BE1003067A5 - Derives de la pyrimidine. - Google Patents

Derives de la pyrimidine. Download PDF

Info

Publication number
BE1003067A5
BE1003067A5 BE8701500A BE8701500A BE1003067A5 BE 1003067 A5 BE1003067 A5 BE 1003067A5 BE 8701500 A BE8701500 A BE 8701500A BE 8701500 A BE8701500 A BE 8701500A BE 1003067 A5 BE1003067 A5 BE 1003067A5
Authority
BE
Belgium
Prior art keywords
pyrimidine derivatives
derivatives
acid addition
addition salts
hydrates
Prior art date
Application number
BE8701500A
Other languages
English (en)
Inventor
Daniel Bozsing
Lax Gyoergyi Kovanyi
Polderman Edit Berenyi
Karoly Magyar
Sandor Tuboly
Attila Mandi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU865514A external-priority patent/HU196763B/hu
Priority claimed from HU551286A external-priority patent/HU197913B/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of BE1003067A5 publication Critical patent/BE1003067A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Dérivés correspondant à la formule générale I, et comprennent aussi leurs sels d'addition acides acceptables du point de vue pharmaceutique et des hydrates de ces dérivés et des sels d'addition acides de ceux-ci. Ces produits sont des constituants des médicaments à effet immunostimulant.
BE8701500A 1986-12-30 1987-12-30 Derives de la pyrimidine. BE1003067A5 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU865514A HU196763B (en) 1986-12-30 1986-12-30 Process for production of piramidine-derivatives
HU551286A HU197913B (en) 1986-12-30 1986-12-30 Process for producing thiazolo-, thiazino- and thiazepinopyrimidine derivatives

Publications (1)

Publication Number Publication Date
BE1003067A5 true BE1003067A5 (fr) 1991-11-12

Family

ID=26317840

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8701500A BE1003067A5 (fr) 1986-12-30 1987-12-30 Derives de la pyrimidine.

Country Status (23)

Country Link
US (1) US4921854A (fr)
KR (1) KR940002669B1 (fr)
CN (1) CN1024277C (fr)
AT (1) AT397802B (fr)
AU (1) AU597770B2 (fr)
BE (1) BE1003067A5 (fr)
BG (1) BG82461A (fr)
CA (1) CA1324788C (fr)
CH (1) CH676599A5 (fr)
DE (1) DE3743935A1 (fr)
DK (1) DK692587A (fr)
ES (1) ES2008945A6 (fr)
FI (1) FI86637C (fr)
FR (1) FR2609033B1 (fr)
GB (1) GB2199581B (fr)
GR (1) GR872084B (fr)
IL (1) IL84988A0 (fr)
NL (1) NL8703148A (fr)
PH (1) PH24290A (fr)
PL (1) PL149618B1 (fr)
SE (1) SE8705196L (fr)
SU (1) SU1650014A3 (fr)
YU (2) YU46433B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds
DE102004035808A1 (de) * 2004-07-21 2006-03-16 Kasch, Helmut, Dr. Ammoniumsalze und Ammoniumsalz-Mineralsalzchlatrate als Transport- und Wirkform für pharmazeutische-medizinische und als Phasentransfermittel für chemische Anwendungen
EP3386990B1 (fr) 2015-12-09 2023-04-19 Novartis AG Modulateurs des récepteurs nmda à base de thiénopyrimidinone et leurs utilisations
RS60834B1 (sr) 2015-12-09 2020-10-30 Cadent Therapeutics Inc Modulatori heteroaromatskog nmda receptora i njihove upotrebe
JP7332472B2 (ja) * 2016-12-22 2023-08-23 ノバルティス アーゲー Ｎｍｄａ受容体モジュレーターおよびその使用
EA202190431A1 (ru) 2018-08-03 2021-06-11 Кэйдент Терапьютикс, Инк. Гетероароматические модуляторы nmda рецептора и их применение

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049902A2 (fr) * 1980-10-15 1982-04-21 Teijin Limited Dérivés de la thiazolo(3,2-a)pyrimidine, procédé pour leur préparation et leur application pharmaceutique

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2032686A1 (de) * 1970-07-02 1972-01-20 Dr Karl Thomae GmbH, 7950 Biberach Verfahren zur Herstellung von neuen 2 Aminoalkylamino thieno eckige Klammer auf 3,2 d eckige Klammer zu Pynmidinen
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
DE3146300A1 (de) * 1981-11-17 1983-08-25 Schering AG, 1000 Berlin und 4709 Bergkamen Thiazolo- und (1,3)thiazino(3,2-b)(1,2,4)triazine, verfahren zur herstellung dieser verbindungen sowie diese enthaltende mittel mit selektiver herbizider wirkung
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
FR2574408B1 (fr) * 1984-12-12 1987-01-30 Rhone Poulenc Sante Procede de preparation d'isomeres optiques de thiazolo(3,2-a) pyrimidines, les nouveaux isomeres ainsi obtenus, les compositions pharmaceutiques qui les contiennent et les intermediaires pour mettre en oeuvre ce procede
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049902A2 (fr) * 1980-10-15 1982-04-21 Teijin Limited Dérivés de la thiazolo(3,2-a)pyrimidine, procédé pour leur préparation et leur application pharmaceutique

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 101, no. 21, 19 novembre 1984, pages 762-763, abrégé no. 191835n, Columbus, Ohio, US; A.S. MIKHAILOV et al.: "Reaction of 2-mercaptopyrimidines with some aplha,omega-dihaloalkanes", & IZV. AKAD. NAUK SSSR, SER. KHIM. 1984, (6), 1396-402 *
CHEMICAL ABSTRACTS, vol. 105, no. 23, 8 décembre 1986, page 591, abrégé no. 208825s, Columbus, Ohio, US; M. DI BRACCIO et al.: "1,2-Condensed pyrimidines derivatives. Note II. Synthesis and pharmacological studies on N,N-disubstituted 5-amino-7H-thiazolo[3,2-aÜpyrimidin-7-ones", & FARMACO, ED. SCI. 1986, 41(3), 183-95 *

Also Published As

Publication number Publication date
ATA345187A (de) 1993-11-15
DK692587A (da) 1988-07-01
YU46433B (sh) 1993-10-20
YU4989A (en) 1989-08-31
GR872084B (en) 1988-04-27
DE3743935A1 (de) 1988-07-14
SE8705196D0 (sv) 1987-12-30
FR2609033A1 (fr) 1988-07-01
FI86637B (fi) 1992-06-15
PH24290A (en) 1990-05-29
GB2199581A (en) 1988-07-13
SE8705196L (sv) 1988-07-01
GB8730297D0 (en) 1988-02-03
CA1324788C (fr) 1993-11-30
SU1650014A3 (ru) 1991-05-15
FR2609033B1 (fr) 1994-09-09
NL8703148A (nl) 1988-07-18
CN1024277C (zh) 1994-04-20
ES2008945A6 (es) 1989-08-16
CH676599A5 (fr) 1991-02-15
YU241987A (en) 1989-08-31
PL269811A1 (en) 1988-09-15
DK692587D0 (da) 1987-12-30
AU597770B2 (en) 1990-06-07
KR940002669B1 (ko) 1994-03-28
FI875766A0 (fi) 1987-12-30
AT397802B (de) 1994-07-25
AU8314487A (en) 1988-06-30
KR880007545A (ko) 1988-08-27
BG82461A (bg) 1993-12-24
FI875766A (fi) 1988-07-01
PL149618B1 (en) 1990-03-31
FI86637C (fi) 1992-09-25
YU46483B (sh) 1993-10-20
CN87105992A (zh) 1988-08-10
IL84988A0 (en) 1988-06-30
GB2199581B (en) 1990-07-18
US4921854A (en) 1990-05-01

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: EGIS GYOGYSZERGYAR

Effective date: 19941231