AR015899A1 - Derivado de insulina o sales compatibles de los mismos, procedimiento para su preparacion, secuencias de adn, vector de expresion, celula hospedante incapaz de conducir a la regeneracion de un animal o planta, composicion farmaceutica, solucion inyectable con actividad de insulina y utilizacion de d - Google Patents

Derivado de insulina o sales compatibles de los mismos, procedimiento para su preparacion, secuencias de adn, vector de expresion, celula hospedante incapaz de conducir a la regeneracion de un animal o planta, composicion farmaceutica, solucion inyectable con actividad de insulina y utilizacion de d

Info

Publication number
AR015899A1
AR015899A1 ARP980102911A ARP980102911A AR015899A1 AR 015899 A1 AR015899 A1 AR 015899A1 AR P980102911 A ARP980102911 A AR P980102911A AR P980102911 A ARP980102911 A AR P980102911A AR 015899 A1 AR015899 A1 AR 015899A1
Authority
AR
Argentina
Prior art keywords
injectable
insulin
chain
procedure
preparation
Prior art date
Application number
ARP980102911A
Other languages
English (en)
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7833099&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR015899(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of AR015899A1 publication Critical patent/AR015899A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Derivados de insulina que presentan una iniciacion del efecto que haya sido acelerada en comparacion con la insulina humana, a un procedimiento parasu preparacion y a su utilizacion especialmente en preparados farmacéuticos para el tratamiento de diabetes mellitus. En particular, el presente inventoconcierne a derivados de insulina o sales fisiologicamente compatibles de los mismos, en los cuales la asparagina (Asn) en posicion B3 de la cadena Bha sido cambiada por un resto de aminoácido básicoque aparece en la naturaleza y por lo menos un resto de aminoácido en las posiciones B27, B28 o B29 de lacadena B ha sido cambiada por otro resto de aminoácido que aparece en la naturaleza, pudiendo facultativamente ser cambiada la asparagina (Asn) en laposicion 21 de la cadena A por Asp, Gly, Ser, Thr o Ala, y faltar la fenilalanina (Phe) en la posicion B1 de la cadena B y el resto de aminoácido situadoen la posicion B30 de la cadena B.
ARP980102911A 1997-06-20 1998-06-18 Derivado de insulina o sales compatibles de los mismos, procedimiento para su preparacion, secuencias de adn, vector de expresion, celula hospedante incapaz de conducir a la regeneracion de un animal o planta, composicion farmaceutica, solucion inyectable con actividad de insulina y utilizacion de d AR015899A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19726167A DE19726167B4 (de) 1997-06-20 1997-06-20 Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung

Publications (1)

Publication Number Publication Date
AR015899A1 true AR015899A1 (es) 2001-05-30

Family

ID=7833099

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980102911A AR015899A1 (es) 1997-06-20 1998-06-18 Derivado de insulina o sales compatibles de los mismos, procedimiento para su preparacion, secuencias de adn, vector de expresion, celula hospedante incapaz de conducir a la regeneracion de un animal o planta, composicion farmaceutica, solucion inyectable con actividad de insulina y utilizacion de d

Country Status (32)

Country Link
US (1) US6221633B1 (es)
EP (1) EP0885961B1 (es)
JP (1) JP3676573B2 (es)
KR (1) KR100546225B1 (es)
CN (1) CN1195777C (es)
AR (1) AR015899A1 (es)
AT (1) ATE283919T1 (es)
AU (1) AU740344C (es)
BR (1) BRPI9803708B8 (es)
CA (1) CA2235443C (es)
CY (1) CY2005004I2 (es)
CZ (1) CZ295964B6 (es)
DE (3) DE19726167B4 (es)
DK (1) DK0885961T3 (es)
ES (1) ES2232900T3 (es)
FR (1) FR05C0009I2 (es)
HK (1) HK1016616A1 (es)
HU (1) HU221176B1 (es)
ID (1) ID20462A (es)
IL (1) IL125006A (es)
LU (1) LU91138I2 (es)
NL (1) NL300170I2 (es)
NO (2) NO321720B1 (es)
NZ (1) NZ330700A (es)
PL (1) PL196626B1 (es)
PT (1) PT885961E (es)
RU (1) RU2207874C9 (es)
SK (1) SK285267B6 (es)
TR (1) TR199801144A2 (es)
TW (1) TW562806B (es)
UA (1) UA65529C2 (es)
ZA (1) ZA985363B (es)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
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DE19726167A1 (de) 1999-01-28
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ZA985363B (en) 1999-01-19
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CA2235443A1 (en) 1998-12-20
CN1203238A (zh) 1998-12-30
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CN1195777C (zh) 2005-04-06
KR100546225B1 (ko) 2006-10-19
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JP3676573B2 (ja) 2005-07-27
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LU91138I2 (fr) 2005-04-04
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