AR057056A1 - Proceso para la sintesis de imidazol bencilaminas - Google Patents

Proceso para la sintesis de imidazol bencilaminas

Info

Publication number
AR057056A1
AR057056A1 ARP060102367A ARP060102367A AR057056A1 AR 057056 A1 AR057056 A1 AR 057056A1 AR P060102367 A ARP060102367 A AR P060102367A AR P060102367 A ARP060102367 A AR P060102367A AR 057056 A1 AR057056 A1 AR 057056A1
Authority
AR
Argentina
Prior art keywords
imidazol
bencilaminas
synthesis
methyl
halogen
Prior art date
Application number
ARP060102367A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37149980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR057056(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR057056A1 publication Critical patent/AR057056A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicacion 1: Un proceso para la preparacion de 5-(4-metil-1H-imidazol-1-il)-3-(trifluoro-metil)-bencenamina (I), el cual comprende hacer reaccionar 4-metil-1H-imidazol, o una sal del mismo, y un compuesto de formula (1) en donde: X es halogeno, sulfonato, o NO2; e Y es NH2, NO2, halogeno, o CN, en la presencia de una base adecuada o de un catalizador de metal de transicion adecuado o una combinacion de los mismos, en un solvente apropiado.
ARP060102367A 2005-06-09 2006-06-07 Proceso para la sintesis de imidazol bencilaminas AR057056A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68897605P 2005-06-09 2005-06-09

Publications (1)

Publication Number Publication Date
AR057056A1 true AR057056A1 (es) 2007-11-14

Family

ID=37149980

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102367A AR057056A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de imidazol bencilaminas

Country Status (25)

Country Link
US (2) US7781597B2 (es)
EP (3) EP1896426B1 (es)
JP (2) JP5225078B2 (es)
KR (2) KR101283109B1 (es)
CN (6) CN102174020B (es)
AR (1) AR057056A1 (es)
AT (1) ATE540931T1 (es)
AU (3) AU2006258050B2 (es)
BR (1) BRPI0611683A2 (es)
CA (4) CA2611280C (es)
DK (2) DK2292607T3 (es)
ES (3) ES2380489T3 (es)
GT (1) GT200600202AA (es)
HU (1) HUE028024T2 (es)
IN (2) IN2014DN08588A (es)
JO (1) JO2758B1 (es)
MX (1) MX2007015609A (es)
MY (1) MY146795A (es)
PE (3) PE20100716A1 (es)
PL (3) PL2266961T3 (es)
PT (3) PT1896426E (es)
RU (1) RU2446162C2 (es)
SI (2) SI2292607T1 (es)
TW (1) TWI380981B (es)
WO (1) WO2006135640A2 (es)

Families Citing this family (30)

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ES2526614T3 (es) 2004-03-05 2015-01-13 Nissan Chemical Industries, Ltd. Compuesto de benzamida sustituida con isoxazolina y agente de control de organismos nocivos
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
MX2009013469A (es) 2007-06-13 2010-01-20 Du Pont Insecticidas de isoxazolina.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX368680B (es) 2007-06-27 2019-10-11 Du Pont Administración subcutánea de un derivado de isoxazol-benzamida para usarse en un método para proteger un mamífero de una pulga.
TWI461411B (zh) 2007-08-17 2014-11-21 Du Pont 製備５－鹵烷基－４，５－二氫異唑衍生物之方法
MX2010003557A (es) 2007-10-03 2010-04-12 Du Pont Compuestos de isoxazolina de naftaleno para el control de plagas de invertebrados.
TWI455919B (zh) * 2008-04-09 2014-10-11 Du Pont 製備３－三氟甲基查耳酮（ｃｈａｌｃｏｎｅ）之方法
WO2010009402A2 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
ES2394258T3 (es) 2008-11-05 2013-01-30 Teva Pharmaceutical Industries Ltd. Formas cristalinas de Nilotinib HCL
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
CA2799963C (en) 2010-05-27 2018-01-23 E. I. Du Pont De Nemours And Company Crystalline form of 4- [5 - [3 -chloro-5 - (trifluoromethyl) phenyl] -4,5 -dihydro-5 - (trifluoromethyl) -3 - isoxazolyl] -n- [2-0x0-2- [(2,2,2-trifluoroethyl)amino]ethyl] -1-naphthalenecarboxamide
RU2705577C2 (ru) 2011-12-30 2019-11-08 Ханми Фарм. Ко., Лтд. ПРОИЗВОДНЫЕ ТИЕНО[3,2-d]ПИРИМИДИНА, ОБЛАДАЮЩИЕ ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ ПРОТЕИНКИНАЗ
CN102592837B (zh) * 2012-03-12 2014-01-15 河北师范大学 制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法
CN103694176B (zh) 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
CN104592122B (zh) * 2014-12-09 2018-01-23 凯莱英医药集团（天津）股份有限公司 3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
CN105985293B (zh) * 2015-03-04 2018-04-03 埃斯特维华义制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN107201532B (zh) * 2017-05-09 2019-08-27 吉林凯莱英医药化学有限公司 芳香化合物的硝化方法
US11053220B2 (en) 2018-01-01 2021-07-06 Laurus Labs Ltd Process for 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) aniline
CN108530364B (zh) 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
TWI815137B (zh) 2018-06-15 2023-09-11 漢達生技醫藥股份有限公司 尼洛替尼十二烷基硫酸鹽之結晶
CA3136189A1 (en) * 2019-04-06 2020-10-15 Trinapco, Inc. Sulfonyldiazoles and n-(fluorosulfonyl)azoles, and methods of making the same
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
CN114751836A (zh) * 2021-02-23 2022-07-15 成都硕德药业有限公司 3-(4-甲基-1h-咪唑-1-基)-5-(三氟甲基)苯胺合成方法及其中间体
CN114853734A (zh) * 2022-06-14 2022-08-05 海南鑫开源医药科技有限公司 一种尼洛替尼游离碱的制备方法
CN115626880B (zh) * 2022-11-15 2023-11-14 常州大学 3-硝基-5-氰基三氟甲苯的合成方法

Family Cites Families (12)

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Publication number Priority date Publication date Assignee Title
SU1051076A1 (ru) * 1982-04-09 1983-10-30 Алтайский политехнический институт Способ получени производных имидазола
GB8413685D0 (en) * 1984-05-29 1984-07-04 Pfizer Ltd Quinolone inotropic agents
NZ212209A (en) * 1984-05-29 1988-08-30 Pfizer Quinolone derivatives and pharmaceutical compositions
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
GB0023383D0 (en) * 2000-09-23 2000-11-08 Synprotec Ltd 3,5-Bis (Trifluormethyl)Benzene derivatives
AR037647A1 (es) 2002-05-29 2004-12-01 Novartis Ag Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0222514D0 (en) 2002-09-27 2002-11-06 Novartis Ag Organic compounds
CN1939910A (zh) * 2004-12-31 2007-04-04 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
GT200600207A (es) * 2005-06-09 2007-01-15 Novartis Ag Proceso para la síntesis de compuestos orgánicos
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds

Also Published As

Publication number Publication date
RU2007148238A (ru) 2009-07-20
CA2833394A1 (en) 2006-12-21
KR101283109B1 (ko) 2013-07-05
SI2292607T1 (sl) 2014-09-30
PT2266961E (pt) 2016-02-05
US20080200692A1 (en) 2008-08-21
PL1896426T3 (pl) 2012-06-29
ES2380489T3 (es) 2012-05-14
DK2266961T3 (en) 2016-01-25
ES2380489T8 (es) 2012-06-22
AU2010241374A1 (en) 2010-12-02
AU2011201044A1 (en) 2011-03-31
GT200600202AA (es) 2014-06-09
CA2611280A1 (en) 2006-12-21
PL2292607T3 (pl) 2014-09-30
WO2006135640A2 (en) 2006-12-21
IN2014DN08578A (es) 2015-07-10
ES2558696T3 (es) 2016-02-08
PE20070109A1 (es) 2007-04-02
CN102174021B (zh) 2013-02-27
US20100280257A1 (en) 2010-11-04
CN102174020A (zh) 2011-09-07
CN102180836B (zh) 2012-11-21
PT2292607E (pt) 2014-06-24
EP2292607A3 (en) 2011-04-27
PT1896426E (pt) 2012-04-12
AU2010241374B2 (en) 2011-11-03
EP1896426B1 (en) 2012-01-11
JO2758B1 (en) 2014-03-15
PL2266961T3 (pl) 2016-04-29
CN101189212A (zh) 2008-05-28
CN102174020B (zh) 2012-11-07
CA2942046A1 (en) 2006-12-21
AU2006258050B2 (en) 2010-12-09
AU2006258050A1 (en) 2006-12-21
CN101189212B (zh) 2011-05-18
TWI380981B (zh) 2013-01-01
DK2292607T3 (da) 2014-06-30
CA2886482C (en) 2017-09-05
US8008504B2 (en) 2011-08-30
WO2006135640A3 (en) 2007-08-02
EP2292607B1 (en) 2014-04-09
JP2008546645A (ja) 2008-12-25
CN102180796A (zh) 2011-09-14
EP1896426A2 (en) 2008-03-12
CN102174019B (zh) 2013-02-13
CA2886482A1 (en) 2006-12-21
EP2266961B1 (en) 2015-10-21
EP2292607A2 (en) 2011-03-09
CA2833394C (en) 2016-03-29
CN102180836A (zh) 2011-09-14
MY146795A (en) 2012-09-28
ES2465522T3 (es) 2014-06-06
KR20080014010A (ko) 2008-02-13
RU2446162C2 (ru) 2012-03-27
JP5225078B2 (ja) 2013-07-03
KR20120099028A (ko) 2012-09-06
TW200716563A (en) 2007-05-01
JP2013035855A (ja) 2013-02-21
HUE028024T2 (en) 2016-11-28
KR101249199B1 (ko) 2013-04-03
PE20100716A1 (es) 2010-10-25
BRPI0611683A2 (pt) 2010-09-28
MX2007015609A (es) 2008-02-25
PE20100715A1 (es) 2010-10-25
CA2611280C (en) 2014-01-28
EP2266961A3 (en) 2011-07-27
IN2014DN08588A (es) 2015-07-10
CN102174019A (zh) 2011-09-07
EP2266961A2 (en) 2010-12-29
CN102174021A (zh) 2011-09-07
SI2266961T1 (sl) 2016-02-29
US7781597B2 (en) 2010-08-24
ATE540931T1 (de) 2012-01-15

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