BE904835A - Nouveaux derives d'isoquinoleine, leur procede de preparation, leur application en therapeutique et produits intermediaires. - Google Patents

Nouveaux derives d'isoquinoleine, leur procede de preparation, leur application en therapeutique et produits intermediaires.

Info

Publication number
BE904835A
BE904835A BE0/216713A BE216713A BE904835A BE 904835 A BE904835 A BE 904835A BE 0/216713 A BE0/216713 A BE 0/216713A BE 216713 A BE216713 A BE 216713A BE 904835 A BE904835 A BE 904835A
Authority
BE
Belgium
Prior art keywords
therapeutics
novel
application
preparation process
intermediate products
Prior art date
Application number
BE0/216713A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE904835A publication Critical patent/BE904835A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Abstract

Composés de la formule générale I dans laquelle R1, R2, R3 et R4 peuvent etre autres représenter chacun un atome d'hydrogène, et R5 et R6 représentent chacun un atome d'hydrogène ou un groupe -OCOCH2NR7R8 (où R7 et R8 peuvent etre autres représenter chacun un atome d'hydrogène, pourvu que si l'un de R7 et R8 est un atome d'hydrogène, l'autre soit un groupe -OCOCH2NR7R8. Ces composés et leurs sels physiologiquement acceptables sont utiles en thérapie anticancéreuse.
BE0/216713A 1985-05-29 1986-05-28 Nouveaux derives d'isoquinoleine, leur procede de preparation, leur application en therapeutique et produits intermediaires. BE904835A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858513460A GB8513460D0 (en) 1985-05-29 1985-05-29 Chemical compounds

Publications (1)

Publication Number Publication Date
BE904835A true BE904835A (fr) 1986-11-28

Family

ID=10579796

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216713A BE904835A (fr) 1985-05-29 1986-05-28 Nouveaux derives d'isoquinoleine, leur procede de preparation, leur application en therapeutique et produits intermediaires.

Country Status (18)

Country Link
US (1) US4900737A (fr)
JP (1) JPS6212778A (fr)
KR (1) KR860009015A (fr)
BE (1) BE904835A (fr)
CH (2) CH668596A5 (fr)
DE (1) DE3617938A1 (fr)
DK (1) DK246986A (fr)
ES (2) ES8800942A1 (fr)
FI (1) FI862277A (fr)
FR (1) FR2584072B1 (fr)
GB (2) GB8513460D0 (fr)
IT (1) IT1191931B (fr)
NL (1) NL8601381A (fr)
NO (1) NO862120L (fr)
NZ (1) NZ216338A (fr)
PH (2) PH24002A (fr)
SE (2) SE8602434L (fr)
ZA (1) ZA864015B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK616087A (da) * 1986-11-27 1988-05-28 Glaxo Group Ltd Isoquinolinderivater og farmaceutiske praeparater indeholdende dem
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process
FR2801309B1 (fr) * 1999-11-18 2002-01-04 Adir Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN114805204B (zh) * 2022-04-01 2023-09-15 云南师范大学 一种制备4-碘异喹啉-1(2h)-酮类化合物的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029659A (en) * 1971-03-29 1977-06-14 Omnium Chimique Societe Anonyme N-disubstituted aminoethyl esters of 11-methoxy-raubasinic acid
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
US3903276A (en) * 1972-03-20 1975-09-02 American Home Prod N-carboxymethyl-N-substituted glycinate esters of 3-hydroxy-1,4-benzodiazepin-2-ones for inducing a calming effect
US4301285A (en) * 1980-10-02 1981-11-17 American Home Products Corporation Sydnonimine CNS stimulants
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
CA1268178A (fr) * 1984-05-03 1990-04-24 Gordon H. Phillipps Derives d'isoquinoline

Also Published As

Publication number Publication date
SE8904107D0 (sv) 1989-12-05
FI862277A0 (fi) 1986-05-29
ES8800942A1 (es) 1987-12-01
AU5807386A (en) 1986-12-04
NZ216338A (en) 1989-03-29
NO862120L (no) 1986-12-01
DK246986A (da) 1986-11-30
CH668596A5 (de) 1989-01-13
SE464523B (sv) 1991-05-06
FI862277A (fi) 1986-11-30
GB8513460D0 (en) 1985-07-03
DE3617938A1 (de) 1986-12-04
ES557703A0 (es) 1988-01-01
IT1191931B (it) 1988-03-31
FR2584072B1 (fr) 1991-04-19
PH24375A (en) 1990-06-13
NL8601381A (nl) 1986-12-16
CH671959A5 (fr) 1989-10-13
AU591905B2 (en) 1989-12-21
KR860009015A (ko) 1986-12-19
IT8648070A0 (it) 1986-05-28
ES555407A0 (es) 1987-12-01
JPS6212778A (ja) 1987-01-21
ES8801212A1 (es) 1988-01-01
SE8602434D0 (sv) 1986-05-28
GB8612950D0 (en) 1986-07-02
SE8602434L (sv) 1986-11-30
GB2175587A (en) 1986-12-03
FR2584072A1 (fr) 1987-01-02
DK246986D0 (da) 1986-05-27
GB2175587B (en) 1989-10-11
ZA864015B (en) 1988-01-27
US4900737A (en) 1990-02-13
PH24002A (en) 1990-02-09

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 19910531