BE902213A - Composes de phenethanolamine. - Google Patents
Composes de phenethanolamine.Info
- Publication number
- BE902213A BE902213A BE0/214856A BE214856A BE902213A BE 902213 A BE902213 A BE 902213A BE 0/214856 A BE0/214856 A BE 0/214856A BE 214856 A BE214856 A BE 214856A BE 902213 A BE902213 A BE 902213A
- Authority
- BE
- Belgium
- Prior art keywords
- compounds
- derivatives
- phenethanolamine compounds
- phenethanolamine
- adreno
- Prior art date
Links
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical class NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 title abstract 2
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 abstract 1
- 101710152983 Beta-2 adrenergic receptor Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/28—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/34—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Dérivés de la phénéthanol-amine de formule générale (I) dans laquelle Ar et Y et les substituants R1 et R2 possèdent les significations définies, ainsi que les sels et produits de solvatation physiologiquement acceptables de ces dérivés. Ces composés ont une action stimulante sélective sur les béta 2-adréno-récepteurs et conviennent notamment pour le traitement d'affections des voies aériennes.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848409909A GB8409909D0 (en) | 1984-04-17 | 1984-04-17 | Chemical compounds |
GB848409910A GB8409910D0 (en) | 1984-04-17 | 1984-04-17 | Chemical compounds |
GB848426206A GB8426206D0 (en) | 1984-10-17 | 1984-10-17 | Chemical compounds |
GB848426197A GB8426197D0 (en) | 1984-10-17 | 1984-10-17 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BE902213A true BE902213A (fr) | 1985-10-17 |
Family
ID=27449546
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/214856A BE902213A (fr) | 1984-04-17 | 1985-04-17 | Composes de phenethanolamine. |
Country Status (20)
Country | Link |
---|---|
US (1) | US4990505A (fr) |
KR (1) | KR850007422A (fr) |
AU (1) | AU582573B2 (fr) |
BE (1) | BE902213A (fr) |
CH (1) | CH667264A5 (fr) |
DE (1) | DE3513885A1 (fr) |
DK (1) | DK173785A (fr) |
ES (2) | ES8702880A1 (fr) |
FI (1) | FI851523L (fr) |
FR (1) | FR2562889B1 (fr) |
GB (1) | GB2159151B (fr) |
GR (1) | GR850936B (fr) |
IL (1) | IL74940A (fr) |
IT (1) | IT1181642B (fr) |
LU (1) | LU85856A1 (fr) |
NL (1) | NL8501124A (fr) |
NO (1) | NO162113C (fr) |
NZ (1) | NZ211822A (fr) |
PT (1) | PT80304B (fr) |
SE (1) | SE8501895L (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
GB8426206D0 (en) * | 1984-10-17 | 1984-11-21 | Glaxo Holdings Ltd | Chemical compounds |
DE3571808D1 (en) * | 1984-04-17 | 1989-08-31 | Glaxo Group Ltd | Ethanolamine compounds |
DE3524990A1 (de) * | 1984-07-13 | 1986-01-23 | Glaxo Group Ltd., London | Aminophenolverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen |
JPS63290852A (ja) * | 1987-02-10 | 1988-11-28 | グラクソ、グループ、リミテッド | 化合物 |
JPS6485964A (en) * | 1987-03-12 | 1989-03-30 | Glaxo Group Ltd | Compound |
GB8718938D0 (en) * | 1987-08-11 | 1987-09-16 | Glaxo Group Ltd | Chemical compounds |
GB8718940D0 (en) * | 1987-08-11 | 1987-09-16 | Glaxo Group Ltd | Chemical compounds |
PT88988B (pt) * | 1987-11-13 | 1993-02-26 | Glaxo Group Ltd | Processo para a preparacao de derivados da fenetanolamina |
EP0322164B1 (fr) * | 1987-12-18 | 1993-09-22 | Glaxo Group Limited | Dérivés d'éthanolamine |
ZA889405B (en) * | 1987-12-18 | 1989-12-27 | Glaxo Group Ltd | Ethanolamine derivatives |
NZ228329A (en) * | 1988-03-18 | 1991-12-23 | Mitsui Toatsu Chemicals | Catechol derivatives and pharmaceutical compositions thereof |
GB2230775A (en) * | 1989-04-24 | 1990-10-31 | Glaxo Group Ltd | Phenethanolamine compounds |
GB9215274D0 (en) * | 1992-07-17 | 1992-09-02 | Scras | Derivatives of(phenylethyl-beta-ol)amine |
GB0103630D0 (en) | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
US7144908B2 (en) | 2001-03-08 | 2006-12-05 | Glaxo Group Limited | Agonists of beta-adrenoceptors |
DE60224172T2 (de) | 2001-03-22 | 2008-12-04 | Glaxo Group Ltd., Greenford | Formanilid-derivative als beta2-adrenorezeptor-agonisten |
CN1302007C (zh) | 2001-04-30 | 2007-02-28 | 葛兰素集团有限公司 | 具有抗炎性的在17.α位上具有环酯基的雄甾烷的17.β.-硫代羧酸酯衍生物 |
KR100912324B1 (ko) | 2001-09-14 | 2009-08-14 | 글락소 그룹 리미티드 | 호흡기 질환 치료용 펜에탄올아민 유도체 |
GB0204719D0 (en) * | 2002-02-28 | 2002-04-17 | Glaxo Group Ltd | Medicinal compounds |
ES2298511T3 (es) | 2002-04-25 | 2008-05-16 | Glaxo Group Limited | Derivados de fenetanolamina. |
GB0217225D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicinal compounds |
GB0220730D0 (en) * | 2002-09-06 | 2002-10-16 | Glaxo Group Ltd | Medicinal compounds |
PL377122A1 (pl) | 2002-10-28 | 2006-01-23 | Glaxo Group Limited | Pochodne fenetanoloaminy do leczenia chorób układu oddechowego |
GB0225540D0 (en) * | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
DE10253220A1 (de) * | 2002-11-15 | 2004-05-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Dihydroxy-Methyl-Phenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
GB0303396D0 (en) | 2003-02-14 | 2003-03-19 | Glaxo Group Ltd | Medicinal compounds |
BRPI0508927A (pt) * | 2004-03-17 | 2007-08-14 | Pfizer | compostos úteis para o tratamento de doenças |
EP1577291A1 (fr) * | 2004-03-17 | 2005-09-21 | Pfizer Limited | Dérivés béta-2 agonistes de la phényléthanolamine |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
DE1543372A1 (de) * | 1966-10-18 | 1971-04-01 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von o-substituierten 3,4-Dioxyphenylalkanolaminen |
AT310146B (de) * | 1971-04-26 | 1973-09-25 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen N,N'-Bis-(β-hydroxyaryläthyl)-diaminoalkanen und deren Säureadditionssalzen |
US3879442A (en) * | 1972-07-27 | 1975-04-22 | Warner Lambert Co | 5-hydroxy-{60 (substituted aminomethyl)-mu-xylene-{60 ,{60 -diols |
HU168618B (fr) * | 1974-06-17 | 1976-06-28 | ||
US4160036A (en) * | 1975-07-29 | 1979-07-03 | Allen & Hanburys Limited | 4-Hydroxy-1,3-benzenedimethanol derivatives |
US4154761A (en) * | 1976-02-09 | 1979-05-15 | Allen & Hanburys Limited | Pharmacologically active compounds |
JPS52113934A (en) * | 1976-03-19 | 1977-09-24 | Eisai Co Ltd | Phenethylamine derivatives and bronchodilator containing the same |
DE2965655D1 (en) * | 1978-06-28 | 1983-07-21 | Beecham Group Plc | Secondary amines, their preparation, pharmaceutical compositions containing them and their use |
EP0021636B1 (fr) * | 1979-06-16 | 1982-12-01 | Beecham Group Plc | Amines secondaires, leur préparation et utilisation dans des compositions pharmaceutiques |
US4379166A (en) * | 1981-08-03 | 1983-04-05 | Schering Corporation | Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols |
ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
-
1985
- 1985-04-17 NL NL8501124A patent/NL8501124A/nl not_active Application Discontinuation
- 1985-04-17 PT PT80304A patent/PT80304B/pt not_active IP Right Cessation
- 1985-04-17 GR GR850936A patent/GR850936B/el unknown
- 1985-04-17 DE DE19853513885 patent/DE3513885A1/de not_active Withdrawn
- 1985-04-17 CH CH1639/85A patent/CH667264A5/fr not_active IP Right Cessation
- 1985-04-17 FR FR8505819A patent/FR2562889B1/fr not_active Expired
- 1985-04-17 NZ NZ211822A patent/NZ211822A/xx unknown
- 1985-04-17 NO NO851524A patent/NO162113C/no unknown
- 1985-04-17 KR KR1019850002572A patent/KR850007422A/ko not_active Application Discontinuation
- 1985-04-17 ES ES542351A patent/ES8702880A1/es not_active Expired
- 1985-04-17 BE BE0/214856A patent/BE902213A/fr not_active IP Right Cessation
- 1985-04-17 AU AU41348/85A patent/AU582573B2/en not_active Ceased
- 1985-04-17 FI FI851523A patent/FI851523L/fi not_active Application Discontinuation
- 1985-04-17 DK DK173785A patent/DK173785A/da active IP Right Grant
- 1985-04-17 SE SE8501895A patent/SE8501895L/xx not_active Application Discontinuation
- 1985-04-17 IL IL74940A patent/IL74940A/xx unknown
- 1985-04-17 LU LU85856A patent/LU85856A1/fr unknown
- 1985-04-17 GB GB08509821A patent/GB2159151B/en not_active Expired
- 1985-05-15 IT IT47971/85A patent/IT1181642B/it active
-
1986
- 1986-01-31 ES ES551507A patent/ES8800132A1/es not_active Expired
-
1989
- 1989-04-18 US US07/339,688 patent/US4990505A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2562889B1 (fr) | 1988-10-28 |
ES551507A0 (es) | 1987-10-16 |
IT1181642B (it) | 1987-09-30 |
IL74940A (en) | 1988-06-30 |
FI851523A0 (fi) | 1985-04-17 |
NO162113C (no) | 1989-11-08 |
GR850936B (fr) | 1985-11-25 |
NO162113B (no) | 1989-07-31 |
SE8501895D0 (sv) | 1985-04-17 |
US4990505A (en) | 1991-02-05 |
KR850007422A (ko) | 1985-12-04 |
FR2562889A1 (fr) | 1985-10-18 |
DK173785D0 (da) | 1985-04-17 |
NZ211822A (en) | 1988-11-29 |
ES8800132A1 (es) | 1987-10-16 |
AU582573B2 (en) | 1989-04-06 |
GB2159151B (en) | 1987-10-07 |
CH667264A5 (fr) | 1988-09-30 |
IL74940A0 (en) | 1985-08-30 |
DE3513885A1 (de) | 1985-10-17 |
GB2159151A (en) | 1985-11-27 |
SE8501895L (sv) | 1985-10-18 |
FI851523L (fi) | 1985-10-18 |
NL8501124A (nl) | 1985-11-18 |
GB8509821D0 (en) | 1985-05-22 |
DK173785A (da) | 1985-10-18 |
PT80304A (en) | 1985-05-01 |
ES8702880A1 (es) | 1987-01-16 |
AU4134885A (en) | 1985-10-24 |
ES542351A0 (es) | 1987-01-16 |
NO851524L (no) | 1985-10-18 |
IT8547971A0 (it) | 1985-04-17 |
LU85856A1 (fr) | 1986-06-11 |
IT8547971A1 (it) | 1986-11-15 |
PT80304B (en) | 1987-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: GLAXO GROUP LTD Effective date: 19920430 |