GT201300102A - Dispersiones solidas extruidas por fusion que contienen un agente inductor de apoptosis - Google Patents
Dispersiones solidas extruidas por fusion que contienen un agente inductor de apoptosisInfo
- Publication number
- GT201300102A GT201300102A GT201300102A GT201300102A GT201300102A GT 201300102 A GT201300102 A GT 201300102A GT 201300102 A GT201300102 A GT 201300102A GT 201300102 A GT201300102 A GT 201300102A GT 201300102 A GT201300102 A GT 201300102A
- Authority
- GT
- Guatemala
- Prior art keywords
- extruded
- solid dispersions
- inductive agent
- fusion containing
- apoptosis
- Prior art date
Links
- 230000006907 apoptotic process Effects 0.000 title abstract 2
- 230000001939 inductive effect Effects 0.000 title abstract 2
- 239000007962 solid dispersion Substances 0.000 title abstract 2
- 230000004927 fusion Effects 0.000 title 1
- 239000006185 dispersion Substances 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 108010063104 Apoptosis Regulatory Proteins Proteins 0.000 abstract 1
- 102000010565 Apoptosis Regulatory Proteins Human genes 0.000 abstract 1
- 102000051485 Bcl-2 family Human genes 0.000 abstract 1
- 108700038897 Bcl-2 family Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
Classifications
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- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCIÓN SE RELACIONA CON DISPERSIONES SÓLIDAS QUE COMPRENDEN UN AGENTE INDUCTOR DE APOPTOSIS, CON FORMAS DE DOSIFICACIÓN FARMACÉUTICAS QUE COMPRENDEN DICHAS DISPERSIONES, CON PROCESOS PARA PREPARAR DICHAS DISPERSIONES Y FORMAS DE DOSIFICACIÓN Y CON MÉTODOS DE USO DE LAS MISMAS PARA TRATAR ENFERMEDADES CARACTERIZADAS POR LA SOBREEXPRESIÓN DE PROTEÍNAS ANTI-APOPTÓTICAS DE LA FAMILIA BCL-2
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40852710P | 2010-10-29 | 2010-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
GT201300102A true GT201300102A (es) | 2014-05-20 |
Family
ID=44903438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT201300102A GT201300102A (es) | 2010-10-29 | 2013-04-22 | Dispersiones solidas extruidas por fusion que contienen un agente inductor de apoptosis |
Country Status (40)
Country | Link |
---|---|
US (2) | US20120108590A1 (es) |
EP (3) | EP3219308A1 (es) |
JP (2) | JP5902187B2 (es) |
KR (2) | KR101957137B1 (es) |
CN (2) | CN108175749B (es) |
AR (2) | AR083656A1 (es) |
AU (1) | AU2011361704B2 (es) |
BR (1) | BR112013010524A8 (es) |
CA (1) | CA2813985C (es) |
CL (1) | CL2013001120A1 (es) |
CO (1) | CO6781472A2 (es) |
CR (2) | CR20180289A (es) |
CY (1) | CY1119993T1 (es) |
DK (1) | DK2613769T3 (es) |
DO (2) | DOP2013000092A (es) |
EC (2) | ECSP13012647A (es) |
ES (1) | ES2647583T3 (es) |
GT (1) | GT201300102A (es) |
HK (1) | HK1243761A1 (es) |
HR (1) | HRP20171884T1 (es) |
HU (1) | HUE035169T2 (es) |
IL (2) | IL226215A (es) |
LT (1) | LT2613769T (es) |
ME (1) | ME02942B (es) |
MX (2) | MX362113B (es) |
MY (1) | MY189224A (es) |
NO (1) | NO2613769T3 (es) |
NZ (1) | NZ608907A (es) |
PE (2) | PE20140381A1 (es) |
PL (1) | PL2613769T3 (es) |
PT (1) | PT2613769T (es) |
RS (1) | RS56718B1 (es) |
RU (2) | RU2633353C1 (es) |
SG (2) | SG2014015077A (es) |
SI (1) | SI2613769T1 (es) |
TW (2) | TWI535699B (es) |
UA (1) | UA113500C2 (es) |
UY (3) | UY33692A (es) |
WO (1) | WO2012121758A1 (es) |
ZA (2) | ZA201302669B (es) |
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US9034875B2 (en) | 2009-05-26 | 2015-05-19 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US20220315555A1 (en) | 2009-05-26 | 2022-10-06 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
UA113500C2 (xx) | 2010-10-29 | 2017-02-10 | Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб | |
KR20180059560A (ko) | 2010-10-29 | 2018-06-04 | 애브비 인코포레이티드 | 아폽토시스―유도제를 포함하는 고체 분산체 |
AU2011332043C1 (en) | 2010-11-23 | 2016-11-10 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
UY33746A (es) | 2010-11-23 | 2012-06-29 | Abbott Lab | Método de tratamiento que usa inhibidores selectivos de bcl-2 |
US20140189897A1 (en) | 2011-06-21 | 2014-07-03 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
MX2014007093A (es) | 2011-12-13 | 2014-10-13 | Buck Inst For Res On Aging | Metodos para mejorar terapias medicas. |
WO2013158664A2 (en) | 2012-04-17 | 2013-10-24 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
US9539251B2 (en) | 2012-09-07 | 2017-01-10 | Genentech, Inc. | Combination therapy of a type II anti-CD20 antibody with a selective Bcl-2 inhibitor |
EP2900219B1 (en) * | 2012-09-27 | 2016-07-06 | Basf Se | A storage-stable dust-free homogeneous particulate formulation comprising at least one water-soluble vitamin e-derivative and at least one hydrophilic polymer |
RS57569B1 (sr) | 2013-03-13 | 2018-10-31 | Abbvie Inc | Postupci za pripremanje agensa koji uzrokuje apoptozu |
AR095265A1 (es) | 2013-03-13 | 2015-09-30 | Abbvie Inc | Procesos para la preparación de un agente inductor de la apoptosis |
US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
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WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
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HUE056329T2 (hu) | 2014-08-11 | 2022-02-28 | Acerta Pharma Bv | BTK-inhibitor és BCL-2-inhibitor terápiás kombinációi |
US10894058B2 (en) | 2014-08-29 | 2021-01-19 | Kao Corporation | Method for producing solid dispersion containing hardly soluble polyphenol |
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