MX2010001229A - Procedimiento para la resolucion de zopiclona y compuestos intermedios. - Google Patents
Procedimiento para la resolucion de zopiclona y compuestos intermedios.Info
- Publication number
- MX2010001229A MX2010001229A MX2010001229A MX2010001229A MX2010001229A MX 2010001229 A MX2010001229 A MX 2010001229A MX 2010001229 A MX2010001229 A MX 2010001229A MX 2010001229 A MX2010001229 A MX 2010001229A MX 2010001229 A MX2010001229 A MX 2010001229A
- Authority
- MX
- Mexico
- Prior art keywords
- resolution
- formula
- zopiclone
- intermediate compounds
- enantiomers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
La presente invención se refiere a un procedimiento para la resolución en uno de sus enantiómeros del racemato del compuesto de la fórmula (I): (ver fórmula (I), que comprende separar dicho uno de sus enantiómeros de una sal diastereoisomérica de fórmula (II), que se forma mediante la reacción de la mezcla racémica con un aminoácido acetilado ópticamente activo de fórmula (III). La invención también se refiere a nuevos productos intermediados que son útiles para llevar a cabo el procedimiento de la invención.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07380226A EP2020403A1 (en) | 2007-08-02 | 2007-08-02 | Process for the resolution of zopiclone and intermediate compounds |
PCT/EP2008/060115 WO2009016251A1 (en) | 2007-08-02 | 2008-08-01 | Process for the resolution of zopiclone and intermediate compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010001229A true MX2010001229A (es) | 2010-03-04 |
Family
ID=38871700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010001229A MX2010001229A (es) | 2007-08-02 | 2008-08-01 | Procedimiento para la resolucion de zopiclona y compuestos intermedios. |
Country Status (17)
Country | Link |
---|---|
US (2) | US7772396B2 (es) |
EP (2) | EP2020403A1 (es) |
JP (1) | JP2010535177A (es) |
KR (1) | KR20100044241A (es) |
CN (1) | CN101772475B (es) |
AT (1) | ATE551312T1 (es) |
AU (1) | AU2008281717A1 (es) |
CA (1) | CA2695254A1 (es) |
ES (1) | ES2385120T3 (es) |
HR (1) | HRP20120306T1 (es) |
IL (1) | IL203557A (es) |
MX (1) | MX2010001229A (es) |
NZ (1) | NZ583097A (es) |
PL (1) | PL2183201T3 (es) |
RU (1) | RU2010107453A (es) |
SI (1) | SI2183201T1 (es) |
WO (1) | WO2009016251A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7476737B2 (en) * | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
PL2123650T3 (pl) * | 2005-12-19 | 2012-09-28 | Sicor Inc | Nowa postać bromku tiotropium i sposób jej wytwarzania |
CN101607961B (zh) | 2008-06-18 | 2011-08-10 | 天津天士力集团有限公司 | 一种右佐匹克隆结晶及其组合物 |
EP2345654A1 (en) * | 2010-01-05 | 2011-07-20 | LEK Pharmaceuticals d.d. | Eszopiclone particles and a process for their preparation |
CN103193779B (zh) * | 2012-01-05 | 2016-04-20 | 成都弘达药业有限公司 | 一种右佐匹克隆的制备方法 |
JP6225998B2 (ja) * | 2014-02-06 | 2017-11-08 | 宇部興産株式会社 | インドリン化合物の製造方法 |
DE102020205560B4 (de) | 2020-04-30 | 2022-05-25 | Zettl Interieur Gmbh | Flexible atemschutzmaske und deren verwendung |
CN113214267B (zh) * | 2021-05-08 | 2022-06-28 | 上海中西三维药业有限公司 | 一种制备纯净且光学富集的右佐匹克隆精制方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
OA04285A (fr) | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. |
FR2671800B1 (fr) | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
ES2203319B1 (es) | 2002-04-03 | 2005-03-01 | Universidad De Oviedo | Nuevos carbonatos opticamente activos como intermedios en la sintesis de (+)-zopiclona. |
PT1691811E (pt) | 2003-12-11 | 2014-10-30 | Sunovion Pharmaceuticals Inc | Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão |
EP1742624B1 (en) | 2004-02-18 | 2010-01-06 | Sepracor, Inc. | Dopamine-agonist combination therapy with sedatives for improving sleep quality |
CA2677470A1 (en) | 2004-04-05 | 2005-10-20 | Sepracor Inc. | Methods of treatment using eszopiclone |
AU2006260686A1 (en) | 2005-06-21 | 2006-12-28 | Generics [Uk] Limited | Process for enantiomeric separation of zopiclone |
US7476737B2 (en) | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
CA2637542A1 (en) | 2006-01-17 | 2007-07-26 | Glenmark Pharmaceuticals Limited | Improved process for the preparation of an optically active 5h-pyrrolo [3,4-b] pyrazine derivative |
EP1984371A1 (en) | 2006-02-03 | 2008-10-29 | Synthon B.V. | Zopiclone resolution using l-tartaric acid |
US20080027223A1 (en) | 2006-03-23 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Polymorphs of eszopiclone malate |
EP2007768A2 (en) | 2006-04-20 | 2008-12-31 | Teva Pharmaceutical Industries Ltd | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
-
2007
- 2007-08-02 EP EP07380226A patent/EP2020403A1/en not_active Withdrawn
- 2007-10-03 US US11/866,584 patent/US7772396B2/en not_active Expired - Fee Related
-
2008
- 2008-08-01 MX MX2010001229A patent/MX2010001229A/es active IP Right Grant
- 2008-08-01 WO PCT/EP2008/060115 patent/WO2009016251A1/en active Application Filing
- 2008-08-01 CA CA2695254A patent/CA2695254A1/en not_active Abandoned
- 2008-08-01 KR KR1020107004730A patent/KR20100044241A/ko not_active Application Discontinuation
- 2008-08-01 NZ NZ583097A patent/NZ583097A/en not_active IP Right Cessation
- 2008-08-01 AU AU2008281717A patent/AU2008281717A1/en not_active Abandoned
- 2008-08-01 JP JP2010518689A patent/JP2010535177A/ja not_active Withdrawn
- 2008-08-01 PL PL08786735T patent/PL2183201T3/pl unknown
- 2008-08-01 CN CN200880101463XA patent/CN101772475B/zh not_active Expired - Fee Related
- 2008-08-01 AT AT08786735T patent/ATE551312T1/de active
- 2008-08-01 EP EP08786735A patent/EP2183201B1/en active Active
- 2008-08-01 SI SI200830601T patent/SI2183201T1/sl unknown
- 2008-08-01 RU RU2010107453/04A patent/RU2010107453A/ru not_active Application Discontinuation
- 2008-08-01 ES ES08786735T patent/ES2385120T3/es active Active
-
2010
- 2010-01-27 IL IL203557A patent/IL203557A/en not_active IP Right Cessation
- 2010-07-02 US US12/830,147 patent/US7968712B2/en not_active Expired - Fee Related
-
2012
- 2012-04-10 HR HR20120306T patent/HRP20120306T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
RU2010107453A (ru) | 2011-09-10 |
US7772396B2 (en) | 2010-08-10 |
CA2695254A1 (en) | 2009-02-05 |
CN101772475B (zh) | 2013-11-06 |
JP2010535177A (ja) | 2010-11-18 |
AU2008281717A1 (en) | 2009-02-05 |
CN101772475A (zh) | 2010-07-07 |
KR20100044241A (ko) | 2010-04-29 |
EP2183201B1 (en) | 2012-03-28 |
US20090036681A1 (en) | 2009-02-05 |
WO2009016251A1 (en) | 2009-02-05 |
HRP20120306T1 (hr) | 2012-04-30 |
NZ583097A (en) | 2011-03-31 |
US20100274018A1 (en) | 2010-10-28 |
SI2183201T1 (sl) | 2012-05-31 |
ATE551312T1 (de) | 2012-04-15 |
US7968712B2 (en) | 2011-06-28 |
IL203557A (en) | 2014-11-30 |
EP2020403A1 (en) | 2009-02-04 |
ES2385120T3 (es) | 2012-07-18 |
EP2183201A1 (en) | 2010-05-12 |
PL2183201T3 (pl) | 2012-09-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |