MX2009004904A - Sintesis de estereoisomeros seleccionados de ciertos alcoholes sustituidos. - Google Patents

Sintesis de estereoisomeros seleccionados de ciertos alcoholes sustituidos.

Info

Publication number
MX2009004904A
MX2009004904A MX2009004904A MX2009004904A MX2009004904A MX 2009004904 A MX2009004904 A MX 2009004904A MX 2009004904 A MX2009004904 A MX 2009004904A MX 2009004904 A MX2009004904 A MX 2009004904A MX 2009004904 A MX2009004904 A MX 2009004904A
Authority
MX
Mexico
Prior art keywords
synthesis
certain substituted
substituted alcohols
selected stereoisomers
stereoisomers
Prior art date
Application number
MX2009004904A
Other languages
English (en)
Inventor
Arthur E Harms
Original Assignee
Bausch & Lomb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bausch & Lomb filed Critical Bausch & Lomb
Publication of MX2009004904A publication Critical patent/MX2009004904A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Proceso para producir un estereoisómero seleccionado de un alcohol sustituido comprende hacer reaccionar un epóxido estereoisómerico con una amina, un ácido carboxílico, una amida, un sulfonilo o un cianuro. El proceso evita la producción de una mezcla racémica de estereoisómeros de la técnica anterior. Este alcohol sustituido estereoisomérico puede usarse como terapia anti-inflamatoria.
MX2009004904A 2006-11-09 2007-10-17 Sintesis de estereoisomeros seleccionados de ciertos alcoholes sustituidos. MX2009004904A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85802806P 2006-11-09 2006-11-09
PCT/US2007/081632 WO2008060799A2 (en) 2006-11-09 2007-10-17 Synthesis of selected stereoisomers of certain substituted alcohols

Publications (1)

Publication Number Publication Date
MX2009004904A true MX2009004904A (es) 2009-05-19

Family

ID=39301156

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004904A MX2009004904A (es) 2006-11-09 2007-10-17 Sintesis de estereoisomeros seleccionados de ciertos alcoholes sustituidos.

Country Status (11)

Country Link
US (2) US20080114172A1 (es)
EP (1) EP2086921A2 (es)
JP (1) JP2010509347A (es)
KR (1) KR20090077946A (es)
CN (1) CN101535239A (es)
AU (1) AU2007319590A1 (es)
BR (1) BRPI0718559A2 (es)
CA (1) CA2666685A1 (es)
MX (1) MX2009004904A (es)
TW (1) TW200827353A (es)
WO (1) WO2008060799A2 (es)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3673091A (en) * 1970-07-16 1972-06-27 Shell Oil Co Lubricants containing oxidation inhibitors
US6002004A (en) * 1995-03-28 1999-12-14 Witco Vinyl Additives Gmbh Pyrrolodiazine derivatives as stabilizers for chilorine-containing polymers
EE9800172A (et) * 1995-12-06 1998-12-15 Astra Pharmaceuticals Limited Ühendid
HUP0103403A3 (en) * 1998-03-31 2002-12-28 Procter & Gamble C11 oxymyl and hydroxylamino prostaglandins useful as fp agonists
DE10215316C1 (de) * 2002-04-02 2003-12-18 Schering Ag Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
US6897224B2 (en) * 2002-04-02 2005-05-24 Schering Ag Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors
CA2531060A1 (en) * 2003-07-01 2005-01-13 Schering Aktiengesellschaft Heterocyclically-substitued pentanol derivatives, process for their production and their use as anti-inflammatory agents
WO2005100335A1 (en) * 2004-03-30 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Stereoselective synthesis of certain trifluoromethyl-substituted oxiranes
US7417056B2 (en) * 2004-11-12 2008-08-26 Schering Ag 5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents
DE102004055633A1 (de) * 2004-11-12 2006-05-18 Schering Ag 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005020331A1 (de) * 2005-04-26 2006-11-02 Schering Ag 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
ES2414479T3 (es) * 2005-04-14 2013-07-19 Glaxo Group Limited Indazoles como ligandos del receptor de glucocorticoides
GB0513297D0 (en) * 2005-06-29 2005-08-03 Glaxo Group Ltd Novel compounds
GB0522880D0 (en) * 2005-11-09 2005-12-21 Glaxo Group Ltd Novel compounds

Also Published As

Publication number Publication date
US20110137038A1 (en) 2011-06-09
WO2008060799A3 (en) 2008-12-31
CN101535239A (zh) 2009-09-16
EP2086921A2 (en) 2009-08-12
TW200827353A (en) 2008-07-01
AU2007319590A1 (en) 2008-05-22
BRPI0718559A2 (pt) 2013-11-19
KR20090077946A (ko) 2009-07-16
US20080114172A1 (en) 2008-05-15
JP2010509347A (ja) 2010-03-25
CA2666685A1 (en) 2008-05-22
WO2008060799A2 (en) 2008-05-22

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal