 (en) 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
US6926713B2 (en) 2002-12-11 2005-08-09 Boston Scientific Scimed, Inc. Angle indexer for medical devices
US6945956B2 (en) 2002-12-23 2005-09-20 Medtronic, Inc. Steerable catheter
US7087051B2 (en) 2003-01-15 2006-08-08 Boston Scientific Scimed, Inc. Articulating radio frequency probe handle
US7819866B2 (en) 2003-01-21 2010-10-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Ablation catheter and electrode
US6923808B2 (en) 2003-02-24 2005-08-02 Boston Scientific Scimed, Inc. Probes having helical and loop shaped inflatable therapeutic elements
DE10308383A1 (en) 2003-02-27 2004-09-16 Storz Endoskop Produktions Gmbh Method and optical system for measuring the topography of a measurement object
US7001369B2 (en) 2003-03-27 2006-02-21 Scimed Life Systems, Inc. Medical device
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US6939348B2 (en) 2003-03-27 2005-09-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US7758520B2 (en) 2003-05-27 2010-07-20 Boston Scientific Scimed, Inc. Medical device having segmented construction
US7763012B2 (en) 2003-09-02 2010-07-27 St. Jude Medical, Cardiology Division, Inc. Devices and methods for crossing a chronic total occlusion
US7435248B2 (en) 2003-09-26 2008-10-14 Boston Scientific Scimed, Inc. Medical probes for creating and diagnosing circumferential lesions within or around the ostium of a vessel
US7896873B2 (en) 2003-12-01 2011-03-01 Biotronik Crm Patent Ag Electrode catheter for the electrotherapy of cardiac tissue
EP1709922A4 (en) 2004-01-06 2008-06-11 Toray Industries Balloon catheter
US8460286B2 (en) 2004-01-16 2013-06-11 St. Jude Medical, Atrial Fibrillation Division, Inc. Conforming electrode
US7238184B2 (en) 2004-03-15 2007-07-03 Boston Scientific Scimed, Inc. Ablation probe with peltier effect thermal control
US20050228286A1 (en) 2004-04-07 2005-10-13 Messerly Jeffrey D Medical system having a rotatable ultrasound source and a piercing tip
US20060004323A1 (en) 2004-04-21 2006-01-05 Exploramed Nc1, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US8012201B2 (en) 2004-05-05 2011-09-06 Direct Flow Medical, Inc. Translumenally implantable heart valve with multiple chamber formed in place support
US7285116B2 (en) 2004-05-15 2007-10-23 Irvine Biomedical Inc. Non-contact tissue ablation device and methods thereof
US8007462B2 (en) 2004-05-17 2011-08-30 C. R. Bard, Inc. Articulated catheter
US20060025765A1 (en) 2004-07-30 2006-02-02 Jaime Landman Electrosurgical systems and methods
WO2006016481A1 (en) 2004-08-10 2006-02-16 Kaneka Corporation Catheter tube for medical treatment and method of manufacturing the same
WO2006031541A1 (en) 2004-09-09 2006-03-23 Vnus Medical Technologies, Inc. Methods and apparatus for treatment of hollow anatomical structures
US7458971B2 (en) 2004-09-24 2008-12-02 Boston Scientific Scimed, Inc. RF ablation probe with unibody electrode element
US20060074403A1 (en) 2004-09-29 2006-04-06 Nasser Rafiee Curved catheter comprising a solid-walled metal tube with varying stiffness
US8535345B2 (en) * 2004-10-07 2013-09-17 DePuy Synthes Products, LLC Vasoocclusive coil with biplex windings to improve mechanical properties
US20060089637A1 (en) 2004-10-14 2006-04-27 Werneth Randell L Ablation catheter
US7938830B2 (en) 2004-10-15 2011-05-10 Baxano, Inc. Powered tissue modification devices and methods
WO2006055845A1 (en) 2004-11-15 2006-05-26 Cytyc Corporation System for drug delivery
JP2008520364A (en) 2004-11-17 2008-06-19 バイオセンス・ウェブスター・インコーポレイテッドBiosense Webster, Inc. Real-time evaluation apparatus of the tissue ablation
EP3175827B1 (en) 2004-12-15 2019-03-06 Cook Medical Technologies LLC Multifilar cable catheter
US8007440B2 (en) 2005-02-08 2011-08-30 Volcano Corporation Apparatus and methods for low-cost intravascular ultrasound imaging and for crossing severe vascular occlusions
US20060206140A1 (en) 2005-02-24 2006-09-14 Samuel Shaolian Adjustable embolic aneurysm coil
CN2782017Y (en) 2005-03-08 2006-05-24 深圳市惠泰医疗器械有限公司 Electrical physiological electrode conduit
US7670337B2 (en) 2005-03-25 2010-03-02 Boston Scientific Scimed, Inc. Ablation probe having a plurality of arrays of electrodes
ES2565342T3 (en) 2005-03-28 2016-04-04 Vessix Vascular, Inc. electrical characterization and tissue intraluminal RF energy for controlled selective treatment of atheroma, and other target tissues
US20060224153A1 (en) 2005-04-05 2006-10-05 Fischell Robert E Catheter system for the treatment of atrial fibrillation
US20080108867A1 (en) 2005-12-22 2008-05-08 Gan Zhou Devices and Methods for Ultrasonic Imaging and Ablation
US7806871B2 (en) 2005-05-09 2010-10-05 Boston Scientific Scimed, Inc. Method and device for tissue removal and for delivery of a therapeutic agent or bulking agent
US7942874B2 (en) 2005-05-12 2011-05-17 Aragon Surgical, Inc. Apparatus for tissue cauterization
US20080091193A1 (en) 2005-05-16 2008-04-17 James Kauphusman Irrigated ablation catheter having magnetic tip for magnetic field control and guidance
US8961516B2 (en) * 2005-05-18 2015-02-24 Sonoma Orthopedic Products, Inc. Straight intramedullary fracture fixation devices and methods
KR20120099730A (en) 2005-05-20 2012-09-11 오메로스 코포레이션 Cyclooxygenase inhibitor and calcium channel antagonist compositions and methods for use in urological procedures
WO2007117359A2 (en) 2006-02-21 2007-10-18 Worley Seth J Coronary sinus lead for pacing the left atrium
AU2006262447A1 (en) 2005-06-20 2007-01-04 Medtronic Ablation Frontiers Llc Ablation catheter
US7717853B2 (en) 2005-06-24 2010-05-18 Henry Nita Methods and apparatus for intracranial ultrasound delivery
DE102005032755B4 (en) 2005-07-13 2014-09-04 Siemens Aktiengesellschaft System for implementation and monitoring minimally invasive surgery
DE102005041601B4 (en) 2005-09-01 2010-07-08 Siemens Ag An ablation catheter for setting a lesion and methods of making an ablation catheter
US20070073151A1 (en) 2005-09-13 2007-03-29 General Electric Company Automated imaging and therapy system
US7623899B2 (en) 2005-09-16 2009-11-24 Biosense Webster, Inc. Catheter with flexible pre-shaped tip section
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US20070112327A1 (en) 2005-11-03 2007-05-17 Yun Anthony J Methods and compositions for treating a renal disease condition in a subject
WO2007059277A1 (en) 2005-11-16 2007-05-24 William Cook Europe Aps Cannula
US8190238B2 (en) 2005-12-09 2012-05-29 Hansen Medical, Inc. Robotic catheter system and methods
US7896874B2 (en) 2005-12-29 2011-03-01 Boston Scientific Scimed, Inc. RF ablation probes with tine valves
US7993334B2 (en) 2005-12-29 2011-08-09 Boston Scientific Scimed, Inc. Low-profile, expanding single needle ablation probe
US20070156114A1 (en) 2005-12-29 2007-07-05 Worley Seth J Deflectable catheter with a flexibly attached tip section
US7620451B2 (en) 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US20070179496A1 (en) 2006-01-31 2007-08-02 Medtronic, Inc. Flexible catheter for ablation therapy
US7869854B2 (en) 2006-02-23 2011-01-11 Magnetecs, Inc. Apparatus for magnetically deployable catheter with MOSFET sensor and method for mapping and ablation
US8571650B2 (en) * 2006-03-03 2013-10-29 Palo Alto Investors Methods and compositions for treating a renal associated condition in a subject
US8027718B2 (en) 2006-03-07 2011-09-27 Mayo Foundation For Medical Education And Research Regional anesthetic
US8246574B2 (en) 2006-04-21 2012-08-21 Abbott Laboratories Support catheter
US7905877B1 (en) * 2006-05-12 2011-03-15 Micrus Design Technology, Inc. Double helix reinforced catheter
EP1857134A1 (en) 2006-05-15 2007-11-21 JOANNEUM RESEARCH Forschungsgesellschaft mbH Catheter having an oblong slit
US8103356B2 (en) 2006-05-23 2012-01-24 Vertech, Inc. High frequency epidural neuromodulation catheter without needle for effectuating RF treatment
EP2043540A2 (en) 2006-07-10 2009-04-08 Lina Medical ApS An electrosurgical instrument
US20090221955A1 (en) 2006-08-08 2009-09-03 Bacoustics, Llc Ablative ultrasonic-cryogenic methods
US8486060B2 (en) 2006-09-18 2013-07-16 Cytyc Corporation Power ramping during RF ablation
US20080071269A1 (en) 2006-09-18 2008-03-20 Cytyc Corporation Curved Endoscopic Medical Device
US7785289B2 (en) 2006-10-17 2010-08-31 Boston Scientific Scimed, Inc. Catheter with flexible, non-kinking elongate member
US20070073331A1 (en) 2006-10-17 2007-03-29 Conor Medsystems, Inc. Rapid exchange stent delivery catheter
US8388680B2 (en) 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
JP5312337B2 (en) 2006-10-18 2013-10-09 べシックス・バスキュラー・インコーポレイテッド Adjusted characterization of rf energy and electrical organization for selective treatment of target tissues
US20080172037A1 (en) * 2006-11-01 2008-07-17 Percutaneous Systems, Inc. Catheter with adjustable column stability and methods for its use
CA2670149A1 (en) 2006-11-28 2008-06-05 Cathrx Ltd Catheter steering/insertion mechanism
AU2007231733B2 (en) 2006-11-28 2014-03-13 Cathrx Ltd A catheter steering system
US7699809B2 (en) 2006-12-14 2010-04-20 Urmey William F Catheter positioning system
US8043288B2 (en) 2006-12-28 2011-10-25 St. Jude Medical, Atrial Fibrillation Division, Inc. Virtual electrode ablation catheter with electrode tip and variable radius capability actuated with at least one rack and pinion mechanisms
WO2008100590A1 (en) * 2007-02-14 2008-08-21 Flex Technology Inc Flexible spine components
WO2008101244A2 (en) 2007-02-18 2008-08-21 Via Biomedical, Inc. Guiding catheter support devices and methods
JP2010525913A (en) 2007-05-09 2010-07-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Sensor probe for measuring physical properties of the lumen of the body
US20090118620A1 (en) 2007-11-06 2009-05-07 General Electric Company System and method for tracking an ultrasound catheter
US8702609B2 (en) 2007-07-27 2014-04-22 Meridian Cardiovascular Systems, Inc. Image-guided intravascular therapy catheters
US8821477B2 (en) 2007-08-06 2014-09-02 Boston Scientific Scimed, Inc. Alternative micromachined structures
US8066731B2 (en) 2007-08-20 2011-11-29 Olympus Medical Systems Corp. Treatment device
US7863897B2 (en) 2007-09-07 2011-01-04 The General Hospital Corporation Method and apparatus for characterizing the temporal resolution of an imaging device
US20090069671A1 (en) 2007-09-10 2009-03-12 General Electric Company Electric Motor Tracking System and Method
EP2231060B1 (en) 2007-12-10 2015-05-27 Medtronic Ablation Frontiers LLC Ablation catheter
US8118809B2 (en) 2007-12-21 2012-02-21 St. Jude Medical, Atrial Fibrillation Division, Inc. Flexible conductive polymer electrode and method for ablation
WO2009085666A1 (en) 2007-12-27 2009-07-09 Boston Scientific Scimed, Inc. System for controllably delivering liquid coolant to a cryo-ablation device
US8226648B2 (en) 2007-12-31 2012-07-24 St. Jude Medical, Atrial Fibrillation Division, Inc. Pressure-sensitive flexible polymer bipolar electrode
US8401650B2 (en) 2008-04-10 2013-03-19 Electrocore Llc Methods and apparatus for electrical treatment using balloon and electrode
CN102014779B (en) 2008-05-09 2014-10-22 赫莱拉公司 A system, components and methods for treating bronchial tree
US8437832B2 (en) 2008-06-06 2013-05-07 Biosense Webster, Inc. Catheter with bendable tip
US20100030061A1 (en) 2008-07-31 2010-02-04 Canfield Monte R Navigation system for cardiac therapies using gating
US8663196B2 (en) * 2008-09-23 2014-03-04 Kassab Kughn Endovascular Devices Llc Endovascular sheath with gradable stiffness device and method
JP2012517306A (en) 2009-02-12 2012-08-02 イューエムセー ユトレヒト ホールディング ベースローテン フェンノートシャップ The method for electrically insulating the ablation catheter and cardiac tissue
US20100249604A1 (en) 2009-03-31 2010-09-30 Boston Scientific Corporation Systems and methods for making and using a motor distally-positioned within a catheter of an intravascular ultrasound imaging system
US8517955B2 (en) 2009-05-08 2013-08-27 Broncus Medical Inc. Tissue sampling devices, systems and methods
JP5444840B2 (en) 2009-05-21 2014-03-19 東レ株式会社 Ablation catheter and balloon ablation catheter system with the balloon
US8292881B2 (en) 2009-05-27 2012-10-23 Vivant Medical, Inc. Narrow gauge high strength choked wet tip microwave ablation antenna
US8911474B2 (en) * 2009-07-16 2014-12-16 Howmedica Osteonics Corp. Suture anchor implantation instrumentation system
US20110028962A1 (en) 2009-07-31 2011-02-03 Randell Werneth Adjustable pulmonary vein ablation catheter
CA2812775C (en) * 2009-08-20 2015-09-29 Howmedica Osteonics Corp. Flexible acl instrumentation, kit and method
US9387035B2 (en) 2009-08-25 2016-07-12 Medtronic Ablation Frontiers Llc Bi-modal catheter steering mechanism
US20110071400A1 (en) 2009-09-23 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using intravascular ultrasound imaging systems with sealed imaging cores
US20110071401A1 (en) 2009-09-24 2011-03-24 Boston Scientific Scimed, Inc. Systems and methods for making and using a stepper motor for an intravascular ultrasound imaging system
US8343145B2 (en) 2009-09-28 2013-01-01 Vivant Medical, Inc. Microwave surface ablation using conical probe
US8376991B2 (en) 2009-11-09 2013-02-19 St. Jude Medical, Atrial Fibrillation Division, Inc. Device for reducing axial shortening of catheter or sheath due to repeated deflection
US8608735B2 (en) 2009-12-30 2013-12-17 Biosense Webster (Israel) Ltd. Catheter with arcuate end section
EP2389974B1 (en) 2010-05-25 2014-04-23 Miracor Medical Systems GmbH A balloon catheter for introduction into a body vessel, in particular the coronary sinus
US20120089047A1 (en) * 2010-08-05 2012-04-12 Medtronic Vascular, Inc. Cryoablation apparatuses, systems, and methods for renal neuromodulation
US9144665B2 (en) * 2010-08-09 2015-09-29 Boston Scientific Limited Flexible sheath assemblies and interventional catheter systems incorporating them
US20120059241A1 (en) 2010-09-08 2012-03-08 Boston Scientific Scimed, Inc. Systems and methods for making and using a steerable imaging system configured and arranged for insertion into a patient
US8974451B2 (en) 2010-10-25 2015-03-10 Boston Scientific Scimed, Inc. Renal nerve ablation using conductive fluid jet and RF energy
US20120184952A1 (en) 2011-01-19 2012-07-19 Jenson Mark L Low-profile off-wall electrode device for renal nerve ablation
WO2012100095A1 (en) 2011-01-19 2012-07-26 Boston Scientific Scimed, Inc. Guide-compatible large-electrode catheter for renal nerve ablation with reduced arterial injury
CN102125725A (en) 2011-04-06 2011-07-20 湖南依微迪医疗器械有限公司 Catheter for endovascular treatment on hypertension
WO2013106054A2 (en) 2011-04-08 2013-07-18 Vivant Medical, Inc. Flexible microwave catheters for natural or artificial lumens
CN102125460B (en) 2011-04-15 2012-11-28 深圳市惠泰医疗器械有限公司 Renal artery radio frequency ablation catheter as well as manufacturing method and application method thereof
US9486605B2 (en) * 2011-07-15 2016-11-08 Cook Medical Technologies Llc Introducer sheath with braided filament securement mechanism
US9186209B2 (en) 2011-07-22 2015-11-17 Boston Scientific Scimed, Inc. Nerve modulation system having helical guide
US20130035681A1 (en) 2011-08-04 2013-02-07 Boston Scientific Scimed, Inc. Novel catheter for contiguous rf ablation
US20130053792A1 (en) 2011-08-24 2013-02-28 Ablative Solutions, Inc. Expandable catheter system for vessel wall injection and muscle and nerve fiber ablation
EP2572749A3 (en) * 2011-09-23 2013-04-03 Covidien LP Distal access balloon guide catheter
EP2765942B1 (en) 2011-10-10 2016-02-24 Boston Scientific Scimed, Inc. Medical devices including ablation electrodes
WO2013055685A2 (en) 2011-10-10 2013-04-18 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
US20130090649A1 (en) 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Device and methods for renal nerve modulation
CN103857353B (en) 2011-10-11 2017-03-01 波士顿科学西美德公司 Tip ablation catheter having an insulating
US10085799B2 (en) 2011-10-11 2018-10-02 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9364284B2 (en) 2011-10-12 2016-06-14 Boston Scientific Scimed, Inc. Method of making an off-wall spacer cage
US20130096550A1 (en) 2011-10-18 2013-04-18 Boston Scientific Scimed, Inc. Ablative catheter with electrode cooling and related methods of use
EP2768563B1 (en) 2011-10-18 2016-11-09 Boston Scientific Scimed, Inc. Deflectable medical devices
CN102551874B (en) 2011-10-20 2015-07-22 上海微创电生理医疗科技有限公司 Renal artery radiofrequency ablation catheter
US20130123770A1 (en) 2011-11-14 2013-05-16 Boston Scientific Scimed, Inc. Ablation catheter with cryothermal balloon
US9119632B2 (en) 2011-11-21 2015-09-01 Boston Scientific Scimed, Inc. Deflectable renal nerve ablation catheter
US8911397B2 (en) 2011-12-22 2014-12-16 Boston Scientific Scimed Inc. Steerable sheath handle pulley mechanism
US9050106B2 (en) 2011-12-29 2015-06-09 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US20130172879A1 (en) 2011-12-29 2013-07-04 Boston Scientific Scimed, Inc. Renal nerve modulation medical devices
WO2013109318A1 (en) 2012-01-17 2013-07-25 Boston Scientific Scimed, Inc. Renal nerve modulation devices and methods for making and using the same
US9011480B2 (en) * 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US20130274730A1 (en) 2012-04-12 2013-10-17 Boston Scientific Scimed, Inc. Ablation catheter and methods for nerve modulation
US20130274731A1 (en) 2012-04-16 2013-10-17 Boston Scientific Scimed, Inc. Helical tubing devices and methods for fluid renal nerve modulation
US20130274737A1 (en) 2012-04-16 2013-10-17 Boston Scientific Scimed, Inc. Renal nerve modulation catheter design
DE102012104705A1 (en) 2012-05-31 2013-12-05 Stefan G. Spitzer Catheter system for performing denervation of sympathetic nerve at adventitia of wall of e.g. kidney artery of patient, has electrodes arranged at free ends of respective wires to deliver respective radio frequency energies
CN102743225B (en) 2012-07-18 2014-04-02 深圳市惠泰医疗器械有限公司 Radiofrequency ablation controlled electrode catheter for renal artery
CN104703556B (en) 2012-08-28 2017-05-24 波士顿科学西美德公司 Having renal radiofrequency ablation system and related method for using the movable dummy electrodes
CN102908189B (en) 2012-08-29 2015-04-08 中国人民解放军第三军医大学第一附属医院 Multifunctional ablation catheter system for denervation of renal sympathetic nerves
CN102908188B (en) 2012-08-29 2015-04-08 中国人民解放军第三军医大学第一附属医院 Radio frequency ablation (RFA) catheter system for denervation of renal sympathetic nerves
CN102885649B (en) 2012-08-29 2015-01-21 中国人民解放军第三军医大学第一附属医院 Radio frequency cable controlled ablation catheter system for removing sympathetic nerve from kidney
CN102885648B (en) 2012-08-29 2015-03-18 中国人民解放军第三军医大学第一附属医院 Sympathetic nerve denervation ablation catheter system for kidneys
EP2900160A2 (en) 2012-09-26 2015-08-05 Boston Scientific Scimed, Inc. Catheter having rib and spine structure supporting multiple electrodes for renal nerve ablation
US20140094787A1 (en) 2012-09-28 2014-04-03 Boston Scientific Scimed, Inc. Flexible renal nerve modulation device
US9044575B2 (en) * 2012-10-22 2015-06-02 Medtronic Adrian Luxembourg S.a.r.l. Catheters with enhanced flexibility and associated devices, systems, and methods
US8740849B1 (en) 2012-10-29 2014-06-03 Ablative Solutions, Inc. Peri-vascular tissue ablation catheter with support structures
US9301795B2 (en) 2012-10-29 2016-04-05 Ablative Solutions, Inc. Transvascular catheter for extravascular delivery
US20140135755A1 (en) 2012-11-12 2014-05-15 Boston Scientific Scimed, Inc. Renal catheter shaft design
US20140136350A1 (en) 2012-11-14 2014-05-15 Risto K. Savolainen System and method for secure mobile contactless payment
EP2759314A1 (en) 2013-01-28 2014-07-30 Biotronik AG Catheter for renal nerve modulation
US20140249524A1 (en) 2013-03-01 2014-09-04 Boston Scientific Scimed, Inc. System and method for performing renal nerve modulation
US20140276613A1 (en) 2013-03-12 2014-09-18 St. Jude Medical, Cardiology Division, Inc. Catheter system
US9808311B2 (en) 2013-03-13 2017-11-07 Boston Scientific Scimed, Inc. Deflectable medical devices
US20140276752A1 (en) 2013-03-15 2014-09-18 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use
EP2990070A4 (en) 2013-04-26 2016-12-07 Terumo Corp Ablation catheter
US10022182B2 (en) 2013-06-21 2018-07-17 Boston Scientific Scimed, Inc. Medical devices for renal nerve ablation having rotatable shafts
JP2015029652A (en) 2013-08-01 2015-02-16 テルモ株式会社 Guiding catheter for renal artery, and using method of the same
WO2015113027A2 (en) 2014-01-27 2015-07-30 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US20150265339A1 (en) 2014-03-18 2015-09-24 Boston Scientific Scimed, Inc. Nerve ablation devices and related methods of use and manufacture
US20190069949A1 (en) 2014-12-03 2019-03-07 Metavention, Inc. Systems and methods for modulatng nerves or other tissue

Patent Citations (238)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4764504A (en) 1984-04-19 1988-08-16 Biotechnology Research Associates J.V. Novel atrial natriuretic/vasodilator polypeptides
US4649936A (en) 1984-10-11 1987-03-17 Case Western Reserve University Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking
US4602624A (en) 1984-10-11 1986-07-29 Case Western Reserve University Implantable cuff, method of manufacture, and method of installation
US5558643A (en) 1985-07-30 1996-09-24 Advanced Cardiovascular Systems, Inc. Catheter with NiTi tubular shaft
US4709698A (en) 1986-05-14 1987-12-01 Thomas J. Fogarty Heatable dilation catheter
US7119183B2 (en) 1988-02-25 2006-10-10 The General Hospital Corporation Rapid immunoselection cloning method
EP0348136B1 (en) 1988-06-22 1993-08-04 EVANS, John Martin Catheters and methods of manufacture
US4998923A (en) 1988-08-11 1991-03-12 Advanced Cardiovascular Systems, Inc. Steerable dilatation catheter
US5368591A (en) 1988-10-28 1994-11-29 Prutech Research And Development Partnership Ii Heated balloon catheters
US5626576A (en) 1989-01-06 1997-05-06 Advanced Coronary Intervention, Inc. Electrosurgical catheter for resolving atherosclerotic plaque by radio frequency sparking
US4976711A (en) 1989-04-13 1990-12-11 Everest Medical Corporation Ablation catheter with selectively deployable electrodes
US5322505A (en) 1990-02-07 1994-06-21 Smith & Nephew Dyonics, Inc. Surgical instrument
US5477856A (en) 1991-02-15 1995-12-26 Lundquist; Ingemar H. Torquable catheter and torquable tubular member for use therewith
US5425364A (en) 1991-02-15 1995-06-20 Cardiac Pathways Corporation Flexible strip assembly without feedthrough holes and device utilizing the same
US5685868A (en) 1991-02-15 1997-11-11 Lundquist; Ingemar H. Torquable tubular assembly and torquable catheter utilizing the same
EP0521595B1 (en) 1991-02-15 1999-05-12 Ingemar H. Lundquist Torquable catheter
US5688266A (en) 1991-11-08 1997-11-18 Ep Technologies, Inc. Electrode and associated systems using thermally insulated temperature sensing elements
US5358514A (en) 1991-12-18 1994-10-25 Alfred E. Mann Foundation For Scientific Research Implantable microdevice with self-attaching electrodes
US6066134A (en) 1992-01-07 2000-05-23 Arthrocare Corporation Method for electrosurgical cutting and ablation
US6224592B1 (en) 1992-01-07 2001-05-01 Arthrocare Corporation Systems and methods for electrosurgical tissue treatment in conductive fluid
US5300068A (en) 1992-04-21 1994-04-05 St. Jude Medical, Inc. Electrosurgical apparatus
US5772590A (en) 1992-06-30 1998-06-30 Cordis Webster, Inc. Cardiovascular catheter with laterally stable basket-shaped electrode array with puller wire
US5484400A (en) 1992-08-12 1996-01-16 Vidamed, Inc. Dual channel RF delivery system
US5437288A (en) 1992-09-04 1995-08-01 Mayo Foundation For Medical Education And Research Flexible catheter guidewire
US5865787A (en) 1992-10-06 1999-02-02 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery
EP1334743A3 (en) 1992-11-02 2004-01-02 Catheter Imaging Systems Catheter
EP0680355A1 (en) 1992-11-02 1995-11-08 Catheter Imaging Systems Catheter having a multiple durometer
US5399164A (en) 1992-11-02 1995-03-21 Catheter Imaging Systems Catheter having a multiple durometer
US5423744A (en) 1992-12-22 1995-06-13 Gencheff; Nelson Catheter system for the deployment of biological material
US5935102A (en) 1993-05-14 1999-08-10 C. R. Bard Steerable electrode catheter
US6004269A (en) 1993-07-01 1999-12-21 Boston Scientific Corporation Catheters for imaging, sensing electrical potentials, and ablating tissue
US5571147A (en) 1993-11-02 1996-11-05 Sluijter; Menno E. Thermal denervation of an intervertebral disc for relief of back pain
US5599345A (en) 1993-11-08 1997-02-04 Zomed International, Inc. RF treatment apparatus
US6099524A (en) 1994-01-28 2000-08-08 Cardiac Pacemakers, Inc. Electrophysiological mapping and ablation catheter and method
WO1995025472A1 (en) 1994-03-23 1995-09-28 Vidamed, Inc. Dual-channel rf power delivery system
US6009877A (en) 1994-06-24 2000-01-04 Edwards; Stuart D. Method for treating a sphincter
US6405732B1 (en) 1994-06-24 2002-06-18 Curon Medical, Inc. Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors
US5599319A (en) 1994-09-01 1997-02-04 Cordis Corporation Soft flexible catheter tip for use in angiography
US5916178A (en) 1995-03-30 1999-06-29 Medtronic, Inc. Steerable high support guidewire with thin wall nitinol tube
US6506189B1 (en) 1995-05-04 2003-01-14 Sherwood Services Ag Cool-tip electrode thermosurgery system
US6322558B1 (en) 1995-06-09 2001-11-27 Engineering & Research Associates, Inc. Apparatus and method for predicting ablation depth
WO1997003611A1 (en) 1995-07-18 1997-02-06 Edwards, Garland, U. Flexible shaft
US5672174A (en) 1995-08-15 1997-09-30 Rita Medical Systems, Inc. Multiple antenna ablation apparatus and method
EP0787019B1 (en) 1995-08-23 2004-02-11 C.R. Bard Inc. Steerable catheter
US5707400A (en) 1995-09-19 1998-01-13 Cyberonics, Inc. Treating refractory hypertension by nerve stimulation
US5700282A (en) 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
US6254588B1 (en) 1995-11-13 2001-07-03 Micro Therapeutics, Inc. Microcatheter
US6149620A (en) 1995-11-22 2000-11-21 Arthrocare Corporation System and methods for electrosurgical tissue treatment in the presence of electrically conductive fluid
US5931830A (en) 1995-12-07 1999-08-03 Sarcos L.C. Hollow coil guide wire apparatus for catheters
US5871444A (en) 1996-03-25 1999-02-16 Terumo Kabushiki Kaisha Electrode catheter
WO1997036548A1 (en) 1996-03-29 1997-10-09 Rita Medical Systems, Inc. Rf treatment apparatus
US5944710A (en) 1996-06-24 1999-08-31 Genetronics, Inc. Electroporation-mediated intravascular delivery
US6246912B1 (en) 1996-06-27 2001-06-12 Sherwood Services Ag Modulated high frequency tissue modification
US5983141A (en) 1996-06-27 1999-11-09 Radionics, Inc. Method and apparatus for altering neural tissue function
US6685648B2 (en) 1996-10-11 2004-02-03 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US6283951B1 (en) 1996-10-11 2001-09-04 Transvascular, Inc. Systems and methods for delivering drugs to selected locations within the body
US5893885A (en) 1996-11-01 1999-04-13 Cordis Webster, Inc. Multi-electrode ablation catheter
EP0951244B1 (en) 1996-11-01 2004-03-03 Cordis Webster, Inc. Multi-electrode ablation catheter
US6024730A (en) 1996-11-08 2000-02-15 Smiths Industries Plc Catheter assemblies and inner cannulae
US5954719A (en) 1996-12-11 1999-09-21 Irvine Biomedical, Inc. System for operating a RF ablation generator
US6135999A (en) 1997-02-12 2000-10-24 Oratec Internationals, Inc. Concave probe for arthroscopic surgery
US6669670B1 (en) 1997-03-06 2003-12-30 Medtronic Ave, Inc. Catheter core wire
US20050187579A1 (en) 1997-04-07 2005-08-25 Asthmatx, Inc. Method for treating an asthma attack
US6161048A (en) 1997-06-26 2000-12-12 Radionics, Inc. Method and system for neural tissue modification
WO1999000060A1 (en) 1997-06-26 1999-01-07 Advanced Coronary Intervention Electrosurgical catheter for resolving obstructions by radio frequency ablation
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
WO1999011313A1 (en) 1997-09-04 1999-03-11 Alcon Laboratories, Inc. Flexible tube with circular grooves of varying width and depth
US6048338A (en) 1997-10-15 2000-04-11 Scimed Life Systems, Inc. Catheter with spiral cut transition member
US7744586B2 (en) 1997-10-15 2010-06-29 Boston Scientific Scimed, Inc. Catheter with spiral cut transition member
US7115183B2 (en) 1997-10-15 2006-10-03 Scimed Life Systems, Inc. Catheter with spiral cut transition member
US5891110A (en) 1997-10-15 1999-04-06 Scimed Life Systems, Inc. Over-the-wire catheter with improved trackability
US6475209B1 (en) 1997-10-15 2002-11-05 Scimed Life Systems, Inc. Catheter with spiral cut transition member
US20070005009A1 (en) 1997-10-15 2007-01-04 Scimed Life Systems, Inc. Catheter with spiral cut transition member
US6273876B1 (en) 1997-12-05 2001-08-14 Intratherapeutics, Inc. Catheter segments having circumferential supports with axial projection
US6251092B1 (en) 1997-12-30 2001-06-26 Medtronic, Inc. Deflectable guiding catheter
US20060064123A1 (en) 1998-02-06 2006-03-23 Possis Medical, Inc. Rapid exchange fluid jet thrombectomy device and method
EP0937481A1 (en) 1998-02-19 1999-08-25 Precision Vascular Systems, Inc. Catheter or guidewire with varying flexibility
US6562034B2 (en) 1998-02-19 2003-05-13 Curon Medical, Inc. Electrodes for creating lesions in tissue regions at or near a sphincter
US6273886B1 (en) 1998-02-19 2001-08-14 Curon Medical, Inc. Integrated tissue heating and cooling apparatus
US6314325B1 (en) 1998-04-07 2001-11-06 William R. Fitz Nerve hyperpolarization method and apparatus for pain relief
US6219577B1 (en) 1998-04-14 2001-04-17 Global Vascular Concepts, Inc. Iontophoresis, electroporation and combination catheters for local drug delivery to arteries and other body tissues
US6292695B1 (en) 1998-06-19 2001-09-18 Wilton W. Webster, Jr. Method and apparatus for transvascular treatment of tachycardia and fibrillation
US6322559B1 (en) 1998-07-06 2001-11-27 Vnus Medical Technologies, Inc. Electrode catheter having coil structure
US6488679B1 (en) 1998-09-10 2002-12-03 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US20030199863A1 (en) 1998-09-10 2003-10-23 Swanson David K. Systems and methods for controlling power in an electrosurgical probe
US6059769A (en) 1998-10-02 2000-05-09 Medtronic, Inc. Medical catheter with grooved soft distal segment
US6387075B1 (en) 1998-10-23 2002-05-14 Scimed Life Systems, Inc. Catheter having improved proximal shaft design
US6102890A (en) 1998-10-23 2000-08-15 Scimed Life Systems, Inc. Catheter having improved proximal shaft design
US20030050681A1 (en) 1998-11-20 2003-03-13 Pianca Anne M. Self-anchoring coronary sinus lead
US6413255B1 (en) 1999-03-09 2002-07-02 Thermage, Inc. Apparatus and method for treatment of tissue
US7771421B2 (en) 1999-04-05 2010-08-10 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US7682319B2 (en) 1999-04-09 2010-03-23 Evalve, Inc. Steerable access sheath and methods of use
US6939346B2 (en) 1999-04-21 2005-09-06 Oratec Interventions, Inc. Method and apparatus for controlling a temperature-controlled probe
US20020183682A1 (en) 1999-06-04 2002-12-05 Nissim Darvish Drug delivery device
US7171275B2 (en) 1999-08-12 2007-01-30 Irvine Biomedical Inc. High torque balloon catheter possessing multi-directional deflectability and methods thereof
US6246914B1 (en) 1999-08-12 2001-06-12 Irvine Biomedical, Inc. High torque catheter and methods thereof
US6611720B2 (en) 1999-08-12 2003-08-26 Irvine Biomedical Inc. High torque catheter possessing multi-directional deflectability and methods thereof
WO2001022897A1 (en) 1999-09-28 2001-04-05 Novasys Medical, Inc. Treatment of tissue by application of energy and drugs
US6749560B1 (en) 1999-10-26 2004-06-15 Circon Corporation Endoscope shaft with slotted tube
US6885888B2 (en) 2000-01-20 2005-04-26 The Cleveland Clinic Foundation Electrical stimulation of the sympathetic nerve chain
US6514226B1 (en) 2000-02-10 2003-02-04 Chf Solutions, Inc. Method and apparatus for treatment of congestive heart failure by improving perfusion of the kidney
WO2001070114A1 (en) 2000-03-17 2001-09-27 Rita Medical Systems Inc. Lung treatment apparatus
US6635054B2 (en) 2000-07-13 2003-10-21 Transurgical, Inc. Thermal treatment methods and apparatus with focused energy application
US7702397B2 (en) 2000-09-07 2010-04-20 Covidien Ag Apparatus and method for treatment of an intervertebral disc
US6656195B2 (en) 2000-09-22 2003-12-02 Medtronic Xomed, Inc. Flexible inner tubular members and rotary tissue cutting instruments having flexible inner tubular members
US20030060858A1 (en) 2000-09-27 2003-03-27 Kieval Robert S. Stimulus regimens for cardiovascular reflex control
US6522926B1 (en) 2000-09-27 2003-02-18 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US6845267B2 (en) 2000-09-28 2005-01-18 Advanced Bionics Corporation Systems and methods for modulation of circulatory perfusion by electrical and/or drug stimulation
US20030181897A1 (en) 2000-10-02 2003-09-25 Thomas Simon W.H. Apparatus and methods for treating female urinary incontinence
US20040010289A1 (en) 2000-10-17 2004-01-15 Broncus Technologies, Inc. Control system and process for application of energy to airway walls and other mediums
US6616624B1 (en) 2000-10-30 2003-09-09 Cvrx, Inc. Systems and method for controlling renovascular perfusion
US6622731B2 (en) 2001-01-11 2003-09-23 Rita Medical Systems, Inc. Bone-treatment instrument and method
US20020165532A1 (en) 2001-05-01 2002-11-07 Cardima, Inc. Helically shaped electrophysiology catheter
US6585718B2 (en) 2001-05-02 2003-07-01 Cardiac Pacemakers, Inc. Steerable catheter with shaft support system for resisting axial compressive loads
US20100324482A1 (en) 2001-05-22 2010-12-23 Boston Scientific Scimed, Inc. Torqueable and Deflectable Medical Device Shaft
US7780646B2 (en) 2001-05-22 2010-08-24 Boston Scientific Scimed, Inc. Torqueable and deflectable medical device shaft
US6716207B2 (en) 2001-05-22 2004-04-06 Scimed Life Systems, Inc. Torqueable and deflectable medical device shaft
US20080077119A1 (en) 2001-07-05 2008-03-27 Precision Vascular Systems, Inc. Torqueable soft tip medical device and method of usage
US7778703B2 (en) 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
US6850801B2 (en) 2001-09-26 2005-02-01 Cvrx, Inc. Mapping methods for cardiovascular reflex control devices
US7815637B2 (en) 2001-11-29 2010-10-19 Ormsby Theodore C Radio-frequency-based catheter system with improved deflection and steering mechanisms
US20030125790A1 (en) 2001-12-27 2003-07-03 Vitaly Fastovsky Deployment device, system and method for medical implantation
US6893436B2 (en) 2002-01-03 2005-05-17 Afx, Inc. Ablation instrument having a flexible distal portion
US6736835B2 (en) 2002-03-21 2004-05-18 Depuy Acromed, Inc. Early intervention spinal treatment methods and devices for use therein
US20080147001A1 (en) 2002-03-22 2008-06-19 Laila Al-Marashi Rapid-exchange balloon catheter shaft and method
US20110034989A1 (en) 2002-03-22 2011-02-10 Cordis Corporation Rapid-exchange balloon catheter shaft and method
US7520863B2 (en) 2002-03-22 2009-04-21 Cordis Corporation Guidewire with deflectable tip having improved torque characteristics
US7128718B2 (en) 2002-03-22 2006-10-31 Cordis Corporation Guidewire with deflectable tip
US7815600B2 (en) 2002-03-22 2010-10-19 Cordis Corporation Rapid-exchange balloon catheter shaft and method
US20050253680A1 (en) * 2002-04-04 2005-11-17 Mathews Eric D Temperature-controlled actuator
US20090036948A1 (en) 2002-04-08 2009-02-05 Ardian, Inc. Renal nerve stimulation methods for treatment of patients
US20060271111A1 (en) 2002-04-08 2006-11-30 Ardian, Inc. Methods and apparatus for treating contrast nephropathy
US8131372B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Renal nerve stimulation method for treatment of patients
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8150520B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods for catheter-based renal denervation
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20100137860A1 (en) 2002-04-08 2010-06-03 Ardian, Inc. Apparatus for performing a non-continuous circumferential treatment of a body lumen
US7717948B2 (en) 2002-04-08 2010-05-18 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20100137952A1 (en) 2002-04-08 2010-06-03 Ardian, Inc. Apparatuses for thermally-induced renal neuromodulation
US20070129720A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20100191112A1 (en) 2002-04-08 2010-07-29 Ardian, Inc. Ultrasound apparatuses for thermally-induced renal neuromodulation
US20070265687A1 (en) 2002-04-08 2007-11-15 Ardian, Inc. Apparatuses for renal neuromodulation
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US20120172837A1 (en) 2002-04-08 2012-07-05 Ardian, Inc. Methods for inhibiting renal nerve activity via an intra-to-extravascular approach
US8150518B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US7647115B2 (en) 2002-04-08 2010-01-12 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US20120130345A1 (en) 2002-04-08 2012-05-24 Ardian, Inc. Renal nerve stimulation method for treatment of patients
US20030216792A1 (en) 2002-04-08 2003-11-20 Levin Howard R. Renal nerve stimulation method and apparatus for treatment of patients
US20100222854A1 (en) 2002-04-08 2010-09-02 Ardian, Inc. Apparatuses for inhibiting renal nerve activity via an intra-to-extravascular approach
US20100222851A1 (en) 2002-04-08 2010-09-02 Ardian, Inc. Methods for monitoring renal neuromodulation
US20120130289A1 (en) 2002-04-08 2012-05-24 Ardian, Inc. Methods for renal neuromodulation
US20050228460A1 (en) 2002-04-08 2005-10-13 Levin Howard R Renal nerve stimulation method and apparatus for treatment of patients
US20060206150A1 (en) 2002-04-08 2006-09-14 Ardian, Inc. Methods and apparatus for treating acute myocardial infarction
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8043279B2 (en) 2002-06-26 2011-10-25 Terumo Kabushiki Kaisha Catheter and medical tube
US7914467B2 (en) 2002-07-25 2011-03-29 Boston Scientific Scimed, Inc. Tubular member having tapered transition for use in a medical device
US20070287955A1 (en) 2002-07-25 2007-12-13 Boston Scientific Scimed, Inc. Tubular member having tapered transition for use in a medical device
US7058456B2 (en) 2002-08-09 2006-06-06 Concentric Medical, Inc. Methods and devices for changing the shape of a medical device
US20110066105A1 (en) 2002-11-15 2011-03-17 Applied Medical Resources Corporation Steerable kink-resistant sheath
US7771410B2 (en) 2002-11-25 2010-08-10 Invatec S.R.L. Pipe having at least a portion with a variable flexibility
US20050251094A1 (en) * 2003-01-27 2005-11-10 Cardiac Pacemakers, Inc. System and method for accessing the coronary sinus to facilitate insertion of pacing leads
US20040215186A1 (en) 2003-03-03 2004-10-28 Sinus Rhythm Technologies, Inc. Electrical block positioning devices and methods of use therefor
US7276062B2 (en) 2003-03-12 2007-10-02 Biosence Webster, Inc. Deflectable catheter with hinge
US7221979B2 (en) 2003-04-30 2007-05-22 Medtronic, Inc. Methods and apparatus for the regulation of hormone release
US7381200B2 (en) 2003-05-06 2008-06-03 Asahi Intecc Co., Ltd. Infusion device
US20050080400A1 (en) 2003-05-27 2005-04-14 Cardia, Inc. Flexible medical device
US7149574B2 (en) 2003-06-09 2006-12-12 Palo Alto Investors Treatment of conditions through electrical modulation of the autonomic nervous system
WO2005041748A3 (en) 2003-09-12 2006-02-23 Minnow Medical Llc Selectable eccentric remodeling and/or ablation of atherosclerotic material
US20050080409A1 (en) 2003-10-10 2005-04-14 Scimed Life Systems, Inc. Multi-zone bipolar ablation probe assembly
US7637903B2 (en) 2004-02-09 2009-12-29 Cryocor, Inc. Catheter articulation segment with alternating cuts
US20100100073A1 (en) 2004-02-09 2010-04-22 Cryocor, Inc. Catheter articulation segment with alternating cuts
US20120232529A1 (en) * 2004-03-26 2012-09-13 Lawrence Livermore National Security, Llc Shape memory system with integrated actuation using embedded particles
US20080319418A1 (en) 2004-03-30 2008-12-25 Cathrx Pty Ltd Catheter Steering Device
WO2005110528A1 (en) 2004-05-06 2005-11-24 Boston Scientific Limited Intravascular self-anchoring electrode body
US20060064055A1 (en) * 2004-05-24 2006-03-23 John Pile-Spellman Steerable devices
US20060004346A1 (en) 2004-06-17 2006-01-05 Begg John D Bend relief
WO2006041881B1 (en) 2004-10-05 2007-05-10 Ardian Inc Methods and apparatus for renal neuromodulation
US20060095029A1 (en) 2004-10-28 2006-05-04 Scimed Life Systems, Inc. Ablation probe with flared electrodes
US20060100618A1 (en) 2004-11-08 2006-05-11 Cardima, Inc. System and method for performing ablation and other medical procedures using an electrode array with flex circuit
US20060100687A1 (en) 2004-11-10 2006-05-11 Creganna Technologies Limited Elongate tubular member for use in medical device shafts
EP1656963B1 (en) 2004-11-10 2007-11-21 Creganna Technologies Limited Stent delivery catheter assembly
US7989042B2 (en) 2004-11-24 2011-08-02 Boston Scientific Scimed, Inc. Medical devices with highly flexible coated hypotube
US7402151B2 (en) 2004-12-17 2008-07-22 Biocardia, Inc. Steerable guide catheters and methods for their use
US20080287918A1 (en) 2004-12-17 2008-11-20 Biocardia, Inc. Steerable Guide Catheters and Methods For Their Use
US7727187B2 (en) 2005-04-04 2010-06-01 Cook Incorporated Scored catheter device
US7947016B2 (en) 2005-04-04 2011-05-24 Cook Incorporated Scored catheter device
US20060224112A1 (en) 2005-04-04 2006-10-05 Cook Incorporated Scored catheter device
US7390894B2 (en) 2005-07-07 2008-06-24 Mayo Foundation For Medical Education And Research Glutathione S-transferase sequence variants
WO2007008954A3 (en) 2005-07-11 2007-05-10 Ablation Frontiers Low power tissue ablation system
US20070049999A1 (en) * 2005-07-21 2007-03-01 Esch Brady D Apparatus and method for ensuring safe operation of a thermal treatment catheter
US8140170B2 (en) 2005-09-12 2012-03-20 The Cleveland Clinic Foundation Method and apparatus for renal neuromodulation
US7744856B2 (en) 2005-10-03 2010-06-29 Biotech Research And Development Corporation Formulations with feruloyl glycerides and methods of preparation
US20070213687A1 (en) 2006-03-07 2007-09-13 Barlow David E Cannulation device with segmented tip
EP1839697B1 (en) 2006-03-29 2010-09-08 Cordis Development Corporation Joined metal tubing
US20090312606A1 (en) 2006-03-31 2009-12-17 Boston Scientific Scimed, Inc. Flexible device shaft with angled spiral wrap
US7615067B2 (en) 2006-06-05 2009-11-10 Cambridge Endoscopic Devices, Inc. Surgical instrument
US20080097397A1 (en) 2006-06-08 2008-04-24 Vrba Anthony C Vascular introducer sheath
US8376865B2 (en) 2006-06-20 2013-02-19 Cardiacmd, Inc. Torque shaft and torque shaft drive
US7708704B2 (en) 2006-07-31 2010-05-04 Codman & Shurtleff, Pc Interventional medical device component having an interrupted spiral section and method of making the same
US20100305682A1 (en) * 2006-09-21 2010-12-02 Cleveny Technologies Specially configured and surface modified medical device with certain design features that utilize the intrinsic properties of tungsten, zirconium, tantalum and/or niobium
US20120204387A1 (en) * 2007-03-12 2012-08-16 Cook Medical Technologies Llc Woven fabric with shape memory element strands
EP1982741B1 (en) 2007-04-18 2010-06-23 Medical Service GmbH Catheter set
US20090125001A1 (en) 2007-06-15 2009-05-14 Anderson Neil L Deflectable stylet
US20080319513A1 (en) 2007-06-25 2008-12-25 Cardiac Pacemakers, Inc. Neural stimulation with respiratory rhythm management
US20100228112A1 (en) 2007-10-26 2010-09-09 St. Jude Medical Systems Ab Sensor guide wire with micro-cable winding
US20090157048A1 (en) 2007-12-18 2009-06-18 Boston Scientific Scimed, Inc. Spiral cut hypotube
WO2009108997A1 (en) 2008-03-03 2009-09-11 Mk International Pty Ltd Catheter with friction reducing surface shaping
EP2106821A1 (en) 2008-03-31 2009-10-07 Astra Tech AB Catheter assembly comprising a tubular member having pleated regions, and a method of activating the same
WO2009125575A1 (en) 2008-04-11 2009-10-15 日本ライフライン株式会社 Catheter
US7833191B2 (en) 2008-04-19 2010-11-16 Biotronik Crm Patent Ag Controllable electrode for deep brain stimulation
US20100010526A1 (en) 2008-07-10 2010-01-14 B&M Precislon, Inc. Flexible Inner Member Having a Flexible Region Comprising a Labyrinthine Cut
US20100030217A1 (en) 2008-08-01 2010-02-04 Miroslav Mitusina Flexible Inner Member Having a Flexible Region Comprising a Cut with Convoluted Path Areas
US20100057037A1 (en) 2008-09-02 2010-03-04 Abbott Cardiovascular Systems Inc. Agent Delivery Catheters
US20100069882A1 (en) 2008-09-18 2010-03-18 Boston Scientific Scimed, Inc. Medical device with preferential bending
US20100099952A1 (en) 2008-10-22 2010-04-22 Boston Scientific Scimed, Inc. Steerable Shaft Having Micromachined Tube
US20110276034A1 (en) 2009-01-15 2011-11-10 Cathrx Ltd Steerable stylet
EP2398540B1 (en) 2009-02-20 2018-04-25 Boston Scientific Scimed, Inc. Steerable catheter having intermediate stiffness transition zone
US20100217184A1 (en) 2009-02-20 2010-08-26 Boston Scientific Scimed, Inc. Steerable catheter having intermediate stiffness transition zone
US20100331618A1 (en) 2009-06-24 2010-12-30 Gyrus Acmi, Inc. Endoscope shaft frame member with wavy slot
US20100331776A1 (en) 2009-06-24 2010-12-30 Amr Salahieh Steerable Medical Delivery Devices and Methods of Use
US20110054464A1 (en) 2009-08-25 2011-03-03 Randell Werneth Bi-modal linear and loop ablation catheter, and method
EP2332607A1 (en) 2009-12-14 2011-06-15 The Royal College of Surgeons in Ireland A urethral catheter
US20110288392A1 (en) 2009-12-31 2011-11-24 De La Rama Alan Kit for Non-Invasive Electrophysiology Procedures and Method of its Use
EP2351593A2 (en) 2010-01-29 2011-08-03 Cordis Corporation Highly flexible tubular device for medical use
US20110245808A1 (en) 2010-03-31 2011-10-06 Boston Scientific Scimed, Inc. Guidewire with an improved flexural rigidity profile
US20120101413A1 (en) 2010-10-20 2012-04-26 Medtronic Ardian Luxembourg S.a.r.I. Catheter apparatuses having expandable mesh structures for renal neuromodulation and associated systems and methods
US20120136350A1 (en) * 2010-10-21 2012-05-31 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses, systems, and methods for renal neuromodulation
US20120143293A1 (en) 2010-10-25 2012-06-07 Medtronic Ardian Luxembourg S.a.r.I. Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods
US20120123328A1 (en) * 2010-11-17 2012-05-17 Micrus Endovascular Llc Guide catheter composed of shape memory polymer
US20130006238A1 (en) * 2011-06-30 2013-01-03 Tom Allen Ditter Catheter with variable arcuate distal section
WO2014066439A1 (en) 2012-10-22 2014-05-01 Medtronic Ardian Luxembourg Sarl Catheters with enhanced flexibility
WO2014066432A2 (en) 2012-10-22 2014-05-01 Medtronic Ardian Luxembourg Sarl Catheters with enhanced flexibility and associated devices, systems, and methods
US20140114288A1 (en) 2012-10-22 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US20140135736A1 (en) * 2012-11-10 2014-05-15 Stephen J. Hebert Coaxial bi-directional catheter
US20140142509A1 (en) * 2012-11-21 2014-05-22 P Tech, Llc Expandable access systems and methods

Non-Patent Citations (146)

* Cited by examiner, † Cited by third party
Title
"2011 Edison Award Winners." Edison Awards: Honoring Innovations & Innovators, 2011, 6 pages, .
"2011 Edison Award Winners." Edison Awards: Honoring Innovations & Innovators, 2011, 6 pages, <http://www.edisonawards.com/BestNewProduct-2011.php>.
"2012 top 10 advances in heart disease and stroke research: American Heart Association/America Stroke Association Top 10 Research Report." American Heart Association, Dec. 17, 2012, 5 pages, .
"2012 top 10 advances in heart disease and stroke research: American Heart Association/America Stroke Association Top 10 Research Report." American Heart Association, Dec. 17, 2012, 5 pages, <http://newsroom.heart.org/news/2012-top-10-advances-in-heart-241901>.
"Ardian(R) Receives 2010 EuroPCR Innovation Award and Demonstrates Further Durability of Renal Denervation Treatment for Hypertension." PR Newswire, Jun. 3, 2010, 2 pages, <http://www.prnewswire.com/news-releases/ardianr-receives-2010-europcr-innovation-award-and-demonstrates-further-durability-of-renal-denervation-treatment-for-hypertension-95545014.html>.
"Boston Scientific to Acquire Vessix Vascular, Inc.: Company to Strengthen Hypertension Program with Acquisition of Renal Denervation Technology." Boston Scientific: Advancing science for life-Investor Relations, Nov. 8, 2012, 2 pages, .
"Boston Scientific to Acquire Vessix Vascular, Inc.: Company to Strengthen Hypertension Program with Acquisition of Renal Denervation Technology." Boston Scientific: Advancing science for life-Investor Relations, Nov. 8, 2012, 2 pages, <http://phx.corporate-ir.net/phoenix.zhtml?c=62272&p=irol-newsArticle&id=1756108>.
"Cleveland Clinic Unveils Top 10 Medical Innovations for 2012: Experts Predict Ten Emerging Technologies that will Shape Health Care Next Year." Cleveland Clinic, Oct. 6, 2011, 2 pages. <http://my.clevelandclinic.org/media-relations/library/2011/2011-10-6-cleveland-clinic-unveils-top-10-medical-innovations-for-2012.aspx>.
"Does renal denervation represent a new treatment option for resistant hypertension?" Interventional News, Aug. 3, 2010, 2 pages. <http://www.cxvascular.com/in-latest-news/interventional-news---latest-news/does-renal-denervation-represent-a-new-treatment-option-for-resistant-hypertension>.
"Iberis-Renal Sympathetic Denervation System: Turning innovation into quality care." [Brochure], Terumo Europe N.V., 2013, Europe, 3 pages.
"Neurotech Reports Announces Winners of Gold Electrode Awards." Neurotech business report, 2009. 1 page. .
"Neurotech Reports Announces Winners of Gold Electrode Awards." Neurotech business report, 2009. 1 page. <http://www.neurotechreports.com/pages/goldelectrodes09.html>.
"Quick. Consistent. Controlled. OneShot renal Denervation System" [Brochure], Covidien: positive results for life, 2013, (n. l.), 4 pages.
"Renal Denervation Technology of Vessix Vascular, Inc. been acquired by Boston Scientific Corporation (BSX) to pay up to $425 Million." Vessix Vascular Pharmaceutical Intelligence: A blog specializing in Pharmaceutical Intelligence and Analytics, Nov. 8, 2012, 21 pages, .
"Renal Denervation Technology of Vessix Vascular, Inc. been acquired by Boston Scientific Corporation (BSX) to pay up to $425 Million." Vessix Vascular Pharmaceutical Intelligence: A blog specializing in Pharmaceutical Intelligence and Analytics, Nov. 8, 2012, 21 pages, <http://pharmaceuticalintelligence.com/tag/vessix-vascular/>.
"The Edison AwardsIM" Edison Awards: Honoring Innovations & Innovators, 2013, 2 pages, .
"The Edison AwardsIM" Edison Awards: Honoring Innovations & Innovators, 2013, 2 pages, <http://www.edisonawards.com/Awards.php>.
"The Future of Renal denervation for the Treatment of Resistant Hypertension." St. Jude Medical, Inc., 2012, 12 pages.
"Vessix Renal Denervation System: So Advanced It's Simple." [Brochure], Boston Scientific: Advancing science for life, 2013, 6 pages.
Ahmed, Humera et al., Renal Sympathetic Denervation Using an Irrigated Radiofrequency Ablation Catheter for the Management of Drug-Resistant Hypertension, JACC Cardiovascular Interventions, vol. 5, No. 7, 2012, pp. 758-765.
Allen, E.V., Sympathectomy for essential hypertension, Circulation, 1952, 6:131-140.
Asbell, Penny, "Conductive Keratoplasty for the Correction of Hyperopia." Tr Am Ophth Soc, 2001, vol. 99, 10 pages.
Avitall et al., "The creation of linear contiguous lesions in the atria with an expandable loop catheter," Journal of the American College of Cardiology, 1999; 33; pp. 972-984.
Badoer, Emilio, "Cardiac afferents play the dominant role in renal nerve inhibition elicited by volume expansion in the rabbit." Am J Physiol Regul Integr Comp Physiol, vol. 274, 1998, 7 pages.
Bello-Reuss, E. et al., "Effects of Acute Unilateral Renal Denervation in the Rat," Journal of Clinical Investigation, vol. 56, Jul. 1975, pp. 208-217.
Bello-Reuss, E. et al., "Effects of Renal Sympathetic Nerve Stimulation on Proximal Water and Sodium Reabsorption," Journal of Clinical Investigation, vol. 57, Apr. 1976, pp. 1104-1107.
Bengel, Frank, "Serial Assessment of Sympathetic Reinnervation After Orthotopic Heart Transplantation: A longitudinal Study Using PET and C-11 Hydroxyephedrine." Circulation, vol. 99, 1999,7 pages.
Benito, F., et al. "Radiofrequency catheter ablation of accessory pathways in infants." Heart, 78:160-162 (1997).
Bettmann, Michael, Carotid Stenting and Angioplasty: A Statement for Healthcare Professionals From the Councils on Cardiovascular Radiology, Stroke, Cardio-Thoracic and Vascular Surgery, Epidemiology and Prevention, and Clinical Cardiology, American Heart Association, Circulation, vol. 97, 1998, 4 pages.
Bhandari, A. and Ellias, M., "Loin Pain Hemaluria Syndrome: Pain Control with RFA to the Splanchanic Plexus," The Pain Clinc, 2000, vol. 12, No. 4, pp. 323-327.
Blessing, Erwin et al., Cardiac Ablation and Renal Denervation Systems Have Distinct Purposes and Different Technical Requirements, JACC Cardiovascular Interventions, vol. 6, No. 3, 2013, 1 page.
Bohm, Michael et al., "Rationale and design of a large registry on renal denervation: the Global Symplicity registry." EuroIntervention, vol. 9, 2013, 9 pages.
Brosky, John, "EuroPCR 2013: CE-approved devices line up for renal denervation approval." Medical Device Daily, May 28, 2013, 3 pages, <http://www.medicaldevicedaily.com/servlet/com.accumedia.web.Dispatcher?next=bioWorldHeadlines-article&forceid=83002>.
ClinicalTrials.gov, Renal Denervation in Patients with uncontrolled Hypertension in Chinese (2011), 6pages. www.clinicaltrials.gov/ct2/show/NCT01390831.
Curtis, John J. et al., "Surgical Therapy for Persistent Hypertension After Renal Transplantation" Transplantation, 31:125-128 (1981).
Davis, Mark et al., "Effectiveness of Renal Denervation Therapy for Resistant Hypertension." Journal of the American College of Cardiology, vol. 62, No. 3, 2013, 11 pages.
Dibona, G.F. "Sympathetic nervous system and kidney in hypertension." Nephrol and Hypertension, 11: 197-200 (2002).
Dibona, Gerald F. et al., "Neural Control of Renal Function," Physiological Reviews, vol. 77, No. 1, Jan. 1997, The American Physiological Society 1997, pp. 75-197.
Dibona, Gerald F., "Neural Control of the Kidney-Past, Present and Future," Nov. 4, 2002, Novartis Lecture, Hypertension 2003, 41 part 2, 2002 American Heart Association, Inc., pp. 621-624.
Doumas, Michael et al., "Renal Nerve Ablation for Resistant Hypertension: The Dust Has Not Yet Settled." The Journal of Clinical Hypertension. 2014; vol. 16, No. 6, 2 pages.
Dubuc, M., et al., "Feasibility of cardiac cryoablation using a transvenous steerable electrode catheter." J Interv Cardiac Electrophysiol, 2:285-292 (1998).
European Search Report for European Application No. 13159256, Date Mailed: Oct. 17, 2013, 6 pages.
Excerpt of Operator's Manual of Boston Scientific's EPT-1000 XP Cardiac Ablation Controller & Accessories, Version of Apr. 2003, (6 pages).
Excerpt of Operator's Manual of Boston Scientific's Maestro 30000 Cardiac Ablation System, Version of Oct. 17, 2005 , (4 pages).
Final Office Action; U.S. Appl. No. 12/827,700; Mailed on Feb. 5, 2013, 61 pages.
Geisler, Benjamin et al., "Cost-Effectiveness and Clinical Effectiveness of Catheter-Based Renal Denervation for Resistant Hypertension." Journal of the American College of Cardiology, Col. 60, No. 14, 2012, 7 pages.
Gelfand, M., et al., "Treatment of renal failure and hypertension." U.S. Appl. No. 60/442,970, Jan. 29, 2003, 23 pages.
Gertner, Jon, "Meet the Tech Duo That's Revitalizing the Medical Device Industry." Fast Company, Apr. 15, 2013, 6:00 AM, 17 pages, .
Gertner, Jon, "Meet the Tech Duo That's Revitalizing the Medical Device Industry." Fast Company, Apr. 15, 2013, 6:00 AM, 17 pages, <http://www.fastcompany.com/3007845/meet-tech-duo-thats-revitalizing-medical-device-industry>.
Golwyn, D. H., Jr., et al. "Percutaneous Transcatheter Renal Ablation with Absolute Ethanol for Uncontrolled Hypertension or Nephrotic Syndrome: Results in 11 Patients with End-Stage Renal Disease." JVIR, 8: 527-533 (1997).
Hall, W. H., et al. "Combined embolization and percutaneous radiofrequency ablation of a solid renal tumor." Am. J. Roentgenol,174: 1592-1594 (2000).
Han, Y.-M, et al., "Renal artery ebolization with diluted hot contrast medium: An experimental study." J Vasc Interv Radiol, 12: 862-868 (2001).
Hansen, J. M., et al. "The transplanted human kidney does not achieve functional reinnervation." Clin. Sci, 87: 13-19 (1994).
Hendee, W. R. et al. "Use of Animals in Biomedical Research: The Challenge and Response." American Medical Association White Paper (1988) 39 pages.
Hering, Dagmara et al., "Chronic kidney disease: role of sympathetic nervous system activation and potential benefits of renal denervation." EuroIntervention, vol. 9, 2013, 9 pages.
Holmes et al., Pulmonary Vein Stenosis Complicating Ablation for Atrial Fibrillation: Clinical Spectrum and Interventional Considerations, JACC: Cardiovascular Interventions, 2: 4, 2009, 10 pages.
Huang et al., "Renal denervation prevents and reverses hyperinsulinemia-induced hypertension in rats." Hypertension 32 (1998) pp. 249-254.
Imimdtanz, "Medtronic awarded industry's highest honour for renal denervation system." The official blog of Medtronic Australasia, Nov. 12, 2012, 2 pages, <http://97waterlooroad.wordpress.com/2012/11/12/medtronic-awarded-industrys-highest-honour-for-renal-denervation-system/>.
International Search Report and Written Opinion for International Application No. PCT/US2013/066248, Mailed Apr. 14, 2014, 28 pages.
International Search Report and Written Opinion for International Application No. PCT/US2013/066256, Mailed Apr. 14, 2014, 28 pages.
Janssen, Ben J.A. et al., "Effects of Complete Renal Denervation and Selective Afferent Renal Denervation on the Hypertension Induced by Intrenal Norepinephrine Infusion in Conscious Rats", Journal of Hypertension 1989, 7: 447-455.
Kaiser, Chris, AHA Lists Year's Big Advances in CV Research, medpage Today, Dec. 18, 2012, 4 pages, .
Kaiser, Chris, AHA Lists Year's Big Advances in CV Research, medpage Today, Dec. 18, 2012, 4 pages, <http://www.medpagetoday.com/Cardiology/PCI/36509>.
Kandarpa, Krishna et al., "Handbook of Interventional Radiologic Procedures", Third Edition, pp. 194-210 (2002).
Katholi, Richard E., "Renal Nerves in the Pathogenesis of Hypertension in Experimental Animals and Humans," Am J. Physiol. vol. 245, 1983, the American Physiological Society 1983, pp. F1-F14.
Kompanowska, E., et al., "Early Effects of renal denervation in the anaesthetised rat: Natriuresis and increased cortical blood flow." J Physiol, 531. 2:527-534 (2001).
Krum, et al., "Renal Sympathetic-Nerve Ablation for Uncontrolled Hypertension." New England Journal of Med, Aug. 2009, 361;9.
Krum, Henry et al., "Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension: A Mulitcentre Safety and Proof-of Principle Cohort Study," Lancet 2009; 373:1275-81.
Lee, S.J., et al. "Ultrasonic energy in endoscopic surgery." Yonsei Med J, 40:545-549 (1999).
Linz, Dominik et al., "Renal denervation suppresses ventricular arrhythmias during acute ventricular ischemia in pigs." Heart Rhythm, vol. 0, No. 0, 2013, 6 pages.
Luippold, Gerd et al., "Chronic Renal Denervation Prevents Glomerular Hyperfiltration in Diabetic Rats", Nephrol Dial Transplant, vol. 19, No. 2, 2004, pp. 342-347.
Lustgarten, D.L.,et al., "Cryothermal ablation: Mechanism of tissue injury and current experience in the treatment of tachyarrhythmias." Progr Cardiovasc Dis, 41:481-498 (1999).
Mabin, Tom et al., "First experience with endovascular ultrasound renal denervation for the treatment of resistant hypertension." EuroIntervention, vol. 8, 2012, 5 pages.
Mahfoud et al. "Treatment strategies for resistant arterial hypertension" Dtsch Arztebl Int. 2011;108:725-731.
Mahfoud, Felix et al., "Ambulatory Blood Pressure Changes after Renal Sympathetic Denervation in Patients with Resistant Hypertension." Circulation, 2013, 25 pages.
Mahfoud, Felix et al., "Expert consensus document from the European Society of Cardiology on catheter-based renal denervation." European Heart Journal, 2013, 9 pages.
Mahfoud, Felix et al., "Renal Hemodynamics and Renal Function After Catheter-Based Renal Sympathetic Denervation in Patients With Resistant Hypertension." Hypertension, 2012, 6 pages.
Medical-Dictionary.com, Definition of "Animal Model," http://medical-dictionary.com (search "Animal Model"), 2005, 1 page.
Medtronic, Inc., Annual Report (Form 10-K) (Jun. 28, 2011) 44 pages.
Messerli, Franz H. et al. "Renal Denervation for Resistant Hypertension: Dead or Alive?" Healio: Cardiology today's Intervention, May/Jun. 2014, 2 pages.
Millard, F. C., et al, "Renal Embolization for ablation of function in renal failure and hypertension." Postgraduate Medical Journal, 65, 729-734, (1989).
Miller, Reed, "Finding a Future for Renal Denervation With Better Controlled Trials." Pharma & Medtech Business Intelligence, Article # 01141006003, Oct. 6, 2014, 4 pages.
Mount Sinai School of Medicine clinical trial for Impact of Renal Sympathetic Denervation of Chronic Hypertension, Mar. 2013, 11 pages. http://clinicaltrials.gov/ct2/show/NCT01628198.
Oliveira, V., et al., "Renal denervation normalizes pressure and baroreceptor reflex in high renin hypertension in conscious rats." Hypertension, 19:II-17-II-21 (1992).
Ong, K. L., et al. "Prevalence, Awareness, Treatment, and Control of Hypertension Among United States Adults 1999-2004." Hypertension, 49: 69-75 (2007) (originally published online Dec. 11, 2006).
Opposition to European Patent No. EP1802370, Granted Jan. 5, 2011, Date of Opposition Oct. 5, 2011, 20 pages.
Opposition to European Patent No. EP2037840, Granted Dec. 7, 2011, Date of Opposition Sep. 7, 2012, 25 pages.
Opposition to European Patent No. EP2092957, Granted Jan. 5, 2011, Date of Opposition Oct. 5, 2011, 26 pages.
Ormiston, John et al., "First-in-human use of the OneShotIM renal denervation system from Covidien." EuroIntervention, vol. 8, 2013, 4 pages.
Ormiston, John et al., "Renal denervation for resistant hypertension using an irrigated radiofrequency balloon: 12-month results from the Renal Hypertension Ablation System (RHAS) trial." EuroIntervention, vol. 9, 2013, 5 pages.
Osborn, et al., "Effect of Renal Nerve Stimulation on Renal Blood Flow Autoregulation and Antinatriuresis During Reductions in Renal Perfusion Pressure," Proceedings of the Society for Experimentla Biology and Medicine, vol. 168, 77-81, 1981.
Oz, Mehmet, Pressure Relief, Time, Jan. 9, 2012, 2 pages. .
Oz, Mehmet, Pressure Relief, Time, Jan. 9, 2012, 2 pages. <www.time.come/time/printout/0,8816,2103278,00.html>.
Page, I.H. et al., "The Effect of Renal Denervation on Patients Suffering From Nephritis," Feb. 27, 1935;443-458.
Page, I.H. et al., "The Effect of Renal Denervation on the Level of Arterial Blood Pressure and Renal Function in Essential Hypertension," J. Clin Invest. 1934;14:27-30.
Papademetriou, Vasilios et al., "Catheter-Based Renal Denervation for Resistant Hypertension: 12-Month Results of the EnligHTN I First-in-Human Study Using a Multielectrode Ablation System." Hypertension. 2014; 64: 565-572.
Papademetriou, Vasilios et al., "Renal Nerve Ablation for Resistant Hypertension: How Did We Get Here, Present Status, and Future Directions." Circulation. 2014; 129: 1440-1450.
Papademetriou, Vasilios, "Renal Denervation and Symplicity HTN-3: "Dubium Sapientiae Initium" (Doubt Is the Beginning of Wisdom)", Circulation Research, 2014; 115: 211-214.
Papademetriou, Vasilios, Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension, Int. Journal of Hypertension, 2011, 8 pages.
Pedersen, Amanda, "TCT 2012: Renal denervation device makers play show and tell." Medical Device Daily, Oct. 26, 2012, 2 pages, <http://www.medicaldevicedaily.com/servlet/com.accumedia.web.Dispatcher?next=bioWorldHeadlines-article&forceid=80880>.
Peet, M., "Hypertension and its Surgical Treatment by bilateral supradiaphragmatic splanchnicectomy" Am J Surgery (1948) pp. 48-68.
Prochnau, Dirk et al., Catheter-based renal denervation for drug-resistant hypertension by using a standard electrophysiology catheter; Euro Intervention 2012, vol. 7, pp. 1077-1080.
Purerfellner, Helmut et al., Incidence, Management, and Outcome in Significant Pulmonary Vein Stenosis Complicating Ablation for Atrial Fibrillation, Am. J. Cardiol , 93, Jun. 1, 2004, 4 pages.
Purerfellner, Helmut et al., Pulmonary Vein Stenosis Following Catheter Ablation of Atrial Fibrillation, Curr. Opin. Cardio. 20 :484-490, 2005.
Renal Denervation (RDN), Symplicity RDN System Common Q&A (2011), 4 pages, http://www.medtronic.com/rdn/mediakit/RDN%20FAQ.pdf.
Rocha-Singh, "Catheter-Based Sympathetic Renal Denervation," Endovascular Today, Aug. 2009.
Schauerte, P., et al. "Catheter ablation of cardiac autonomic nerves for prevention of vagal atrial fibrillation." Circulation, 102:2774-2780 (2000).
Schlaich, M.P. et al., "Renal Denervation as a Therapeutic Approach for Hypertension: Novel Implictions for an Old Concept," Hypertension, 2009; 54:1195-1201.
Schlaich, M.P. et al., "Renal Sympathetic-Nerve Ablation for Uncontrolled Hypertension," N Engl J Med 2009; 361(9): 932-934.
Schlaich, Markus et al., "Renal Denervation in Human Hypertension: Mechanisms, Current Findings, and Future Prospects." Curr Hypertens Rep, vol. 14, 2012, 7 pages.
Schmid, Axel et al., "Does Renal Artery Supply Indicate Treatment Success of Renal Denervation." Cardiovasc Intervent Radiol, vol. 36, 2013, 5 pages.
Schmieder, Roland E. et al., "Updated ESH position paper on interventional therapy of resistant hypertension." EuroIntervention, vol. 9, 2013, 9 pages.
Schneider, Peter A., "Endovascular Skills-Guidewire and Catheter Skills for Endovascular Surgery," Second Edition Revised and Expanded, 10 pages, (2003).
Sievert, Horst, "Novelty Award EuroPCR 2010." Euro PCR, 2010, 15 pages.
Smithwick, R.H. et al., "Splanchnicectomy for Essential Hypertension," Journal Am Med Assn, 1953; 152:1501-1504.
Solis-Herruzo et al., "Effects of lumbar sympathetic block on kidney function in cirrhotic patients with hepatorenal syndrome," J. Hepatol. 5 (1987), pp. 167-173.
Stella, A., et al., "Effects of reversible renal deneravation on haemodynamic and excretory functions on the ipsilateral and contralateral kidney in the cat." Hypertension, 4:181-188 (1986).
Stouffer, G. A. et al., Journal of Molecular and Cellular Cardiology, vol. 62, 2013, 6 pages.
Swartz, J.F., et al., "Radiofrequency endocardial catheter ablation of accessory atrioventricular pathway atrial insertion sites." Circulation, 87: 487-499 (1993).
Symplicity HTN-1 Investigators; Krum H, Barman N, Schlaich M, et al. Catheter-based renal sympathetic denervation for resistant hypertension: durability of blood pressure reduction out to 24 months. Hypertension. 2011 ;57(5):911-917.
Symplicity HTN-2 Investigators, "Renal Sympathetic Denervation in Patients with Treatment-Resistant Hypertension (The Symplicity HTN-2 Trial): A Randomised Controlled Trial"; Lancet, Dec. 4, 2010, vol. 376, pp. 1903-1909.
ThermoCool Irrigated Catheter and Integrated Ablation System, Biosense Webster (2006), 6 pages.
Tsao, Hsuan-Ming, Evaluation of Pulmonary Vein Stenosis after Catheter Ablation of Atrial Fibrillation, Cardiac Electrophysiology Review, 6, 2002, 4 pages.
U.S. Appl. No. 95/002,110, filed Aug. 29, 2012, Demarais et al.
U.S. Appl. No. 95/002,209, filed Sep. 13, 2012, Levin et al.
U.S. Appl. No. 95/002,233, filed Sep. 13, 2012, Levin et al.
U.S. Appl. No. 95/002,243, filed Sep. 13, 2012, Levin et al.
U.S. Appl. No. 95/002,253, filed Sep. 13, 2012, Demarais et al.
U.S. Appl. No. 95/002,255, filed Sep. 13, 2012, Demarais et al.
U.S. Appl. No. 95/002,292, filed Sep. 14, 2012, Demarais et al.
U.S. Appl. No. 95/002,327, filed Sep. 14, 2012, Demarais et al.
U.S. Appl. No. 95/002,335, filed Sep. 14, 2012, Demarais et al.
U.S. Appl. No. 95/002,336, filed Sep. 14, 2012, Levin et al.
U.S. Appl. No. 95/002,356, filed Sep. 14, 2012, Demarais et al.
Uchida, F., et al., "Effect of radiofrequency catheter ablation on parasympathetic denervation: A comparison of three different ablation sites." PACE, 21:2517-2521 (1998).
United States Renal Data System, USRDS 2003 Annual Data Report: Atlas of End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2003, 593 pages.
Valente, John F. et al., "Laparoscopic Renal Denervation for Intractable ADPKD-Related Pain", Nephrol Dial Transplant (2001) 16:160.
Verloop, W. L. et al., "Renal denervation: a new treatment option in resistant arterial hypertension." Neth Heart J., Nov. 30, 2012, 6 pages, <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547427/>.
Wagner, C.D. et al., "Very Low Frequency Oscillations in Arterial Blood Pressure After Autonomic Blockade in Conscious Dogs," Feb. 5, 1997, Am J Physiol Regul Integr Comp Physiol 1997, vol. 272, 1997 the American Physiological Society, pp. 2034-2039.
Weinstock, M., et al., "Renal denervation prevents sodium rentention and hypertension in salt sensitive rabbits with genetic baroreflex impairment." Clinical Science, 90:287-293 (1996).
Wilcox, Josiah N., Scientific Basis Behind Renal Denervation for the Control of Hypertension, ICI 2012, Dec. 5-6, 2012. 38 pages.
Wittkampf et al., "Control of radiofrequency lesion size by power regulation," Journal of the American Heart Associate, 1989, 80: pp. 962-968.
Worthley, Stephen et al., "Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial." European Heart Journal, vol. 34, 2013, 9 pages.
Worthley, Stephen, "The St. Jude Renal Denervation System Technology and Clinical Review." The University of Adelaide Australia, 2012, 24 pages.
Zheng et al., "Comparison of the temperature profile and pathological effect at unipolar, bipolar and phased radiofrequency current configurations," Journal of Interventional Cardiac Electrophysiology, 2001, pp. 401-410.
Zuern, Christine S., "Impaired Cardiac Baroflex Sensitivity Predicts Response to Renal Sympathetic Denervation in Patients with Resistant Hypertension." Journal of the American College of Cardiology, 2013, doi: 10.1016/j.jacc.2013.07.046, 24 pages.

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10111704B2 (en) 2002-09-30 2018-10-30 Relievant Medsystems, Inc. Intraosseous nerve treatment
US10028753B2 (en) 2008-09-26 2018-07-24 Relievant Medsystems, Inc. Spine treatment kits
US9492635B2 (en) 2012-10-22 2016-11-15 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US20180064907A1 (en) * 2012-10-22 2018-03-08 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US9399115B2 (en) 2012-10-22 2016-07-26 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US10188829B2 (en) * 2012-10-22 2019-01-29 Medtronic Ardian Luxembourg S.A.R.L. Catheters with enhanced flexibility and associated devices, systems, and methods
US9775627B2 (en) 2012-11-05 2017-10-03 Relievant Medsystems, Inc. Systems and methods for creating curved paths through bone and modulating nerves within the bone
US9724151B2 (en) 2013-08-08 2017-08-08 Relievant Medsystems, Inc. Modulating nerves within bone using bone fasteners

Also Published As

Publication number Publication date
US20150250981A1 (en) 2015-09-10
US9844643B2 (en) 2017-12-19
US10188829B2 (en) 2019-01-29
US20170056619A1 (en) 2017-03-02
US20180064907A1 (en) 2018-03-08
US9492635B2 (en) 2016-11-15
US20140114287A1 (en) 2014-04-24

Similar Documents

Publication Publication Date Title
CN202654228U (en) Catheter device for treating human being patient through renal denervation
US6048329A (en) Catheter distal assembly with pull wires
KR101751258B1 (en) Apparatus, systems and methods for achieving intravascular, thermally-induced renal neuromodulation
US5910129A (en) Catheter distal assembly with pull wires
US7419477B2 (en) Catheterization method using proximal articulation and pre-formed distal end
EP1341463B1 (en) Ablation catheter assembly for isolating a pulmonary vein
CN103857353B (en) Tip ablation catheter having an insulating
CN202478392U (en) Associated system of catheter device
US7044934B2 (en) Tortuous path injection device
CN101940816B (en) Methods and apparatus for renal neuromodulation
US7063682B1 (en) Catheter distal assembly with pull wires
US8152799B2 (en) Radio frequency-based catheter system with improved deflection and steering mechanisms
US9358365B2 (en) Precision electrode movement control for renal nerve ablation
EP1824404B1 (en) Devices for energy assisted arterio-venous fistula creation
US20070112342A1 (en) Tissue ablation apparatus and method
EP2465574A1 (en) Systems for thermally-induced renal neuromodulation
US6203525B1 (en) Catheterdistal assembly with pull wires
US20050065474A1 (en) Catheter assembly
US8777942B2 (en) Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
JP2935571B2 (en) Method and apparatus for performing the ablation procedure
US7416552B2 (en) Multipolar, multi-lumen, virtual-electrode catheter with at least one surface electrode and method for ablation
JP6266516B2 (en) Catheter system for wall injection and perivascular renal denervation
CN104023662B (en) Renal nerve ablation hole
US20020198520A1 (en) Irrigation sheath
JP4653918B2 (en) Drug delivery catheter and methods of use thereof attached to the tissue

Legal Events

Date Code Title Description
AS Assignment

Owner name: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L., LUXEMBOURG

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BEASLEY, RUDY;GOSHGARIAN, JUSTIN;KU, VINCENT;SIGNING DATES FROM 20131113 TO 20131126;REEL/FRAME:032156/0020

MAFP

Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1551); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY

Year of fee payment: 4