EA201791421A1 - Антитела против csf1r для лечения pvns - Google Patents

Антитела против csf1r для лечения pvns

Info

Publication number
EA201791421A1
EA201791421A1 EA201791421A EA201791421A EA201791421A1 EA 201791421 A1 EA201791421 A1 EA 201791421A1 EA 201791421 A EA201791421 A EA 201791421A EA 201791421 A EA201791421 A EA 201791421A EA 201791421 A1 EA201791421 A1 EA 201791421A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pvns
treatment
antibodies against
csf1r
against csf1r
Prior art date
Application number
EA201791421A
Other languages
English (en)
Inventor
Роберт Сикорски
Джули ХАМБЛТОН
Нилакантан Санкар
Original Assignee
Файв Прайм Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Файв Прайм Терапьютикс, Инк. filed Critical Файв Прайм Терапьютикс, Инк.
Publication of EA201791421A1 publication Critical patent/EA201791421A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Раскрыты способы лечения пигментного виллезонодулярного синовита (PVNS) антителами, которые связывают рецептор колониестимулирующего фактора 1 (CSF1R).
EA201791421A 2014-12-22 2015-12-21 Антитела против csf1r для лечения pvns EA201791421A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462095297P 2014-12-22 2014-12-22
US201562163251P 2015-05-18 2015-05-18
PCT/US2015/067012 WO2016106180A1 (en) 2014-12-22 2015-12-21 Anti-csf1r antibodies for treating pvns

Publications (1)

Publication Number Publication Date
EA201791421A1 true EA201791421A1 (ru) 2017-10-31

Family

ID=55135539

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791421A EA201791421A1 (ru) 2014-12-22 2015-12-21 Антитела против csf1r для лечения pvns

Country Status (16)

Country Link
US (3) US10040858B2 (ru)
EP (1) EP3237447B1 (ru)
JP (1) JP6797801B2 (ru)
KR (1) KR20170096187A (ru)
CN (1) CN107257806B (ru)
AU (1) AU2015369854B2 (ru)
BR (1) BR112017013111A2 (ru)
CA (1) CA2969341C (ru)
EA (1) EA201791421A1 (ru)
ES (1) ES2843586T3 (ru)
HK (1) HK1245804A1 (ru)
IL (1) IL252716A0 (ru)
MX (1) MX2017008218A (ru)
SG (1) SG11201704792UA (ru)
TW (1) TW201630937A (ru)
WO (1) WO2016106180A1 (ru)

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CN109053887B (zh) * 2018-07-18 2019-07-23 博奥信生物技术（南京）有限公司 一种抗人csf-1r单克隆抗体及用途
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WO2024059508A2 (en) * 2022-09-12 2024-03-21 AmMax Bio, Inc. Treatment of tenosynovial giant cell tumor

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Also Published As

Publication number Publication date
WO2016106180A1 (en) 2016-06-30
EP3237447B1 (en) 2020-12-02
IL252716A0 (en) 2017-08-31
AU2015369854B2 (en) 2021-07-01
US10730949B2 (en) 2020-08-04
EP3237447A1 (en) 2017-11-01
HK1245804A1 (zh) 2018-08-31
JP6797801B2 (ja) 2020-12-09
TW201630937A (zh) 2016-09-01
US20190119390A1 (en) 2019-04-25
CN107257806A (zh) 2017-10-17
KR20170096187A (ko) 2017-08-23
CA2969341C (en) 2023-07-04
BR112017013111A2 (pt) 2018-05-15
ES2843586T3 (es) 2021-07-19
MX2017008218A (es) 2017-10-18
US10040858B2 (en) 2018-08-07
CA2969341A1 (en) 2016-06-30
CN107257806B (zh) 2021-08-10
JP2018501254A (ja) 2018-01-18
AU2015369854A1 (en) 2017-06-15
US20210009700A1 (en) 2021-01-14
US20160185869A1 (en) 2016-06-30
SG11201704792UA (en) 2017-07-28

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