PE20070109A1 - Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina - Google Patents

Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina

Info

Publication number
PE20070109A1
PE20070109A1 PE2006000628A PE2006000628A PE20070109A1 PE 20070109 A1 PE20070109 A1 PE 20070109A1 PE 2006000628 A PE2006000628 A PE 2006000628A PE 2006000628 A PE2006000628 A PE 2006000628A PE 20070109 A1 PE20070109 A1 PE 20070109A1
Authority
PE
Peru
Prior art keywords
methyl
imidazol
trifluoromethyl
benzenamine
synthesis
Prior art date
Application number
PE2006000628A
Other languages
English (en)
Inventor
Stephan Abel
Murat Acemoglu
Christoph Krell
Mark Meisenbach
Wen-Chung Shieh
Song Xue
Mahavir Prashad
Joseph Sclafani
Bernhard Erb
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37149980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070109(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20070109A1 publication Critical patent/PE20070109A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA PREPARACION DE 5-(4-METIL-1H-IMIDAZOL-1-IL)-3-(TRIFLUOROMETIL)-BENCENAMIDA, EL CUAL COMPRENDE: A) HACER REACCIONAR 4-METIL-1H-IMIDAZOL CON UN COMPUESTO DE FORMULA I, DONDE X ES HALOGENO, SULFONATO, NO2; Y ES NH2, NO2, HALOGENO, CN EN PRESENCIA DE UNA BASE ADECUADA SELECCIONADA ENTRE ALCOXIDO DE POTASIO, ALCOXIDO DE SODIO, HIDRURO DE POTASIO, CARBONATO DE LITIO, CESIO, ENTRE OTROS. SE CONDUCE A UNA TEMPERATURA DE 70 A 130 C; B) REDUCIR EL 4-METIL-1-(3-NITRO-5-TRIFLUORO-METIL-FENIL)-1H-IMIDAZOL CON UN CATALIZADOR DE METAL DE TRANSICION SELECCIONADO ENTRE Pd(OAC)2, TETRAQUIS-EN UN SOLVENTE POLAR ADECUADO TAL COMO ETANOL. DICHO COMPUESTO ES INTERMEDIARIO CLAVE PARA LA PREPARACION DE PIRIMIDINIL-AMINO-BENZAMIDAS SUSTITUIDAS
PE2006000628A 2005-06-09 2006-06-07 Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina PE20070109A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68897605P 2005-06-09 2005-06-09

Publications (1)

Publication Number Publication Date
PE20070109A1 true PE20070109A1 (es) 2007-04-02

Family

ID=37149980

Family Applications (3)

Application Number Title Priority Date Filing Date
PE2010000467A PE20100715A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina
PE2010000468A PE20100716A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno
PE2006000628A PE20070109A1 (es) 2005-06-09 2006-06-07 Procesos para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PE2010000467A PE20100715A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de 5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)-bencenamina
PE2010000468A PE20100716A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de 1-bromo-3-nitro-5-trifluorometil-benceno

Country Status (25)

Country Link
US (2) US7781597B2 (es)
EP (3) EP1896426B1 (es)
JP (2) JP5225078B2 (es)
KR (2) KR101283109B1 (es)
CN (6) CN102180796A (es)
AR (1) AR057056A1 (es)
AT (1) ATE540931T1 (es)
AU (3) AU2006258050B2 (es)
BR (1) BRPI0611683A2 (es)
CA (4) CA2833394C (es)
DK (2) DK2292607T3 (es)
ES (3) ES2380489T3 (es)
GT (1) GT200600202AA (es)
HU (1) HUE028024T2 (es)
IN (2) IN2014DN08588A (es)
JO (1) JO2758B1 (es)
MX (1) MX2007015609A (es)
MY (1) MY146795A (es)
PE (3) PE20100715A1 (es)
PL (3) PL2292607T3 (es)
PT (3) PT2266961E (es)
RU (1) RU2446162C2 (es)
SI (2) SI2266961T1 (es)
TW (1) TWI380981B (es)
WO (1) WO2006135640A2 (es)

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MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
TWI412322B (zh) 2005-12-30 2013-10-21 Du Pont 控制無脊椎害蟲之異唑啉
MX2009013469A (es) 2007-06-13 2010-01-20 Du Pont Insecticidas de isoxazolina.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
EP2957284B1 (en) 2007-06-27 2018-01-17 E. I. du Pont de Nemours and Company Animal pest control method
TWI600639B (zh) 2007-08-17 2017-10-01 杜邦股份有限公司 製備５-鹵烷基-４，５-二氫異唑衍生物之化合物
WO2009045999A1 (en) 2007-10-03 2009-04-09 E. I. Du Pont De Nemours And Company Naphthalene isoxazoline compounds for control of invertebrate pests
TWI518076B (zh) 2008-04-09 2016-01-21 杜邦股份有限公司 製備雜環化合物之方法
WO2010009402A2 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
PL2262793T3 (pl) 2008-11-05 2013-01-31 Teva Pharma Formy krystaliczne nilotynibu HCL
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) * 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
MD4363C1 (ro) 2010-05-27 2016-03-31 E.I. Du Pont De Nemours And Company Forma cristalină a 4-[5-[3-cloro-5-(trifluorometil)fenil]-4,5-dihidro-5-(trifluorometil)-3-izoxazolil]-N-[2-oxo-2-[(2,2,2-trifluoroetil)amino]etil]-1-naftalencarboxamidei şi utilizările sale
EP3617213A1 (en) 2011-12-30 2020-03-04 Hanmi Pharm. Co., Ltd. Thieno[3,2-d]pyrimidine derivatives having inhibitory activity for protein kinases
CN102592837B (zh) * 2012-03-12 2014-01-15 河北师范大学 制备超级电容器用四氯合金属季铵盐掺杂聚苯胺电极的方法
CN103694176B (zh) * 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
CN104592122B (zh) * 2014-12-09 2018-01-23 凯莱英医药集团（天津）股份有限公司 3‑(4‑甲基‑1h‑咪唑‑1‑基)‑5‑(三氟甲基)苯胺的制备方法
CN105985293B (zh) * 2015-03-04 2018-04-03 埃斯特维华义制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN107201532B (zh) * 2017-05-09 2019-08-27 吉林凯莱英医药化学有限公司 芳香化合物的硝化方法
WO2019130254A1 (en) * 2018-01-01 2019-07-04 Laurus Labs Ltd An improved process for 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl) aniline
CN108530364B (zh) 2018-04-10 2020-01-21 江苏创诺制药有限公司 一种3-(4-甲基-1h-咪唑-1-基)-5-三氟甲基苯胺单盐酸盐的晶型及其应用
CN113292537B (zh) 2018-06-15 2024-04-05 汉达癌症医药责任有限公司 激酶抑制剂的盐类及其组合物
EP3953336A4 (en) * 2019-04-06 2023-05-03 Trinapco, Inc SULFONYLDIAZOLES AND N-(FLUOROSULFONYL)AZOLES, AND METHODS FOR THE PREPARATION THEREOF
EP3904342A1 (en) 2020-04-28 2021-11-03 Grindeks, A Joint Stock Company Process for the preparation of 3-(trifluoromethyl)-5-(4-methyl-1h-imidazole-1-yl)-benzeneamine hydrochloride
CN114853734A (zh) * 2022-06-14 2022-08-05 海南鑫开源医药科技有限公司 一种尼洛替尼游离碱的制备方法
CN115626880B (zh) * 2022-11-15 2023-11-14 常州大学 3-硝基-5-氰基三氟甲苯的合成方法

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GB0023383D0 (en) * 2000-09-23 2000-11-08 Synprotec Ltd 3,5-Bis (Trifluormethyl)Benzene derivatives
TW200406374A (en) * 2002-05-29 2004-05-01 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0222514D0 (en) * 2002-09-27 2002-11-06 Novartis Ag Organic compounds
CN1939910A (zh) * 2004-12-31 2007-04-04 孙飘扬 氨基嘧啶类化合物及其盐和其制备方法与药物用途
GT200600207A (es) * 2005-06-09 2007-01-15 Novartis Ag Proceso para la síntesis de compuestos orgánicos
MY146795A (en) * 2005-06-09 2012-09-28 Novartis Ag Process for the synthesis of organic compounds

Also Published As

Publication number Publication date
CN102174019B (zh) 2013-02-13
CN101189212B (zh) 2011-05-18
TWI380981B (zh) 2013-01-01
US20100280257A1 (en) 2010-11-04
ES2380489T3 (es) 2012-05-14
HUE028024T2 (en) 2016-11-28
IN2014DN08578A (es) 2015-07-10
PE20100715A1 (es) 2010-10-25
CN102174020A (zh) 2011-09-07
JP5225078B2 (ja) 2013-07-03
EP2292607A3 (en) 2011-04-27
EP2266961A2 (en) 2010-12-29
ES2558696T3 (es) 2016-02-08
WO2006135640A2 (en) 2006-12-21
PT1896426E (pt) 2012-04-12
CN102174019A (zh) 2011-09-07
CA2833394C (en) 2016-03-29
AU2006258050A1 (en) 2006-12-21
US20080200692A1 (en) 2008-08-21
PL2292607T3 (pl) 2014-09-30
CN101189212A (zh) 2008-05-28
CN102174020B (zh) 2012-11-07
KR20080014010A (ko) 2008-02-13
CA2611280C (en) 2014-01-28
JP2013035855A (ja) 2013-02-21
AR057056A1 (es) 2007-11-14
CA2886482C (en) 2017-09-05
SI2266961T1 (sl) 2016-02-29
RU2446162C2 (ru) 2012-03-27
IN2014DN08588A (es) 2015-07-10
CN102180796A (zh) 2011-09-14
CN102174021B (zh) 2013-02-27
BRPI0611683A2 (pt) 2010-09-28
DK2266961T3 (en) 2016-01-25
KR101283109B1 (ko) 2013-07-05
CA2942046A1 (en) 2006-12-21
EP2292607A2 (en) 2011-03-09
US8008504B2 (en) 2011-08-30
WO2006135640A3 (en) 2007-08-02
DK2292607T3 (da) 2014-06-30
PT2266961E (pt) 2016-02-05
AU2011201044A1 (en) 2011-03-31
KR20120099028A (ko) 2012-09-06
TW200716563A (en) 2007-05-01
CA2611280A1 (en) 2006-12-21
RU2007148238A (ru) 2009-07-20
AU2010241374A1 (en) 2010-12-02
PE20100716A1 (es) 2010-10-25
JP2008546645A (ja) 2008-12-25
CN102180836A (zh) 2011-09-14
JO2758B1 (en) 2014-03-15
EP1896426A2 (en) 2008-03-12
EP2292607B1 (en) 2014-04-09
SI2292607T1 (sl) 2014-09-30
US7781597B2 (en) 2010-08-24
EP1896426B1 (en) 2012-01-11
AU2006258050B2 (en) 2010-12-09
CN102180836B (zh) 2012-11-21
PL2266961T3 (pl) 2016-04-29
EP2266961B1 (en) 2015-10-21
PL1896426T3 (pl) 2012-06-29
CA2833394A1 (en) 2006-12-21
EP2266961A3 (en) 2011-07-27
MY146795A (en) 2012-09-28
PT2292607E (pt) 2014-06-24
ES2380489T8 (es) 2012-06-22
MX2007015609A (es) 2008-02-25
CA2886482A1 (en) 2006-12-21
AU2010241374B2 (en) 2011-11-03
CN102174021A (zh) 2011-09-07
ES2465522T3 (es) 2014-06-06
GT200600202AA (es) 2014-06-09
KR101249199B1 (ko) 2013-04-03
ATE540931T1 (de) 2012-01-15

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