AR083656A1 - Dispersiones solidas extruidas por fusion que contienen un agente inductor de apoptosis, proceso para preparar, metodo de tratamiento - Google Patents
Dispersiones solidas extruidas por fusion que contienen un agente inductor de apoptosis, proceso para preparar, metodo de tratamientoInfo
- Publication number
- AR083656A1 AR083656A1 ARP110104026A ARP110104026A AR083656A1 AR 083656 A1 AR083656 A1 AR 083656A1 AR P110104026 A ARP110104026 A AR P110104026A AR P110104026 A ARP110104026 A AR P110104026A AR 083656 A1 AR083656 A1 AR 083656A1
- Authority
- AR
- Argentina
- Prior art keywords
- independently
- groups
- halo
- amino
- heterocyclic ring
- Prior art date
Links
- 239000007962 solid dispersion Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 230000006907 apoptotic process Effects 0.000 title 1
- 230000004927 fusion Effects 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 8
- 125000001475 halogen functional group Chemical group 0.000 abstract 8
- 125000000623 heterocyclic group Chemical group 0.000 abstract 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 7
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 7
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 6
- -1 4 - {[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl] methyl} piperazin-1-yl Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 4
- 125000003282 alkyl amino group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 abstract 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 2
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000005157 alkyl carboxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 239000008180 pharmaceutical surfactant Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 239000008247 solid mixture Substances 0.000 abstract 2
- 229920003169 water-soluble polymer Polymers 0.000 abstract 2
- 125000005940 1,4-dioxanyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000004628 isothiazolidinyl group Chemical group S1N(CCC1)* 0.000 abstract 1
- 125000003965 isoxazolidinyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000000160 oxazolidinyl group Chemical group 0.000 abstract 1
- 125000003566 oxetanyl group Chemical group 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 abstract 1
- 125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Reivindicación 1: Una dispersión sólida caracterizada porque comprende, en forma esencialmente no cristalina, un compuesto de fórmula (1) donde: R0 es halo; R1 y R2 son H o son en forma independiente metilo o metoxi; R3 y R4 son en forma independiente metilo o metoxi si R1 y R2 son H, o son H si R1 y R2 son en forma independiente metilo o metoxi; A1 y A2 son en forma independiente entre sí CH o N; R5 es alquilo C1-4 o haloalquilo, alquilsulfonilo C1-4 o haloalquilsulfonilo, halo, nitro o ciano; X es -O- o -NH-; Y es -(CH2)n- donde n es 0, 1, 2 ó 3; y R6 es un anillo carbocíclico o heterocíclico de entre 3 y 7 miembros no sustituido o sustituido como se define en la presente, o es NR7R8 donde, si R6 es NR7R8, R7 y R8 son en forma independiente entre sí H o grupos R9-(CH2)m-, donde no más que uno de R7 y R8 es H, donde cada R9 es en forma independiente un anillo carbocíclico o heterocíclico de entre 3 y 7 miembros, opcionalmente sustituido con no más que dos grupos Z1 como se define más adelante, y cada m es en forma independiente 0 ó 1; y donde, si R6 es un anillo carbocíclico o heterocíclico sustituido, los sustituyentes sobre el mismo son no más que dos grupos Z1 y/o no más que un grupo Z2, donde los grupos Z1 se seleccionan en forma independiente entre (a) alquilo C1-4, alquenilo C2-4, alcoxi C1-4, alquiltio C1-4, alquilamino C1-4, alquilsulfonilo C1-4, alquilsulfonilamino C1-4, alquilcarbonilo C1-4, alquilcarbonilamino C1-4 y alquilcarboxi C1-4, cada uno opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halo, hidroxi, alcoxi C1-4, amino, alquilamino C1-4, di-(alquil C1-4)amino y ciano, grupos (b) halo, (e) hidroxi, (f) amino y (g) oxo, y Z2 es (i) otro anillo carbocíclico o heterocíclico de entre 3 y 6 miembros, opcionalmente sustituido con no más que dos grupos Z1 como se define precedentemente, o (ii) NR7R8 donde R7 y R8 son como se definen precedentemente; o una sal aceptable farmacéuticamente del mismo; dispersado en una matriz sólida que comprende (a) al menos un vehículo polimérico soluble en agua farmacéuticamente aceptable y (b) al menos un surfactante farmacéuticamente aceptable.Reivindicación 10: La dispersión sólida de la reivindicación 9, caracterizada porque el compuesto es 4-(4-{[2-(4-clorofenil)-4,4-dimetilciclohex-1-en-1-il]metil}piperazin-1-il)-N-({3-nitro-4-[(tetrahidro-2H-piran-4-ilmetil)amino]fenil}sulfonil)-2-(1H-pirrolo[2,3-b]piridin-5-iloxi)benzamida. Reivindicación 15: La dispersión sólida de la reivindicación 14, caracterizada porque, en el compuesto de fórmula (1), dicho anillo saturado se selecciona entre el grupo que consiste en los anillos ciclopropilo, ciclobutilo, ciclopentilo, ciclohexilo, azetidinilo, oxetanilo, tietanilo, pirrolidinilo, imazolidinilo, pirazolidinilo, tetrahidrofuranilo, oxazolidinilo, isoxazolidinilo, tiophanilo, tiazolidinilo, isotiazolidinilo, piperidinilo, piperazinilo, tetrahidropiranilo, 1,4-dioxanilo, morfolinilo y tetrahidrotiopiranilo. Reivindicación 32: Un proceso para preparar una dispersión sólida, caracterizado porque comprende: (a) someter a temperatura elevada (i) un ingrediente farmacéuticamente activo (API) que comprende un compuesto de fórmula (1) donde: R0 es halo; R1 y R2 son H o son en forma independiente metilo o metoxi; R3 y R4 son en forma independiente metilo o metoxi si R1 y R2 son H, o son H si R1 y R2 son en forma independiente metilo o metoxi; A1 y A2 son en forma independiente entre sí CH o N; R5 es alquilo C1-4 o haloalquilo, alquilsulfonilo C1-4 o haloalquilsulfonilo, halo, nitro o ciano; X es -O- o -NH-; Y es -(CH2)n- donde n es 0, 1, 2 ó 3; y R6 es un anillo carbocíclico o heterocíclico de entre 3 y 7 miembros no sustituido o sustituido como se define en la presente, o es NR7R8 donde, si R6 es NR7R8, R7 y R8 son en forma independiente entre sí H o grupos R9-(CH2)m-, donde no más que uno de R7 y R8 es H, donde cada R9 es en forma independiente un anillo carbocíclico o heterocíclico de entre 3 y 7 miembros, opcionalmente sustituido con no más que dos grupos Z1 como se define más adelante, y cada m es en forma independiente 0 ó 1; y donde, si R6 es un anillo carbocíclico o heterocíclico sustituido, los sustituyentes sobre el mismo son no más que dos grupos Z1 y/o no más que un grupo Z2, donde los grupos Z1 se seleccionan en forma independiente entre (a) alquilo C1-4, alquenilo C2-4, alcoxi C1-4, alquiltio C1-4, alquilamino C1-4, alquilsulfonilo C1-4, alquilsulfonilamino C1-4, alquilcarbonilo C1-4, alquilcarbonilamino C1-4 y alquilcarboxi C1-4, cada uno opcionalmente sustituido con uno o más sustituyentes seleccionados en forma independiente entre halo, hidroxi, alcoxi C1-4, amino, alquilamino C1-4, di-(alquil C1-4)amino y ciano, grupos (b) halo, (e) hidroxi, (f) amino y (g) oxo, y Z2 es (i) otro anillo carbocíclico o heterocíclico de entre 3 y 6 miembros, opcionalmente sustituido con no más que dos grupos Z1 como se define precedentemente, o (ii) NR7R8 donde R7 y R8 son como se definen precedentemente; o una sal aceptable farmacéuticamente del mismo, (ii) un vehículo polimérico soluble en agua farmacéuticamente aceptable y (iii) un surfactante farmacéuticamente aceptable para dar una mezcla semisólida extruíble; (b) extruir la mezcla semi-sólida; y (c) enfriar el extrudato resultante para dar una matriz sólida que comprende el vehículo polimérico y el surfactante y que tiene el compuesto o sal del mismo dispersado en forma esencialmente no cristalina sobre el mismo. Reivindicación 42: El proceso de la reivindicación 41, caracterizado porque el API es 4-(4-{[2-(4-clorofenil)-4,4-dimetilciclohex-1-en-1-il]metil}piperazin-1-il)-N-({3-nitro-4-[(tetrahidro-2H-piran-4-ilmetil)amino]fenil}sulfonil)-2-(1H-pirrolo[2,3-b]piridin-5-iloxi)benzamida.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40852710P | 2010-10-29 | 2010-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR083656A1 true AR083656A1 (es) | 2013-03-13 |
Family
ID=44903438
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110104026A AR083656A1 (es) | 2010-10-29 | 2011-10-28 | Dispersiones solidas extruidas por fusion que contienen un agente inductor de apoptosis, proceso para preparar, metodo de tratamiento |
ARP210101264A AR122475A2 (es) | 2010-10-29 | 2021-05-10 | Dispersiones sólidas extruidas por fusión que contienen un agente inductor de apoptosis |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP210101264A AR122475A2 (es) | 2010-10-29 | 2021-05-10 | Dispersiones sólidas extruidas por fusión que contienen un agente inductor de apoptosis |
Country Status (40)
Country | Link |
---|---|
US (2) | US20120108590A1 (es) |
EP (3) | EP2613769B1 (es) |
JP (2) | JP5902187B2 (es) |
KR (2) | KR101836820B1 (es) |
CN (2) | CN108175749B (es) |
AR (2) | AR083656A1 (es) |
AU (1) | AU2011361704B2 (es) |
BR (1) | BR112013010524A8 (es) |
CA (1) | CA2813985C (es) |
CL (1) | CL2013001120A1 (es) |
CO (1) | CO6781472A2 (es) |
CR (2) | CR20180289A (es) |
CY (1) | CY1119993T1 (es) |
DK (1) | DK2613769T3 (es) |
DO (2) | DOP2013000092A (es) |
EC (2) | ECSP13012647A (es) |
ES (1) | ES2647583T3 (es) |
GT (1) | GT201300102A (es) |
HK (1) | HK1243761A1 (es) |
HR (1) | HRP20171884T1 (es) |
HU (1) | HUE035169T2 (es) |
IL (2) | IL226215A (es) |
LT (1) | LT2613769T (es) |
ME (1) | ME02942B (es) |
MX (2) | MX362113B (es) |
MY (1) | MY189224A (es) |
NO (1) | NO2613769T3 (es) |
NZ (1) | NZ608907A (es) |
PE (2) | PE20140381A1 (es) |
PL (1) | PL2613769T3 (es) |
PT (1) | PT2613769T (es) |
RS (1) | RS56718B1 (es) |
RU (2) | RU2577859C2 (es) |
SG (2) | SG2014015077A (es) |
SI (1) | SI2613769T1 (es) |
TW (2) | TWI648261B (es) |
UA (1) | UA113500C2 (es) |
UY (3) | UY39192A (es) |
WO (1) | WO2012121758A1 (es) |
ZA (2) | ZA201302669B (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
US20220315555A1 (en) | 2009-05-26 | 2022-10-06 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
KR102095698B1 (ko) | 2010-10-29 | 2020-04-01 | 애브비 인코포레이티드 | 아폽토시스―유도제를 포함하는 고체 분산체 |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
ES2603129T3 (es) | 2010-11-23 | 2017-02-23 | Abbvie Ireland Unlimited Company | Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2 |
DK2643322T3 (en) | 2010-11-23 | 2017-12-11 | Abbvie Inc | SALTS AND CRYSTAL FORMS OF AN APOPTOSIS-INducing Agent |
WO2012177927A1 (en) | 2011-06-21 | 2012-12-27 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
RU2014128010A (ru) | 2011-12-13 | 2016-02-10 | Бак Инститьют Фо Рисерч Он Эйджин | Способы улучшения средств консервативной терапии |
WO2013158664A2 (en) | 2012-04-17 | 2013-10-24 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
US9539251B2 (en) | 2012-09-07 | 2017-01-10 | Genentech, Inc. | Combination therapy of a type II anti-CD20 antibody with a selective Bcl-2 inhibitor |
JP6275726B2 (ja) * | 2012-09-27 | 2018-02-07 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 少なくとも1種の水溶性ビタミンe誘導体および少なくとも1種の親水性ポリマーを含む、保存において安定な無塵の均質な粒子製剤 |
US9006438B2 (en) | 2013-03-13 | 2015-04-14 | Abbvie Inc. | Processes for the preparation of an apoptosis-inducing agent |
EP4019491A1 (en) | 2013-03-13 | 2022-06-29 | AbbVie Ireland Unlimited Company | Process for preparing a synthetic intermediate useful in the preparation of an apoptosis-inducing agent |
US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US9993472B2 (en) | 2014-01-28 | 2018-06-12 | Unity Biotechnology, Inc. | Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2 |
WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
RU2696578C1 (ru) * | 2014-02-05 | 2019-08-05 | Мерк Шарп И Доум Корп. | Технология приготовления таблеток для cgrp-активных соединений |
US9238652B2 (en) | 2014-03-04 | 2016-01-19 | Abbvie Inc. | Processes for the preparation of an apoptosis-inducing agent |
DK3179991T3 (da) | 2014-08-11 | 2021-12-06 | Acerta Pharma Bv | Terapeutiske kombinationer af en btk-inhibitor og en bcl-2-inhibitor |
WO2016031651A1 (ja) | 2014-08-29 | 2016-03-03 | 花王株式会社 | 難溶解性ポリフェノール類を含有する固体分散体の製造方法 |
CN104586770A (zh) * | 2014-12-30 | 2015-05-06 | 山东博迈康药物研究有限公司 | 一种盐酸帕唑帕尼的热熔挤出制剂及其制备方法 |
GB201502073D0 (en) * | 2015-02-09 | 2015-03-25 | Cubic Pharmaceuticals Ltd And Delta Pharmaceuticals Ltd | HDEG technology |
US10195213B2 (en) | 2015-03-13 | 2019-02-05 | Unity Biotechnology, Inc. | Chemical entities that kill senescent cells for use in treating age-related disease |
MX2018005233A (es) | 2015-11-03 | 2019-04-29 | Genentech Inc | Combinacion de inhibidor de bcl-2 e inhibidor de mek para el tratamiento de cancer. |
CN106957315B (zh) * | 2016-01-08 | 2019-08-13 | 中国人民解放军第二军医大学 | N-取代苯磺酰基-氮杂吲哚氧基苯甲酰胺类化合物及其制备药物的用途 |
US11001582B2 (en) | 2016-03-10 | 2021-05-11 | Assia Chemical Industries Ltd. | Solid state forms of Venetoclax and processes for preparation of Venetoclax |
US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
JP2019521110A (ja) * | 2016-06-09 | 2019-07-25 | ドクター レディズ ラボラトリーズ リミテッド | ベネトクラクスの固体形態およびベネトクラクスの調製のためのプロセス |
US20190225607A1 (en) * | 2016-07-06 | 2019-07-25 | Concert Pharmaceuticals, Inc. | Deuterated Venetoclax |
CN107648185A (zh) * | 2016-07-25 | 2018-02-02 | 常州爱诺新睿医药技术有限公司 | 一种无定型Venetoclax与药用辅料的固体分散体及其制备方法 |
US10800777B2 (en) | 2016-10-14 | 2020-10-13 | Mylan Laboratories Limited | Polymorphic forms of VENCLEXTA |
EP3333167A1 (en) * | 2016-12-09 | 2018-06-13 | LEK Pharmaceuticals d.d. | Solid forms of venetoclax |
WO2018127130A1 (en) * | 2017-01-07 | 2018-07-12 | Shanghai Fochon Pharmaceutical Co., Ltd. | Compounds as bcl-2-selective apoptosis-inducing agents |
RS63603B1 (sr) | 2017-04-18 | 2022-10-31 | Shanghai Fochon Pharmaceutical Co Ltd | Sredstva za indukciju apoptoze |
AU2018321496B2 (en) | 2017-08-23 | 2023-11-02 | Guangzhou Lupeng Pharmaceutical Company Ltd. | Condensed heterocyclic derivatives as BCL-2 inhibitors for the treatment of neoplastic diseases |
WO2019135253A1 (en) | 2018-01-02 | 2019-07-11 | Mylan Laboratories Limited | Polymorphic forms of venetoclax |
JP7355741B2 (ja) | 2018-01-10 | 2023-10-03 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | ベンズアミド化合物 |
WO2020023435A1 (en) | 2018-07-24 | 2020-01-30 | Albany Molecular Research, Inc. | Venetoclax basic salts and processes for the purification of venetoclax |
WO2020041405A1 (en) | 2018-08-22 | 2020-02-27 | Newave Pharmaceutical Inc. | Bcl-2 inhibitors |
EP4031136A1 (en) | 2019-09-18 | 2022-07-27 | Aprea Therapeutics AB | Combination treatment with a p53 reactivator and an inhibitor of an antiapoptotic bcl-2 family protein |
IL295803A (en) * | 2020-02-24 | 2022-10-01 | Newave Pharmaceutical Inc | Hot melt solid dispersions containing a bcl2 inhibitor |
CA3190176A1 (en) | 2020-07-29 | 2022-02-03 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
US20240016747A1 (en) * | 2020-11-25 | 2024-01-18 | Ascentage Pharma (Suzhou) Co., Ltd. | Solid dispersion, pharmaceutical preparations, preparation method, and application thereof |
MX2023007575A (es) | 2020-12-22 | 2023-09-21 | Allergan Pharmaceuticals Int Ltd | Tratamiento de la migraña. |
Family Cites Families (131)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5665379A (en) | 1990-09-28 | 1997-09-09 | Pharmacia & Upjohn Aktiebolag | Lipid particle forming matrix, preparation and use thereof |
MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
US5536729A (en) | 1993-09-30 | 1996-07-16 | American Home Products Corporation | Rapamycin formulations for oral administration |
IL111004A (en) | 1993-09-30 | 1998-06-15 | American Home Prod | Oral formulations of rapamycin |
WO1995014037A1 (en) | 1993-11-17 | 1995-05-26 | Ibah, Inc. | Transparent liquid for encapsulated drug delivery |
US5759548A (en) | 1993-11-30 | 1998-06-02 | Lxr Biotechnology Inc. | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof |
GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US5538737A (en) | 1994-11-30 | 1996-07-23 | Applied Analytical Industries, Inc. | Oral compositions of H2 -antagonists |
FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
PT1019385E (pt) | 1995-09-15 | 2004-06-30 | Upjohn Co | N-oxidos de aminoaril-oxazolidinona |
US6964946B1 (en) | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
BRPI9715219B8 (pt) | 1996-02-09 | 2015-07-07 | Abbvie Biotechnology Ltd | Vetor recombinante de expressão, e célula hospedeira procariótica. |
US5891469A (en) | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
BE1011899A6 (fr) | 1998-04-30 | 2000-02-01 | Ucb Sa | Compositions pharmaceutiques gelifiables utilisables. |
AU767456B2 (en) | 1998-07-06 | 2003-11-13 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
DE19913692A1 (de) | 1999-03-25 | 2000-09-28 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
DE19929361A1 (de) | 1999-06-25 | 2001-01-04 | Basf Ag | Mechanisch stabile pharmazeutische Darreichungsformen, enthaltend flüssige oder halbfeste oberflächenaktive Substanzen |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
US20030236236A1 (en) | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
GB9918037D0 (en) | 1999-07-30 | 1999-09-29 | Biochemie Gmbh | Organic compounds |
ATE305302T1 (de) | 1999-12-28 | 2005-10-15 | Eisai Co Ltd | Heterozyklische verbindungen mit sulfonamid- gruppen |
US20060183776A9 (en) | 2000-03-03 | 2006-08-17 | Eisai Co., Ltd. | Liquid dosage formulations of donepezil |
UY26942A1 (es) | 2000-09-20 | 2002-04-26 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
US6720338B2 (en) | 2000-09-20 | 2004-04-13 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
US20020055631A1 (en) | 2000-09-20 | 2002-05-09 | Augeri David J. | N-acylsulfonamide apoptosis promoters |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
OA12541A (en) | 2001-01-31 | 2006-06-05 | Pfizer Prod Inc | Ether derivatives useful as inhibitors of PDE4 isozymes. |
US6927009B2 (en) | 2001-05-22 | 2005-08-09 | Fuji Photo Film Co., Ltd. | Positive photosensitive composition |
MXPA03011197A (es) | 2001-06-06 | 2004-02-26 | Lilly Co Eli | Benzoilsufonamidas y sulfonilbenzamidinas que se usan como agentes antitumorales. |
GB0123400D0 (en) | 2001-09-28 | 2001-11-21 | Novartis Ag | Organic compounds |
DK1471887T3 (da) | 2002-02-04 | 2010-06-07 | Elan Pharma Int Ltd | Nanopartikelkompositioner der har lysozym som overfladestabiliseringsmiddel |
EP1480679B1 (en) | 2002-02-26 | 2007-05-23 | Astrazeneca AB | Pharmaceutical formulation of iressa comprising a water-soluble cellulose derivative |
ES2342660T3 (es) | 2002-02-26 | 2010-07-12 | Astrazeneca Ab | Nuevas formas cristalinas del compuesto anticancerigeno zd1839. |
FR2836914B1 (fr) | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | Indazoles substitues, compositions les contenant, procede de fabrication et utilisation |
TWI262077B (en) | 2002-04-29 | 2006-09-21 | Merck & Co Inc | Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity |
US20060177430A1 (en) | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US20050048112A1 (en) | 2003-08-28 | 2005-03-03 | Jorg Breitenbach | Solid pharmaceutical dosage form |
WO2005024636A1 (ja) | 2003-09-04 | 2005-03-17 | Hitachi Ulsi Systems Co., Ltd. | 半導体装置 |
US7767684B2 (en) | 2003-11-13 | 2010-08-03 | Abbott Laboratories | Apoptosis promoters |
US8614318B2 (en) | 2003-11-13 | 2013-12-24 | Abbvie Inc. | Apoptosis promoters |
US7642260B2 (en) | 2003-11-13 | 2010-01-05 | Abbott Laboratories, Inc. | Apoptosis promoters |
US7973161B2 (en) | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
WO2005049593A2 (en) | 2003-11-13 | 2005-06-02 | Abbott Laboratories | N-acylsulfonamide apoptosis promoters |
US7790190B2 (en) | 2004-03-20 | 2010-09-07 | Yasoo Health, Inc. | Aqueous emulsions of lipophile solubilized with vitamin E TPGS and linoleic acid |
EP1737850B1 (en) | 2004-04-19 | 2007-10-03 | Symed Labs Limited | A novel process for the preparation of linezolid and related compounds |
US7318503B2 (en) | 2004-04-26 | 2008-01-15 | Akebono Corporation (North America) | Pad retaining clips |
JP2007536299A (ja) | 2004-05-04 | 2007-12-13 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ltb4アンタゴニトを含有する固形医薬形態 |
DE602004020812D1 (de) | 2004-07-20 | 2009-06-04 | Symed Labs Ltd | Neue zwischenprodukte für linezolid und verwandte verbindungen |
MY191349A (en) | 2004-08-27 | 2022-06-17 | Bayer Pharmaceuticals Corp | New pharmaceutical compositions for the treatment of hyper-proliferative disorders |
US20060078617A1 (en) | 2004-08-27 | 2006-04-13 | Fritz Schueckler | Pharmaceutical compositions for the treatment of cancer |
FR2875409B1 (fr) | 2004-09-17 | 2010-05-07 | Sanofi Aventis | Composition pharmaceutique comprenant une dispersion solide a matrice polymere comprenant une phase continue de polydextrose et une phase continue d'un polymere autre que du polydextrose |
US7511013B2 (en) | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
WO2007040650A2 (en) | 2005-05-12 | 2007-04-12 | Abbott Laboratories | Apoptosis promoters |
US8624027B2 (en) | 2005-05-12 | 2014-01-07 | Abbvie Inc. | Combination therapy for treating cancer and diagnostic assays for use therein |
MX2007014327A (es) | 2005-05-16 | 2008-02-11 | Irm Llc | Derivados de pirrolopiridina como inhibidores de cinasa de proteina. |
CN1706371B (zh) | 2005-05-27 | 2010-11-10 | 沈阳药科大学 | 一种高效的马蔺子素制剂及其制备方法 |
TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
WO2007002433A1 (en) | 2005-06-22 | 2007-01-04 | Plexxikon, Inc. | Pyrrolo [2, 3-b] pyridine derivatives as protein kinase inhibitors |
US7514068B2 (en) | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
EP1933809B1 (en) | 2005-10-11 | 2012-02-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions for nasal delivery |
US20070104780A1 (en) | 2005-10-25 | 2007-05-10 | Lipari John M | Formulation comprising a drug of low water solubility and method of use thereof |
US7151188B1 (en) | 2005-11-16 | 2006-12-19 | General Electric Company | Process for the production of mercaptoalkylalkoxysilanes |
JP2009537535A (ja) | 2006-05-15 | 2009-10-29 | エンサイシブ・ファーマシューティカルズ・インコーポレイテッド | エンドセリンアンタゴニストの投与を含む睡眠時無呼吸を治療するための方法および組成物 |
EP2037919A2 (en) | 2006-06-30 | 2009-03-25 | Schering Corporation | Method of using substituted piperidines that increase p53 activity |
DE602007012261D1 (de) | 2006-07-14 | 2011-03-10 | Chemocentryx Inc | Triazolyl-pyridyl-benzolsulfonamide als ccr2- oder ccr9-modulatoren zur behandlung von atherosklerose |
EP1880715A1 (en) | 2006-07-19 | 2008-01-23 | Abbott GmbH & Co. KG | Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same |
US7799790B2 (en) | 2006-07-20 | 2010-09-21 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
AU2007284615B2 (en) | 2006-08-16 | 2011-10-27 | Novartis Ag | Method for making solid dispersions of highly crystalline therapeutic compounds |
CN101534904B (zh) | 2006-09-05 | 2013-11-06 | Abbvie公司 | 治疗血小板过量的bcl抑制剂 |
US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
EP2089003A1 (en) | 2006-11-09 | 2009-08-19 | Abbott GmbH & Co. KG | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor |
EP2112925A4 (en) * | 2006-11-15 | 2013-01-09 | Abbott Lab | SOLID PHARMACEUTICAL DOSAGE FORMULATIONS |
WO2008064116A2 (en) | 2006-11-16 | 2008-05-29 | Abbott Laboratories | Method of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection |
MX2009008465A (es) | 2007-02-15 | 2009-08-20 | Hoffmann La Roche | Nuevas 2-aminooxazolinas como ligandos de taar1. |
RU2351352C2 (ru) | 2007-04-09 | 2009-04-10 | Закрытое акционерное общество "Санкт-Петербургский институт фармации" | Твердая нанокомпозиция для доставки биологически активных веществ |
WO2008124878A1 (en) | 2007-04-13 | 2008-10-23 | Cryptopharma Pty Ltd | Non-steroidal compounds |
JP2010524972A (ja) | 2007-04-19 | 2010-07-22 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化したモルホリニル化合物 |
US7531685B2 (en) | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
WO2009035598A1 (en) | 2007-09-10 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
US20090118238A1 (en) | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
US20090082471A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
US20090088416A1 (en) | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
MX2010003548A (es) | 2007-10-01 | 2010-06-02 | Univ Johns Hopkins | Metodos para el tratamiento de padecimientos neurologicos autoinmunes con ciclofosfamida. |
EP2209774A1 (en) | 2007-10-02 | 2010-07-28 | Concert Pharmaceuticals Inc. | Pyrimidinedione derivatives |
BRPI0817664A2 (pt) | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
US8410124B2 (en) | 2007-10-18 | 2013-04-02 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
US20090105338A1 (en) | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
CA2703591C (en) | 2007-10-26 | 2013-05-07 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
CN101969951B (zh) | 2007-11-16 | 2012-10-31 | 雅培制药有限公司 | 化合物在制备治疗关节炎的药物中的方法 |
WO2009073835A1 (en) | 2007-12-06 | 2009-06-11 | Abbott Laboratories | Oral compositions of abt-263 for treating cancer |
WO2009091912A2 (en) | 2008-01-15 | 2009-07-23 | Abbott Laboratories | Improved mammalian expression vectors and uses thereof |
CN101220008B (zh) | 2008-01-21 | 2011-04-27 | 中国科学院广州生物医药与健康研究院 | 化合物abt-263的合成方法 |
WO2009100176A2 (en) | 2008-02-07 | 2009-08-13 | Abbott Laboratories | Pharmaceutical dosage form for oral administration of tyrosine kinase inhibitor |
CN101548960B (zh) | 2008-04-01 | 2012-11-07 | 沈阳药科大学 | 高溶出度口服联苯双酯胶囊及其制备方法 |
US8168784B2 (en) | 2008-06-20 | 2012-05-01 | Abbott Laboratories | Processes to make apoptosis promoters |
LT2346495T (lt) | 2008-10-07 | 2016-10-10 | Astrazeneca Uk Limited | Farmacinė kompozicija 514 |
US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
UA108193C2 (uk) * | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
US8563735B2 (en) * | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
CN106008322B (zh) * | 2008-12-05 | 2018-09-04 | Abbvie 公司 | 作为用于治疗癌症和免疫疾病的bcl-2-选择性诱发细胞凋亡药剂的磺酰胺衍生物 |
US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US20110245156A1 (en) | 2008-12-09 | 2011-10-06 | Cytokine Pharmasciences, Inc. | Novel antiviral compounds, compositions, and methods of use |
US8959548B2 (en) * | 2008-12-22 | 2015-02-17 | Verizon Patent And Licensing Inc. | Presenting advertisements with video program descriptions |
US20120094963A1 (en) | 2008-12-23 | 2012-04-19 | of Queen Elizabeth near Dublin | Targeting prodrugs and compositions for the treatment of gastrointestinal diseases |
NZ703941A (en) * | 2009-01-19 | 2016-04-29 | Abbvie Inc | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
CN104945311A (zh) | 2009-01-19 | 2015-09-30 | Abbvie公司 | 用于治疗癌症和免疫和自身免疫疾病的细胞程序死亡诱导药剂 |
US8728516B2 (en) | 2009-04-30 | 2014-05-20 | Abbvie Inc. | Stabilized lipid formulation of apoptosis promoter |
US20100297194A1 (en) * | 2009-04-30 | 2010-11-25 | Nathaniel Catron | Formulation for oral administration of apoptosis promoter |
US8362013B2 (en) | 2009-04-30 | 2013-01-29 | Abbvie Inc. | Salt of ABT-263 and solid-state forms thereof |
US20100280031A1 (en) | 2009-04-30 | 2010-11-04 | Paul David | Lipid formulation of apoptosis promoter |
US20100278921A1 (en) | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
SG175253A1 (en) * | 2009-05-26 | 2011-11-28 | Abbott Lab | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
TWI532484B (zh) | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
TWI471321B (zh) | 2009-06-08 | 2015-02-01 | Abbott Gmbh & Co Kg | Bcl-2族群抑制劑之口服醫藥劑型 |
CN102333772B (zh) | 2009-06-11 | 2013-12-11 | 雅培制药有限公司 | 抗病毒化合物 |
RU2012101627A (ru) | 2009-06-18 | 2013-07-27 | Эбботт Лэборетриз | Стабильная суспензия лекарственного средства в виде наночастиц |
NZ598461A (en) | 2009-09-20 | 2013-12-20 | Abbvie Inc | Abt-263 crystalline forms and solvates for use in treating bcl-2 protein related diseases |
CN101798292A (zh) | 2010-03-29 | 2010-08-11 | 无锡好芳德药业有限公司 | ABT-263衍生的新型Bcl-2蛋白抑制剂的制备 |
TWI520960B (zh) | 2010-05-26 | 2016-02-11 | 艾伯維有限公司 | 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑 |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
KR102095698B1 (ko) | 2010-10-29 | 2020-04-01 | 애브비 인코포레이티드 | 아폽토시스―유도제를 포함하는 고체 분산체 |
DK2643322T3 (en) | 2010-11-23 | 2017-12-11 | Abbvie Inc | SALTS AND CRYSTAL FORMS OF AN APOPTOSIS-INducing Agent |
ES2603129T3 (es) | 2010-11-23 | 2017-02-23 | Abbvie Ireland Unlimited Company | Métodos de tratamiento utilizando inhibidores selectivos de Bcl-2 |
EP2776603B1 (en) | 2011-11-11 | 2019-03-06 | SiO2 Medical Products, Inc. | PASSIVATION, pH PROTECTIVE OR LUBRICITY COATING FOR PHARMACEUTICAL PACKAGE, COATING PROCESS AND APPARATUS |
-
2011
- 2011-05-10 UA UAA201306667A patent/UA113500C2/uk unknown
- 2011-10-05 PE PE2013000918A patent/PE20140381A1/es active IP Right Grant
- 2011-10-05 ES ES11770975.8T patent/ES2647583T3/es active Active
- 2011-10-05 KR KR1020137013700A patent/KR101836820B1/ko active Protection Beyond IP Right Term
- 2011-10-05 PE PE2017001230A patent/PE20171242A1/es unknown
- 2011-10-05 WO PCT/US2011/054959 patent/WO2012121758A1/en active Application Filing
- 2011-10-05 EP EP11770975.8A patent/EP2613769B1/en active Active
- 2011-10-05 KR KR1020187005383A patent/KR101957137B1/ko active IP Right Grant
- 2011-10-05 SG SG2014015077A patent/SG2014015077A/en unknown
- 2011-10-05 NZ NZ608907A patent/NZ608907A/en unknown
- 2011-10-05 RS RS20171320A patent/RS56718B1/sr unknown
- 2011-10-05 EP EP17169667.7A patent/EP3219308A1/en not_active Withdrawn
- 2011-10-05 PL PL11770975T patent/PL2613769T3/pl unknown
- 2011-10-05 CA CA2813985A patent/CA2813985C/en active Active
- 2011-10-05 NO NO11770975A patent/NO2613769T3/no unknown
- 2011-10-05 MY MYPI2018001778A patent/MY189224A/en unknown
- 2011-10-05 US US13/253,727 patent/US20120108590A1/en not_active Abandoned
- 2011-10-05 HU HUE11770975A patent/HUE035169T2/en unknown
- 2011-10-05 BR BR112013010524A patent/BR112013010524A8/pt not_active Application Discontinuation
- 2011-10-05 DK DK11770975.8T patent/DK2613769T3/en active
- 2011-10-05 SG SG2013029913A patent/SG189477A1/en unknown
- 2011-10-05 MX MX2017001658A patent/MX362113B/es unknown
- 2011-10-05 SI SI201131373T patent/SI2613769T1/en unknown
- 2011-10-05 MX MX2013004843A patent/MX345603B/es active IP Right Grant
- 2011-10-05 RU RU2013124823/04A patent/RU2577859C2/ru active
- 2011-10-05 LT LTEP11770975.8T patent/LT2613769T/lt unknown
- 2011-10-05 CR CR20180289A patent/CR20180289A/es unknown
- 2011-10-05 ME MEP-2017-299A patent/ME02942B/me unknown
- 2011-10-05 EP EP23152636.9A patent/EP4218731A3/en active Pending
- 2011-10-05 CN CN201711309600.6A patent/CN108175749B/zh active Active
- 2011-10-05 RU RU2016104763A patent/RU2633353C1/ru active
- 2011-10-05 PT PT117709758T patent/PT2613769T/pt unknown
- 2011-10-05 JP JP2013536646A patent/JP5902187B2/ja active Active
- 2011-10-05 CN CN201180063724.5A patent/CN103282025B/zh active Active
- 2011-10-05 AU AU2011361704A patent/AU2011361704B2/en active Active
- 2011-10-21 TW TW105108567A patent/TWI648261B/zh active
- 2011-10-21 TW TW100138348A patent/TWI535699B/zh active
- 2011-10-27 UY UY0001039192A patent/UY39192A/es not_active Application Discontinuation
- 2011-10-27 UY UY0001033692A patent/UY33692A/es active IP Right Grant
- 2011-10-28 AR ARP110104026A patent/AR083656A1/es not_active Application Discontinuation
-
2013
- 2013-04-12 ZA ZA2013/02669A patent/ZA201302669B/en unknown
- 2013-04-22 GT GT201300102A patent/GT201300102A/es unknown
- 2013-04-24 CL CL2013001120A patent/CL2013001120A1/es unknown
- 2013-04-26 DO DO2013000092A patent/DOP2013000092A/es unknown
- 2013-05-07 IL IL226215A patent/IL226215A/en active IP Right Grant
- 2013-05-15 CR CR20130224A patent/CR20130224A/es unknown
- 2013-05-17 CO CO13122333A patent/CO6781472A2/es not_active Application Discontinuation
- 2013-05-29 EC ECSP13012647 patent/ECSP13012647A/es unknown
- 2013-12-20 HK HK18103255.4A patent/HK1243761A1/zh unknown
-
2014
- 2014-02-25 ZA ZA2014/01440A patent/ZA201401440B/en unknown
- 2014-07-24 US US14/340,435 patent/US11369599B2/en active Active
-
2016
- 2016-03-08 JP JP2016044090A patent/JP6153638B2/ja active Active
-
2017
- 2017-01-05 DO DO2017000003A patent/DOP2017000003A/es unknown
- 2017-04-24 IL IL251877A patent/IL251877B/en active IP Right Grant
- 2017-07-13 UY UY0001037326A patent/UY37326A/es active IP Right Grant
- 2017-12-05 HR HRP20171884TT patent/HRP20171884T1/hr unknown
- 2017-12-20 CY CY20171101338T patent/CY1119993T1/el unknown
-
2021
- 2021-05-10 AR ARP210101264A patent/AR122475A2/es unknown
-
2022
- 2022-11-10 EC ECSENADI202286925A patent/ECSP22086925A/es unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR083656A1 (es) | Dispersiones solidas extruidas por fusion que contienen un agente inductor de apoptosis, proceso para preparar, metodo de tratamiento | |
CL2017002610A1 (es) | Compuestos derivados de triazolopiridina hidrogenadas, inhibidores p2x7, composición farmacéutica que los comprende; proceso de preparación de estos; y su uso en el tratamiento de enfermedades oseas, sns, cardiovasculares, entre otras (divisional de cl 2655-2015) | |
AR087591A1 (es) | Derivados de ciclohexil azetidina como inhibidores de jak | |
PE20191496A1 (es) | 2-heteroaril-3-oxo-2,3-dihidropiridazin-4-carboxamidas | |
PE20060648A1 (es) | Procesos para la preparacion de 2-(2,6-dioxopiperidin-3-il)-1-oxoisoindolinas sustituidas | |
PE20191613A1 (es) | Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret | |
AR113909A1 (es) | Compuestos y sus composiciones farmacéuticas para el tratamiento de hepatitis b | |
ECSP099461A (es) | Compuesto heteromonocíclico y uso del mismo | |
NI201600166A (es) | Compuestos de imidazo[4, 5-c]quinolin-2-ona y su uso para tratar cáncer | |
ECSP088830A (es) | Compuestos de benzoxazole y benzotiazole sustituidos-6-o y métodos para inhibir la señalización csf-1r | |
PE20181345A1 (es) | Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cancer | |
AR085489A1 (es) | Derivados de triazolopiridinas, composiciones farmaceuticas que los contienen, proceso para prepararlos, intermediarios de dicho proceso y uso de los mismos para el tratamiento de enfermedades autoinmunes e inflamatorias | |
AR077130A1 (es) | Inhibidores de la replicacion de los virus de influenza | |
CO2018002829A2 (es) | Derivados de 8-[6-[3-(amino)propoxi]-3-piridil]1-isopropilimidazo[4,5-c]quinolin-2-ona como moduladores selectivos de la cinasa de la ataxia telangiectasia mutada (atm) | |
RU2015108898A (ru) | 3-ЦИКЛОГЕКСЕНИЛ И ЦИКЛОГЕКСИЛ ЗАМЕЩЕННЫЕ ИНДОЛЬНЫЕ И ИНДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RORгаммаТ И ИХ ПРИМЕНЕНИЯ | |
PE20190336A1 (es) | Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen | |
CL2012000001A1 (es) | Compuestos derivados de heteroarilo-pirazolopirimidina-carboxamida, inhibidores de jak; composicion farmaceutica que los comprende; utiles para el tratamiento de la artritis reumatoide, enfermedad de chron, dermatitis, psoriasis, entre otros. | |
AR060489A1 (es) | Derivados del acido benzoazepin - oxi- acetico como agonistas de ppar - delta usados para aumentar hdl- c, reducir ldl-c y reducir colesterol | |
SV2005001918A (es) | Metodos para preparar derivados 7-(b-d-ribofuranosilo sustituido en 2')-4 (nr2r3)-5(etin-1-ilo sustituido)-pirrol[2,3-d]pirimidina | |
AR056979A1 (es) | Derivados de dihidrobenzofuranos y usos de los mismos | |
AR082826A2 (es) | Inhibidores heterociclicos de mek, composiciones farmaceuticas que los contienen, usos, y metodos de preparacion de los mismos | |
ECSP12012104A (es) | Inhibidores de virus flaviviridae | |
DOP2018000115A (es) | Compuestos de imidazo[4,5-c]quinolin-2-ona y su uso en el tratamiento del cáncer | |
PE20091099A1 (es) | Derivados de aminobenzamida como agentes utiles para controlar parasitos animales | |
PE20220806A1 (es) | Pirazolo piridinas heteroaromaticas sustituidas y su uso como moduladores del receptor glun2b |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |