FR2506772A1 - Glycosides d'anthracycline, procede pour les preparer et leur usage comme medicament - Google Patents

Glycosides d'anthracycline, procede pour les preparer et leur usage comme medicament

Info

Publication number
FR2506772A1
FR2506772A1 FR8209040A FR8209040A FR2506772A1 FR 2506772 A1 FR2506772 A1 FR 2506772A1 FR 8209040 A FR8209040 A FR 8209040A FR 8209040 A FR8209040 A FR 8209040A FR 2506772 A1 FR2506772 A1 FR 2506772A1
Authority
FR
France
Prior art keywords
hydrogen atom
medicament
preparing
anthracycline glycosides
hydroxy group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8209040A
Other languages
English (en)
Other versions
FR2506772B1 (fr
Inventor
Francesco Angelucci
Sergio Penco
Federico Arcamone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of FR2506772A1 publication Critical patent/FR2506772A1/fr
Application granted granted Critical
Publication of FR2506772B1 publication Critical patent/FR2506772B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/38—Quinones containing —CHO or non—quinoid keto groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

GLYCOSIDES D'ANTHRACYCLINE, PROCEDE POUR LES PREPARER ET LEUR USAGE COMME MEDICAMENT. CES COMPOSES REPONDENT A LA FORMULE GENERALE I: (CF DESSIN DANS BOPI) DANS LAQUELLE L'UN DE R ET DE R REPRESENTE UN ATOME D'HYDROGENE ET L'AUTRE REPRESENTE UN GROUPE HYDROXY, CHACUN DE R, R ET R REPRESENTE INDEPENDAMMENT UN ATOME D'HYDROGENE OU UN GROUPE HYDROXY ET X REPRESENTE UN ATOME D'HYDROGENE, AVEC LA CONDITION QUE R ET R NE REPRESENTENT PAS SIMULTANEMENT DES GROUPES HYDROXY, Y COMPRIS LES SELS D'ADDITION ACIDE PHARMACEUTIQUEMENT ACCEPTABLES.
FR8209040A 1981-05-28 1982-05-25 Glycosides d'anthracycline, procede pour les preparer et leur usage comme medicament Expired FR2506772B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8116264 1981-05-28
GB8125949 1981-08-22

Publications (2)

Publication Number Publication Date
FR2506772A1 true FR2506772A1 (fr) 1982-12-03
FR2506772B1 FR2506772B1 (fr) 1985-10-18

Family

ID=26279611

Family Applications (2)

Application Number Title Priority Date Filing Date
FR8209040A Expired FR2506772B1 (fr) 1981-05-28 1982-05-25 Glycosides d'anthracycline, procede pour les preparer et leur usage comme medicament
FR8218988A Expired FR2514754B1 (fr) 1981-05-28 1982-11-12

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR8218988A Expired FR2514754B1 (fr) 1981-05-28 1982-11-12

Country Status (16)

Country Link
US (2) US4465671A (fr)
AU (2) AU564016B2 (fr)
CA (1) CA1210390A (fr)
CH (1) CH652131A5 (fr)
DE (2) DE3219380C2 (fr)
DK (1) DK239382A (fr)
FI (1) FI75833C (fr)
FR (2) FR2506772B1 (fr)
GB (1) GB2100257B (fr)
HU (2) HU190015B (fr)
IE (1) IE53120B1 (fr)
IL (1) IL65858A (fr)
IT (1) IT1210476B (fr)
NL (1) NL8202102A (fr)
SE (2) SE458685B (fr)
YU (2) YU113082A (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549046A1 (fr) * 1983-06-23 1985-01-18 Erba Farmitalia 6-desoxyanthracyclines et procede pour les preparer
EP0135806A2 (fr) * 1983-08-30 1985-04-03 Laboratoires Hoechst S.A. Aglycones utiles pour la préparation des antibiotiques et des antitumoraux de la série des anthracyclines et leurs procédés de préparation
FR2560600A1 (fr) * 1983-06-23 1985-09-06 Erba Farmitalia Glycosides d'anthracyclines, procede pour les preparer, medicament les contenant
FR2569405A1 (fr) * 1984-08-24 1986-02-28 Erba Farmitalia Glycosides d'anthracycline, procede pour les preparer et composition pharmaceutique en contenant
EP0495528A1 (fr) * 1989-03-13 1992-07-22 FARMITALIA CARLO ERBA S.r.l. Dérivés de 3'-(4-morpholinyl)-anthracycline
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
DE3233020A1 (de) * 1981-09-18 1983-04-07 Farmitalia Carlo Erba S.p.A., 20159 Milano Verfahren zur herstellung von 4-demethoxy-7,9-dideoxydaunomycinon
IT1155446B (it) * 1982-12-23 1987-01-28 Erba Farmitalia Procedimento per la purificazione di glucosidi antraciclinonici mediante adsobimento selettivo su resine
DE3422735C2 (de) * 1983-06-23 1996-07-11 Erba Carlo Spa Anthracyclinglykoside, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents
GB2182926B (en) * 1985-11-19 1989-10-04 Erba Farmitalia Nitro anthracyclines, process for their preparation and use thereof
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
US5942605A (en) * 1998-03-03 1999-08-24 Gem Pharmaceuticals, Inc. 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049403A2 (fr) * 1980-09-22 1982-04-14 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Dérivé d'anthracycline, procédé de préparation et composition pharmaceutique contenant ce dérivé

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE44954C (de) * FARBENFABRIKEN VORM. FRIEDR. BAYER & CO. in Elberfeld Verfahren zur Darstellung gelbbis rothbrauner, im alkalischen Bade färbender Azofarbstoffe aus Chrysoidin
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues
NL7900869A (nl) * 1978-02-09 1979-08-13 Erba Farmitalia Anthracyclinenantibiotica.
IT1098212B (it) * 1978-05-09 1985-09-07 Farmaceutici Italia Antracioline antitumorali sostituite
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049403A2 (fr) * 1980-09-22 1982-04-14 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Dérivé d'anthracycline, procédé de préparation et composition pharmaceutique contenant ce dérivé

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF ANTIBIOTICS, vol. 33, no. 12, décembre 1980, TOKYO (JP), *
TETRAHEDRON LETTERS, vol. 22, no. 14, 1981, Pergamon Press Ltd., OXFORD (GB), *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
FR2549046A1 (fr) * 1983-06-23 1985-01-18 Erba Farmitalia 6-desoxyanthracyclines et procede pour les preparer
FR2560600A1 (fr) * 1983-06-23 1985-09-06 Erba Farmitalia Glycosides d'anthracyclines, procede pour les preparer, medicament les contenant
US5037970A (en) * 1983-06-23 1991-08-06 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
EP0135806A2 (fr) * 1983-08-30 1985-04-03 Laboratoires Hoechst S.A. Aglycones utiles pour la préparation des antibiotiques et des antitumoraux de la série des anthracyclines et leurs procédés de préparation
EP0135806A3 (fr) * 1983-08-30 1985-10-09 Laboratoires Hoechst S.A. Aglycones utiles pour la préparation des antibiotiques et des antitumoraux de la série des anthracyclines et leurs procédés de préparation
US4731468A (en) * 1983-08-30 1988-03-15 Laboratoires Hoechst S.A. Aglycons
FR2569405A1 (fr) * 1984-08-24 1986-02-28 Erba Farmitalia Glycosides d'anthracycline, procede pour les preparer et composition pharmaceutique en contenant
EP0495528A1 (fr) * 1989-03-13 1992-07-22 FARMITALIA CARLO ERBA S.r.l. Dérivés de 3'-(4-morpholinyl)-anthracycline

Also Published As

Publication number Publication date
IT1210476B (it) 1989-09-14
HU190015B (en) 1986-08-28
FI75833B (fi) 1988-04-29
SE8704116D0 (sv) 1987-10-22
GB2100257B (en) 1985-09-25
SE8704116L (sv) 1987-10-22
SE8203274L (sv) 1982-11-29
FI75833C (fi) 1988-08-08
US4465671A (en) 1984-08-14
CH652131A5 (de) 1985-10-31
FR2506772B1 (fr) 1985-10-18
HU199767B (en) 1990-03-28
AU6173186A (en) 1987-01-08
YU113082A (en) 1985-04-30
DE3219380A1 (de) 1982-12-16
NL8202102A (nl) 1982-12-16
IE821260L (en) 1982-11-28
US4600537A (en) 1986-07-15
YU191984A (en) 1985-04-30
AU564016B2 (en) 1987-07-30
DE3249834C2 (fr) 1989-08-03
DE3219380C2 (de) 1986-12-04
AU576684B2 (en) 1988-09-01
GB2100257A (en) 1982-12-22
IL65858A0 (en) 1982-08-31
AU8412782A (en) 1982-12-02
IL65858A (en) 1985-07-31
FR2514754B1 (fr) 1985-12-13
CA1210390A (fr) 1986-08-26
IT8220606A0 (it) 1982-04-06
SE458685B (sv) 1989-04-24
FR2514754A1 (fr) 1983-04-22
FI821833A0 (fi) 1982-05-24
DK239382A (da) 1982-11-29
IE53120B1 (en) 1988-07-06

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