AT397802B - Pyrimidinderivate - Google Patents

Pyrimidinderivate Download PDF

Info

Publication number
AT397802B
AT397802B AT0345187A AT345187A AT397802B AT 397802 B AT397802 B AT 397802B AT 0345187 A AT0345187 A AT 0345187A AT 345187 A AT345187 A AT 345187A AT 397802 B AT397802 B AT 397802B
Authority
AT
Austria
Prior art keywords
general formula
hydrogen
compound
compounds
acid addition
Prior art date
Application number
AT0345187A
Other languages
German (de)
English (en)
Other versions
ATA345187A (de
Inventor
Daniel Chem Ing Dr Bozsing
Gyoergyi Chem Ing Dr Kovanyi
Edit Chem Ing Dr Berenyi
Karoly Dr Magyar
Sandor Dr Tuboly
Attila Chem Ing Dr Mandi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU865514A external-priority patent/HU196763B/hu
Priority claimed from HU551286A external-priority patent/HU197913B/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of ATA345187A publication Critical patent/ATA345187A/de
Application granted granted Critical
Publication of AT397802B publication Critical patent/AT397802B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT0345187A 1986-12-30 1987-12-30 Pyrimidinderivate AT397802B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU865514A HU196763B (en) 1986-12-30 1986-12-30 Process for production of piramidine-derivatives
HU551286A HU197913B (en) 1986-12-30 1986-12-30 Process for producing thiazolo-, thiazino- and thiazepinopyrimidine derivatives

Publications (2)

Publication Number Publication Date
ATA345187A ATA345187A (de) 1993-11-15
AT397802B true AT397802B (de) 1994-07-25

Family

ID=26317840

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0345187A AT397802B (de) 1986-12-30 1987-12-30 Pyrimidinderivate

Country Status (22)

Country Link
US (1) US4921854A (no)
KR (1) KR940002669B1 (no)
CN (1) CN1024277C (no)
AT (1) AT397802B (no)
AU (1) AU597770B2 (no)
BE (1) BE1003067A5 (no)
CA (1) CA1324788C (no)
CH (1) CH676599A5 (no)
DE (1) DE3743935A1 (no)
DK (1) DK692587A (no)
ES (1) ES2008945A6 (no)
FI (1) FI86637C (no)
FR (1) FR2609033B1 (no)
GB (1) GB2199581B (no)
GR (1) GR872084B (no)
IL (1) IL84988A0 (no)
NL (1) NL8703148A (no)
PH (1) PH24290A (no)
PL (1) PL149618B1 (no)
SE (1) SE8705196L (no)
SU (1) SU1650014A3 (no)
YU (2) YU46433B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds
DE102004035808A1 (de) * 2004-07-21 2006-03-16 Kasch, Helmut, Dr. Ammoniumsalze und Ammoniumsalz-Mineralsalzchlatrate als Transport- und Wirkform für pharmazeutische-medizinische und als Phasentransfermittel für chemische Anwendungen
WO2017100593A1 (en) 2015-12-09 2017-06-15 Luc Therapeutics Thienopyrimidinone nmda receptor modulators and uses thereof
ES2821010T3 (es) 2015-12-09 2021-04-23 Cadent Therapeutics Inc Moduladores heteroaromáticos del receptor NMDA y usos de los mismos
JP7332472B2 (ja) * 2016-12-22 2023-08-23 ノバルティス アーゲー Ｎｍｄａ受容体モジュレーターおよびその使用
JP7319369B2 (ja) 2018-08-03 2023-08-01 ノバルティス アーゲー ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2032686A1 (de) * 1970-07-02 1972-01-20 Dr Karl Thomae GmbH, 7950 Biberach Verfahren zur Herstellung von neuen 2 Aminoalkylamino thieno eckige Klammer auf 3,2 d eckige Klammer zu Pynmidinen
DE3146300A1 (de) * 1981-11-17 1983-08-25 Schering AG, 1000 Berlin und 4709 Bergkamen Thiazolo- und (1,3)thiazino(3,2-b)(1,2,4)triazine, verfahren zur herstellung dieser verbindungen sowie diese enthaltende mittel mit selektiver herbizider wirkung
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049902A3 (en) * 1980-10-15 1982-09-01 Teijin Limited Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
FR2574408B1 (fr) * 1984-12-12 1987-01-30 Rhone Poulenc Sante Procede de preparation d'isomeres optiques de thiazolo(3,2-a) pyrimidines, les nouveaux isomeres ainsi obtenus, les compositions pharmaceutiques qui les contiennent et les intermediaires pour mettre en oeuvre ce procede
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2032686A1 (de) * 1970-07-02 1972-01-20 Dr Karl Thomae GmbH, 7950 Biberach Verfahren zur Herstellung von neuen 2 Aminoalkylamino thieno eckige Klammer auf 3,2 d eckige Klammer zu Pynmidinen
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
DE3146300A1 (de) * 1981-11-17 1983-08-25 Schering AG, 1000 Berlin und 4709 Bergkamen Thiazolo- und (1,3)thiazino(3,2-b)(1,2,4)triazine, verfahren zur herstellung dieser verbindungen sowie diese enthaltende mittel mit selektiver herbizider wirkung
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones

Also Published As

Publication number Publication date
PH24290A (en) 1990-05-29
PL269811A1 (en) 1988-09-15
YU4989A (en) 1989-08-31
IL84988A0 (en) 1988-06-30
GB8730297D0 (en) 1988-02-03
FI875766A (fi) 1988-07-01
SE8705196D0 (sv) 1987-12-30
SU1650014A3 (ru) 1991-05-15
YU241987A (en) 1989-08-31
KR940002669B1 (ko) 1994-03-28
KR880007545A (ko) 1988-08-27
DK692587D0 (da) 1987-12-30
FR2609033B1 (fr) 1994-09-09
FI86637C (fi) 1992-09-25
NL8703148A (nl) 1988-07-18
GR872084B (en) 1988-04-27
YU46433B (sh) 1993-10-20
CN87105992A (zh) 1988-08-10
FI875766A0 (fi) 1987-12-30
DK692587A (da) 1988-07-01
SE8705196L (sv) 1988-07-01
FI86637B (fi) 1992-06-15
FR2609033A1 (fr) 1988-07-01
CA1324788C (en) 1993-11-30
DE3743935A1 (de) 1988-07-14
GB2199581B (en) 1990-07-18
US4921854A (en) 1990-05-01
ES2008945A6 (es) 1989-08-16
YU46483B (sh) 1993-10-20
CH676599A5 (no) 1991-02-15
GB2199581A (en) 1988-07-13
AU597770B2 (en) 1990-06-07
BE1003067A5 (fr) 1991-11-12
AU8314487A (en) 1988-06-30
ATA345187A (de) 1993-11-15
PL149618B1 (en) 1990-03-31
CN1024277C (zh) 1994-04-20

Similar Documents

Publication Publication Date Title
DD203052A5 (de) Verfahren zur herstellung von 9-(1,3-dihydroxy-2-propoxy-methyl)-guanin, dessen salzen und bestimmten benzylderivaten desselben
DE1470053A1 (de) 5,6-disubstituierte (3-Aminopyrazinoyl)-guanidinverbindungen und Verfahren zu deren Herstellung
AT397802B (de) Pyrimidinderivate
DE2505297A1 (de) Neue 2-arylamino-2-imidazolinderivate und ein verfahren zu deren herstellung
DE3026214A1 (de) Salicylsaeure-derivate, ihre pharmazeutisch vertraeglichen salze und verfahren zu ihrer herstellung
DE2920182A1 (de) Salze von thiazolyliden-oxo-propionitrilen, insektizide mittel enthaltend diese salze sowie verfahren zu ihrer herstellung
DE2521523A1 (de) Lactamverbindungen und konjugate
EP0454060A1 (de) 3-(Mercaptoalkyl)-chinazolin-2,4(1H,3H)-dione, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen
DE3337925C2 (de) N-(6-Aminopurinyl)-4-hydroxy-2-methyl-2H-1,2-benzothiazin-3-carboxamid-1,1-dioxid, Verfahren zu dessen Herstellung und seine Verwendung
EP0003788B1 (de) Glucofuranosyl-nitrosoharnstoffderivate, Verfahren zu deren Herstellung und ihre pharmazeutischen Präparate
EP0085275A1 (de) Substituierte Thiazolidinylester von Mineralsäuren
CH646875A5 (de) Verfahren zur gewinnung eines interferons und interferon hergestellt nach diesem verfahren.
DD279676A5 (de) Verfahren zur herstellung von neuen kondensierten pyrimidinderivaten
DE2421930A1 (de) Neue 2-(1,3-diaza-2-cycloalken-2ylamino)chinazoline und verfahren zu ihrer herstellung
DE1695414A1 (de) Verfahren zur Herstellung von Chinolinderivaten
DE2609574B2 (de) 1-(4-fluor-3-trifluormethylthio- phenyl)-piperazin, dessen salze, verfahren zu dessen herstellung und arzneimittel
DE2242375C3 (de) 1,4-Disubstituierte 6-Nitro-2(1 H(-chinazolinone
DE2116252A1 (de) Dihydrotnazine, ihre Saureadditions salze und N Acyldenvate, Verfahren zu ihrer Herstellung und Arzneimittel, die diese Verbindungen als Wirkstoffe ent halten
DE1620034A1 (de) 2,4-Diamino-6-halogen-7-X-pteridine und Verfahren zu deren Herstellung
DE2411276A1 (de) Pyrimidinone und verfahren zu deren herstellung
DE1770326A1 (de) Neue Chinolinderivate und Verfahren zu ihrer Herstellung
DD298784A5 (de) 3-(mercaptoalkyl)chinazolin-2,4(1h,3h)-dione, verfahren zu ihrer herstellung und pharmazeutische zubereitungen
DE2617198A1 (de) 6-n-propoxybenzthiazol-2-methylcarbamat, verfahren zu seiner herstellung und es enthaltende arzneimittel
DE1795309B2 (de) 2,4-Diamino-6-acylamino-chinazolinverbindungen und Verfahren zu ihrer Herstellung
EP0193066A1 (de) Neue Ketosultame und Verfahren zu ihrer Herstellung

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee