AR063122A1 - Derivados de piridido [4,3-d] pirimidin -4( 3h)- ona como antagonistas de los receptores de calcio - Google Patents
Derivados de piridido [4,3-d] pirimidin -4( 3h)- ona como antagonistas de los receptores de calcioInfo
- Publication number
- AR063122A1 AR063122A1 ARP070104390A ARP070104390A AR063122A1 AR 063122 A1 AR063122 A1 AR 063122A1 AR P070104390 A ARP070104390 A AR P070104390A AR P070104390 A ARP070104390 A AR P070104390A AR 063122 A1 AR063122 A1 AR 063122A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- cycloalkyl
- halo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
También se proporcionan composiciones farmacéuticas que comprenden los compuestos de formula 1 así corno los procedimientos de tratamiento que emplean los compuestos de formula 1 para tratar una enfermedad o trastorno caracterizado por homeostasis osea o mineral anormal tal como hipoparatiroidismo, osteoporosis, osteopenia, enfermedad periodontal, enfermedad de Paget, fractura osea, osteoartritis, artritis reumatoide e hipercalcemia humoral de malignidad. Reivindicacion 1: Un compuesto de formula 1 en la que R1 es -Q o alquil C1-10-Q; R2 es alquilo C1-6, cicloalquilo C3-7, arilo o heteroarilo; en la que dicho arilo o heteroarilo está sustituido con hidroxi y adicionalmente dicho alquilo C1-6, cicloalquilo C3-7, arilo o heteroarilo dentro de la definicion de R2 está opcionalmente sustituido con uno a tres sustituyentes seleccionados independientemente entre halo, ciano.,trifluorometilo, trifluorometoxi, alquilo C1-6, alcoxi C1-6 o hidroxi; R3 es hidrogeno, alquilo C1-6, cicloalquilo C3-7, alquil C1-6-Q, arilo, heteroarilo, OR6, o NR7R8, en la que dicho alquilo C1-6, cicloalquilo C3-7, arilo o heteroarilo está opcionalmente sustituido con uno a tres sustituyentes seleccionados independientemente entre halo, ciano, trifluorometilo, trifluorometoxi, alquilo C1-6, alcoxi C1-6, NR7R8 o hidroxi; R4 y R5 son cada uno de ellos independientemente hidrogeno, halo, ciano, alquilo C1-6 opcionalmente sustituido con uno a tres fluoro, arilo, heteroarilo, u OR6; R6 en cada caso es independientemente alquilo C1- 6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-6, arilo, heteroarilo, alquil C1-6-arilo, o alquil C16-heteroarilo; cada uno de dichos alquilo C1-6, cicloalquilo C3-7, cicloalquil C3-7-alquilo C1-6, arilo, heteroarilo, alquil C1-6-arilo, o alquil C16-heteroarilo; opcionalmente sustituido con uno a tres sustituyentes seleccionados independientemente entre halo, hidroxi o alquilo C1-3; R7 y R8 en cada caso son independientemente hidrogeno, alquilo C1-6, o cicloalquilo C3-7; o R7 y R8: tomados juntos con el nitrogeno al que están unidos forman un anillo de 3 a 7 miembros completamente saturado, parcialmente saturado o completamente insaturado que opcionalmente contiene uno a dos heteroátomos adicionales seleccionados independientemente entre N(R9)n; O o S(O)p; n es 0 o 1 con la condicion de que n es 1 cuando N(R9)n es parte de un anillo de 3 a 7 miembros completamente saturado y con la condicion adicional de que n es 0 cuando N(R9)n es parle de un anillo de 3-7 miembros completamente insaturado; p es 0, 1 o 2; R9 es hidrogeno o alquilo C1-6; Q, en cada caso, es independientemente arilo o heteroarilo; en la que dicho arilo o heteroarilo está opcionalmente sustituido con uno a tres sustituyentes seleccionados independientemente entre halo, ciano, trifluorometilo, trifluorometoxi, alquilo C1-6, alcoxi C1-6, NR7R8 o hidroxi; o una sal farmacéuticamente aceptables del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82816206P | 2006-10-04 | 2006-10-04 | |
US96908307P | 2007-08-30 | 2007-08-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063122A1 true AR063122A1 (es) | 2008-12-30 |
Family
ID=39183043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070104390A AR063122A1 (es) | 2006-10-04 | 2007-10-03 | Derivados de piridido [4,3-d] pirimidin -4( 3h)- ona como antagonistas de los receptores de calcio |
Country Status (17)
Country | Link |
---|---|
US (2) | US7829572B2 (es) |
EP (1) | EP2079739A2 (es) |
JP (1) | JP2010505811A (es) |
KR (1) | KR101129868B1 (es) |
CN (1) | CN101547922B (es) |
AR (1) | AR063122A1 (es) |
AU (1) | AU2007303846B2 (es) |
CA (1) | CA2663436A1 (es) |
CL (1) | CL2007002864A1 (es) |
HK (1) | HK1137753A1 (es) |
IL (1) | IL197536A0 (es) |
MX (1) | MX2009003673A (es) |
NO (1) | NO20091328L (es) |
PE (1) | PE20081455A1 (es) |
TW (1) | TW200822929A (es) |
UY (1) | UY30620A1 (es) |
WO (1) | WO2008041118A2 (es) |
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-
2007
- 2007-09-26 CA CA002663436A patent/CA2663436A1/en not_active Abandoned
- 2007-09-26 CN CN2007800374756A patent/CN101547922B/zh not_active Expired - Fee Related
- 2007-09-26 MX MX2009003673A patent/MX2009003673A/es active IP Right Grant
- 2007-09-26 JP JP2009530962A patent/JP2010505811A/ja active Pending
- 2007-09-26 EP EP07825294A patent/EP2079739A2/en not_active Withdrawn
- 2007-09-26 WO PCT/IB2007/002976 patent/WO2008041118A2/en active Application Filing
- 2007-09-26 KR KR1020097008869A patent/KR101129868B1/ko not_active IP Right Cessation
- 2007-09-26 AU AU2007303846A patent/AU2007303846B2/en not_active Ceased
- 2007-10-03 PE PE2007001339A patent/PE20081455A1/es not_active Application Discontinuation
- 2007-10-03 UY UY30620A patent/UY30620A1/es not_active Application Discontinuation
- 2007-10-03 AR ARP070104390A patent/AR063122A1/es not_active Application Discontinuation
- 2007-10-03 TW TW096137122A patent/TW200822929A/zh unknown
- 2007-10-04 CL CL200702864A patent/CL2007002864A1/es unknown
- 2007-10-04 US US11/867,255 patent/US7829572B2/en not_active Expired - Fee Related
-
2009
- 2009-03-11 IL IL197536A patent/IL197536A0/en unknown
- 2009-04-01 NO NO20091328A patent/NO20091328L/no not_active Application Discontinuation
-
2010
- 2010-03-15 HK HK10102651.4A patent/HK1137753A1/xx not_active IP Right Cessation
- 2010-09-30 US US12/894,525 patent/US20110028452A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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US20080085887A1 (en) | 2008-04-10 |
CL2007002864A1 (es) | 2008-04-04 |
KR20090074066A (ko) | 2009-07-03 |
US7829572B2 (en) | 2010-11-09 |
MX2009003673A (es) | 2009-04-22 |
PE20081455A1 (es) | 2008-10-18 |
WO2008041118A2 (en) | 2008-04-10 |
CN101547922B (zh) | 2012-06-20 |
UY30620A1 (es) | 2008-05-31 |
JP2010505811A (ja) | 2010-02-25 |
CN101547922A (zh) | 2009-09-30 |
KR101129868B1 (ko) | 2012-04-12 |
WO2008041118A3 (en) | 2008-10-23 |
IL197536A0 (en) | 2009-12-24 |
TW200822929A (en) | 2008-06-01 |
AU2007303846B2 (en) | 2011-03-10 |
HK1137753A1 (en) | 2010-08-06 |
EP2079739A2 (en) | 2009-07-22 |
AU2007303846A1 (en) | 2008-04-10 |
US20110028452A1 (en) | 2011-02-03 |
NO20091328L (no) | 2009-05-04 |
CA2663436A1 (en) | 2008-04-10 |
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