BE905751A - Nitro-anthracycline, aglycone correspondante, procedes pour les preparer, composition pharmaceutique correspondante. - Google Patents

Nitro-anthracycline, aglycone correspondante, procedes pour les preparer, composition pharmaceutique correspondante.

Info

Publication number
BE905751A
BE905751A BE0/217405A BE217405A BE905751A BE 905751 A BE905751 A BE 905751A BE 0/217405 A BE0/217405 A BE 0/217405A BE 217405 A BE217405 A BE 217405A BE 905751 A BE905751 A BE 905751A
Authority
BE
Belgium
Prior art keywords
nitro
anthracycline
preparing
processes
pharmaceutical composition
Prior art date
Application number
BE0/217405A
Other languages
English (en)
Inventor
Angelucci Francesco
Gigli Mauro
Penco Sergio
Giuliani Fernando
Francesco Angelucci
Mauro Gigli
Sergio Penco
Fernando Giuliani
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of BE905751A publication Critical patent/BE905751A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Ces glycosides d'anthracycline répondent à la formule générale (A') : dans laquelle R1 représente un atome d'hydrogène, un groupe hydroxy ou un groupe méthoxy, l'un de R2 et R3 représente un groupe hydroxy et l'autre de R2 et R3 représente un groupe nitro, R4 représente un atome d'hydrogène ou un groupe hydroxy; l'invention concerne aussi leurs sels pharmaceutiquement acceptables et leur usage dans les domaines pharmaceutique ou vétérinaire, notamment en raison de leur activité antitumorale.
BE0/217405A 1985-11-19 1986-11-14 Nitro-anthracycline, aglycone correspondante, procedes pour les preparer, composition pharmaceutique correspondante. BE905751A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8528440A GB2182926B (en) 1985-11-19 1985-11-19 Nitro anthracyclines, process for their preparation and use thereof

Publications (1)

Publication Number Publication Date
BE905751A true BE905751A (fr) 1987-03-02

Family

ID=10588420

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/217405A BE905751A (fr) 1985-11-19 1986-11-14 Nitro-anthracycline, aglycone correspondante, procedes pour les preparer, composition pharmaceutique correspondante.

Country Status (22)

Country Link
US (1) US4749693A (fr)
JP (1) JPH0778073B2 (fr)
AT (1) AT390618B (fr)
AU (1) AU590639B2 (fr)
BE (1) BE905751A (fr)
CA (1) CA1296325C (fr)
DE (1) DE3638386C2 (fr)
DK (1) DK548086A (fr)
ES (1) ES2002909A6 (fr)
FI (1) FI864566A (fr)
FR (1) FR2590260B1 (fr)
GB (1) GB2182926B (fr)
GR (1) GR862719B (fr)
HU (1) HU195667B (fr)
IL (1) IL80589A0 (fr)
IT (1) IT1206480B (fr)
NL (1) NL8602914A (fr)
NZ (1) NZ218256A (fr)
PT (1) PT83757B (fr)
SE (1) SE8604870L (fr)
SU (1) SU1553015A3 (fr)
ZA (1) ZA868700B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2591599B1 (fr) * 1985-12-17 1988-08-05 Hoechst Lab Nouvelles anthracyclines et medicaments les contenant
GB8818167D0 (en) * 1988-07-29 1988-09-01 Erba Carlo Spa Novel 4-substituted anthracyclinones & process for their preparation
JP2779652B2 (ja) * 1988-12-27 1998-07-23 武田薬品工業株式会社 生理活性物質ｔａｎ―１１２０，その還元体，それらの製造法および用途ならびに微生物
US5412081A (en) * 1989-02-07 1995-05-02 Farmitalia Carlo Erba S.R.L. New 4'-epi-4'-amino anthracyclines
IT1275953B1 (it) * 1995-03-22 1997-10-24 Sicor Spa Procedimento per la preparazione di antibiotici della classe delle antracicline
US5874412A (en) * 1996-03-22 1999-02-23 Priebe; Waldemar Bis-anthracyclines with high activity against doxorubicin resistant tumors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
US4521592A (en) * 1981-10-23 1985-06-04 Svenska Sockerfabriks Ab Compounds for therapeutic or diagnostic use, a process and intermediates for their preparation
NL8300150A (nl) * 1982-01-26 1983-08-16 Erba Farmitalia Daunorubicine en doxorubicine-analoga, hun bereiding en toepassing.
US4563444A (en) * 1982-05-26 1986-01-07 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides, use and compositions containing same

Also Published As

Publication number Publication date
FI864566A0 (fi) 1986-11-11
DE3638386C2 (de) 1995-09-14
FI864566A (fi) 1987-05-20
HU195667B (en) 1988-06-28
JPS62120395A (ja) 1987-06-01
AU6510086A (en) 1987-05-21
ES2002909A6 (es) 1988-10-01
GB8528440D0 (en) 1985-12-24
NZ218256A (en) 1988-11-29
DK548086A (da) 1987-05-20
GR862719B (en) 1987-03-16
IT1206480B (it) 1989-04-27
FR2590260A1 (fr) 1987-05-22
GB2182926B (en) 1989-10-04
FR2590260B1 (fr) 1988-09-23
SE8604870L (sv) 1987-05-20
IT8622180A0 (it) 1986-10-29
PT83757B (en) 1988-12-07
PT83757A (en) 1986-12-01
NL8602914A (nl) 1987-06-16
ATA298586A (de) 1989-11-15
AT390618B (de) 1990-06-11
CA1296325C (fr) 1992-02-25
JPH0778073B2 (ja) 1995-08-23
HUT42100A (en) 1987-06-29
DK548086D0 (da) 1986-11-17
SU1553015A3 (ru) 1990-03-23
DE3638386A1 (de) 1987-05-21
ZA868700B (en) 1987-07-29
AU590639B2 (en) 1989-11-09
US4749693A (en) 1988-06-07
GB2182926A (en) 1987-05-28
IL80589A0 (en) 1987-02-27
SE8604870D0 (sv) 1986-11-13

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A.

Effective date: 19901130