CH624395A5 - - Google Patents

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Publication number
CH624395A5
CH624395A5 CH16176A CH16176A CH624395A5 CH 624395 A5 CH624395 A5 CH 624395A5 CH 16176 A CH16176 A CH 16176A CH 16176 A CH16176 A CH 16176A CH 624395 A5 CH624395 A5 CH 624395A5
Authority
CH
Switzerland
Prior art keywords
formula
group
compounds
salts
acid
Prior art date
Application number
CH16176A
Other languages
German (de)
English (en)
Inventor
Knut A Dr Jaeggi
Franz Dr Ostermayer
Herbert Dr Schroeter
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Priority to CH16176A priority Critical patent/CH624395A5/de
Priority to US05/751,233 priority patent/US4140789A/en
Priority to AR265940A priority patent/AR214869A1/es
Priority to NZ182963A priority patent/NZ182963A/xx
Priority to GB53633/76A priority patent/GB1549945A/en
Priority to SE7700056A priority patent/SE7700056L/xx
Priority to ES454779A priority patent/ES454779A1/es
Priority to DE19772700193 priority patent/DE2700193A1/de
Priority to IL51222A priority patent/IL51222A/xx
Priority to CA269,205A priority patent/CA1083150A/en
Priority to PL1977214709A priority patent/PL112441B1/pl
Priority to FR7700232A priority patent/FR2337718A1/fr
Priority to FI770036A priority patent/FI770036A/fi
Priority to AU21105/77A priority patent/AU507884B2/en
Priority to PL1977214708A priority patent/PL112491B1/pl
Priority to DD7700196843A priority patent/DD129444A5/xx
Priority to PL1977214710A priority patent/PL112442B1/pl
Priority to PL1977195154A priority patent/PL110654B1/pl
Priority to PT6603677A priority patent/PT66036A1/pt
Priority to CS77117A priority patent/CS201040B2/cs
Priority to SU772435952A priority patent/SU648091A3/ru
Priority to NL7700141A priority patent/NL7700141A/xx
Priority to IE31/77A priority patent/IE44246B1/en
Priority to BE173895A priority patent/BE850166A/xx
Priority to ZA770087A priority patent/ZA7787B/xx
Priority to AT4677A priority patent/AT355564B/de
Priority to NO770061A priority patent/NO770061L/no
Priority to DK6177A priority patent/DK6177A/da
Priority to GR52536A priority patent/GR73132B/el
Priority to JP55977A priority patent/JPS5285166A/ja
Priority to AR268661A priority patent/AR215643A1/es
Priority to AR268662A priority patent/AR217258A1/es
Priority to AR268660A priority patent/AR214746A1/es
Priority to SU772525452A priority patent/SU648092A3/ru
Priority to SU772525901A priority patent/SU651695A3/ru
Priority to SU772526202A priority patent/SU645568A3/ru
Priority to CS791289A priority patent/CS201041B2/cs
Priority to CS791290A priority patent/CS201042B2/cs
Priority to CS791291A priority patent/CS201043B2/cs
Priority to US06/018,397 priority patent/US4310527A/en
Priority to AT194579A priority patent/AT355039B/de
Priority to AT194479A priority patent/AT355038B/de
Priority to AT194679A priority patent/AT355040B/de
Publication of CH624395A5 publication Critical patent/CH624395A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
CH16176A 1976-01-08 1976-01-08 CH624395A5 (es)

Priority Applications (43)

Application Number Priority Date Filing Date Title
CH16176A CH624395A5 (es) 1976-01-08 1976-01-08
US05/751,233 US4140789A (en) 1976-01-08 1976-12-16 Etherified hydroxy-benzodiheterocyclic compounds
AR265940A AR214869A1 (es) 1976-01-08 1976-12-21 Procedimiento para la elaboracion de compuestos sustituidos por(3-amino-2-hidroxi-propiloxi)de la benzimidazol-2-ona,2-(3h)-benzoxazolona,(1h)(3h)-quinazolin-2,4-diona,3,4-dihidro-1h-quinazolin-2-ona,1,2,3,4-tetrahidro-2,3-dioxo-quinazolina,2,3-dihidro-4h-benze(5,6)oxazin-3-ona y 4h-1,3-benzoxazin-2(1h)-ona
NZ182963A NZ182963A (en) 1976-01-08 1976-12-22 C-(3-alkylamino-2-hydroxypropoxy)benz(diaza or azaoxa)-cycloalkan-2-ones
GB53633/76A GB1549945A (en) 1976-01-08 1976-12-22 Etherified hydroxy-benzodiheterocyclic compounds
SE7700056A SE7700056L (sv) 1976-01-08 1977-01-04 Foretrade hydroxibensidiheterocykler
ES454779A ES454779A1 (es) 1976-01-08 1977-01-04 Procedimiento para la obtencion de hidroxidiheterociclos eterados.
DE19772700193 DE2700193A1 (de) 1976-01-08 1977-01-04 Veraetherte hydroxy-benzodiheterocyclen
IL51222A IL51222A (en) 1976-01-08 1977-01-06 Etherified hydroxy-benzodiheterocyclic compounds,their prearation and pharmaceutical compositions containing them
CA269,205A CA1083150A (en) 1976-01-08 1977-01-06 Process for the manufacture of etherified hydroxy- benzodiheterocyclic compounds
PL1977214709A PL112441B1 (en) 1976-01-08 1977-01-06 Process for preparing novel ethers of hydroxy-benzodiheterocyclic compounds
FR7700232A FR2337718A1 (fr) 1976-01-08 1977-01-06 Nouveaux hydroxy-benzodiheterocycles etherifies, leur procede de preparation et leur application en tant que medicaments
FI770036A FI770036A (es) 1976-01-08 1977-01-06
AU21105/77A AU507884B2 (en) 1976-01-08 1977-01-06 Etherified hydroxy-benzodiheterocyclic compounds
PL1977214708A PL112491B1 (en) 1976-01-08 1977-01-06 Process for preparing novel ethers of hydroxy-benzodiheterocyclic compounds
DD7700196843A DD129444A5 (de) 1976-01-08 1977-01-06 Veraetherte hydroxy-benzodiheterocyclen
PL1977214710A PL112442B1 (en) 1976-01-08 1977-01-06 Process for preparing novel ethers of hydroxy-benzodiheterocyclic compounds
PL1977195154A PL110654B1 (en) 1976-01-08 1977-01-06 Method of producing new ethers of hydroxy-benzodiheterocyclic compounds
PT6603677A PT66036A1 (en) 1976-01-08 1977-01-06 Process for preparation of etherified hydroxibenzodiheterocyclic compounds
CS77117A CS201040B2 (en) 1976-01-08 1977-01-07 Method of producing etherified hydroxy-benzo-diheterocyclic compounds
SU772435952A SU648091A3 (ru) 1976-01-08 1977-01-07 Способ получени этерифицированных окси-бензодигетероциклов или их солей, или рацематов, или оптически активных антиподов
NL7700141A NL7700141A (nl) 1976-01-08 1977-01-07 Heterocyclische benzoverbindingen met een ver- etherde hydroxylgroep.
IE31/77A IE44246B1 (en) 1976-01-08 1977-01-07 Etherified hydroxy-benzodiheterocyclic compounds
BE173895A BE850166A (fr) 1976-01-08 1977-01-07 Nouveaux hydroxy-benzodiheterocycles etherifies
ZA770087A ZA7787B (en) 1976-01-08 1977-01-07 Etherified hydroxy-benzodiheterocyclic compounds
AT4677A AT355564B (de) 1976-01-08 1977-01-07 Verfahren zur herstellung von neuen veraetherten hydroxy-benzimidazolonen,-benzoxazolonen,- benzoxazinonen,-chinozolinonen und-chino- xalinonen
NO770061A NO770061L (no) 1976-01-08 1977-01-07 Foretrede hydroksy-benzodiheterocykler.
DK6177A DK6177A (da) 1976-01-08 1977-01-07 Foretherede hydroxy-benzodiheterocycler eller salte deraf og fremgangsmade til fremstilling deraf
GR52536A GR73132B (es) 1976-01-08 1977-01-08
JP55977A JPS5285166A (en) 1976-01-08 1977-01-08 Production of etherified hydroxyybenzodiheterocyclic compound and pharmaceutical composition
AR268661A AR215643A1 (es) 1976-01-08 1977-08-02 Procedimiento para la elaboracion de compuestos de 4-(3-amino-2-hidroxi-propiloxi)-benzimidazol-2-ona,5-(3-amino-2-hidroxi-propiloxi)-3,4-dihidro-1h-quinazolin-2-ona,5-(3-amino-2-hideoxi-propiloxi)-(1h)(3h)-quina-zolin-2,4-diona,7-(3-amino-2-hidroxi-propiloxi)-2(3h)-benzoxazolona,5-(3-amino-2-hidroxi-propiloxi)-1,2,3,4-tetrahidro-2,3-dioxo-quinoxazolina,8-(3-amino-2-hidroxi-propiloxi)-2,3-dihidro-4-h-benz(5,6)oxazin-3-ona y 7-(3-amino-2-hidroxi-propiloxi)-4h-1,3-benzoxazin-2(1h)ona
AR268662A AR217258A1 (es) 1976-01-08 1977-08-02 Procedimiento para la elaboracion de compuestos(3-amino-2-hidroxi-propiloxi)-benzimidazol-2-ona,2(3h)-benzoxazolona,(1h)(3h)-quinazolin-2,4-dional,3,4-dihidro-1h-quinazolin-2-ona 1,2,3,4-tetra-dihidro-2,3-dioxo-quinazolina,2,3-hidro-4h-benz(5,6)oxazin-3-ona y 4h-1,3-benzoxazin-2(1h)-(ona)
AR268660A AR214746A1 (es) 1976-01-08 1977-08-02 Procedimiento para la elaboracion de 4-(3-amino-2-hidroxi-propiloxi)-benzimidazol-2-onas y 5-(3-amino-2-hidroxi-propiloxi)-1,2,3,4-tetrahidro-2,3-dioxo-quinoxazolinas
SU772525452A SU648092A3 (ru) 1976-01-08 1977-09-29 Способ получени этерифицированных оксибензодигетероциклов или их солей, или рацематов или оптически активных антиподов
SU772525901A SU651695A3 (ru) 1976-01-08 1977-09-29 Способ получени этерифицированных оксибензодигетероциклов или их солей, или рацематов, или оптически активных антиподов
SU772526202A SU645568A3 (ru) 1976-01-08 1977-09-29 Способ получени этерифицированных окси-бензодигетероциклов или их солей, или рацематов или оптически активных антиподов
CS791289A CS201041B2 (cs) 1976-01-08 1979-02-26 Způsob výroby etherifikovaných hydroxybenzodiheterocyklických sloučenin
CS791290A CS201042B2 (cs) 1976-01-08 1979-02-26 Způsob výroby etherifikovaných hydroxybenzodiheterocyklických sloučenin
CS791291A CS201043B2 (cs) 1976-01-08 1979-02-26 Způsob výroby etherifikovaných hydroxybenzodiheterocyklických sloučenin
US06/018,397 US4310527A (en) 1976-01-08 1979-03-08 Etherified hydroxy quinazolone compounds
AT194579A AT355039B (de) 1976-01-08 1979-03-15 Verfahren zur herstellung von neuen veraetherten hydroxy-benzimidazolonen, - benzoxazolonen, -benzoxazinonen,- china- zolinonen und -chinoxazolinonen
AT194479A AT355038B (de) 1976-01-08 1979-03-15 Verfahren zur herstellung von neuen veraetherten hydroxy-benzimidazolonen, -benzoxazolonen, - -benzoxazinonen, -chinazolinonen und- chino- xazolinonen
AT194679A AT355040B (de) 1976-01-08 1979-03-15 Verfahren zur herstellung von neuen veraetherten hydroxy-benzimidazolonen, - -benzoxazolonen, -benzoxazinonen, - chinazolinonen und-chinoxazolinonen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH16176A CH624395A5 (es) 1976-01-08 1976-01-08

Publications (1)

Publication Number Publication Date
CH624395A5 true CH624395A5 (es) 1981-07-31

Family

ID=4180641

Family Applications (1)

Application Number Title Priority Date Filing Date
CH16176A CH624395A5 (es) 1976-01-08 1976-01-08

Country Status (26)

Country Link
US (2) US4140789A (es)
JP (1) JPS5285166A (es)
AR (4) AR214869A1 (es)
AT (1) AT355564B (es)
AU (1) AU507884B2 (es)
BE (1) BE850166A (es)
CA (1) CA1083150A (es)
CH (1) CH624395A5 (es)
CS (1) CS201040B2 (es)
DD (1) DD129444A5 (es)
DE (1) DE2700193A1 (es)
DK (1) DK6177A (es)
ES (1) ES454779A1 (es)
FI (1) FI770036A (es)
FR (1) FR2337718A1 (es)
GB (1) GB1549945A (es)
GR (1) GR73132B (es)
IE (1) IE44246B1 (es)
IL (1) IL51222A (es)
NL (1) NL7700141A (es)
NO (1) NO770061L (es)
NZ (1) NZ182963A (es)
PL (4) PL112442B1 (es)
SE (1) SE7700056L (es)
SU (4) SU648091A3 (es)
ZA (1) ZA7787B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH624395A5 (es) * 1976-01-08 1981-07-31 Ciba Geigy Ag
DE2644833A1 (de) * 1976-10-05 1978-04-20 Boehringer Sohn Ingelheim Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung
NZ187066A (en) * 1977-05-03 1981-02-11 Hoffmann La Roche 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones)
CA1108619A (en) * 1977-08-12 1981-09-08 Carl H. Ross 4-hydroxy-2-benzimidazolinone derivatives and the preparation thereof
DE2801980A1 (de) * 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
EP0003758A1 (de) * 1978-02-09 1979-09-05 Ciba-Geigy Ag Verätherte Hydroxy-benzodiheterocyclen und ihre Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate
DE2905877A1 (de) 1979-02-16 1980-08-28 Boehringer Mannheim Gmbh Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DD150456A5 (de) * 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
DK187980A (da) 1979-05-04 1980-11-05 Continental Pharma Fremgangsmaade til fremstilling af benzimidazolderivater
DE2922084A1 (de) 1979-05-31 1980-12-11 Boehringer Mannheim Gmbh Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4656168A (en) * 1980-12-23 1987-04-07 Merck & Co., Inc. (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
US4349673A (en) * 1980-12-23 1982-09-14 Merck & Co., Inc. Benzoxazines
US4442094A (en) * 1980-12-23 1984-04-10 Merck & Co., Inc. (3-Aralkylamino-2-or-propoxy)heterocyclic compounds
US4331679A (en) * 1980-12-23 1982-05-25 Merck Sharp & Dohme (I.A.) Corp. (3-Aralkylamino-2-or-propoxy) heterocyclic compounds
DE3217012A1 (de) * 1982-05-06 1983-11-10 Dr. Karl Thomae Gmbh, 7950 Biberach Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel
IT1212552B (it) * 1982-10-20 1989-11-30 Italo Britannica L Manet Ti H Alcanolaminossi derivati di 3,4-diidro-2h-1.4-benzotiazin-3-one, loro procedimento di produzione e loro utilizzazione farmaceutica
GB8419797D0 (en) * 1984-08-03 1984-09-05 Beecham Group Plc Compounds
DE3800096A1 (de) * 1988-01-05 1989-07-13 Bayer Ag Verwendung von benzimidazolderivaten als leistungsfoerderer
FR2653430B1 (fr) * 1989-10-23 1991-12-20 Pf Medicament Nouveaux derives de dihydro-1,2 oxo-2 quinoxalines, leur preparation et leur application en therapeutique.
US6075040A (en) * 1996-09-05 2000-06-13 Eli Lilly And Company Selective β3 adrenergic agonists
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
DE69711519T2 (de) 1996-09-05 2002-10-31 Lilly Co Eli Carbazolanaloge als selektive beta3-adrenergische Agonisten
US5972958A (en) * 1997-02-18 1999-10-26 American Home Products Corporation 4-aminoalkoxy-1,3-dihydro-benzoimidazol-2-thiones
US5990144A (en) * 1997-02-18 1999-11-23 American Home Products Corporation 4-aminoalkoxy-1,3-dihydrobenzoimidazol-2-one dopamine autoreceptor agonists
US5922715A (en) * 1997-02-18 1999-07-13 American Home Products Corporation 5-aminoalkoxy-1, 4-dihydroquinoxaline-2, 3-diones
EP0905121B1 (de) * 1997-09-24 2002-07-03 Infineon Technologies AG o-Nitro(thio)phenolderivate und deren Herstellung
CO5011072A1 (es) 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
WO2001036412A1 (en) * 1999-11-15 2001-05-25 Eli Lilly And Company Process for the preparation of aryloxy propanolamines
FR2805159B1 (fr) 2000-02-23 2005-06-10 Oreal Compositions pour la teinture d'oxydation des fibres keratiniques comprenant un n-(2-hydroxybenzene)-carbamate ou un n-(2-hydroxybenzene)-uree a titre de coupleur, et procedes de teinture
ATE329901T1 (de) 2000-11-10 2006-07-15 Lilly Co Eli 3-substituierte oxindolderivate als beta-3- agonisten
ES2272749T3 (es) 2001-08-14 2007-05-01 Eli Lilly And Company Derivados de indol como agonistas beta-3 adrenergicos para el tratamiento de diabetes tipo 2.
DE60211199T2 (de) 2001-08-14 2007-02-01 Eli Lilly And Co., Indianapolis 3-substituierte oxindol-beta-3-agonisten
AU2002353844A1 (en) 2001-11-20 2003-06-10 Eli Lilly And Company Beta 3 adrenergic agonists
DE60204718T2 (de) 2001-11-20 2006-05-18 Eli Lilly And Co., Indianapolis 3-substituierte oxindol beta 3 agonisten
US7009060B2 (en) 2002-01-11 2006-03-07 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as β3 agonists
ATE486861T1 (de) * 2002-08-29 2010-11-15 Nissan Chemical Ind Ltd Verfahren zur herstellung einer aminobenzopyranverbindung
CN1852906A (zh) * 2003-07-15 2006-10-25 史密丝克莱恩比彻姆公司 新化合物
CA2663436A1 (en) * 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
US9784726B2 (en) 2013-01-08 2017-10-10 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA726737A (en) * 1966-01-25 C. Scarborough Homer 4-substituted quinolines and quinazolines
US3686176A (en) * 1970-03-09 1972-08-22 Frosst & Co Charles E 1-morpholino phenoxy-3-alkylamino-2-propanols
US3763153A (en) * 1972-02-22 1973-10-02 Squibb & Sons Inc Benzothiazines
GB1488330A (en) * 1973-12-19 1977-10-12 Smith Kline French Lab Dihydropyridazinones
CH624395A5 (es) * 1976-01-08 1981-07-31 Ciba Geigy Ag

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CA1083150A (en) 1980-08-05
DD129444A5 (de) 1978-01-18
US4310527A (en) 1982-01-12
CS201040B2 (en) 1980-10-31
ES454779A1 (es) 1978-01-01
IE44246L (en) 1977-07-08
DK6177A (da) 1977-07-09
IL51222A0 (en) 1977-03-31
ZA7787B (en) 1977-11-30
AR217258A1 (es) 1980-03-14
AU2110577A (en) 1978-07-13
AR214746A1 (es) 1979-07-31
NL7700141A (nl) 1977-07-12
GB1549945A (en) 1979-08-08
AR215643A1 (es) 1979-10-31
SU648092A3 (ru) 1979-02-15
NZ182963A (en) 1978-07-28
AR214869A1 (es) 1979-08-15
SE7700056L (sv) 1977-07-09
PL112442B1 (en) 1980-10-31
AT355564B (de) 1980-03-10
GR73132B (es) 1984-02-07
PL195154A1 (pl) 1979-05-07
BE850166A (fr) 1977-07-07
SU648091A3 (ru) 1979-02-15
PL110654B1 (en) 1980-07-31
US4140789A (en) 1979-02-20
AU507884B2 (en) 1980-02-28
FR2337718A1 (fr) 1977-08-05
SU645568A3 (ru) 1979-01-30
DE2700193A1 (de) 1977-07-14
PL112441B1 (en) 1980-10-31
FI770036A (es) 1977-07-09
NO770061L (no) 1977-07-11
ATA4677A (de) 1979-08-15
JPS5285166A (en) 1977-07-15
FR2337718B1 (es) 1980-11-07
SU651695A3 (ru) 1979-03-05
PL112491B1 (en) 1980-10-31
IL51222A (en) 1980-12-31
IE44246B1 (en) 1981-09-23

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