ATE65397T1 - Pharmazeutische zusammensetzungen mit gehalt an einem derivat der 3-hydroxy-buttersaeure, ausgewaehlt aus den oligomeren dieser saeure und den estern dieser saeure oder dieser oligomere mit dem 1,3-butan-diol. - Google Patents
Pharmazeutische zusammensetzungen mit gehalt an einem derivat der 3-hydroxy-buttersaeure, ausgewaehlt aus den oligomeren dieser saeure und den estern dieser saeure oder dieser oligomere mit dem 1,3-butan-diol.Info
- Publication number
- ATE65397T1 ATE65397T1 AT88202492T AT88202492T ATE65397T1 AT E65397 T1 ATE65397 T1 AT E65397T1 AT 88202492 T AT88202492 T AT 88202492T AT 88202492 T AT88202492 T AT 88202492T AT E65397 T1 ATE65397 T1 AT E65397T1
- Authority
- AT
- Austria
- Prior art keywords
- acid
- oligomers
- butanediol
- esters
- derivative
- Prior art date
Links
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 4
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical class CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE8701314A BE1001209A3 (fr) | 1987-11-19 | 1987-11-19 | Compositions pharmaceutiques contenant un derive de l'acide 3-hydroxybutanoique choisi parmi les oligomeres de cet acide et les esters de cet acide ou de ces oligomeres avec du 1,3-butanediol. |
EP88202492A EP0316993B1 (de) | 1987-11-19 | 1988-11-08 | Pharmazeutische Zusammensetzungen mit Gehalt an einem Derivat der 3-Hydroxy-Buttersäure, ausgewählt aus den Oligomeren dieser Säure und den Estern dieser Säure oder dieser Oligomere mit dem 1,3-Butan-diol |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE65397T1 true ATE65397T1 (de) | 1991-08-15 |
Family
ID=3882973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88202492T ATE65397T1 (de) | 1987-11-19 | 1988-11-08 | Pharmazeutische zusammensetzungen mit gehalt an einem derivat der 3-hydroxy-buttersaeure, ausgewaehlt aus den oligomeren dieser saeure und den estern dieser saeure oder dieser oligomere mit dem 1,3-butan-diol. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5112865A (de) |
EP (1) | EP0316993B1 (de) |
JP (1) | JPH01160917A (de) |
AT (1) | ATE65397T1 (de) |
BE (1) | BE1001209A3 (de) |
CA (1) | CA1330307C (de) |
DE (1) | DE3863904D1 (de) |
DK (1) | DK168269B1 (de) |
ES (1) | ES2037818T3 (de) |
GR (1) | GR3002605T3 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5126373A (en) * | 1987-11-19 | 1992-06-30 | Henri Brunengraber | Composition for parenteral and oral nutrition |
US20090253781A1 (en) * | 2002-05-24 | 2009-10-08 | Btg International Limited | Therapeutic compositions |
US6323237B1 (en) * | 1997-03-17 | 2001-11-27 | Btg International Limited | Therapeutic compositions |
EP2283834B1 (de) * | 1997-03-17 | 2016-07-13 | BTG International Limited | Therapeutische Zusammensetzungen enthaltend Ketonkörper oder ihre Vorläufer |
US6164451A (en) * | 1998-03-16 | 2000-12-26 | Trish Mcevoy, Ltd. | Cosmetics case |
DE19830310A1 (de) * | 1998-07-07 | 2000-01-13 | Riedel De Haen Gmbh | Verfahren zur Abreicherung des Bromidgehaltes aus einer wäßrigen Bromid enthaltenden Lösung unter Verwendung von Wasserstoffperoxid |
EP1098655B1 (de) * | 1998-07-22 | 2004-11-24 | Metabolix, Inc. | Nahrungs- und therapeutische verwendung von hydroxyalkanoat oligomere |
US20020077269A1 (en) * | 2000-10-27 | 2002-06-20 | Whitehouse Robert S. | Alkanoic acid ester monomer compositions and methods of making same |
US6897338B2 (en) * | 2001-12-18 | 2005-05-24 | Metabolix, Inc. | Methods of making intermediates from polyhydroxyalkanoates |
AU2004245567B2 (en) * | 2003-06-03 | 2011-06-23 | Oxford University Innovation Limited | Nutritional supplements and therapeutic compositions comprising (R)-3-hydroxybutyrate derivatives |
GB0410266D0 (en) * | 2004-05-07 | 2004-06-09 | Ketocytonyx Inc | Treatment of apoptosis |
AU2009204370B2 (en) | 2008-01-04 | 2014-12-04 | Gvmt Of The Usa, As Represented By The Secretary, Department Of Health & Human Services | Ketone bodies and ketone body esters as blood lipid lowering agents |
CN102164884B (zh) * | 2008-08-21 | 2015-03-11 | 伊希斯创新有限公司 | 羟基丁酸酯及其医学用途 |
US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
RU2012132908A (ru) | 2010-02-11 | 2014-03-20 | Метаболикс, Инк. | Способ получения производных химических соединений |
GB201002983D0 (en) | 2010-02-22 | 2010-04-07 | Tdeltas Ltd | Nutritinal composition |
CA2922223C (en) | 2012-11-05 | 2021-11-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services And Human Services | Ketone bodies to protect tissues from damage by ionizing radiation |
GB201304467D0 (en) | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
GB2515603B (en) | 2013-03-14 | 2015-10-14 | Isis Innovation | Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate |
WO2017213999A1 (en) | 2016-06-07 | 2017-12-14 | The J. David Gladstone Institutes | Medium chain fatty acid esters of beta-hydroxybutyrate and butanediol and compositions and methods for using same |
US20180057846A1 (en) | 2016-08-30 | 2018-03-01 | KetoneAid Inc. | Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy |
BR112020001285A2 (pt) * | 2017-07-21 | 2020-07-28 | Buck Institute For Research On Aging | s-enantiômeros de beta-hidroxibutirato e butanodiol e métodos para sua utilização |
US11760963B2 (en) | 2017-08-23 | 2023-09-19 | KetoneAid Inc. | Ketogenic beer and alcoholic beverage mixture containing non-racemic ethyl 3-hydroxybutyrate and/or 1,3 butanediol |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2500312C2 (de) * | 1975-01-07 | 1984-01-19 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol-(1,3)-3-mono-(3'-hydroxybutyraten)sowie einige dieser Butandiol-(1,3)-3-mono-(3'-hydroxybutyrate) |
DE2500310C2 (de) * | 1975-01-07 | 1984-01-19 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol-(1,3)-1-mono-(3'-hydroxybutyraten)sowie einige dieser Butandiol-(1,3)-1-mono-(3'-hydroxybutyrate) |
FR2486072A1 (fr) | 1980-07-03 | 1982-01-08 | Solvay | Procede pour la fabrication de l'acide b-hydroxybutyrique et de ses oligocondensats |
US4574085A (en) * | 1981-05-15 | 1986-03-04 | Baxter Travenol Laboratories, Inc. | Method for using dialysis solution containing glycerol |
FR2521857B1 (fr) * | 1982-02-23 | 1985-10-31 | Solvay | Compositions pharmaceutiques contenant de l'acide 3-hydroxybutanoique ou un sel derive de cet acide et sels derives de l'acide 3-hydroxybutanoique et d'une base organique azotee |
AU6776887A (en) * | 1985-12-18 | 1987-07-15 | Veech, R.L. | Fluid therapy with l-lactate and/or pyruvate anions |
-
1987
- 1987-11-19 BE BE8701314A patent/BE1001209A3/fr not_active IP Right Cessation
-
1988
- 1988-11-08 AT AT88202492T patent/ATE65397T1/de active
- 1988-11-08 DE DE8888202492T patent/DE3863904D1/de not_active Expired - Fee Related
- 1988-11-08 ES ES198888202492T patent/ES2037818T3/es not_active Expired - Lifetime
- 1988-11-08 EP EP88202492A patent/EP0316993B1/de not_active Expired - Lifetime
- 1988-11-09 CA CA000582648A patent/CA1330307C/fr not_active Expired - Fee Related
- 1988-11-17 JP JP63291033A patent/JPH01160917A/ja active Pending
- 1988-11-18 DK DK644388A patent/DK168269B1/da not_active IP Right Cessation
-
1990
- 1990-08-15 US US07/568,546 patent/US5112865A/en not_active Expired - Fee Related
-
1991
- 1991-08-26 GR GR91400508T patent/GR3002605T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
BE1001209A3 (fr) | 1989-08-22 |
JPH01160917A (ja) | 1989-06-23 |
CA1330307C (fr) | 1994-06-21 |
GR3002605T3 (en) | 1993-01-25 |
DK644388D0 (da) | 1988-11-18 |
DK168269B1 (da) | 1994-03-07 |
EP0316993B1 (de) | 1991-07-24 |
DK644388A (da) | 1989-07-03 |
DE3863904D1 (de) | 1991-08-29 |
ES2037818T3 (es) | 1993-07-01 |
EP0316993A1 (de) | 1989-05-24 |
US5112865A (en) | 1992-05-12 |
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