ECSP088830A - Compuestos de benzoxazole y benzotiazole sustituidos-6-o y métodos para inhibir la señalización csf-1r - Google Patents

Compuestos de benzoxazole y benzotiazole sustituidos-6-o y métodos para inhibir la señalización csf-1r

Info

Publication number
ECSP088830A
ECSP088830A EC2008008830A ECSP088830A ECSP088830A EC SP088830 A ECSP088830 A EC SP088830A EC 2008008830 A EC2008008830 A EC 2008008830A EC SP088830 A ECSP088830 A EC SP088830A EC SP088830 A ECSP088830 A EC SP088830A
Authority
EC
Ecuador
Prior art keywords
benzoxazole
csf
compounds
benzotiazole
signaling
Prior art date
Application number
EC2008008830A
Other languages
English (en)
Inventor
Jiong Lan
Hong Yang
Elizabeth Mieuli
Savithri Ramurthy
Anu Sharma
James C Sutton
Weibo Wang
Allan Wagman
Simon Ng
Keith Pfister
Marion Wiesmann
Mika K Lindvall
Liana M Klivansky
William P Lenahan
Susan Kaufman
Victoria Sung
Martin Sendzik
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP088830A publication Critical patent/ECSP088830A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se describen compuestos de benzoxazole y benzotiazole y los estereoisómeros, tautómeros, solvatos, óxidos, ésteres y profármacos de los mismos y sales farmacéuticamente aceptables de los mismos. También se describen composiciones de los compuestos, ya sea solos o en combinación con al menos un agente terapéutico adicional, con un transportador farmacéuticamente aceptable, y los usos de los compuestos, ya sea solos o en combinación con al menos un agente terapéutico adicional. Las modalidades son útiles para inhibir proliferación celular, inhibir el crecimiento y/o metástasis de tumores, tratar o prevenir cáncer, tratar o prevenir degeneración de enfermedades de los huesos tales como artritis reumatoide y/o inhibir moléculas tales como CSF-1R.
EC2008008830A 2006-04-19 2008-10-17 Compuestos de benzoxazole y benzotiazole sustituidos-6-o y métodos para inhibir la señalización csf-1r ECSP088830A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79351706P 2006-04-19 2006-04-19
US89385707P 2007-03-08 2007-03-08

Publications (1)

Publication Number Publication Date
ECSP088830A true ECSP088830A (es) 2008-11-27

Family

ID=38610468

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008830A ECSP088830A (es) 2006-04-19 2008-10-17 Compuestos de benzoxazole y benzotiazole sustituidos-6-o y métodos para inhibir la señalización csf-1r

Country Status (30)

Country Link
US (3) US7553854B2 (es)
EP (1) EP2010528B1 (es)
JP (1) JP5328640B2 (es)
KR (1) KR101464385B1 (es)
AR (1) AR060545A1 (es)
AU (1) AU2007237904B2 (es)
BR (1) BRPI0710540B1 (es)
CA (1) CA2649288C (es)
CR (1) CR10365A (es)
CY (1) CY1119679T1 (es)
DK (1) DK2010528T3 (es)
EA (1) EA018917B1 (es)
EC (1) ECSP088830A (es)
ES (1) ES2654847T3 (es)
HR (1) HRP20171924T1 (es)
HU (1) HUE035654T2 (es)
IL (1) IL194662A0 (es)
LT (1) LT2010528T (es)
MA (1) MA30407B1 (es)
MX (1) MX2008013427A (es)
NO (1) NO20084800L (es)
PE (1) PE20080359A1 (es)
PL (1) PL2010528T3 (es)
PT (1) PT2010528T (es)
RS (1) RS56600B1 (es)
SI (1) SI2010528T1 (es)
SM (1) SMP200800063B (es)
TN (1) TNSN08406A1 (es)
TW (1) TW200813039A (es)
WO (1) WO2007121484A2 (es)

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