CY1110520T1 - Παραγωγα 5-υποκατεστημενης κινολινης και ισοκινολινης· μεθοδος για την παραγωγη τους και η χρηση τους ως αντιφλεγμονωδη - Google Patents

Παραγωγα 5-υποκατεστημενης κινολινης και ισοκινολινης· μεθοδος για την παραγωγη τους και η χρηση τους ως αντιφλεγμονωδη

Info

Publication number
CY1110520T1
CY1110520T1 CY20091101074T CY091101074T CY1110520T1 CY 1110520 T1 CY1110520 T1 CY 1110520T1 CY 20091101074 T CY20091101074 T CY 20091101074T CY 091101074 T CY091101074 T CY 091101074T CY 1110520 T1 CY1110520 T1 CY 1110520T1
Authority
CY
Cyprus
Prior art keywords
isokinoline
inflammatory
derivatives
production
substituted quinoline
Prior art date
Application number
CY20091101074T
Other languages
English (en)
Inventor
Stefan Jaroch
Hartmut Rehwinkel
Heike Schäcke
Norbert Schmees
Werner SKUBALA
Matthias Schneider
Jan Hübner
Orlin Petrov
Christian Dinter
Original Assignee
Bayer Schering Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102005020331A external-priority patent/DE102005020331A1/de
Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft
Publication of CY1110520T1 publication Critical patent/CY1110520T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η εφεύρεση αναφέρεται σε ενώσεις τω γενικών τύπων (ΙΙa) ή (IIb) και στη χρήση αυτών ως φάρμακα.
CY20091101074T 2004-11-12 2009-10-15 Παραγωγα 5-υποκατεστημενης κινολινης και ισοκινολινης· μεθοδος για την παραγωγη τους και η χρηση τους ως αντιφλεγμονωδη CY1110520T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004055633A DE102004055633A1 (de) 2004-11-12 2004-11-12 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005020331A DE102005020331A1 (de) 2005-04-26 2005-04-26 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
EP05808294A EP1844039B1 (de) 2004-11-12 2005-11-11 5-substituierte chinolin- und isochinolin-derivate; ein verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer

Publications (1)

Publication Number Publication Date
CY1110520T1 true CY1110520T1 (el) 2015-04-29

Family

ID=35613753

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101074T CY1110520T1 (el) 2004-11-12 2009-10-15 Παραγωγα 5-υποκατεστημενης κινολινης και ισοκινολινης· μεθοδος για την παραγωγη τους και η χρηση τους ως αντιφλεγμονωδη

Country Status (31)

Country Link
EP (1) EP1844039B1 (el)
JP (1) JP4460608B2 (el)
KR (1) KR101168462B1 (el)
CN (1) CN101124220B (el)
AR (1) AR051767A1 (el)
AU (1) AU2005303926B2 (el)
BR (1) BRPI0517797A (el)
CA (1) CA2586689C (el)
CY (1) CY1110520T1 (el)
DE (2) DE102004055633A1 (el)
DK (1) DK1844039T3 (el)
EA (1) EA013076B1 (el)
ES (1) ES2329599T3 (el)
GT (1) GT200500330A (el)
HK (1) HK1112243A1 (el)
HR (1) HRP20090509T1 (el)
IL (1) IL182933A (el)
ME (2) ME00155B (el)
MX (1) MX2007005736A (el)
MY (1) MY141780A (el)
NO (1) NO332405B1 (el)
NZ (1) NZ555064A (el)
PA (1) PA8652701A1 (el)
PE (1) PE20061052A1 (el)
PL (1) PL1844039T3 (el)
PT (1) PT1844039E (el)
RS (2) RS20070205A (el)
SI (1) SI1844039T1 (el)
TW (1) TWI311559B (el)
UY (1) UY29213A1 (el)
WO (1) WO2006050998A1 (el)

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US7297700B2 (en) 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
BRPI0714155A2 (pt) * 2006-07-07 2012-12-25 Bausch & Lomb composiÇço, e, uso de um agonista do receptor de glucocorticàide dissociado (digra), uma prà-droga do mesmo, ou um sal farmaceuticamente aceitÁvel do mesmo
JP2010500363A (ja) * 2006-08-07 2010-01-07 ボーシュ アンド ローム インコーポレイティド 感染症とその後遺症を治療、または制御、または軽減、または改善するための組成物と方法
DK2051710T3 (da) * 2006-08-07 2012-02-20 Bausch & Lomb Sammensætninger og fremgangsmåder til behandling, reducering, forbedring eller lindring af sygdomme i det bageste øjensegment
PL2056799T3 (pl) * 2006-08-31 2014-01-31 Bausch & Lomb Kompozycje i sposoby do leczenia lub zapobiegania jaskrze lub jej rozwojowi
US20110104159A1 (en) * 2006-09-11 2011-05-05 Rohrs Brian R Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy
US20110105559A1 (en) * 2006-09-11 2011-05-05 Rohrs Brian R Compositions and Methods for Treating, Controlling, Reducing, Ameliorating, or Preventing Allergy
PT2061444E (pt) 2006-09-11 2011-07-08 Bausch & Lomb Composições e métodos de tratamento, controlo, redução, melhoramento ou prevenção de alergias
MX2009004904A (es) * 2006-11-09 2009-05-19 Bausch & Lomb Sintesis de estereoisomeros seleccionados de ciertos alcoholes sustituidos.
EP1982976A1 (en) * 2007-04-18 2008-10-22 Intendis GmbH Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof
US8071796B2 (en) * 2007-04-18 2011-12-06 Intendis Gmbh Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof
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US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
US20090087443A1 (en) * 2007-09-27 2009-04-02 Bartels Stephen P Pharmacological Adjunctive Treatment Associated with Glaucoma Filtration Surgery
US20090118262A1 (en) * 2007-11-01 2009-05-07 Rohrs Brian R Non-Aqueous Water-Miscible Materials as Vehicles for Drug Delivery
US20110077270A1 (en) * 2009-04-21 2011-03-31 Pfeffer Bruce A Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure
CN101983961B (zh) * 2010-11-24 2012-05-09 浙江启明生化科技有限公司 5-氨基-2-甲基喹啉的制备方法
US20120316199A1 (en) 2011-06-07 2012-12-13 Ward Keith W Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain
WO2017137375A1 (en) 2016-02-12 2017-08-17 Bayer Animal Health Gmbh Mapracorat for use in the treatment of canine dermatitis
CN111732493B (zh) * 2017-01-16 2023-01-24 宜昌尚诺德生物医药科技有限公司 一种芳胺化合物的合成工艺
CN113382730A (zh) 2019-01-22 2021-09-10 阿克里斯生物医药有限公司 用于治疗受损的皮肤伤口愈合的选择性糖皮质激素受体修饰剂

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Also Published As

Publication number Publication date
UY29213A1 (es) 2006-05-31
NO20072963L (no) 2007-08-03
JP4460608B2 (ja) 2010-05-12
HRP20090509T1 (hr) 2009-11-30
MY141780A (en) 2010-06-30
PE20061052A1 (es) 2006-11-08
SI1844039T1 (sl) 2009-12-31
CN101124220A (zh) 2008-02-13
EA200700982A1 (ru) 2007-10-26
PL1844039T3 (pl) 2009-12-31
GT200500330A (es) 2006-09-21
IL182933A (en) 2011-10-31
MX2007005736A (es) 2007-09-07
EP1844039A1 (de) 2007-10-17
DE502005007725D1 (de) 2009-08-27
RS51161B (sr) 2010-10-31
DK1844039T3 (da) 2009-11-09
IL182933A0 (en) 2007-09-20
MEP13608A (en) 2010-06-10
ES2329599T3 (es) 2009-11-27
DE102004055633A1 (de) 2006-05-18
KR101168462B1 (ko) 2012-07-27
EP1844039B1 (de) 2009-07-15
WO2006050998A1 (de) 2006-05-18
JP2008519803A (ja) 2008-06-12
AU2005303926B2 (en) 2011-05-19
EA013076B1 (ru) 2010-02-26
AU2005303926A1 (en) 2006-05-18
TW200640913A (en) 2006-12-01
ME00155B (me) 2010-10-10
TWI311559B (en) 2009-07-01
PT1844039E (pt) 2009-10-19
HK1112243A1 (en) 2008-08-29
AR051767A1 (es) 2007-02-07
BRPI0517797A (pt) 2008-10-21
RS20070205A (en) 2008-11-28
CA2586689C (en) 2012-04-17
CN101124220B (zh) 2012-04-25
CA2586689A1 (en) 2006-05-18
NZ555064A (en) 2009-09-25
KR20070084192A (ko) 2007-08-24
PA8652701A1 (es) 2006-07-03
NO332405B1 (no) 2012-09-10

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