DE69620393D1 - PHARMAZEUTISCHE NICHTINORGANISCHE SALZLÖSUNGEN FÜR ENDONASALE VERABREICHUNG EINEs CALCITONINs - Google Patents
PHARMAZEUTISCHE NICHTINORGANISCHE SALZLÖSUNGEN FÜR ENDONASALE VERABREICHUNG EINEs CALCITONINsInfo
- Publication number
- DE69620393D1 DE69620393D1 DE69620393T DE69620393T DE69620393D1 DE 69620393 D1 DE69620393 D1 DE 69620393D1 DE 69620393 T DE69620393 T DE 69620393T DE 69620393 T DE69620393 T DE 69620393T DE 69620393 D1 DE69620393 D1 DE 69620393D1
- Authority
- DE
- Germany
- Prior art keywords
- calcitonin
- inorganic salt
- salt solutions
- pharmaceutical non
- endonasal administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000055006 Calcitonin Human genes 0.000 title abstract 2
- 108060001064 Calcitonin Proteins 0.000 title abstract 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title abstract 2
- 229960004015 calcitonin Drugs 0.000 title abstract 2
- 229910017053 inorganic salt Inorganic materials 0.000 title 1
- 239000012266 salt solution Substances 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 241000972773 Aulopiformes Species 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 159000000021 acetate salts Chemical class 0.000 abstract 1
- 239000007857 degradation product Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008012 organic excipient Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000019515 salmon Nutrition 0.000 abstract 1
- 230000009291 secondary effect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 230000009967 tasteless effect Effects 0.000 abstract 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 1
- 229960000281 trometamol Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95101681A EP0726075A1 (de) | 1995-02-08 | 1995-02-08 | Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung |
| PCT/EP1996/000446 WO1996024370A1 (en) | 1995-02-08 | 1996-02-08 | Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69620393D1 true DE69620393D1 (de) | 2002-05-08 |
| DE69620393T2 DE69620393T2 (de) | 2003-01-16 |
Family
ID=8218965
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0726075T Pending DE726075T1 (de) | 1995-02-08 | 1995-02-08 | Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung |
| DE29622959U Expired - Lifetime DE29622959U1 (de) | 1995-02-08 | 1996-02-02 | Analoge des Lachs-Calcitonin |
| DE69607749T Expired - Fee Related DE69607749T2 (de) | 1995-02-08 | 1996-02-02 | Analoge des calcitonin aus lachs, ihre herstellung und ihre verwendung als medizin und als analytische reagentien |
| DE69620393T Expired - Lifetime DE69620393T2 (de) | 1995-02-08 | 1996-02-08 | PHARMAZEUTISCHE NICHTINORGANISCHE SALZLÖSUNGEN FÜR ENDONASALE VERABREICHUNG EINEs CALCITONINs |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0726075T Pending DE726075T1 (de) | 1995-02-08 | 1995-02-08 | Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung |
| DE29622959U Expired - Lifetime DE29622959U1 (de) | 1995-02-08 | 1996-02-02 | Analoge des Lachs-Calcitonin |
| DE69607749T Expired - Fee Related DE69607749T2 (de) | 1995-02-08 | 1996-02-02 | Analoge des calcitonin aus lachs, ihre herstellung und ihre verwendung als medizin und als analytische reagentien |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6087338A (de) |
| EP (3) | EP0726075A1 (de) |
| JP (2) | JPH11506416A (de) |
| KR (2) | KR100430101B1 (de) |
| AT (2) | ATE191719T1 (de) |
| AU (2) | AU4787996A (de) |
| BR (1) | BR9607410A (de) |
| CA (2) | CA2210664A1 (de) |
| DE (4) | DE726075T1 (de) |
| ES (2) | ES2146869T3 (de) |
| GB (1) | GB9523442D0 (de) |
| HU (1) | HUP9600266A3 (de) |
| PE (1) | PE28397A1 (de) |
| PL (1) | PL183398B1 (de) |
| PT (2) | PT809654E (de) |
| WO (2) | WO1996024618A1 (de) |
| ZA (2) | ZA96779B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0726075A1 (de) * | 1995-02-08 | 1996-08-14 | Therapicon Srl | Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung |
| US6034064A (en) * | 1995-04-07 | 2000-03-07 | Hoechst Pharmaceuticals & Chemicals K.K. | Peptides and therapeutic agent for autoimmune diseases containing the same |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
| IT1298780B1 (it) * | 1998-03-24 | 2000-02-02 | Therapicon Srl | Preparazioni parenterali a base di calcitonina |
| WO2001052937A1 (en) * | 2000-01-24 | 2001-07-26 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
| WO2001056594A1 (en) * | 2000-02-04 | 2001-08-09 | Unigene Laboratories, Inc. | Nasal calcitonin formulations |
| DE10024451A1 (de) * | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
| US6737401B2 (en) | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
| WO2003002139A1 (fr) * | 2001-06-29 | 2003-01-09 | Asahi Kasei Kabushiki Kaisha | Procede permettant d'ameliorer la stabilite de la preparation de proteines |
| ITMI20021684A1 (it) * | 2002-07-29 | 2004-01-29 | Therapicon Srl | Composizione farmaceutica di peptide nasale |
| US20090035260A1 (en) * | 2002-07-29 | 2009-02-05 | Therapicon Srl | Enhanced nasal composition of active peptide |
| US7812120B2 (en) | 2003-03-21 | 2010-10-12 | Par Pharmaceutical, Inc. | Nasal calcitonin formulations containing chlorobutanol |
| ITMI20040235A1 (it) * | 2004-02-13 | 2004-05-13 | Therapicon Srl | Preparazione farmaceutica per il cavo orale |
| GB0422644D0 (en) * | 2004-10-12 | 2004-11-10 | Novartis Ag | Organic compounds |
| EP1870458B1 (de) | 2005-03-31 | 2018-05-09 | Chugai Seiyaku Kabushiki Kaisha | sc(Fv)2-STRUKTURISOMERE |
| CN101262885B (zh) | 2005-06-10 | 2015-04-01 | 中外制药株式会社 | 含有sc(Fv)2的药物组合物 |
| WO2006132363A1 (ja) * | 2005-06-10 | 2006-12-14 | Chugai Seiyaku Kabushiki Kaisha | メグルミンを含有するタンパク質製剤の安定化剤、およびその利用 |
| CN100349611C (zh) * | 2005-11-25 | 2007-11-21 | 中国药科大学 | 鲑降钙素吸入粉雾剂及其制备方法 |
| CA2750035C (en) * | 2009-01-22 | 2018-02-27 | Unigene Laboratories Inc. | Treatment for obesity |
| US9533022B2 (en) | 2011-11-02 | 2017-01-03 | KeyBioscience A/S | Peptide analogs for treating diseases and disorders |
| KR102019911B1 (ko) | 2011-11-02 | 2019-09-09 | 키바이오사이언스 아게 | 질병 및 장애 치료용 펩타이드 유사체 |
| WO2024189611A1 (en) * | 2023-03-13 | 2024-09-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Stabilized analogues of calcitonin |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3926938A (en) * | 1974-08-12 | 1975-12-16 | Armour Pharma | Synthesis of salmon calcitonin |
| US4217268A (en) * | 1978-07-20 | 1980-08-12 | Hughes John L | Synthesis of peptides |
| CH657779A5 (de) * | 1982-10-05 | 1986-09-30 | Sandoz Ag | Galenische zusammensetzungen enthaltend calcitonin. |
| GB2127689B (en) * | 1982-10-05 | 1986-07-09 | Sandoz Ltd | Calcitonin inhalation compositions |
| JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
| US4659804A (en) * | 1984-11-01 | 1987-04-21 | Armour Pharmaceutical Company | (Bis-1,7-S-acetamidomethyl-L-cysteine)salmon calcitonin |
| JPS61267528A (ja) * | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | 吸収促進剤を含有するカルシトニン経鼻剤 |
| US4622386A (en) * | 1985-03-28 | 1986-11-11 | Armour Pharmaceutical Company | [1,7-di-alanine]calcitonin |
| US4639510A (en) * | 1985-10-04 | 1987-01-27 | Armour Pharmaceutical Company | (1-S-acetamidomethyl cysteine, 7-alanine)calcitonin |
| NL8602950A (nl) * | 1985-12-04 | 1987-07-01 | Sandoz Ag | Calcitonine-derivaten en werkwijzen voor het bereiden van deze derivaten en van farmaceutische preparaten die ze bevatten. |
| EP0298474B1 (de) * | 1987-07-08 | 1992-11-19 | Mitsubishi Petrochemical Co., Ltd. | Calcitonin-Derivate und deren Salze |
| US5059587A (en) * | 1987-08-03 | 1991-10-22 | Toyo Jozo Company, Ltd. | Physiologically active peptide composition for nasal administration |
| DE3887494T2 (de) * | 1987-11-13 | 1994-05-19 | Smithkline Beecham Farma | Ein Calcitonin sowie ein Glycyrrhizinat als Absorptionsförderer enthaltende Arzneimittel. |
| AU629552B2 (en) * | 1988-06-16 | 1992-10-08 | Teijin Limited | S-sulfonated calcitonin derivatives |
| JPH0694851B2 (ja) * | 1988-06-27 | 1994-11-24 | 株式会社日立製作所 | 蒸発燃料制御装置 |
| US5026825A (en) * | 1988-09-08 | 1991-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Intranasal calcitonin formulations |
| JPH02104531A (ja) * | 1988-10-14 | 1990-04-17 | Toyo Jozo Co Ltd | 経鼻投与用生理活性ペプチド組成物 |
| JPH0643339B2 (ja) * | 1990-05-25 | 1994-06-08 | 旭化成工業株式会社 | カルシトニン類水溶液組成物の安定化法 |
| IT1248725B (it) * | 1990-06-12 | 1995-01-26 | Sclavo Spa | Composizione farmaceutica in polvere per somministrazione per via nasale contenente essenzialmente calcitonina ed un eccipiente idrosolubile |
| JPH078806B2 (ja) * | 1990-08-16 | 1995-02-01 | 旭化成工業株式会社 | カルシトニン類含有経鼻投与用乳剤 |
| JP3179538B2 (ja) * | 1990-12-11 | 2001-06-25 | ノバルティス アクチエンゲゼルシャフト | 安定なヒトカルシトニンの水性溶液 |
| IT1244500B (it) * | 1991-03-21 | 1994-07-15 | Pulitzer Italiana | Impiego di sali minerali di trometamina in composizioni farmaceutiche a base di calcitonina somministrabili per via rettale in terapia umana |
| IT1251685B (it) * | 1991-10-11 | 1995-05-19 | Isf Spa | Composizioni farmaceutiche contenenti una calcitonina |
| US5571788A (en) * | 1991-12-09 | 1996-11-05 | Ciba-Geigy Corporation | Stable calcitonin pharmaceutical compositions |
| IT1255895B (it) * | 1992-10-20 | 1995-11-17 | Laura Chiodini | Composizioni farmaceutiche contenenti una calcitonina |
| EP0726075A1 (de) * | 1995-02-08 | 1996-08-14 | Therapicon Srl | Nicht-inorganische pharmazeutische salzige Lösungen zur endonasale Verabreichung |
-
1995
- 1995-02-08 EP EP95101681A patent/EP0726075A1/de not_active Withdrawn
- 1995-02-08 DE DE0726075T patent/DE726075T1/de active Pending
- 1995-11-15 GB GBGB9523442.3A patent/GB9523442D0/en active Pending
-
1996
- 1996-02-01 ZA ZA96779A patent/ZA96779B/xx unknown
- 1996-02-02 JP JP8523975A patent/JPH11506416A/ja not_active Ceased
- 1996-02-02 DE DE29622959U patent/DE29622959U1/de not_active Expired - Lifetime
- 1996-02-02 KR KR1019970705486A patent/KR100430101B1/ko not_active Expired - Fee Related
- 1996-02-02 CA CA002210664A patent/CA2210664A1/en not_active Abandoned
- 1996-02-02 ES ES96903997T patent/ES2146869T3/es not_active Expired - Lifetime
- 1996-02-02 DE DE69607749T patent/DE69607749T2/de not_active Expired - Fee Related
- 1996-02-02 PT PT96903997T patent/PT809654E/pt unknown
- 1996-02-02 AT AT96903997T patent/ATE191719T1/de not_active IP Right Cessation
- 1996-02-02 WO PCT/EP1996/000487 patent/WO1996024618A1/en not_active Ceased
- 1996-02-02 AU AU47879/96A patent/AU4787996A/en not_active Abandoned
- 1996-02-02 EP EP96903997A patent/EP0809654B1/de not_active Expired - Lifetime
- 1996-02-02 ZA ZA96835A patent/ZA96835B/xx unknown
- 1996-02-05 KR KR1019960002720A patent/KR100397034B1/ko not_active Expired - Fee Related
- 1996-02-07 JP JP02092496A patent/JP4123309B2/ja not_active Expired - Fee Related
- 1996-02-07 PL PL96312683A patent/PL183398B1/pl not_active IP Right Cessation
- 1996-02-07 HU HU9600266A patent/HUP9600266A3/hu unknown
- 1996-02-08 PE PE1996000091A patent/PE28397A1/es not_active Application Discontinuation
- 1996-02-08 ES ES96903969T patent/ES2173267T3/es not_active Expired - Lifetime
- 1996-02-08 BR BR9607410A patent/BR9607410A/pt not_active IP Right Cessation
- 1996-02-08 DE DE69620393T patent/DE69620393T2/de not_active Expired - Lifetime
- 1996-02-08 AT AT96903969T patent/ATE215381T1/de not_active IP Right Cessation
- 1996-02-08 PT PT96903969T patent/PT809512E/pt unknown
- 1996-02-08 WO PCT/EP1996/000446 patent/WO1996024370A1/en not_active Ceased
- 1996-02-08 EP EP96903969A patent/EP0809512B1/de not_active Expired - Lifetime
- 1996-02-08 AU AU47863/96A patent/AU4786396A/en not_active Abandoned
- 1996-02-08 CA CA002212520A patent/CA2212520A1/en not_active Abandoned
-
1997
- 1997-08-08 US US08/908,986 patent/US6087338A/en not_active Expired - Fee Related
- 1997-08-08 US US08/907,602 patent/US6107277A/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69620393D1 (de) | PHARMAZEUTISCHE NICHTINORGANISCHE SALZLÖSUNGEN FÜR ENDONASALE VERABREICHUNG EINEs CALCITONINs | |
| ES2526707T3 (es) | Purificación y estabilización de péptidos y proteínas en agentes farmacéuticos | |
| WO1996024370B1 (en) | Pharmaceutical non inorganic saline solutions for endonasal administration of a calcitonin | |
| FR2651677B1 (fr) | Composition pharmaceutique a base de salmeterol et du propionate de fluticasone. | |
| CA2288143A1 (en) | Activated protein c formulations | |
| ATE204467T1 (de) | Orale darreichungsform | |
| ES2062417T3 (es) | Composiciones farmaceuticas de cimetidina. | |
| KR930702022A (ko) | 인슐린의 경구 투여에 의한 타잎 1 당뇨병의 치료 또는 예방법 | |
| BR9106114A (pt) | Metodo para tratar ou prevenir uma doenca auto-imune (ad) e formulacao farmaceutica | |
| DK0725648T3 (da) | Leverspecifikke farmaceutiske aktivstoffer | |
| ATE217188T1 (de) | Granulierte pharmazeutische zusammensetzung | |
| PT90466A (pt) | Processo de preparacao de composicoes farmaceuticas compreendendo um excipiente extragranular, higroscopio insoluvel em agua e um ingrediente activo, em particular a cimetidina | |
| NO941276D0 (no) | Lipofile, oligosakkaride antibiotikasaltpreparater | |
| ATE92762T1 (de) | Medikamente. | |
| ATE12649T1 (de) | Optisch aktives dipeptide, seine pharmazeutisch vertraeglichen salze, verfahren zur herstellung und diese enthaltende pharmazeutische praeparate. | |
| BE893312A (fr) | Composition antibiotique pour l'administration de la phosphomycine sous forme de comprimes a dissolution lente | |
| AR002040A1 (es) | Soluciones farmacéuticas salinas no inorgánicas para administración endonasal conteniendo una calcitonina natural o modificada y excipientes orgánicos. | |
| CO5150206A1 (es) | Metodo para la prevencion o reduccion de episodios cardiovasculares asociados con intervenciones coronarias | |
| KR910005856A (ko) | 호흡기 질환 치료용 제약 조성물 | |
| TH43276A (de) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8320 | Willingness to grant licences declared (paragraph 23) |