AP887A - Novel 5-0-deoaminyl 6-0-methyl erythronolide a derivatives method for preparing same application thereof for preparing biologically active products. - Google Patents

Novel 5-0-deoaminyl 6-0-methyl erythronolide a derivatives method for preparing same application thereof for preparing biologically active products. Download PDF

Info

Publication number
AP887A
AP887A APAP/P/1998/001210A AP9801210A AP887A AP 887 A AP887 A AP 887A AP 9801210 A AP9801210 A AP 9801210A AP 887 A AP887 A AP 887A
Authority
AP
ARIPO
Prior art keywords
formula
radical
compound
methyl
carbon atoms
Prior art date
Application number
APAP/P/1998/001210A
Other languages
English (en)
Other versions
AP9801210A0 (en
Inventor
Alain Bonnet
Michel Delthil
Alain Mazurie
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9482423&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP887(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AP9801210A0 publication Critical patent/AP9801210A0/xx
Application granted granted Critical
Publication of AP887A publication Critical patent/AP887A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
APAP/P/1998/001210A 1995-09-11 1996-09-10 Novel 5-0-deoaminyl 6-0-methyl erythronolide a derivatives method for preparing same application thereof for preparing biologically active products. AP887A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9510601A FR2738571B1 (fr) 1995-09-11 1995-09-11 Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
PCT/FR1996/001384 WO1997010251A1 (fr) 1995-09-11 1996-09-10 Nouveaux derives de la 5-0-desosaminyl 6-0-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs

Publications (2)

Publication Number Publication Date
AP9801210A0 AP9801210A0 (en) 1998-03-31
AP887A true AP887A (en) 2000-11-10

Family

ID=9482423

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1998/001210A AP887A (en) 1995-09-11 1996-09-10 Novel 5-0-deoaminyl 6-0-methyl erythronolide a derivatives method for preparing same application thereof for preparing biologically active products.

Country Status (34)

Country Link
US (1) US5969161A (zh)
EP (1) EP0854880B1 (zh)
JP (1) JP4332218B2 (zh)
KR (1) KR100457755B1 (zh)
CN (2) CN1237069C (zh)
AP (1) AP887A (zh)
AR (1) AR004195A1 (zh)
AT (1) ATE266035T1 (zh)
AU (1) AU708811B2 (zh)
BG (1) BG63822B1 (zh)
BR (1) BR9610503A (zh)
CA (1) CA2228670C (zh)
CZ (3) CZ289945B6 (zh)
DE (1) DE69632405T2 (zh)
DK (1) DK0854880T3 (zh)
EA (1) EA000575B1 (zh)
EE (1) EE03774B1 (zh)
ES (1) ES2219698T3 (zh)
FR (1) FR2738571B1 (zh)
GE (1) GEP20022838B (zh)
HK (2) HK1016187A1 (zh)
HU (1) HU227565B1 (zh)
IL (1) IL123550A (zh)
MX (1) MX9801859A (zh)
NO (2) NO312678B1 (zh)
PL (1) PL183652B1 (zh)
PT (1) PT854880E (zh)
RO (1) RO120137B1 (zh)
SI (1) SI0854880T1 (zh)
SK (3) SK283690B6 (zh)
TR (1) TR199800438T1 (zh)
UA (1) UA53628C2 (zh)
WO (1) WO1997010251A1 (zh)
ZA (1) ZA966837B (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998009978A1 (en) * 1996-09-04 1998-03-12 Abbott Laboratories 6-o-substituted ketolides having antibacterial activity
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
US6034069A (en) * 1997-09-30 2000-03-07 Abbott Laboratories 3-'N-modified 6-O-substituted erythromycin ketolide derivatives having antibacterial activity
US6124269A (en) * 1997-10-29 2000-09-26 Abbott Laboratories 2-Halo-6-O-substituted ketolide derivatives
US6046171A (en) * 1997-10-29 2000-04-04 Abbott Laboratories 6,11-bridged erythromycin derivatives
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
US6420535B1 (en) 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
NZ535354A (en) * 2002-02-15 2008-01-31 Merckle Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US7064110B2 (en) * 2002-05-13 2006-06-20 Enanta Pharmaceuticals, Inc. 6-11 bicycle ketolide derivatives
US7129221B2 (en) * 2002-05-13 2006-10-31 Enanta Pharmaceuticals, Inc. 6,11-bicyclic erythromycin derivatives
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US6878691B2 (en) * 2002-05-13 2005-04-12 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
WO2005070918A1 (en) * 2002-05-13 2005-08-04 Enanta Pharmaceuticals, Inc. Process for the preparation of t-11 bicyclic erythromycin derivatives
US7135573B2 (en) * 2002-05-13 2006-11-14 Enanta Pharmaceuticals, Inc. Processes for the preparation of O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US6764998B1 (en) 2003-06-18 2004-07-20 Enanta Pharmaceuticals, Inc. 6,11-4C-bicyclic 9a-azalide derivatives
US6753318B1 (en) * 2002-07-25 2004-06-22 Enanta Pharmaceuticals, Inc. 6,11-4-carbon bridged erythromycin derivatives
ITMI20021726A1 (it) * 2002-08-01 2004-02-02 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
US6645941B1 (en) 2003-03-26 2003-11-11 Enanta Pharmaceuticals, Inc. 6,11-3C-bicyclic 9a-azalide derivatives
WO2005030227A1 (en) * 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
US7414030B2 (en) 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
KR100924610B1 (ko) 2004-12-07 2009-11-02 이난타 파마슈티칼스, 인코포레이티드 3,6-비시클롤리드
US7229972B2 (en) 2004-12-07 2007-06-12 Enanta Pharmaceuticals, Inc. 3,6-Bicyclolides
US7291602B2 (en) 2004-12-13 2007-11-06 Enanta Pharmaceuticals, Inc. 11,12-lactone bicyclolides
WO2006065743A2 (en) 2004-12-13 2006-06-22 Enanta Pharmaceuticals, Inc. Tetracylic bicyclolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
CN101228171A (zh) * 2005-07-26 2008-07-23 默克勒有限公司 作为5-脂氧化酶和环加氧酶抑制剂的吡咯里嗪和中氮茚化合物的大环内酯偶联物
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
CA2699733C (en) * 2007-09-17 2013-01-22 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
CN103232501A (zh) * 2013-04-11 2013-08-07 宜昌东阳光药业股份有限公司 阿奇霉素或阿奇霉素的中间体脱去克拉定糖化合物的制备工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272110A2 (en) * 1986-12-17 1988-06-22 Taisho Pharmaceutical Co. Ltd Erythromycin a derivatives and method for the preparation of the same
EP0619319A1 (en) * 1991-12-27 1994-10-12 Taisho Pharmaceutical Co. Ltd 5-0-desosaminylerythronolide derivative

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272110A2 (en) * 1986-12-17 1988-06-22 Taisho Pharmaceutical Co. Ltd Erythromycin a derivatives and method for the preparation of the same
EP0619319A1 (en) * 1991-12-27 1994-10-12 Taisho Pharmaceutical Co. Ltd 5-0-desosaminylerythronolide derivative
EP0619320A1 (en) * 1991-12-27 1994-10-12 Taisho Pharmaceutical Co. Ltd 5-o-desosaminylerythronolide derivative

Also Published As

Publication number Publication date
NO981053D0 (no) 1998-03-10
SK285995B6 (sk) 2008-01-07
AR004195A1 (es) 1998-11-04
JP4332218B2 (ja) 2009-09-16
CN1070498C (zh) 2001-09-05
UA53628C2 (uk) 2003-02-17
CZ294865B6 (cs) 2005-04-13
ATE266035T1 (de) 2004-05-15
EP0854880B1 (fr) 2004-05-06
IL123550A (en) 2002-09-12
HK1041489A1 (en) 2002-07-12
DK0854880T3 (da) 2004-08-16
CN1319602A (zh) 2001-10-31
SK29498A3 (en) 1998-12-02
IL123550A0 (en) 1998-10-30
EE03774B1 (et) 2002-06-17
ZA966837B (en) 1997-08-13
DE69632405D1 (de) 2004-06-09
AU6991096A (en) 1997-04-01
CZ294866B6 (cs) 2005-04-13
HUP9802930A3 (en) 1999-12-28
EE9800065A (et) 1998-08-17
PT854880E (pt) 2004-09-30
NO312678B1 (no) 2002-06-17
TR199800438T1 (xx) 1998-05-21
MX9801859A (es) 1998-11-30
BG102312A (en) 1998-09-30
FR2738571B1 (fr) 1997-10-17
AP9801210A0 (en) 1998-03-31
DE69632405T2 (de) 2005-05-19
WO1997010251A1 (fr) 1997-03-20
GEP20022838B (en) 2002-11-25
CN1237069C (zh) 2006-01-18
EA000575B1 (ru) 1999-12-29
PL183652B1 (pl) 2002-06-28
KR100457755B1 (ko) 2005-02-28
BR9610503A (pt) 1999-07-06
NO20021111D0 (no) 2002-03-06
SK283690B6 (sk) 2003-12-02
KR19990044543A (ko) 1999-06-25
NO315048B1 (no) 2003-06-30
RO120137B1 (ro) 2005-09-30
HU227565B1 (en) 2011-08-29
EP0854880A1 (fr) 1998-07-29
CZ289945B6 (cs) 2002-04-17
SI0854880T1 (en) 2004-12-31
HUP9802930A1 (hu) 1999-04-28
EA199800288A1 (ru) 1998-08-27
AU708811B2 (en) 1999-08-12
NO981053L (no) 1998-03-10
ES2219698T3 (es) 2004-12-01
CZ71798A3 (cs) 1998-07-15
JPH11512416A (ja) 1999-10-26
FR2738571A1 (fr) 1997-03-14
HK1016187A1 (en) 1999-10-29
NO20021111L (no) 1998-03-10
PL326274A1 (en) 1998-08-31
CA2228670A1 (fr) 1997-03-20
CN1201462A (zh) 1998-12-09
US5969161A (en) 1999-10-19
SK285853B6 (sk) 2007-09-06
CA2228670C (fr) 2005-04-12
BG63822B1 (bg) 2003-02-28
HK1041489B (zh) 2006-09-08

Similar Documents

Publication Publication Date Title
AP887A (en) Novel 5-0-deoaminyl 6-0-methyl erythronolide a derivatives method for preparing same application thereof for preparing biologically active products.
Baker et al. Modification of macrolide antibiotics. Synthesis of 11-deoxy-11-(carboxyamino)-6-O-methylerythromycin A 11, 12-(cyclic esters) via an intramolecular Michael reaction of O-carbamates with an. alpha.,. beta.-unsaturated ketone
RU2230748C2 (ru) Способ получения кларитромицина в виде кристаллов формы ii
EP0109253A2 (en) Epimeric azahomoerythromycin A derivative and intermediates therefor
EP0226202A2 (en) Synthesis of podophylotoxin type compounds
EP0496160B1 (en) Synthetic conversion of bryostatin 2 into bryostatin 1
HU193157B (en) Process for preparing 4"-epi-erythromycin a and derivatives thereof
EP0201166B1 (en) Erythromycin derivatives
EP0245013A1 (en) Erythromycin derivatives
EP0097925B1 (en) Tylosin derivatives, processes for their production and pharmaceutical compositions containing them
EP0202111B1 (en) Antibacterial mycaminosyl tylonolide derivatives and their production
WO2000015647A2 (en) Synthetic method for the preparation of the antineoplastic agent etoposide
JP2004536075A (ja) Ｏ−アリルエリスロマイシン誘導体を機能化するためのアリール化方法
EP0259496A1 (en) Derivatives of cervinomycin antibiotics and process for their preparation
EP0087915B1 (en) Semi-synthetic oleandomycins and erythromycins
El Khadem et al. Synthesis of 3-amino-2, 3, 6-trideoxy-d-ribo-and-l-lyxo-hexofuranoses suitable for nucleoside synthesis
US20050159371A1 (en) Process for producing erythromycin a derivative
AU2002357482B2 (en) Method for the production of desclarithromycin, and intermediate products
CA1128506A (en) Semi-synthetic 4"-erythromycin a derivatives
WO2005021567A1 (en) O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
JPH11116592A (ja) ４”−置換エリスロマイシンａ誘導体
JPS6360030B2 (zh)
HU211493A9 (en) Derivatives 10, 11, 12, 13-tetrahydrodesmycosin, processes for preparation and use thereof in pharmaceuticals
KR20010100197A (ko) 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
JPH07309889A (ja) 新規１６員環マクロリド誘導体及びそれらの新規製造法