YU46483B - Postupak za dobijanje kondenzovanih derivata pirimidina - Google Patents

Postupak za dobijanje kondenzovanih derivata pirimidina

Info

Publication number
YU46483B
YU46483B YU4989A YU4989A YU46483B YU 46483 B YU46483 B YU 46483B YU 4989 A YU4989 A YU 4989A YU 4989 A YU4989 A YU 4989A YU 46483 B YU46483 B YU 46483B
Authority
YU
Yugoslavia
Prior art keywords
general formula
hydrogen
addition salt
pyrimidine derivatives
procedure
Prior art date
Application number
YU4989A
Other languages
English (en)
Other versions
YU4989A (en
Inventor
D. Bozsing
G. Kovanyi
E. Berenyi
K. Megyar
S. Tuboly
A. Mandi
Original Assignee
Egis Gyogyszer Gyar Budapest
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU551286A external-priority patent/HU197913B/hu
Priority claimed from HU865514A external-priority patent/HU196763B/hu
Application filed by Egis Gyogyszer Gyar Budapest filed Critical Egis Gyogyszer Gyar Budapest
Publication of YU4989A publication Critical patent/YU4989A/xx
Publication of YU46483B publication Critical patent/YU46483B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

POSTUPAK ZA DOBIJANJE KONDENZOVANIH DERIVATA PIRIMIDINA opšte formule I: u kojoj A je -CH2-CH2-, ili -CH=CH-; R4 je vodonik, C1-4 alkil ili po izboru supstituisan fenil; r je ceo broj 0,1,2,3 ili 4; R1 je vodonik; R2 je vodonik; R3 je vodonik; i njihovih farmaceutski prihvatljivih soli sa kiselinama i njihovih hidrata, naznačen time, što reaguje jedinjenje opšte formule II: u kojoj A i r i R4 su kao što je dato napred, sa malonskim dinitrilom formule III: NC-CH2-CH (III) i ako je potrebno, dobiveno jedinjenje opšte formule i se prevodi u svoju farmaceutski prihvatljivu adicionu so sa kiselinom ili se oslobadja baza opšte formule I iz svoje adicione soli ili se adiciona so ili slobodna baza opšte formule I prevode u svoj hidrat. Prijava sadrži još 1 zavisan zahtev.
YU4989A 1986-12-30 1989-01-11 Postupak za dobijanje kondenzovanih derivata pirimidina YU46483B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU551286A HU197913B (en) 1986-12-30 1986-12-30 Process for producing thiazolo-, thiazino- and thiazepinopyrimidine derivatives
HU865514A HU196763B (en) 1986-12-30 1986-12-30 Process for production of piramidine-derivatives

Publications (2)

Publication Number Publication Date
YU4989A YU4989A (en) 1989-08-31
YU46483B true YU46483B (sh) 1993-10-20

Family

ID=26317840

Family Applications (2)

Application Number Title Priority Date Filing Date
YU241987A YU46433B (sh) 1986-12-30 1987-12-29 Postupak za dobijanje kondenzovanih derivata pirimidina
YU4989A YU46483B (sh) 1986-12-30 1989-01-11 Postupak za dobijanje kondenzovanih derivata pirimidina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU241987A YU46433B (sh) 1986-12-30 1987-12-29 Postupak za dobijanje kondenzovanih derivata pirimidina

Country Status (23)

Country Link
US (1) US4921854A (sh)
KR (1) KR940002669B1 (sh)
CN (1) CN1024277C (sh)
AT (1) AT397802B (sh)
AU (1) AU597770B2 (sh)
BE (1) BE1003067A5 (sh)
BG (1) BG82461A (sh)
CA (1) CA1324788C (sh)
CH (1) CH676599A5 (sh)
DE (1) DE3743935A1 (sh)
DK (1) DK692587A (sh)
ES (1) ES2008945A6 (sh)
FI (1) FI86637C (sh)
FR (1) FR2609033B1 (sh)
GB (1) GB2199581B (sh)
GR (1) GR872084B (sh)
IL (1) IL84988A0 (sh)
NL (1) NL8703148A (sh)
PH (1) PH24290A (sh)
PL (1) PL149618B1 (sh)
SE (1) SE8705196L (sh)
SU (1) SU1650014A3 (sh)
YU (2) YU46433B (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds
DE102004035808A1 (de) * 2004-07-21 2006-03-16 Kasch, Helmut, Dr. Ammoniumsalze und Ammoniumsalz-Mineralsalzchlatrate als Transport- und Wirkform für pharmazeutische-medizinische und als Phasentransfermittel für chemische Anwendungen
HUE051395T2 (hu) 2015-12-09 2021-03-01 Cadent Therapeutics Inc Heteroaromás NMDA receptor modulátorok és alkalmazásaik
EP3386990B1 (en) 2015-12-09 2023-04-19 Novartis AG Thienopyrimidinone nmda receptor modulators and uses thereof
ES2975336T3 (es) 2016-12-22 2024-07-04 Novartis Ag Moduladores del receptor NMDA y usos de los mismos
PE20210948A1 (es) 2018-08-03 2021-05-24 Cadent Therapeutics Inc Moduladores del receptor nmda heteroaromatico y usos de los mismos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2032686A1 (de) * 1970-07-02 1972-01-20 Dr Karl Thomae GmbH, 7950 Biberach Verfahren zur Herstellung von neuen 2 Aminoalkylamino thieno eckige Klammer auf 3,2 d eckige Klammer zu Pynmidinen
EP0049902A3 (en) * 1980-10-15 1982-09-01 Teijin Limited Novel thiazolo(3,2-a)pyrimidines, derivatives thereof, processes for production thereof, and pharmaceutical use thereof
US4443451A (en) * 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
DE3146300A1 (de) * 1981-11-17 1983-08-25 Schering AG, 1000 Berlin und 4709 Bergkamen Thiazolo- und (1,3)thiazino(3,2-b)(1,2,4)triazine, verfahren zur herstellung dieser verbindungen sowie diese enthaltende mittel mit selektiver herbizider wirkung
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
FR2574408B1 (fr) * 1984-12-12 1987-01-30 Rhone Poulenc Sante Procede de preparation d'isomeres optiques de thiazolo(3,2-a) pyrimidines, les nouveaux isomeres ainsi obtenus, les compositions pharmaceutiques qui les contiennent et les intermediaires pour mettre en oeuvre ce procede
US4921854A (en) * 1986-12-30 1990-05-01 Egis Gyogyszergyar Condensed thiazolopyrimidine, pyrimido-thiazine or thiazepine pyrimidine compounds

Also Published As

Publication number Publication date
KR880007545A (ko) 1988-08-27
IL84988A0 (en) 1988-06-30
FI875766A (fi) 1988-07-01
FR2609033B1 (fr) 1994-09-09
PL269811A1 (en) 1988-09-15
DK692587A (da) 1988-07-01
ATA345187A (de) 1993-11-15
FI875766A0 (fi) 1987-12-30
AT397802B (de) 1994-07-25
CH676599A5 (sh) 1991-02-15
BE1003067A5 (fr) 1991-11-12
GR872084B (en) 1988-04-27
FI86637B (fi) 1992-06-15
PL149618B1 (en) 1990-03-31
YU241987A (en) 1989-08-31
SU1650014A3 (ru) 1991-05-15
FR2609033A1 (fr) 1988-07-01
ES2008945A6 (es) 1989-08-16
PH24290A (en) 1990-05-29
SE8705196L (sv) 1988-07-01
GB2199581B (en) 1990-07-18
GB2199581A (en) 1988-07-13
GB8730297D0 (en) 1988-02-03
CN1024277C (zh) 1994-04-20
NL8703148A (nl) 1988-07-18
AU597770B2 (en) 1990-06-07
SE8705196D0 (sv) 1987-12-30
DE3743935A1 (de) 1988-07-14
YU46433B (sh) 1993-10-20
CN87105992A (zh) 1988-08-10
YU4989A (en) 1989-08-31
BG82461A (bg) 1993-12-24
AU8314487A (en) 1988-06-30
FI86637C (fi) 1992-09-25
KR940002669B1 (ko) 1994-03-28
CA1324788C (en) 1993-11-30
DK692587D0 (da) 1987-12-30
US4921854A (en) 1990-05-01

Similar Documents

Publication Publication Date Title
ES8506677A1 (es) Un procedimiento para la preparacion de nuevos derivados de 8-cloro71,5-benzotiazepina.
ES8305330A1 (es) Un procedimiento para la preparacion de 1,-4dihidropiridinas.
MX11031A (es) Proceso para la preparacion de nuevas 1-fenil-3-naftaleniloxipropanaminas producto obtenido y composicion farmaceutica que lo incluye.
EP0353955A3 (en) Novel compounds
ES2000346A6 (es) Un procedimiento para la preparacion de derivados de distamicina
DK57281A (da) Fremgangsmaade til fremstilling af substituerede imidazolderivater eller syreadditionssalte deraf
ES8306142A1 (es) "procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil)-bencimidazolonas sustituidas".
YU46547B (sh) 1,4-dihidropiridini i postupak za njihovo dobijanje
YU47580B (sh) Postupak za dobijanje novih derivata benzonitrila
EP0202062A3 (en) Quinuclidine derivatives
YU46483B (sh) Postupak za dobijanje kondenzovanih derivata pirimidina
JPS646261A (en) 4-thioquinazoline derivative, its production and antiulcer agent containing said derivative as active component
DE3665178D1 (en) 1-cyclopropyl-1,4-dihydro-4-oxo-7-û4-(oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl¨-quinoline-3-carboxylic acids, process for their preparation and bactericides containing them
NO170580C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive piperidinderivater
ME00300B (me) NOVI DERIVATI OKT AHIDR0-6, 10-DIOKS0-6N-PIRIDAZINO/l,2-a/ /l,2/DIAZEPIN-1-KARBOKSILNE KISELINE, NJIHOV POSTUPAK DOBIJANJA I NJIHOVA PRIMENA ZA DOBIJANJE TERAPEUTSKI AKTIVNIH JEDINJENJA
ES478643A1 (es) Procedimiento de preparacion de nuevos derivados de la n-fe-nilalanina.
HRP20000027B1 (en) Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds
ES8305758A1 (es) "un procedimiento para la preparacion de 2-(1,4-benzodioxan-2-il-metil)-imidazolina".
ES543790A0 (es) Procedimiento de preparacion de nuevos derivados a-etilami- noetoxibencilalcoholicos con un grupo fenil sustituido en situacion a y de sus sales de adicion acidas y amonicas cua-ternarias
YU46150B (sh) Racemski i optički aktivni derivati 14-hidrpksi-imino-eburnana kao i postupak za njihovo dobijanje
JPS5690070A (en) Novel pyrimidine derivative
IL70103A (en) 4-(6,7-dimethoxyquinazolin-4-yl)-semicarbazides,their preparation and pharmaceutical compositions containing them
YU60790A (sh) Postupak za dobijanje 5-fenilpirimidin jedinjenja i njihovih soli
JPS53119857A (en) Hydroxyindaneacetic acid derivatives and their preparation
JPS5511502A (en) Preparation of condensed heterocyclic compound