PT66036A1 - Process for preparation of etherified hydroxibenzodiheterocyclic compounds - Google Patents

Process for preparation of etherified hydroxibenzodiheterocyclic compounds

Info

Publication number
PT66036A1
PT66036A1 PT6603677A PT6603677A PT66036A1 PT 66036 A1 PT66036 A1 PT 66036A1 PT 6603677 A PT6603677 A PT 6603677A PT 6603677 A PT6603677 A PT 6603677A PT 66036 A1 PT66036 A1 PT 66036A1
Authority
PT
Portugal
Prior art keywords
cpds
substd
opt
atoms
lower alkyl
Prior art date
Application number
PT6603677A
Other languages
German (de)
Portuguese (pt)
Other versions
PT66036B (en
Inventor
Ostermayer Franz
Knut A Jaeggi
Schroter Herbert
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH16176A external-priority patent/CH624395A5/de
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PT66036B publication Critical patent/PT66036B/en
Publication of PT66036A1 publication Critical patent/PT66036A1/en

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Abstract

Hydroxybenzodiheterocyclic cpds. of formula (I) as the racemate or antipodes and their acid addition salts are novel cpds: In (I) R1 is opt. substd. lower alkyl which may be branched at the bonding C atom (the preferred substituents are opt. substd. aryl or aryloxy groups). R2 is H or lower alkanoyl; R3 is -R'3-(R"3)n- (Gp. Ia); R'3 is -NR4 or -O-; R4 is H or lower alkyl; R"3 is -CH2- or when R'3 is -NR4 then R3" may be C=O; n = 0 or 1. When n = 1 the gp. (Ia) may be joined to the -CO of the carbamoyl via R'3 or R"3. Lower groups contain 7C atoms pref. =4C atoms. Cpds. (I) are used to treat cardiac arrhythmia, coronary disorders, such as angina pectoris, and hypertension and cardiac stimulants. Some of the cpds. are alpha-adrenergic receptor blockers and act as hypotensives. They are administered orally (e.g. in daily doses of 1-15 mg for a 70 kg adult) or parenterally. A typical prod. is 5-(3-tert-butylamino-2-hydroxy-propoxy)-(1H)(3H)-quinazolin-2,4-d- ione.
PT6603677A 1976-01-08 1977-01-06 Process for preparation of etherified hydroxibenzodiheterocyclic compounds PT66036A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH16176A CH624395A5 (en) 1976-01-08 1976-01-08
CH145078 1978-02-09
CH559478 1978-05-23

Publications (2)

Publication Number Publication Date
PT66036B PT66036B (en) 1978-06-20
PT66036A1 true PT66036A1 (en) 1979-02-01

Family

ID=27171852

Family Applications (1)

Application Number Title Priority Date Filing Date
PT6603677A PT66036A1 (en) 1976-01-08 1977-01-06 Process for preparation of etherified hydroxibenzodiheterocyclic compounds

Country Status (1)

Country Link
PT (1) PT66036A1 (en)

Also Published As

Publication number Publication date
PT66036B (en) 1978-06-20

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